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41. 发明授权

US6080396A Anthracycline compound derivative and pharmaceutical preparation containing the same 失效
标题翻译：蒽环类化合物衍生物和含有它们的药物制剂
公开(公告)号：US6080396A
公开(公告)日：2000-06-27
申请号：US836965
申请日：1997-08-18
申请人： Masayuki Yokoyama , Kazunori Kataoka , Teruo Okano , Yasuhisa Sakurai , Shigeto Fukushima , Ryuji Uehara , Tomoko Akutsu , Kazuya Okamoto , Hiroko Mashiba , Megumi Machida , Kazuhisa Shimizu
发明人： Masayuki Yokoyama , Kazunori Kataoka , Teruo Okano , Yasuhisa Sakurai , Shigeto Fukushima , Ryuji Uehara , Tomoko Akutsu , Kazuya Okamoto , Hiroko Mashiba , Megumi Machida , Kazuhisa Shimizu
IPC分类号： A61K9/107 , A61K9/51 , A61K9/127 , A61K31/70 , C07M17/08
CPC分类号： A61K9/1075
摘要： A dimer, trimer or tetramer of an anthracycline compound which can be obtained by directly, chemically bonding anthracycline compounds having anticancer activities to each other by an alkali treatment. A high molecular block copolymer-drug complex pharmaceutical preparation in which the high molecular block copolymer having a hydrophilic polymer segment and a hydrophobic polymer segment forms a micelle having the hydrophilic segment as its outer shell and contains in its hydrophobic inner core a dimer, trimer or tetramer of anthracycline compound alone or together with other drugs. A high molecular block copolymer-drug complex pharmaceutical preparation in which the high molecular block copolymer having a hydrophilic polymer segment and a hydrophobic polymer segment forms a micelle having the hydrophilic segment as its outer shell and contains in its hydrophobic inner core an anthracycline anticancer agent, wherein, when the pharmaceutical preparation is intravenously administered to a CDF1 mouse, the amount of the anthracycline anticancer agent in 1 ml of the mouse blood plasma after 1 hour of its administration becomes 10 (% of dose/ml) or more, provided that the amount of anthracycline anticancer agent in the administered preparation is defined as 100. The aforementioned pharmaceutical preparations have high drug effects and low toxicities.
摘要翻译： PCT No.PCT / JP96 / 02789第 371日期：1997年8月18日 102（e）日期1997年8月18日PCT提交1996年9月26日PCT公布。公开号WO97 / 12895 日期1997年04月10日可以通过碱处理直接化学键合具有抗癌活性的蒽环类化合物而获得的蒽环类化合物的二聚体，三聚体或四聚体。一种高分子嵌段共聚物 - 药物复合药物制剂，其中具有亲水性聚合物链段和疏水性聚合物链段的高分子嵌段共聚物形成具有亲水链段作为其外壳的胶束，并且在其疏水内核中含有二聚体，三聚体或蒽环类化合物的四聚体单独或与其他药物一起。一种高分子嵌段共聚物 - 药物复合药物制剂，其中具有亲水性聚合物链段和疏水性聚合物链段的高分子嵌段共聚物形成具有亲水链段作为其外壳并在其疏水内核中含有蒽环类抗癌剂的胶束，其中，当向CDF1小鼠静脉内施用药物制剂时，在施用1小时后1ml小鼠血浆中的蒽环类抗癌剂的量为10（％/剂量）以上，条件是给药制剂中蒽环类抗癌剂的量定义为100.上述药物制剂具有高药物作用和低毒性。

