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41. 发明专利

JPS60209522A Method of treating protozoan infection with novel antibiotic, compound and composition 失效
标题翻译：用新型抗生素，化合物和组合物治疗原生动物感染的方法
公开(公告)号：JPS60209522A
公开(公告)日：1985-10-22
申请号：JP5257385
申请日：1985-03-18
申请人： American Cyanamid Co
发明人： TAIKUWAN TAIKERU RII , DONARUDO BURUUSU BOODAAZU , JIYOSEFU JIEIKOBU GUTSUDOMAN , REIMONDO TOMASU TESUTA , UIRIAMU MAIKERU MEIESU , DEBITSUDO POORU RABEDA , SHIDONII KANTAA , ROBAATO RII KENETSUTO JIYUNIA , GAI TOMASU KAATAA
IPC分类号： A23K20/195 , A61K31/47 , A61P33/00 , A61P33/02 , C07D319/00 , C07D491/16 , C12P17/18 , C12R1/03
CPC分类号： C07D491/16 , A23K20/195 , C12P17/188 , C12R1/03

42. 发明专利

JPS5948084A Antitumor antibiotic substance 失效
标题翻译：抗菌药物
公开(公告)号：JPS5948084A
公开(公告)日：1984-03-19
申请号：JP13528483
申请日：1983-07-26
申请人： Bristol Mayers Kenkyusho Kk
发明人： KONISHI MASATAKA , SAKAI FUMIHIDE , MIYAGI TAKEO , KAWAGUCHI HIROSHI
IPC分类号： C12N1/20 , A61K35/74 , A61P35/00 , C07G11/00 , C07K14/005 , C07K14/195 , C07K14/41 , C12P1/06 , C12R1/03
CPC分类号： C12P1/06 , C12R1/03
摘要： NEW MATERIAL:The antibiotic substance having the following properties: Solubility, soluble in water, insoluble in methanol, ethanol, acetone, ethyl acetate, and n-hexane; infrared absorption spectrum, FIG.1; ultraviolet absorption spectrum, FIG.2; specific rotation, [α]
26 D=-75.6° in 0.25% aqueous solution; melting point, decomposes at ≥240°C; elemental analysis, C 46.6%, H 6.45%, N 13.34%, S 0.20%, O 33.41%; molecular weight, a polymeric peptide having a molecular weight of about 22,000; color reactions, decolors potassium permanganate solution, positive to Folin-Lawry, xanthoprotein, biuret, and ninhydrin reactions, and negative to anthrone and Sakaguchi reactions.
USE: Antibiotic substance BBM-1644 active to inhibit the proliferation of gram- positive and acid-fast bacteria, and inhibit the progress of P388 leukemia of mouse.
PROCESS: A BMM-1644-producing strain of Actinomadura species [e.g. Actinomadura H-710-49 (ATCC-39144)] is cultured in an aqueous medium containing assimilable C and N sources in an aerated deep-tank fermentor.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：具有以下特性的抗生素物质：溶解性，溶于水，不溶于甲醇，乙醇，丙酮，乙酸乙酯和正己烷; 红外吸收光谱，图1; 紫外吸收光谱，图2; 比旋光度，Δ26D= -75.6度。在0.25％水溶液中; 熔点在> = 240℃分解; 元素分析，C 46.6％，H 6.45％，N 13.34％，S 0.20％，O 33.41％; 分子量，分子量约22,000的聚合肽; 颜色反应，脱色高锰酸钾溶液，对Folin-Lawry，黄素蛋白，缩二脲和茚三酮反应呈阳性，对蒽酮和坂口反应呈阴性。用途：抗生素BBM-1644有效抑制革兰氏阳性和酸性细菌增殖，抑制小鼠P388白血病的进展。方法：产生BMM-1644的放线菌属物种[例如将Actinomadura H-710-49（ATCC-39144）]在含有可吸收的C和N源的含水培养基中培养在充气深槽发酵罐中。

