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41. 发明授权

US5589396A Coatings with controlled porosity and chemical properties 失效
标题翻译：具有控制孔隙率和化学性质的涂层
公开(公告)号：US5589396A
公开(公告)日：1996-12-31
申请号：US11518
申请日：1993-02-01
申请人： Gregory C. Frye , C. Jeffrey Brinker , Daniel H. Doughty , Thomas Bein , Karin Moller
发明人： Gregory C. Frye , C. Jeffrey Brinker , Daniel H. Doughty , Thomas Bein , Karin Moller
IPC分类号： B01D53/02 , B01D53/04 , G01N27/00 , G01N29/02 , G01N30/00
CPC分类号： G01N29/022 , B01D53/02 , B01D2253/106 , B01D2253/112 , B01D2253/308 , G01N2291/0255 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N30/00 , Y10S95/902
摘要： Coatings and sensors having both steric and chemical selectivity. Controlled porosity provides the steric selectivity, whereas chemically tailored film properties, using controlled composition or modification by coupling agents, chemical species replacement, or chemical species within pores, provide the chemical selectivity. Single or multiple layers may be provided.
摘要翻译：具有空间和化学选择性的涂料和传感器。受控孔隙度提供空间选择性，而使用受控组合物或通过偶联剂，化学物质置换或孔内化学物质进行改性的化学定制膜性质提供了化学选择性。可以提供单层或多层。

42. 发明授权

US5306445A Inorganic volumetric light source excited by ultraviolet light 失效
标题翻译：紫外线激发的无机体光源
公开(公告)号：US5306445A
公开(公告)日：1994-04-26
申请号：US884445
申请日：1992-05-18
申请人： Scott Reed , Robert J. Walko , Carol S. Ashley , C. Jeffrey Brinker
发明人： Scott Reed , Robert J. Walko , Carol S. Ashley , C. Jeffrey Brinker
IPC分类号： C09K11/04 , G21G4/00
CPC分类号： C09K11/04
摘要： The invention relates to a composition for the volumetric generation of radiation. The composition comprises a porous substrate loaded with a component capable of emitting radiation upon interaction with an exciting radiation. Preferably, the composition is an aerogel substrate loaded with a component, e.g., a phosphor, capable of interacting with exciting radiation of a first energy, e.g., ultraviolet light, to produce radiation of a second energy, e.g., visible light.
摘要翻译：本发明涉及用于辐射体积产生的组合物。所述组合物包含负载有与激发辐射相互作用时能够发射辐射的组分的多孔基材。优选地，组合物是装载有能够与例如紫外光的第一能量的激发辐射相互作用的组分（例如磷光体）的气凝胶基质，以产生例如可见光的第二能量的辐射。

43. 发明授权

US5078919A Composition containing aerogel substrate loaded with tritium 失效
标题翻译：含有装载有氚的气凝胶基质的组合物
公开(公告)号：US5078919A
公开(公告)日：1992-01-07
申请号：US495578
申请日：1990-03-20
申请人： Carol S. Ashley , C. Jeffrey Brinker , Robert E. Ellefson , John T. Gill , Scott Reed , Robert J. Walko
发明人： Carol S. Ashley , C. Jeffrey Brinker , Robert E. Ellefson , John T. Gill , Scott Reed , Robert J. Walko
IPC分类号： C09K11/04
CPC分类号： C09K11/04
摘要： The invention provides a process for loading an aerogel substrate with tritium and the resultant compositions. According to the process, an aerogel substrate is hydrolyzed so that surface OH groups are formed. The hydrolyzed aerogel is then subjected to tritium exchange employing, for example, a tritium-containing gas, whereby tritium atoms replace H atoms of surface OH groups. OH and/or CH groups of residual alcohol present in the aerogel may also undergo tritium exchange.
摘要翻译：本发明提供了一种用氚填充气凝胶基质和所得组合物的方法。根据该方法，将气凝胶基材水解，形成表面OH基。然后使用例如含氚气体对水解气凝胶进行氚交换，由此氚原子代替表面OH基团的H原子。存在于气凝胶中的OH和/或CH基的残余醇也可以进行氚交换。

