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1. 发明申请

US20030124691A1 Method for producing amide compounds 失效
标题翻译：酰胺化合物的制备方法
公开(公告)号：US20030124691A1
公开(公告)日：2003-07-03
申请号：US10172569
申请日：2002-06-13
申请人： Daicel Chemical Industries, Ltd.
发明人： Tohru Nagasawa , Akinobu Matsuyama
IPC分类号： C12P013/02 , C12N001/21
CPC分类号： C12P13/02
摘要： An objective of the present invention is to provide a method for producing amide compounds. The present invention provides a method for producing amide compounds using a microorganism having a cyanide resistant-nitrile hydratase activity. Rhodococcus equi XL-1 can be mentioned as such microorganism. The enzymatic activity of this microorganism can be stably maintained during the reaction. The present invention provides a method for producing amide compounds, comprising the step of reacting the enzyme to nitrile compounds. According to the present invention, amide compounds can be biochemically efficiently produced from corresponding hydroxy nitrile compounds without reducing the enzyme activity.
摘要翻译：本发明的目的是提供一种制备酰胺化合物的方法。本发明提供使用具有氰化物抗性腈水合酶活性的微生物来生产酰胺化合物的方法。可以提及红球菌XL-1这样的微生物。在反应期间可以稳定地保持该微生物的酶活性。本发明提供了一种制备酰胺化合物的方法，包括使酶与腈化合物反应的步骤。根据本发明，酰胺化合物可以从相应的羟基腈化合物生物化学有效地制备而不降低酶的活性。

2. 发明申请

US20020160466A1 Process for producing amide compounds 有权
标题翻译：酰胺化合物的制备方法
公开(公告)号：US20020160466A1
公开(公告)日：2002-10-31
申请号：US09980102
申请日：2001-11-29
发明人： Takeya Abe , Kiyoshi Ito , Kenju Sasaki , Seiichi Watanabe , Toshihisa Tachibana , Tamotsu Asano
IPC分类号： C12P013/02
CPC分类号： C12N9/88 , C12P13/02
摘要： The invention is a process for continuously producing an amide compound by reacting a microorganism fungus body containing nitrile hydratase or a processed product of the microorganism fungus body with a nitrile compound in an aqueous medium, characterized in that after contacting said fungus body or said processed product of said fungus body with said nitrile compound in said aqueous medium, a reaction solution thus obtained is further subjected to reaction under conditions having a plug flow region, and according to the invention, an amide compound aqueous solution of a high concentration a high purity can be easily obtained in an extremely high conversion rate of a nitrile compound without a condensation process.
摘要翻译：本发明是一种通过含腈水合酶的微生物菌体或微生物真菌体的加工产物与腈化合物在水性介质中反应来连续生产酰胺化合物的方法，其特征在于，在使所述真菌体或所述加工产物的所述真菌体与所述腈化合物在所述水性介质中反应，得到的反应溶液在具有活塞流动区域的条件下进一步反应，根据本发明，高浓度高纯度的酰胺化合物水溶液可以容易地以非常高的腈化合物的转化率而不会产生冷凝过程。

3. 发明申请

US20030104586A1 Method of purifying amide compound 有权
标题翻译：酰胺化合物的纯化方法
公开(公告)号：US20030104586A1
公开(公告)日：2003-06-05
申请号：US09936514
申请日：2001-09-14
发明人： Takeya Abe , Kiyoshi Itou , Kenju Sasaki , Seiichi Watanabe , Tamotsu Asano
IPC分类号： C12P013/02 , C07C231/24
CPC分类号： C07C231/24 , C12P13/02
摘要： The invention is to provide a process for effectively removing impurities contained in an amide compound-containing solution by making an amide compound-containing solution, particularly an amide compound-containing solution produced by a hydration reaction of a nitrile compound by using a microorganism fungus body containing nitrile hydratase or a processed product of the microorganism fungus body, in contact with activated carbon under acidic conditions.
摘要翻译：本发明提供一种通过使用含有酰胺化合物的溶液，特别是通过腈化合物的水合反应产生的含酰胺化合物的溶液，通过使用微生物真菌体来有效地除去含酰胺化合物的溶液中所含的杂质的方法含有腈水合酶或微生物真菌体的加工产物，在酸性条件下与活性炭接触。