43. 发明授权

US08476056B2 Thermotolerant actinomadura strain capable of degrading polyesters 有权
标题翻译：能降解聚酯的耐热放线菌素菌株
公开(公告)号：US08476056B2
公开(公告)日：2013-07-02
申请号：US12858492
申请日：2010-08-18
申请人： Kim-Chi Hoang , Shu-Feng Yang , Min Tseng , Gwo-Fang Yuan
发明人： Kim-Chi Hoang , Shu-Feng Yang , Min Tseng , Gwo-Fang Yuan
IPC分类号： C12N1/12
CPC分类号： C12N1/20 , C12P7/42 , C12R1/03
摘要： A new thermotolerant Actinomadura sp., which is capable of degrading polyesters, is provided. Compositions comprising the species for use in degrading polyesters are also provided. The invention also relates to methods for degrading polyesters by using the strain and the composition.
摘要翻译：提供了一种能够降解聚酯的新型耐热耐腐蚀剂Actinomadura sp。还提供了包含用于降解聚酯的物质的组合物。本发明还涉及通过使用菌株和组合物降解聚酯的方法。

44. 发明授权

US07666635B2 Process for the preparation of amides 失效
标题翻译：酰胺的制备方法
公开(公告)号：US07666635B2
公开(公告)日：2010-02-23
申请号：US11931639
申请日：2007-10-31
申请人： Karen Tracey Robins , Toru Nagasawa
发明人： Karen Tracey Robins , Toru Nagasawa
IPC分类号： C12P13/02 , C12N9/78 , C12N9/14 , C12N1/20
CPC分类号： C12N9/88 , C12N9/78 , C12P13/02 , C12R1/01 , C12R1/03 , Y10S435/822 , Y10S435/829
摘要： A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
摘要翻译：描述了从酰胺开始制备腈的新型生物技术方法。该方法采用无菌纲，放线菌属或红球菌属的微生物。

45. 发明申请

US20100028952A1 FERMENTATION AND PURIFICATION OF ACTINOMADURA CHROMOPROTEIN AND RELATED SPECIES 审中-公开
标题翻译： ACTINOMADURA CHROMOPROTEIN及相关物种的发酵和纯化
公开(公告)号：US20100028952A1
公开(公告)日：2010-02-04
申请号：US12305428
申请日：2007-06-21
申请人： Eugene Joseph Vidunas , Gow-Jen Tsai , Ping Cai , Justin Moran , Pamela Sue Fink , Lourdes Jeanette Gordon
发明人： Eugene Joseph Vidunas , Gow-Jen Tsai , Ping Cai , Justin Moran , Pamela Sue Fink , Lourdes Jeanette Gordon
IPC分类号： C12P21/00 , C12N1/20 , C07K1/00
CPC分类号： C07D413/12 , A61K47/6829 , A61K47/6849 , A61K47/6851 , C07K14/36 , C12N1/20 , C12P17/16 , C12R1/03
摘要： The present invention provides methods for production and purification of active chromoproteins produced by Actinomadura sp. 21G792. The chromoproteins are useful for developing pharmaceutical compositions and treating diseases such as cancer or bacterial infections.
摘要翻译：本发明提供了由Actinomadura sp。生产和生产活性色素的方法。 21G792。生色蛋白可用于开发药物组合物和治疗疾病如癌症或细菌感染。

46. 发明申请

US20030148478A1 Process for the preparation of amides 有权
标题翻译：酰胺的制备方法
公开(公告)号：US20030148478A1
公开(公告)日：2003-08-07
申请号：US10234088
申请日：2002-09-03
发明人： Karen Tracey Robins , Toru Nagasawa
IPC分类号： C12P013/02 , C12N009/16 , C12N001/12 , C12N001/20
CPC分类号： C12N9/88 , C12N9/78 , C12P13/02 , C12R1/01 , C12R1/03 , Y10S435/822 , Y10S435/829
摘要： A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
摘要翻译：描述了从酰胺开始制备腈的新型生物技术方法。该方法采用无菌纲，放线菌属或红球菌属的微生物。