44. 发明授权

US4652467A Inorganic-polymer-derived dielectric films 失效
标题翻译：无机聚合物衍生的介电膜
公开(公告)号：US4652467A
公开(公告)日：1987-03-24
申请号：US704697
申请日：1985-02-25
申请人： C. Jeffrey Brinker , Keith D. Keefer , Patrick M. Lenahan
发明人： C. Jeffrey Brinker , Keith D. Keefer , Patrick M. Lenahan
IPC分类号： B05D5/12 , C08G79/00 , C09D4/00 , H01B3/30 , H01L21/312 , B05D5/06 , B05D7/24
CPC分类号： B05D5/12 , C08G79/00 , C09D4/00 , H01B3/30 , H01L21/3121
摘要： A method of coating a substrate with a thin film of a polymer of predetermined porosity comprises depositing the thin film on the substrate from a non-gelled solution comprising at least one hydrolyzable metal alkoxide of a polymeric network forming cation, water, an alcohol compatible with the hydrolysis and the polymerization of the metal alkoxide, and an acid or a base, prior to depositing the film, controlling the structure of the polymer for a given composition of the solution exclusive of the acid or base component and the water component, (a) by adjusting each of the water content, the pH, and the temperature to obtain the desired concentration of alkoxide, and then adjusting the time of standing of the solution prior to lowering the temperature of the solution, and (b) lowering the temperature of the solution after the time of standing to about 15 degrees C. or lower to trap the solution in a state in which, after the depositing step, a coating of the desired porosity will be obtained, and curing the deposited film at a temperature effective for curing whereby there is obtained a thin film of a polymer of a predetermined porosity and corresponding pore size on the substrate.
摘要翻译：用预定孔隙率的聚合物的薄膜涂覆基材的方法包括从包含至少一种形成阳离子的聚合物网络的水解性金属醇盐的非胶凝溶液沉积薄膜，水，与在沉积膜之前金属醇盐和酸或碱的水解和聚合控制聚合物的结构，用于给定不含酸或碱组分和水组分的溶液的组合物（a ），通过调节每个水含量，pH和温度以获得所需的醇盐浓度，然后在降低溶液温度之前调节溶液的静置时间，和（b）降低溶液的温度该溶液在静置至约15℃或更低时将该溶液捕获到其中在沉积步骤之后，所需孔隙率的涂层将为o 获得并在有效固化的温度下固化沉积的膜，从而获得在基材上具有预定孔隙率和相应孔径的聚合物的薄膜。

45. 发明申请

US20210386055A1 Metal-organic Framework-Assisted Cryopreservation of Red Blood-Cells 有权
公开(公告)号：US20210386055A1
公开(公告)日：2021-12-16
申请号：US17309152
申请日：2019-10-30
申请人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
发明人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
IPC分类号： A01N1/02 , B01J20/22 , B01J20/28
摘要： Zr-based MOF NPs for cryopreservation of cells including, for example, red blood cells.

46. 发明申请

US20210315822A1 BIOMIMETIC REBUILDING OF MULTIFUNCTIONAL RED BLOOD CELLS 有权
公开(公告)号：US20210315822A1
公开(公告)日：2021-10-14
申请号：US17264452
申请日：2019-07-30
申请人： Jimin Guo , C. Jeffrey Brinker , Jacob Ongudi Agola
发明人： Jimin Guo , C. Jeffrey Brinker , Jacob Ongudi Agola
IPC分类号： A61K9/127 , C12N5/078 , A61K35/18 , A61K47/69
摘要： Methods of preparing red blood cell mimetics and functionalized red blood cell mimetics, and methods of making and using those mimetics, are provided.

47. 发明授权

US10969364B1 Innovative nanopore sequencing technology including a self-assembled porous membrane 有权
公开(公告)号：US10969364B1
公开(公告)日：2021-04-06
申请号：US15896843
申请日：2018-02-14
申请人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
发明人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
IPC分类号： G01N27/447 , B01L3/00 , C12Q1/6869
摘要： Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

48. 发明申请

US20140301951A1 POROUS NANOPARTICLE SUPPORTED LIPID NANOSTRUCTURES 审中-公开
标题翻译：多孔纳米粒子支持的脂质纳米结构
公开(公告)号：US20140301951A1
公开(公告)日：2014-10-09
申请号：US14253030
申请日：2014-04-15
申请人： Juewen Liu , C. Jeffrey Brinker , Carlee Ashley , Eric C. Carnes
发明人： Juewen Liu , C. Jeffrey Brinker , Carlee Ashley , Eric C. Carnes
IPC分类号： A61K9/127 , A61K39/395 , A61K33/06 , A61K49/00 , A61K33/00 , A61K33/24 , A61K38/16 , A61K31/713
CPC分类号： A61K9/127 , A61K9/1272 , A61K9/5115 , A61K9/5123 , A61K31/713 , A61K33/00 , A61K33/06 , A61K33/24 , A61K38/16 , A61K39/3955 , A61K49/005
摘要： Various exemplary embodiments provide protocell nanostructures and methods for constructing and using the protocell nanostructures. In one embodiment, the protocell nanostructures can include a core-shell structure including a porous particle core surrounded by a shell of lipid bilayer(s). The protocell can be internalized in a bioactive cell. Various cargo components, for example, drugs, can be loaded in and released from the porous particle core of the protocell(s) and then delivered within the bioactive cell.
摘要翻译：各种示例性实施方案提供了用于构建和使用原细胞纳米结构的原细胞纳米结构和方法。在一个实施方案中，原细胞纳米结构可以包括核 - 壳结构，其包括被脂质双层的壳包围的多孔颗粒核。原细胞可以内化在生物活性细胞中。可以将各种货物组分，例如药物装载在原细胞的多孔颗粒核心中并从其释放，然后在生物活性细胞内递送。

