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1. 发明专利

JPH0641182A BBM-2, 478B ANTIBIOTIC 失效
公开(公告)号：JPH0641182A
公开(公告)日：1994-02-15
申请号：JP10714693
申请日：1993-03-30
申请人： BRISTOL MAYERS KENKYUSHO KK
发明人： KONISHI MASATAKA , SUGAWARA TAKAKO , MIYAGI TAKEO , KAWAGUCHI HIROSHI
IPC分类号： C12P19/46 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H17/04 , C12P19/60 , C12R1/01 , C12R1/04 , C12R1/465 , C12R1/52 , A61K31/71
摘要： PURPOSE:To provide a new antibiotic useful as an antimicrobial agent, for treating infectious diseases, disinfecting medical devices, etc., having strongly antimicrobial activity against aerobic Gram-positive bacteria and anaerobic bacteria. CONSTITUTION:Antibiotic BBM-2,478B of the formula. Properties: yellow amorphous powder. Melting point: 271-272 deg.C (decomposition). Analytical value (experimental value): C 63.07, H4.48. Molecular formula: C26H22O10. The antibiotic is obtained by culturing strain J907-21 (ATCC-39417) or its variant capable of producing BBM-2,478B in an aqueous nutritive medium containing an assimilable carbon and nitrogen sources under a submerged aerobic condition and collecting from the medium. The culture is preferably carried out by using a sterile tank at 27-32 deg.C in neutrality or at a pH close to neutrality for 6-7 days. In order to isolate the substance from the medium, mycelium cake separated from the medium is extracted with methanol and the supernatant liquid is extracted with n-butanol and the extracted solutions are purified by chromatography.

2. 发明专利

JPS5936678A Antitumor antibiotic 失效
标题翻译：抗生素抗生素
公开(公告)号：JPS5936678A
公开(公告)日：1984-02-28
申请号：JP13528383
申请日：1983-07-26
申请人： Bristol Mayers Kenkyusho Kk
发明人： HATORI MASAMI , OOKUMA HIROAKI , KONISHI MASATAKA , MIYAGI TAKEO , KAWAGUCHI HIROSHI
IPC分类号： A61K31/55 , A61P31/04 , A61P35/00 , C07D487/04 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D487/04 , C12P17/182 , C12R1/465 , Y10S435/886
摘要： NEW MATERIAL:Antibiotic MMB-2040A shown by the formula I and antibiotic BBM-2040B shown by the formula II. USE:An antibiotic and an antitumor agent. Inhibiting activities of Gram-positive bacteria and acid-fast bacteria, further inhibiting growth of tumor (e.g., leukemia P 338 of mouse). PROCESS:A bacterium[e.g., strain of Streptomyces sp. J 576-99 (ATCC 39143)] belonging to the genus Streptomyces, capable of producing BBM-2040 is cultivated under submerged aerobic conditions in an aqueous nutrient medium containing a source capable of assimilating carbon and nitrogen until a substantial amount of BBM-2040 is produced in the medium, and the use of methanol is avoided in the following extraction and chromatography purification operations, to give a compound shown by the formula II in a demethanol state. When methanol is used as an extraction solvent or eluting solvent, a compound shown by the formula I , an adduct of the compound shown by the formula II with methanol, is obtained.
摘要翻译：新材料：由式I表示的抗生素MMB-2040A和式II所示的抗生素BBM-2040B。用途：抗生素和抗肿瘤剂。抑制革兰氏阳性菌和耐酸细菌的活性，进一步抑制肿瘤的生长（例如小鼠的白血病P 338）。方法：细菌[例如，链霉菌属菌株能够产生BBM-2040的属于链霉菌属的J 576-99（ATCC 39143）]在浸没需氧条件下在含有能够吸收碳和氮的源的含水营养培养基中培养，直到大量的BBM-2040为在以下萃取和色谱纯化操作中避免使用甲醇，得到式II所示的化合物为脱甲醇状态。当使用甲醇作为萃取溶剂或洗脱溶剂时，得到由式I表示的化合物，式II化合物与甲醇的加合物。

