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    • 50. 再颁专利
    • Method of treatment of glutathione deficient mammals
    • 谷胱甘肽缺乏型哺乳动物的治疗方法
    • USRE40849E1
    • 2009-07-14
    • US11651446
    • 2007-01-09
    • Robert H. KellerDavid W. Kirchenbaum
    • Robert H. KellerDavid W. Kirchenbaum
    • A01N37/18A61K38/02
    • A61K31/197A23L33/105A23L33/12A23L33/15A23L33/175A23V2002/00A61K31/375A61K31/70Y10S530/833A61K31/195A61K31/385A61K31/35A61K2300/00A23V2250/0616A23V2250/708A23V2250/026A23V2250/2116A23V2250/062A23V2250/54252A23V2250/206A23V2250/1866A23V2250/02A23V2250/032A23V2250/044A23V2250/51084A23V2250/5118A23V2250/1628A23V2250/161A23V2250/1886
    • Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intracellulary either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels. The disclosure is also of a unique combination of nutritional supplements including n-acetyl cysteine, vitamin C, l-glucosamine, n-acetyl d-glucosamine, quercitin, sylimarin, Alpha lipoic acid and high protein, low fat whey that are combined to support various bodily systems involved in glutathione synthesis, reutilization and storage; all intended to elevate glutathione concentration in the mammalian cell.
    • 谷胱甘肽(GSH)是一种极其重要的三肽作为催化剂,还原剂和反应物。 通过与亲电子试剂形成直接络合物(通过诸如溴苯或马来酸二乙酯的试剂研究性地进行),可以通过抑制合成,或通过使细胞经受氧化应激来消耗细胞内。 除上皮细胞外,大多数细胞不具有完整GSH的直接运输能力。 非上皮细胞必须运输GSH合成的前体底物或循环GSH的补救氨基酸,以在细胞内再合成中重新使用。 膳食半胱氨酸是用于合成谷胱甘肽的速率限制底物,并且还抑制GSH流出。 虽然GSH在几乎所有的细胞中由前体合成,但肝脏是血浆GSH的主要来源。 肝功能的保护和支持对于提高GSH水平至关重要。 本公开还包括营养补充剂的独特组合,所述营养补充剂包括正乙酰半胱氨酸,维生素C,l-葡糖胺,正乙酰基d-葡糖胺,槲皮素,西来林,α-硫辛酸和高蛋白,低脂乳清,其组合成支持 涉及谷胱甘肽合成,再利用和储存的各种身体系统; 所有这些都旨在提高哺乳动物细胞中的谷胱甘肽浓度。