49. 发明授权

US06495352B1 Sol-gel method for encapsulating molecules 有权
标题翻译：用于封装分子的溶胶 - 凝胶法
公开(公告)号：US06495352B1
公开(公告)日：2002-12-17
申请号：US09548638
申请日：2000-04-13
申请人： C. Jeffrey Brinker , Carol S. Ashley , Rimple Bhatia , Anup K. Singh
发明人： C. Jeffrey Brinker , Carol S. Ashley , Rimple Bhatia , Anup K. Singh
IPC分类号： C12N1114
CPC分类号： C12N11/14 , Y10S436/815 , Y10S436/829
摘要： A method for encapsulating organic molecules, and in particular, biomolecules using sol-gel chemistry. A silica sol is prepared from an aqueous alkali metal silicate solution, such as a mixture of silicon dioxide and sodium or potassium oxide in water. The pH is adjusted to a suitably low value to stabilize the sol by minimizing the rate of siloxane condensation, thereby allowing storage stability of the sol prior to gelation. The organic molecules, generally in solution, is then added with the organic molecules being encapsulated in the sol matrix. After aging, either a thin film can be prepared or a gel can be formed with the encapsulated molecules. Depending upon the acid used, pH, and other processing conditions, the gelation time can be from one minute up to several days. In the method of the present invention, no alcohols are generated as by-products during the sol-gel and encapsulation steps. The organic molecules can be added at any desired pH value, where the pH value is generally chosen to achieve the desired reactivity of the organic molecules. The method of the present invention thereby presents a sufficiently mild encapsulation method to retain a significant portion of the activity of the biomolecules, compared with the activity of the biomolecules in free solution.
摘要翻译：一种封装有机分子的方法，特别是使用溶胶 - 凝胶化学的生物分子。二氧化硅溶胶由碱金属硅酸盐水溶液如二氧化硅和氧化钠在水中的混合物制备。通过使硅氧烷缩合的速度最小化，将pH调节到适当的低值以稳定溶胶，由此允许在凝胶化之前溶胶的储存稳定性。然后通常在溶液中的有机分子加入被包封在溶胶基质中的有机分子。老化后，可以制备薄膜或用封装的分子形成凝胶。根据使用的酸，pH和其他加工条件，凝胶化时间可以从一分钟到几天。在本发明的方法中，在溶胶 - 凝胶和包封步骤期间不产生作为副产物的醇。有机分子可以以任何所需的pH值加入，其中通常选择pH值以实现有机分子的所需反应性。因此，与游离溶液中的生物分子的活性相比，本发明的方法提供了足够温和的包封方法以保持生物分子的活性的显着部分。

50. 发明授权

US5565142A Preparation of high porosity xerogels by chemical surface modification. 失效
标题翻译：通过化学表面改性制备高孔隙率干凝胶。
公开(公告)号：US5565142A
公开(公告)日：1996-10-15
申请号：US55069
申请日：1993-04-28
申请人： Ravindra Deshpande , Douglas M. Smith , C. Jeffrey Brinker
发明人： Ravindra Deshpande , Douglas M. Smith , C. Jeffrey Brinker
IPC分类号： B01J13/00 , C01B33/16 , B05D7/00 , C03C17/30 , E04B1/74
CPC分类号： B01J13/0091 , C01B33/163 , Y02P20/544 , Y10T428/2995
摘要： This invention provides an extremely porous xerogel dried at vacuum-to-below supercritical pressures but having the properties of aerogels which are typically dried at supercritical pressures. This is done by reacting the internal pore surface of the wet gel with organic substances in order to change the contact angle of the fluid meniscus in the pores during drying. Shrinkage of the gel (which is normally prevented by use of high autoclave pressures, such that the pore fluid is at temperature and pressure above its critical values) is avoided even at vacuum or ambient pressures.
摘要翻译：本发明提供了在真空至低于超临界压力下干燥但具有通常在超临界压力下干燥的气凝胶的性质的极其多孔的干凝胶。这是通过使湿凝胶的内部孔表面与有机物质反应来实现的，以便在干燥期间改变孔中的流体弯液面的接触角。即使在真空或环境压力下，也避免了凝胶的收缩（通常通过使用高压釜压力来防止孔隙流体处于高于其临界值的温度和压力下）。

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