专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20180355297A1 NANONEEDLES FOR INTRACELLULAR APPLICATIONS 审中-公开
公开(公告)号：US20180355297A1
公开(公告)日：2018-12-13
申请号：US16066724
申请日：2017-01-03
申请人： KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人： Jürgen KOSEL , Mincho Nikolaev KAVALDZHIEV , Jose Efrain PEREZ
IPC分类号： C12M1/26 , C12M1/00 , B81B1/00
CPC分类号： C12M1/26 , A61B5/685 , A61B10/0045 , A61B10/0233 , A61B2010/0225 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B81B1/008 , B81B2201/055 , B81C1/00111 , B82Y5/00 , C12M23/20
摘要： Nanoneedles and nanoneedle arrays and methods of making nanoneedles are provided. The methods can include multilayer fabrication methods using a negative photoresist and/or a positive photoresist. The nanoneedle arrays include one or more nanoneedles attached to a surface of a substrate. The nanoneedle can have both a proximal opening and a distal opening, and an inner passageway connecting the proximal opening and the distal opening. The nanoneedle can have a functional coating. The nanoneedle can include iron, cobalt, nickel, gold, and oxides and alloys thereof. The nanoneedle arrays can be used for the administration and/or the extraction of agents from individual cells. In one or more aspects, the nanoneedles can be magnetic nanoneedles. An oscillating magnetic field applied to a magnetic nanoneedle can induce one or both of heating and vibration of the magnetic nanoneedle. The heating and/or vibration can cause a magnetic nanoneedle to penetrate the wall of a cell.

42. 发明授权

US07695550B2 Structured membrane with controllable permeability 有权
标题翻译：具有可控渗透性的结构膜
公开(公告)号：US07695550B2
公开(公告)日：2010-04-13
申请号：US11460901
申请日：2006-07-28
申请人： Thomas Nikita Krupenkin , Victor Alexander Lifton , Joseph Ashley Taylor , Brijesh Vyas
发明人： Thomas Nikita Krupenkin , Victor Alexander Lifton , Joseph Ashley Taylor , Brijesh Vyas
IPC分类号： B01D53/22
CPC分类号： B01D69/06 , B81B1/008 , B82Y30/00
摘要： An apparatus that comprises a membrane having a plurality of fluid-support-structures and openings located between the fluid-support-structures. The fluid-support-structures have at least one dimension that that is about 1 millimeter or less. The apparatus also comprises a wicking material positioned adjacent to a surface of the membrane. When a fluid locatable on a surface of the fluid-support-structures penetrates the fluid-support-structures, at least a portion of the fluid passes through the openings and into the wicking material.
摘要翻译：一种装置，其包括具有位于流体支撑结构之间的多个流体支撑结构和开口的膜。流体支撑结构具有至少一个尺寸约为1毫米或更小的尺寸。该装置还包括位于膜表面附近的芯吸材料。当可定位在流体支撑结构的表面上的流体穿透流体支撑结构时，至少一部分流体通过开口并进入芯吸材料。

43. 发明授权

US07105812B2 Microfluidic chip with enhanced tip for stable electrospray ionization 失效
标题翻译：具有增强尖端的微流控芯片，用于稳定的电喷雾电离
公开(公告)号：US07105812B2
公开(公告)日：2006-09-12
申请号：US10871498
申请日：2004-06-18
申请人： Mingqi Zhao , Iuliu Blaga , Luc Bousse , John Stults , Jing Ni
发明人： Mingqi Zhao , Iuliu Blaga , Luc Bousse , John Stults , Jing Ni
IPC分类号： H01J49/04 , B01D59/44
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502715 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/027 , B81B1/008 , B81B2201/058 , G01N27/44717 , H01J49/0018
摘要： A microfluidic chip formed with multiple fluid channels terminating at a tapered electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels may terminate at an open-tip region of the electrospray tip. A covering plate may substantially enclose most portions of the fluid channels formed on the channel plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a tapered electrospray tip having an open-tip region.
摘要翻译：微流体芯片形成有多个流体通道，终止于锥形电喷雾离子化尖端，用于质谱分析。流体通道可以形成在与相应的储存器流体连通的通道板上。电喷雾尖端可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。流体通道可以终止于电喷雾尖端的开口尖端区域。覆盖板可以基本上封闭形成在通道板上的除了开口尖端区域之外的流体通道的大部分。本发明的另一方面提供了在单个微流体芯片中流过单个流体通道的多个样品进行质谱分析的方法，所述单个微流体芯片由具有开口尖端区域的锥形电喷雾尖端形成。