47. 发明授权

US06444451B1 Process for preparing amides 有权
标题翻译：酰胺的制备方法
公开(公告)号：US06444451B1
公开(公告)日：2002-09-03
申请号：US09463203
申请日：2000-03-27
申请人： Karen Tracey Robins , Toru Nagasawa
发明人： Karen Tracey Robins , Toru Nagasawa
IPC分类号： C12P104
CPC分类号： C12N9/88 , C12N9/78 , C12P13/02 , C12R1/01 , C12R1/03 , Y10S435/822 , Y10S435/829
摘要： A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Microorganisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
摘要翻译：描述了从酰胺开始制备腈的新型生物技术方法。该过程采用无菌纲，放线菌属或红球菌属的微生物。

48. 发明授权

US5374552A Production of pradimicin antibiotics 失效
标题翻译：生产pradimicin抗生素
公开(公告)号：US5374552A
公开(公告)日：1994-12-20
申请号：US983959
申请日：1992-12-01
申请人： Tamotsu Furumai , Masami Hatori , Masatoshi Kakushima , Chiharu Ikeda , Yoichiro Saitoh , Seikichi Kobaru
发明人： Tamotsu Furumai , Masami Hatori , Masatoshi Kakushima , Chiharu Ikeda , Yoichiro Saitoh , Seikichi Kobaru
IPC分类号： C07H15/24 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , C07H15/244 , C12N1/20 , C12P19/56 , C12P29/00 , C12R1/03 , C12N1/12
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56 , Y10S435/825
摘要： The present invention relates to a fermentation process for producing BMY-28960 and desxylosyl BMY-28960, and to a novel BMY-28960-producing organism belonging to the genus Actinomadura and designated as strain AB 1236 (ATCC 55208).
摘要翻译：本发明涉及一种用于生产BMY-28960和脱木素基BMY-28960的发酵方法，以及属于Actinomadura属的命名为菌株AB1236（ATCC 55208）的新型BMY-28960产生生物体的发酵方法。

49. 发明授权

US5194371A Production of pradimicin antibiotics 失效
标题翻译：生产PRADIMICIN抗生素
公开(公告)号：US5194371A
公开(公告)日：1993-03-16
申请号：US739019
申请日：1991-07-31
申请人： Tamotsu Furumai , Masami Hatori , Masatoshi Kakushima , Chiharu Ikeda , Kyoichiro Saitoh , Seikichi Kobaru
发明人： Tamotsu Furumai , Masami Hatori , Masatoshi Kakushima , Chiharu Ikeda , Kyoichiro Saitoh , Seikichi Kobaru
IPC分类号： C07H15/24 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , C07H15/244 , C12N1/20 , C12P19/56 , C12P29/00 , C12R1/03
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56 , Y10S435/825
摘要： The present invention relates to a fermentation process for producing BMY-28960 and desxylosyl BMY-28960, and to a novel BMY-28960-producing organism belonging to the genus Actinomadura and designated as strain AB 1236 (ATCC 55208).

50. 发明授权

US5024950A Actinomadura fulva subsp indica 失效
公开(公告)号：US5024950A
公开(公告)日：1991-06-18
申请号：US460417
申请日：1990-01-03
申请人： Ann C Horan
发明人： Ann C Horan
IPC分类号： C07H17/02 , C12P19/60
CPC分类号： C12R1/03 , C07H17/02 , C12P19/60
摘要： A macrolactam disaccharide isolated from an antimicrobial complex 530 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva subsp. indica ATCC 53714.
摘要翻译：从在受控条件下的发酵中产生的抗微生物复合物530分离的大内酰胺二糖，其使用生物学纯培养物Actinomadura fulva subsp。 a ATCC 53714。

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