42. 发明授权

US5929451A Symmetric magnetic doublet for charged particle beam lithography 失效
标题翻译：用于带电粒子束光刻的对称磁双曲
公开(公告)号：US5929451A
公开(公告)日：1999-07-27
申请号：US041977
申请日：1998-03-13
申请人： Shin-Ichi Kojima , Kazuya Okamoto
发明人： Shin-Ichi Kojima , Kazuya Okamoto
IPC分类号： G03F7/20 , H01J37/141 , H01J37/30 , H01J37/305 , H01L21/027
CPC分类号： H01J37/3007 , H01J2237/3175
摘要： Symmetric magnetic doublets are disclosed that image a reticle onto a sensitized substrate using a charged-particle beam. The symmetric magnetic doublet comprises an object-side lens and an image-side lens and satisfies certain quantitative conditions. If the object-side lens has a length S.sub.1 and pole-piece apertures of radii R.sub.1, R.sub.2, and the image-side lens has a length S.sub.2 and pole-piece apertures of radii R.sub.3, R.sub.4, then a lens according to an embodiment of the invention produces a demagnification of 1/m in an object-image distance L between the reticle and the substrate. This embodiment satisfies the relations R.sub.3 =R.sub.2 /m, R.sub.4 =R.sub.1 /m, S.sub.2 =S.sub.1 /m, and ##EQU1##
摘要翻译：公开了使用带电粒子束将掩模版图像到致敏基底上的对称磁性双峰。对称磁性双层包括物体侧透镜和图像侧透镜，并且满足一定的定量条件。如果物体侧透镜具有长度S1和半径R1，R2的极片孔径，并且图像侧透镜具有半径R3，R4的长度S2和极片孔径，则根据实施例的透镜本发明在掩模版和基板之间的物象距离L中产生1 / m的缩小。该实施例满足R3 = R2 / m，R4 = R1 / m，S2 = S1 / m的关系

43. 发明授权

US5894221A Magnetic resonance diagnostic apparatus 失效
公开(公告)号：US5894221A
公开(公告)日：1999-04-13
申请号：US909948
申请日：1997-08-12
申请人： Hidehiro Watanabe , Kazuya Okamoto , Koichi Oshio
发明人： Hidehiro Watanabe , Kazuya Okamoto , Koichi Oshio
IPC分类号： G01R33/483 , G01V3/00
CPC分类号： G01R33/4833
摘要： In an improved INEPT pulse sequence, an excitation pulse, a refocus pulse and an excitation pulse are sequentially applied for .sup.1 H spins. A refocus pulse and an excitation pulse are sequentially applied for .sup.13 C spins that are spin--spin coupled with the .sup.1 H spins. A magnetic resonance signal is acquired from .sup.1 H spins or .sup.13 C spins. The second refocus pulse for .sup.1 H is applied as a slice selective pulse at a time different from the time the first refocus pulse for .sup.13 C is applied. This allows localization to be achieved without adversely affecting the flip angle of the first refocus pulse for .sup.13 C.

44. 发明授权

US08865907B2 Method of producing pyrone and pyridone derivatives 有权
标题翻译：吡喃酮和吡啶酮衍生物的制备方法
公开(公告)号：US08865907B2
公开(公告)日：2014-10-21
申请号：US13260063
申请日：2010-03-26
申请人： Yukihito Sumino , Kazuya Okamoto , Moriyasu Masui , Toshiyuki Akiyama
发明人： Yukihito Sumino , Kazuya Okamoto , Moriyasu Masui , Toshiyuki Akiyama
IPC分类号： C07D213/79 , C07D213/80 , C07D471/04 , C07D309/32 , C07D405/06 , C07D498/14
CPC分类号： C07D498/14 , C07D213/80 , C07D309/32 , C07D309/40 , C07D405/06 , C07D471/04 , C07D471/14
摘要： The present invention provides a pyrone derivative and a pyridone derivative, which are novel intermediates for synthesizing an anti-influenza drug, a method of producing the same, and a method of using the same.
摘要翻译：本发明提供了作为合成抗流感药物的新中间体的吡喃酮衍生物和吡啶酮衍生物，其制造方法及其使用方法。