4. 发明申请

US20020012977A1 Enzymatic oxidations 失效
标题翻译：酶促氧化
公开(公告)号：US20020012977A1
公开(公告)日：2002-01-31
申请号：US09867347
申请日：2001-05-29
发明人： Michael Stephen Pacey
IPC分类号： C12P013/00 , C12P013/02 , C12P017/00
CPC分类号： C07D405/14 , C07D231/52 , C07D239/52 , C07D239/69 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14
摘要： The following invention relates to a process for oxidizing alkyl groups attached directly or via a linker, to a sulfonamide moiety (II) by the use of cytochrome P450 enzymes, to give the corresponding alcohol or carboxylic acid (I). 1 wherein R is an organic radical, X is a linker, Y is nullC(CH3)2null or nullCH(CH3)null and Z is nullCH2OH or nullCOOH.
摘要翻译：以下发明涉及通过使用细胞色素P450酶将直接或通过连接基连接的烷基氧化成磺酰胺部分（II）的方法，得到相应的醇或羧酸（I）。其中R是有机基团，X是连接基，Y是-C（CH 3）2 - 或-CH（CH 3） - ，Z是-CH 2 OH或-COOH。

5. 发明申请

US20030157671A1 Process for the preparation of aniline-derived thyroid receptor ligands 失效
公开(公告)号：US20030157671A1
公开(公告)日：2003-08-21
申请号：US10273268
申请日：2002-10-17
发明人： Ramakrishnan Chidambaram , Joydeep Kant , Raymond E. Weaver , Jurong Yu , Arun Ghosh
IPC分类号： C12P013/02 , C07C233/45
CPC分类号： C07C309/65 , C07C45/00 , C07C201/12 , C07C205/12 , C07C205/37 , C07C205/38 , C07C205/43 , C07C213/02 , C07C231/02 , C07C233/25 , C07C309/24 , C07C47/575 , C07C217/90
摘要： Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.

6. 发明申请

US20030059905A1 Multistage process for the preparation of highly pure deferoxamine mesylate salt 失效
标题翻译：用于制备高纯度去铁胺甲磺酸盐的多步法
公开(公告)号：US20030059905A1
公开(公告)日：2003-03-27
申请号：US10168042
申请日：2002-06-18
发明人： Vilmos Keri , Zoltan Czovek , Attila Mezo
IPC分类号： C12P013/02 , C12P013/00 , B01D015/08
CPC分类号： C07C259/06
摘要： The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate salt by precipitation. This process minimizes decomposition of deferoxamine B.
摘要翻译：本发明提供了一种纯化方法，其中由微生物产生的去铁胺B与由微生物产生的其它多羟基羟胺化合物混合可以转化为基本上不含其它多羟基异羟酸酯并基本上不含氯离子的甲磺酸盐。该方法包括去铁胺B在吸附树脂上的吸附和解吸，从吸附树脂中将脱铁胺游离碱从洗脱液中直接沉淀出，脱铁胺B游离碱与甲磺酸接触，并通过以下步骤分离去铁胺B甲磺酸盐：沉淀。该方法使去铁胺B的分解最小化

7. 发明申请

US20040048348A1 Process for producing amide compound using microbial catalyst 有权
标题翻译：使用微生物催化剂生产酰胺化合物的方法
公开(公告)号：US20040048348A1
公开(公告)日：2004-03-11
申请号：US10450532
申请日：2003-06-20
发明人： Kozo Murao , Katsuo Ishii
IPC分类号： C12P013/02
CPC分类号： C12P17/12 , C12P13/02
摘要： This invention relates to a process for producing an amide compound from a nitrile compound using a microbial catalyst, wherein a microbial cell having nitrile hydratase activity of 50 U or higher per mg of dry cell at a reaction temperature of 10null C. is brought into contact with a nitrile compound in an aqueous medium without being immobilized. This method utilizes a microbial cell that exhibits high nitrile hydratase activity in the reaction without being entrap-immobilized. Thus, an amide compound can be effectively produced from a nitrile compound without problems of decreased reaction speed or lowered amount produced per unit cell amount, which are caused by entrap-immobilization. Accordingly, an amide compound can be produced within a very short period of time in the case of a batch reaction and with a very small-scale facility in the case of a continuous reaction.
摘要翻译：本发明涉及一种使用微生物催化剂从腈化合物制备酰胺化合物的方法，其中将在10℃的反应温度下每毫克干细胞的腈水合酶活性为50U或更高的微生物细胞进入在水性介质中与腈化合物接触而不固定。该方法利用在反应中表现出高腈水合酶活性的微生物细胞，而不被夹带固定。因此，可以从腈化合物有效地制备酰胺化合物，而不会由于捕获固定而引起的反应速度降低或每单位电池量产生的量降低的问题。因此，在间歇反应的情况下，在连续反应的情况下，能够在非常短的时间内生成酰胺化合物。