44. 发明申请

US20050269743A1 Nanostructured surfaces having variable permeability 有权
标题翻译：具有可变渗透性的纳米结构表面
公开(公告)号：US20050269743A1
公开(公告)日：2005-12-08
申请号：US10835639
申请日：2004-04-30
申请人： Timofei Kroupenkine , Mary Mandich , Joseph Taylor
发明人： Timofei Kroupenkine , Mary Mandich , Joseph Taylor
IPC分类号： B01D67/00 , B01D69/06 , B81B1/00 , B82B1/00 , C03C17/00 , H01M2/36 , B29C53/04 , B29C55/02
CPC分类号： B01D69/06 , B81B1/008 , B82Y30/00
摘要： A nanostructured substrate is disclosed having a plurality of substrate openings disposed between the nanostructures on the substrate. When a desired fluid comes into contact with the substrate, at least a portion of the fluid is allowed to pass through at least one of the openings. In a first embodiment, the fluid is caused to pass through the openings by causing the fluid to penetrate the nanostructures. In a second embodiment, the substrate is a flexible substrate so that when a mechanical force is applied to the substrate, such as a bending or stretching force, the distance between nanoposts or the diameter of nanocells on the substrate increases and the liquid penetrates the nanostructures. In another embodiment, a first fluid, such as water, is prevented from penetrating the nanostructures on the substrate while a second fluid is permitted to pass through the substrate via the openings in the substrate.
摘要翻译：公开了一种纳米结构化衬底，其具有设置在衬底上的纳米结构之间的多个衬底开口。当期望的流体与基底接触时，允许至少一部分流体通过至少一个开口。在第一实施例中，通过使流体穿透纳米结构，使流体通过开口。在第二实施例中，衬底是柔性衬底，使得当机械力施加到衬底（例如弯曲或拉伸力）时，纳米孔之间的距离或衬底上的纳米细胞的直径增加，液体渗透纳米结构。在另一个实施例中，防止第一流体（例如水）穿过基板上的纳米结构，同时允许第二流体经由基板中的开口穿过基板。

45. 发明授权

US06862925B2 Device for contacting and/or modifying a surface having a cantilever and a method for production of said cantilever 失效
标题翻译：用于接触和/或改变具有悬臂的表面的装置和用于生产所述悬臂的方法
公开(公告)号：US06862925B2
公开(公告)日：2005-03-08
申请号：US10672940
申请日：2003-09-26
申请人： Michel Desponet , Ute Drechsler , Mark I. Lutwyche , Hugo E. Rothuizen , Peter Vettiger
发明人： Michel Desponet , Ute Drechsler , Mark I. Lutwyche , Hugo E. Rothuizen , Peter Vettiger
IPC分类号： B81B1/00 , B81B3/00 , G01Q20/00 , G01Q70/16 , G11B9/00 , G11B11/00 , H01L21/00 , G01B5/28
CPC分类号： B81B1/008 , B81B3/0035 , G11B9/1409 , G11B9/1427 , G11B11/007 , G11B2005/0021
摘要： A device for contacting and/or modifying a surface having a cantilever connected to an almost plane carrier element staying apart from said surface, said cantilever having a tip at its loose end being in close contact to said surface. It is proposed that the cantilever stand out of the plane of said carrier element. Further, a method for producing the cantilever having a tip at its loose end. The device is suitable for thermomechanical writing and thermal readout of binary information, lithographic and imaging techniques, and for surface modification.
摘要翻译：一种用于接触和/或改变表面的装置，其具有连接到与所述表面分开的几乎平面的载体元件的悬臂，所述悬臂在其松动端具有尖端，与所述表面紧密接触。建议悬臂从所述载体元件的平面外突出。此外，一种制造悬臂的方法，其在其松动端具有尖端。该器件适用于二元信息的热机械写入和热读出，光刻和成像技术以及表面改性。

46. 发明授权

US06777227B2 Bio-reactor and cell culture surface with microgeometric surfaces 失效
公开(公告)号：US06777227B2
公开(公告)日：2004-08-17
申请号：US10338076
申请日：2003-01-07
申请人： John L. Ricci , Harold Alexander , John Grew
发明人： John L. Ricci , Harold Alexander , John Grew
IPC分类号： C12M124
CPC分类号： B81B1/008 , B01L3/5085 , C12M23/12 , C12M35/00
摘要： A bioreactor or cell culture surface comprises a multiplicity of microwells appearing, upon enlargement in the range of 200 to 1000 magnifications, as a honeycomb structure consisting of a plurality of rows of irregular hexagons, each having a transverse x-axis, a longitudinal y-axis, and a z-axis which defines a height of each microwell. Co-parallel major bases define the directionality of anticipated cell growth, while pairs of equilateral minor bases define the x-axis width of each microwell. An arrow-like geometry is defined by the equilateral pairs of minor bases which also define an x-axis separation between opposing major bases of the hexagon to induce cell growth directionality. An acute angle exists between the members of the arrow-like pairs of minor bases, while an obtuse angle exists between contiguous major and minor bases.