45. 发明授权

US08841911B2 RF coil assembly for MRI using differently shaped and/or sized coils 有权
标题翻译：用于MRI的RF线圈组件使用不同形状和/或尺寸的线圈
公开(公告)号：US08841911B2
公开(公告)日：2014-09-23
申请号：US13405699
申请日：2012-02-27
申请人： Kazuya Okamoto , Shinji Mitsui , Manabu Ishii
发明人： Kazuya Okamoto , Shinji Mitsui , Manabu Ishii
IPC分类号： G01V3/00 , G01R33/3415
CPC分类号： G01R33/3415
摘要： A radio frequency coil assembly is provided that includes a first radio frequency coil for receiving a magnetic resonance signal from a tested body; a second radio frequency coil for receiving a magnetic resonance signal from the tested body; and a third radio frequency coil for receiving a magnetic resonance signal from the tested body and having a shape that is different from that of at least one of the first and second radio frequency coils so as to increase local sensitivity in an image-picked-up region.
摘要翻译：提供了一种射频线圈组件，其包括用于从测试体接收磁共振信号的第一射频线圈; 第二射频线圈，用于从所测试的身体接收磁共振信号; 以及第三射频线圈，用于从所测试的身体接收磁共振信号，并具有不同于第一和第二射频线圈中的至少一个的形状，以增加拍摄的图像中的局部灵敏度地区。

46. 发明申请

US20130274915A1 Transport Method and Transport Apparatus 审中-公开
标题翻译：运输方式和运输设备
公开(公告)号：US20130274915A1
公开(公告)日：2013-10-17
申请号：US13916149
申请日：2013-06-12
申请人： Hidehiro Maeda , Kazuya Okamoto , Yasuaki Tanaka
发明人： Hidehiro Maeda , Kazuya Okamoto , Yasuaki Tanaka
IPC分类号： H01L21/677
CPC分类号： H01L21/677 , H01L21/67092 , H01L21/67259 , H01L21/68 , H01L24/34 , H01L2924/00014 , Y10T156/10 , H01L2224/37099 , H01L2224/84
摘要： Provided is a transport method comprising judging whether there is a possibility that misalignment greater than or equal to a threshold value occurs between substrates to be layered that are held by a pair of substrate holders aligned and stacked by an aligning section, the misalignment occurring when the pair of substrate holders is transported from the aligning section to a pressure applying section; and if the judgment indicates that there is the possibility of misalignment, transporting the pair of substrate holders to a region other than the pressure applying section. Whether there is the possibility of misalignment may be judged based on acceleration of the substrate holders. Whether there is the possibility of misalignment may be judged based on acceleration of a transporting section that transports the substrate holders. Whether there is the possibility of misalignment may be judged based on relative positions of the substrate holders. Whether there is the possibility of misalignment may be judged based on relative positions of (i) a transporting section that transports the pair of substrate holders and (ii) one of the pair of substrate holders.
摘要翻译：提供了一种传送方法，包括判断是否存在由被对准部对准和堆叠的一对基板保持器保持的要分层的基板之间的大于或等于阈值的偏移的可能性，一对基板支架从对准部分输送到压力施加部分; 并且如果判断表示存在不对准的可能性，则将一对基板保持器传送到除压力施加部以外的区域。可以基于基板保持器的加速度判断是否存在未对准的可能性。可以基于输送基板保持器的输送部的加速度判断是否存在未对准的可能性。可以基于基板保持器的相对位置来判断是否存在未对准的可能性。可以基于（i）输送一对基板保持器的输送部和（ii）一对基板保持件中的一个的相对位置来判断是否存在未对准的可能性。

47. 发明授权

US08489227B2 Transport method and transport apparatus 有权
标题翻译：运输方式和运输设备
公开(公告)号：US08489227B2
公开(公告)日：2013-07-16
申请号：US13548287
申请日：2012-07-13
申请人： Hidehiro Maeda , Kazuya Okamoto , Yasuaki Tanaka
发明人： Hidehiro Maeda , Kazuya Okamoto , Yasuaki Tanaka
IPC分类号： G06F7/00 , G06F19/00 , H01L21/68 , H01L23/544 , B29C65/00 , G01B11/00
CPC分类号： H01L21/677 , H01L21/67092 , H01L21/67259 , H01L21/68 , H01L24/34 , H01L2924/00014 , Y10T156/10 , H01L2224/37099 , H01L2224/84
摘要： Provided is a transport method comprising judging whether there is a possibility that misalignment greater than or equal to a threshold value occurs between substrates to be layered that are held by a pair of substrate holders aligned and stacked by an aligning section, the misalignment occurring when the pair of substrate holders is transported from the aligning section to a pressure applying section; and if the judgment indicates that there is the possibility of misalignment, transporting the pair of substrate holders to a region other than the pressure applying section. Whether there is the possibility of misalignment may be judged based on at least one of an acceleration of the substrate holders, an acceleration of a transporting section that transports the substrate holders, relative positions of the substrate holders, or relative positions of the transporting section and one of the pair of substrate holders.
摘要翻译：提供了一种传送方法，包括判断是否存在由被对准部对准和堆叠的一对基板保持器保持的要分层的基板之间的大于或等于阈值的偏移的可能性，一对基板支架从对准部分输送到压力施加部分; 并且如果判断表示存在不对准的可能性，则将一对基板保持器传送到除压力施加部以外的区域。是否存在未对准的可能性可以基于基板保持器的加速度，输送基板保持器的输送部分的加速度，基板保持器的相对位置或输送部分的相对位置和一对基板支架之一。