8. 发明申请

US20030068789A1 Method for cultivating microorganism 有权
标题翻译：培养微生物的方法
公开(公告)号：US20030068789A1
公开(公告)日：2003-04-10
申请号：US10221200
申请日：2002-09-23
发明人： Koichiro Ryuno , Etsuko Kobayashi
IPC分类号： C12P013/02 , C12N001/20
CPC分类号： C12N9/88 , C12N1/32
摘要： In cultivating a microorganism having nitrile hydratase production ability, by allowing at least one of a ketose, such as fructose, and a sugar alcohol, such as mannitol, to be present, growth inhibition by cobalt ion is prevented, thereby achieving cultivation at a high concentration and with a high activity.
摘要翻译：在培养具有腈水合酶生产能力的微生物时，通过使至少一种酮糖例如果糖和糖醇如甘露糖醇存在，可以防止由钴离子引起的生长抑制，从而实现高的培养浓度高，活性高。

9. 发明申请

US20020137153A1 Enantioselective production of amino carboxylic acids 审中-公开
标题翻译：对映选择性生产氨基羧酸
公开(公告)号：US20020137153A1
公开(公告)日：2002-09-26
申请号：US09972186
申请日：2001-10-04
发明人： Sandra W. Ramer , Gjalt Huisman , Jim Millis , Roger Sheldon , Stephen delCardayre , Matthew Tobin , Anthony Cox , S. Christopher Davis
IPC分类号： C12P013/02 , C12N009/78
CPC分类号： C12P13/04 , C12N9/88 , C12P13/02 , C12P41/006
摘要： Enantioselective or enantiospecific nitrilases and nitrile hydratases are used to produce R or S enantiomers of amides, and carboxylic acids. R-amino acids and S-amino acids are produced using such enantioselective enzymes. In addition, methods of producing and screening enantioselective nitrilases and nitrile hydratases are provided.
摘要翻译：对映选择性或对映体特异性腈水解酶和腈水合酶用于产生酰胺和羧酸的R或S对映异构体。使用这种对映选择性酶产生R-氨基酸和S-氨基酸。另外，提供了生产和筛选对映选择性腈水解酶和腈水合酶的方法。

10. 发明申请

US20020042108A1 Process for preparing optically active 1-amino-4-(hydroxymethyl) cyclopent -2- ene derivatives 失效
标题翻译：光学活性1-氨基-4-（羟甲基）环戊-2-烯衍生物的制备方法
公开(公告)号：US20020042108A1
公开(公告)日：2002-04-11
申请号：US09888068
申请日：2001-06-22
申请人： LONZA AG
发明人： Walter Brieden , Kay-Sara Etter , Michael Petersen
IPC分类号： C12P013/02
CPC分类号： C12P41/004 , C12P13/02
摘要： The invention discloses a new method for producing enantiomer-enriched 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives of the general formulae (I) and (II) in which R1 is hydrogen or a possibly substituted C1-8 alkyl rest, aryl rest or cycloalkyl rest and R2 is a possibly substituted acyl. According to said method a racemic 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivative of general formula (III), in which R1 has the meaning given above, is converted using a hydrolase and in the presence of an acylation agent. 1
摘要翻译：本发明公开了一种制备通式（I）和（II）的对映体富集的1-氨基-4-（羟甲基） - 环戊-2-烯衍生物的新方法，其中R 1是氢或可能被取代的C 1-8 烷基，芳基或环烷基，R2是可能被取代的酰基。根据所述方法，使用水解酶并在酰化存在下转化通式（III）的外消旋1-氨基-4-（羟甲基） - 环戊-2-烯衍生物，其中R 1具有上述含义代理商

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