3. 发明专利

JPH0576350A MICROORGANISM CAPABLE OF PRODUCING ANTITUMOR ANTIBIOTIC SUBSTANCE 失效
公开(公告)号：JPH0576350A
公开(公告)日：1993-03-30
申请号：JP30564391
申请日：1991-10-25
申请人： BRISTOL MAYERS KENKYUSHO KK
发明人： HATORI MASAMI , OKUMA HIROAKI , KONISHI MASATAKA , MIYAGI TAKEO , KAWAGUCHI HIROSHI
IPC分类号： A61K31/395 , A61K31/55 , A61P31/04 , A61P35/00 , C07D487/04 , C12N1/14 , C12N1/20 , C12P1/06 , C12P17/10 , C12P17/18 , C12R1/465
摘要： PURPOSE:To provide the subject microbial strain consisting of a biologically pure culture product of a microbial strain Streptomyces sp. ATCC 39143 and having antibacterial and antitumor activities. CONSTITUTION:The objective microorganism capable of producing an antitumor antibiotic substance is a biologically pure culture product of preferably microbial strain Streptomyces sp. ATCC 39143 capable of producing a collectable amount of an antibiotic substance BBM-2040 when cultured in an aqueous nutrient medium containing assimilable nitrogen and carbon sources.

4. 发明专利

JPH02128693A NOVEL ANTITUMOR ANTIBIOTIC COMPLEX BBM-1675 失效
公开(公告)号：JPH02128693A
公开(公告)日：1990-05-17
申请号：JP21600989
申请日：1989-08-24
申请人： BRISTOL MAYERS KENKYUSHO KK
发明人： KONISHI MASATAKA , SAITO KYOICHIRO , OKUMA HIROAKI , KAWAGUCHI HIROSHI
IPC分类号： A61K31/70 , A61K31/7024 , A61K31/7028 , A61K31/7034 , A61K35/74 , A61P31/04 , A61P35/00 , C07C235/16 , C07C235/28 , C07G11/00 , C07H11/00 , C07H13/08 , C07H15/203 , C12N1/20 , C12P1/02 , C12P1/06 , C12P19/44 , C12R1/03
摘要： NEW MATERIAL:An antibiotic BBM-1675A30 having the following characteristics: Solubility, soluble in acetone, ethanol, etc., slightly soluble in benzene and water and insoluble in n-hexane and carbon tetrachloride; color reaction, positive to ferric chloride and negative to ninhydrin reaction; estimated elementary composition (%): C 54.55, H 6.46, N 3.73, S 7.49 and O 27.77; activity, capable of suppressing growth of microorganism, inducing a prophage with a lysogenic bacterium and suppressing growth of mouse P-388 leukemia. USE:An antiulcer agent and antimicrobial agent. PREPARATION:Actinomadura verrucosospora strain H964-92 (ATCC 39334) is fermented and then is separated from a produced antibiotic complex.