48. 发明申请

US20120053905A1 DESIGN WORKFLOW CONSTRUCTION APPARATUS, DESIGN WORKFLOW CONSTRUCTION METHOD, DESIGN SYSTEM, DESIGN METHOD, DESIGN WORKFLOW CONSTRUCTION PROGRAM, AND COMPUTER READABLE RECORDING MEDIUM IN WHICH DESIGN WORKFLOW CONSTRUCTION PROGRAM IS STORED 有权
标题翻译：设计工作流施工设备，设计工作流程施工方法，设计系统，设计方法，设计工作流程构造程序和设计工作流程构建程序存储的计算机可读记录介质
公开(公告)号：US20120053905A1
公开(公告)日：2012-03-01
申请号：US13201854
申请日：2010-02-16
申请人： Yoshiharu Iwata , Ryohei Satoh , Keiji Kudo , Atsushi Taya , Kazuya Okamoto , Hidenori Murata , Koichiro Atsumi , Eiji Arai , Eiji Morinaga
发明人： Yoshiharu Iwata , Ryohei Satoh , Keiji Kudo , Atsushi Taya , Kazuya Okamoto , Hidenori Murata , Koichiro Atsumi , Eiji Arai , Eiji Morinaga
IPC分类号： G06F17/50
CPC分类号： G06Q10/06 , G06Q10/0633
摘要： A design system (1) is provided with a function of acquiring a design specification of an object to be designed and an evaluation index for evaluating a value of the object to be designed in the design specification; a function of acquiring profile data of the object to be designed; a function (design order determining section (12)) of extracting entity design elements and important design variables from the profile data and prioritizing the entity design elements and the important design variables so as to construct a design workflow; a function (evaluation approach construction section (13)) of constructing an evaluation formula for performance/evaluation of a design result of each of the entity design elements in conformity with the design workflow; a function of finding an appropriate solution by performing automatic optimization while evaluating the design result with use of the evaluation index in accordance with the design workflow with which the evaluation formula is associated; and a function of outputting the appropriate solution thus found. This allows the object to be designed to be parametrically handled, and makes it possible to create a design workflow for efficiently finding an optimum design solution by properly combining a series of design elements and to find an appropriate solution with the use of the design workflow.
摘要翻译：设计系统（1）具有获取要设计的对象的设计规范和评估设计规范中要设计的对象的值的评估指标的功能; 获取要设计的对象的简档数据的功能; 从简档数据中提取实体设计元素和重要设计变量的功能（设计顺序确定部分（12）），并对实体设计元素和重要设计变量进行优先排序，从而构建设计工作流程; （评估方法构建部（13）），其根据设计工作流程构建用于对每个实体设计元素的设计结果进行性能/评估的评估公式; 通过根据与评估公式相关联的设计工作流程使用评估指数来评估设计结果，通过执行自动优化来找到适当的解决方案的功能; 以及输出由此找到的适当解决方案的功能。这允许将对象设计为参数化处理，并且可以创建设计工作流，以通过适当地组合一系列设计元素来有效地找到最佳设计解决方案，并使用设计工作流程找到适当的解决方案。