47. 发明申请

US20040113068A1 Multi-channel microfluidic chip for electrospray ionization 失效
公开(公告)号：US20040113068A1
公开(公告)日：2004-06-17
申请号：US10649350
申请日：2003-08-26
申请人： Biospect Inc.
发明人： Luc Bousse , John T. Stults
IPC分类号： H01J049/04
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502715 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/027 , B81B1/008 , B81B2201/058 , G01N27/44717 , H01J49/0018
摘要： A microfluidic chip formed with multiple fluid channels terminating at a common electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed within a substrate plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined portion of the substrate plate, wherein the electrospray tip includes an open-tip region at which the fluid channels converge. A top laminate plate may substantially enclose most portions of the fluid channels formed in the bottom polymer plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a convergent electrospray tip. The convergent electrospray tip includes an open or exposed distal pointed tip region.

48. 发明申请

US20040107770A1 Device for contacting and/or modifying a surface having a cantilever and a method for production of said cantilever 失效
标题翻译：用于接触和/或改变具有悬臂的表面的装置和用于生产所述悬臂的方法
公开(公告)号：US20040107770A1
公开(公告)日：2004-06-10
申请号：US10672940
申请日：2003-09-26
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION
发明人： Michel Despont , Ute Drechsler , Mark I. Lutwyche , Hugo E. Rothuizen , Peter Vettiger
IPC分类号： G12B021/00 , G11B033/00
CPC分类号： B81B1/008 , B81B3/0035 , G11B9/1409 , G11B9/1427 , G11B11/007 , G11B2005/0021
摘要： A device for contacting and/or modifying a surface having a cantilever connected to an almost plane carrier element staying apart from said surface, said cantilever having a tip at its loose end being in close contact to said surface. It is proposed that the cantilever stand out of the plane of said carrier element. Further, a method for producing the cantilever having a tip at its loose end. The device is suitable for thermomechanical writing and thermal readout of binary information, lithographic and imaging techniques, and for surface modification.
摘要翻译：一种用于接触和/或改变表面的装置，其具有连接到与所述表面分开的几乎平面的载体元件的悬臂，所述悬臂在其松动端具有尖端，与所述表面紧密接触。建议悬臂从所述载体元件的平面外突出。此外，一种制造悬臂的方法，其在其松动端具有尖端。该器件适用于二元信息的热机械写入和热读出，光刻和成像技术以及表面改性。

49. 发明授权

US06647766B2 Device for contacting and/or modifying a surface having a cantilever and a method for production of said cantilever 有权
标题翻译：用于接触和/或改变具有悬臂的表面的装置和用于生产所述悬臂的方法
公开(公告)号：US06647766B2
公开(公告)日：2003-11-18
申请号：US09745273
申请日：2000-12-20
申请人： Michel Despont , Ute Drechsler , Mark I. Lutwyche , Hugo E. Rothuizen , Peter Vettiger
发明人： Michel Despont , Ute Drechsler , Mark I. Lutwyche , Hugo E. Rothuizen , Peter Vettiger
IPC分类号： H01L2100
CPC分类号： B81B1/008 , B81B3/0035 , G11B9/1409 , G11B9/1427 , G11B11/007 , G11B2005/0021
摘要： A device for contacting and/or modifying a surface having a cantilever connected to an almost plane carrier element staying apart from said surface, said cantilever having a tip at its loose end being in close contact to said surface. It is proposed that the cantilever stand out of the plane of said carrier element. Further, a method for producing the cantilever having a tip at its loose end. The device is suitable for thermomechanical writing and thermal readout of binary information, lithographic and imaging techniques, and for surface modification.
摘要翻译：一种用于接触和/或改变表面的装置，其具有连接到与所述表面分开的几乎平面的载体元件的悬臂，所述悬臂在其松动端具有尖端，与所述表面紧密接触。建议悬臂从所述载体元件的平面外突出。此外，一种制造悬臂的方法，其在其松动端具有尖端。该器件适用于二元信息的热机械写入和热读出，光刻和成像技术以及表面改性。

50. 发明授权

EP2598591B1 HAFTVERSCHLUSSTEIL 有权
公开(公告)号：EP2598591B1
公开(公告)日：2017-09-06
申请号：EP11730919.5
申请日：2011-07-08
申请人： Gottlieb Binder GmbH & Co. KG
发明人： TUMA, Jan
IPC分类号： C09J7/00 , A44B18/00 , B81B1/00
CPC分类号： A44B18/0088 , A44B18/0065 , A44B18/0069 , B81B1/008 , C09J7/00 , C09J2201/626 , Y10T24/27

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式