5. 发明专利

JPS5963196A Antibiotic substance produced by fermentation of new strain of streptomyces hygroscopicus 失效
标题翻译：通过发酵新型水解酶抑制剂产生的抗生素
公开(公告)号：JPS5963196A
公开(公告)日：1984-04-10
申请号：JP14970683
申请日：1983-08-18
申请人： Bristol Mayers Kenkyusho Kk
发明人： HANADA MINORU , TSUNAKAWA MITSUAKI , TOMITA KOUJI , TSUKIURA HIROSHI , KAWAGUCHI HIROSHI
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/224 , C07H15/23 , C07H15/232 , C12P19/46 , C12P19/50 , C12P19/52 , C12R1/465
CPC分类号： C12R1/55 , C07H15/232 , C12P19/46 , C12P19/50 , C12P19/52
摘要： PURPOSE:A Bu-2695 antibiotic substance complex obtained by cultivating a strain of Streptomyces hygroscopicus having the identified characteristic of ATCC No. 39150 in an aqueous nutrient culture medium under aerobic conditions by the submerged culture method. CONSTITUTION:A strain of Streptomyces hygroscopicus No. J296-21 having the identified characteristic of ATCC No. 39150 is inoculated into an aqueous nutrient culture medium containing an assimilable carbon source, nitrogen source, nutrient inorganic salt and a very small amount of a heavy metal salt and cultivated aerobically at 5-10 pH and 20-43 deg.C for 4-7 days by the submerged culture method to produce a Bu-2659 complex consisting of Bu-2659A-E. The resultant complex is then separated into the components Bu-2659A, B, C, D and E if necessary by the chromatographic means.
摘要翻译：目的：通过在有氧条件下通过浸没培养法在含水营养培养基中培养具有鉴定特征的ATCC 39150特征的吸水链霉菌菌株获得的Bu-2695抗生素物质复合物。构成：将具有鉴定特征的ATCC No.39350的吸水链霉菌J296-21菌株接种到含有可同化碳源，氮源，营养无机盐和极少量重金属的含水营养培养基中盐，并通过浸没培养方法在5-10℃和20-43℃有氧培养4-7天以产生由Bu-2659A-E组成的Bu-2659复合物。然后，如果必要，通过色谱法将所得的复合物分离成组分Bu-2659A，B，C，D和E.

6. 发明专利

JPS5948084A Antitumor antibiotic substance 失效
标题翻译：抗菌药物
公开(公告)号：JPS5948084A
公开(公告)日：1984-03-19
申请号：JP13528483
申请日：1983-07-26
申请人： Bristol Mayers Kenkyusho Kk
发明人： KONISHI MASATAKA , SAKAI FUMIHIDE , MIYAGI TAKEO , KAWAGUCHI HIROSHI
IPC分类号： C12N1/20 , A61K35/74 , A61P35/00 , C07G11/00 , C07K14/005 , C07K14/195 , C07K14/41 , C12P1/06 , C12R1/03
CPC分类号： C12P1/06 , C12R1/03
摘要： NEW MATERIAL:The antibiotic substance having the following properties: Solubility, soluble in water, insoluble in methanol, ethanol, acetone, ethyl acetate, and n-hexane; infrared absorption spectrum, FIG.1; ultraviolet absorption spectrum, FIG.2; specific rotation, [α]
26 D=-75.6° in 0.25% aqueous solution; melting point, decomposes at ≥240°C; elemental analysis, C 46.6%, H 6.45%, N 13.34%, S 0.20%, O 33.41%; molecular weight, a polymeric peptide having a molecular weight of about 22,000; color reactions, decolors potassium permanganate solution, positive to Folin-Lawry, xanthoprotein, biuret, and ninhydrin reactions, and negative to anthrone and Sakaguchi reactions.
USE: Antibiotic substance BBM-1644 active to inhibit the proliferation of gram- positive and acid-fast bacteria, and inhibit the progress of P388 leukemia of mouse.
PROCESS: A BMM-1644-producing strain of Actinomadura species [e.g. Actinomadura H-710-49 (ATCC-39144)] is cultured in an aqueous medium containing assimilable C and N sources in an aerated deep-tank fermentor.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：具有以下特性的抗生素物质：溶解性，溶于水，不溶于甲醇，乙醇，丙酮，乙酸乙酯和正己烷; 红外吸收光谱，图1; 紫外吸收光谱，图2; 比旋光度，Δ26D= -75.6度。在0.25％水溶液中; 熔点在> = 240℃分解; 元素分析，C 46.6％，H 6.45％，N 13.34％，S 0.20％，O 33.41％; 分子量，分子量约22,000的聚合肽; 颜色反应，脱色高锰酸钾溶液，对Folin-Lawry，黄素蛋白，缩二脲和茚三酮反应呈阳性，对蒽酮和坂口反应呈阴性。用途：抗生素BBM-1644有效抑制革兰氏阳性和酸性细菌增殖，抑制小鼠P388白血病的进展。方法：产生BMM-1644的放线菌属物种[例如将Actinomadura H-710-49（ATCC-39144）]在含有可吸收的C和N源的含水培养基中培养在充气深槽发酵罐中。

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