49. 发明申请

US20110227571A1 MAGNETIC RESONANCE IMAGING APPARATUS 有权
标题翻译：磁共振成像装置
公开(公告)号：US20110227571A1
公开(公告)日：2011-09-22
申请号：US13048314
申请日：2011-03-15
申请人： Takahiro Sekiguchi , Koji Akita , Toshiyuki Nakanishi , Kazuya Okamoto , Sojuro Kato
发明人： Takahiro Sekiguchi , Koji Akita , Toshiyuki Nakanishi , Kazuya Okamoto , Sojuro Kato
IPC分类号： G01R33/44
CPC分类号： G01R33/3692 , G01R33/3607
摘要： According to one embodiment, a apparatus includes a coil, a clock generator, an echo transmitter, a carrier generator, a clock transmitter, a regenerator, an receiver, a reconstructor, a detector, and a controller. The echo transmitter generates and transmits an echo transmission signal synchronously with a clock signal generated by the clock generator to wirelessly transmit an echo signal output from the col. The carrier generator generates a carrier signal have a frequency within a variable range. The clock transmitter wirelessly transmits a clock transmission signal. The regenerator regenerates the clock signal based on the transmitted clock transmission signal. The receiver extracts the echo signal synchronously with the regenerated clock signal from the transmitted echo transmission signal. The detector detects a frequency of an interference wave. The controller controls the carrier generator to generate the carrier signal having a frequency which comparatively small interference with respect to the detected frequency.
摘要翻译：根据一个实施例，一种装置包括线圈，时钟发生器，回波发射器，载波发生器，时钟发射器，再生器，接收器，重建器，检测器和控制器。回波发射机与由时钟发生器产生的时钟信号同步地生成和发送回波发送信号，以无线地发送从该列输出的回波信号。载波发生器产生具有可变范围内的频率的载波信号。时钟发射机无线传输时钟传输信号。再生器基于发送的时钟传输信号再生时钟信号。接收机从发送的回波发送信号中与再生的时钟信号同步地提取回波信号。检测器检测到干扰波的频率。控制器控制载波发生器以产生具有相对于检测到的频率具有相对小的干扰的频率的载波信号。

50. 发明申请

US20110155327A1 Adhesive Injection Device 有权
标题翻译：粘合剂注射装置
公开(公告)号：US20110155327A1
公开(公告)日：2011-06-30
申请号：US12936879
申请日：2009-04-07
申请人： Masahisa Higashi , Hideki Okamoto , Eisaku Nakao , Kazuya Okamoto
发明人： Masahisa Higashi , Hideki Okamoto , Eisaku Nakao , Kazuya Okamoto
IPC分类号： B32B37/12 , B32B37/02 , B32B37/10
CPC分类号： H01L21/67313 , H01L21/67092 , H01L21/6715 , H01L23/3107 , H01L25/50 , H01L2225/06513 , H01L2924/0002 , Y10T156/17 , Y10T156/1798 , H01L2924/00
摘要： Provided is an adhesive injection device for injecting an adhesive between the substrates of laminates which each comprise at least two substrates that face each other. The adhesive injection device is provided with: a cassette which holds multiple laminates aligned along the direction of lamination of the substrates; and an adhesive injector which injects adhesive into each inter-substrate space, as the laminates are being held in the cassette, so that the actions of injecting the adhesive into each inter-substrate space overlap chronologically. Holding multiple laminates in the cassette makes it possible to treat the multiple laminates as a unit. By injecting adhesive into each inter-substrate space, as the laminates are being held, so that the actions of injecting the adhesive into each inter-substrate space overlap chronologically, the injection of adhesive into multiple laminates is simplified, and the time required for injection can be reduced.
摘要翻译：提供了一种用于在层压体的基板之间注入粘合剂的粘合剂注入装置，其各自包括彼此相对的至少两个基板。粘合剂注入装置设置有：保持沿着基板的层压方向对准的多个层压体的盒; 以及粘合剂注入器，当粘合剂被保持在盒中时，粘合剂将粘合剂注射到每个基板间空间中，使得将粘合剂注入每个基板间空间的动作按时间顺序重叠。在盒子中保持多个层压板可以将多个层压板作为一个单元处理。通过将粘合剂注入到每个基板间空间中，当层压体被保持时，使得将粘合剂注入每个基板间空间的动作按时间顺序重叠，将粘合剂注入多个层压板中被简化，并且注入所需的时间可以减少

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