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1. 发明申请

US20160018393A1 TRANSMISSION-LINE-COUPLED MICROFLUIDIC-CHIP TECHNOLOGY FOR ELECTROMAGNETIC SENSING OF BIOMOLECULES AND BIOPARTICLES 审中-公开
标题翻译：传输线耦合微流控芯片技术用于电生理分析和生物分析
公开(公告)号：US20160018393A1
公开(公告)日：2016-01-21
申请号：US14802116
申请日：2015-07-17
申请人： Elliott R. Brown , Leamon Viveros , Edgar A. Mendoza
发明人： Elliott R. Brown , Leamon Viveros , Edgar A. Mendoza
IPC分类号： G01N33/543 , B01L3/00 , H01P3/00
CPC分类号： B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N21/05 , G01N21/7703 , G01N2021/058 , H01P3/003
摘要： A coplanar waveguide transmission line for use in detecting biomolecules and bioparticles is provided that includes a signal conductor disposed on a top surface of the dielectric substrate, a ground conductor disposed on the top surface of the dielectric substrate on each side of the signal conductor, a continuous gap defined between the signal conductor and each of the ground conductors, micro-channels disposed below a top surface of the dielectric substrate, and reservoirs disposed below the top surface of the substrate.
摘要翻译：提供了一种用于检测生物分子和生物颗粒的共面波导传输线，其包括设置在电介质基板的顶表面上的信号导体，设置在信号导体每侧的电介质基板的顶表面上的接地导体，限定在信号导体和每个接地导体之间的连续间隙，设置在电介质基板的顶表面下方的微通道以及设置在基板顶表面下方的储存器。

2. 发明授权

US06535658B1 Hydrogen sensor apparatus and method of fabrication 失效
标题翻译：氢传感器装置及其制造方法
公开(公告)号：US06535658B1
公开(公告)日：2003-03-18
申请号：US09639007
申请日：2000-08-15
申请人： Edgar A. Mendoza , Anil Menon
发明人： Edgar A. Mendoza , Anil Menon
IPC分类号： G02B600
CPC分类号： G01N33/005 , G01N21/7703 , G01N21/783 , G01N2021/7726 , G02B6/02052 , G02B6/241
摘要： A porous glass rod is treated to include tungsten oxide and palladium in an arrangement that is sensitive to hydrogen to produce a color change that is a function of the hydrogen concentration. The rod is attached to the tip of a double fiber into one of which light is launched by a light source. A detector at the end of the second fiber is responsive to light reflected by the rod. The process for forming the rod includes the steps of doping the glass with a tungsten compound and a palladium compound with intervening and subsequent heating steps to bond the tungsten oxide and palladium to available oxygen atoms of the porous glass.
摘要翻译：将多孔玻璃棒处理为包含对氢敏感的排列的氧化钨和钯，以产生作为氢浓度的函数的颜色变化。杆连接到双纤维的尖端，其中一个光由光源发射。在第二光纤末端处的检测器响应于由杆反射的光。用于形成棒的方法包括以下步骤：用钨化合物和钯化合物掺杂玻璃，其间隔和随后的加热步骤将氧化钨和钯结合到多孔玻璃的可用氧原子。

3. 发明授权

US06221028B1 Vitrectomy lens with integrated illuminator 失效
标题翻译：具有集成照明器的玻璃体切割镜片
公开(公告)号：US06221028B1
公开(公告)日：2001-04-24
申请号：US09348366
申请日：1999-07-07
申请人： Robert A. Lieberman , Edgar A. Mendoza
发明人： Robert A. Lieberman , Edgar A. Mendoza
IPC分类号： A61B500
CPC分类号： A61B3/14 , A61B3/0008
摘要： The inner eye of a surgical patient is illuminated by incorporating an optical fiber in a ring configuration imbedded into or attached to a contact lens. The viewing surface of the lens if planar to optimize the surgeon's view. The opposite surface of the lens is curved to conform to the patient's eye. A solution conduit irrigates the eye. The apparatus is easily positioned and easily directed. The apparatus also is sufficiently inexpensive to be disposable.
摘要翻译：手术患者的内眼通过将嵌入或附接到隐形眼镜的环形结构中的光纤结合来照亮。透镜的观察表面如果是平面的，以优化外科医生的视野。透镜的相对表面是弯曲的，以符合患者的眼睛。溶液管道冲洗眼睛。该装置易于定位并且易于导向。该装置也足够便宜以便一次性使用。

4. 发明授权

US10969364B1 Innovative nanopore sequencing technology including a self-assembled porous membrane 有权
公开(公告)号：US10969364B1
公开(公告)日：2021-04-06
申请号：US15896843
申请日：2018-02-14
申请人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
发明人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
IPC分类号： G01N27/447 , B01L3/00 , C12Q1/6869
摘要： Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

5. 发明授权

US07496267B2 Integrated optic devices and photosensitive sol-gel process for producing integrated optic devices 失效
标题翻译：用于生产集成光学器件的集成光学器件和光敏溶胶 - 凝胶法
公开(公告)号：US07496267B2
公开(公告)日：2009-02-24
申请号：US11975030
申请日：2007-10-16
申请人： Edgar A. Mendoza , Lothar U. Kempen , Robert A. Lieberman
发明人： Edgar A. Mendoza , Lothar U. Kempen , Robert A. Lieberman
IPC分类号： G02B6/10
CPC分类号： G02B6/12009 , G02B6/122 , G02B6/13 , G02B6/132 , G02B6/2821 , G02B2006/12107 , G02B2006/12119 , G02B2006/12173 , G02F1/01 , G02F1/0126 , G02F1/095 , G02F2001/0113 , G02F2201/307 , G02F2202/38 , H04J14/021
摘要： A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.
摘要翻译：含有有机金属光敏剂的光敏溶胶 - 凝胶膜沉积在硅衬底的含氧化物表面层上。入射到光敏溶胶 - 凝胶膜的白色或紫外光的图案导致光敏剂从溶胶 - 凝胶膜的暴露区域的解离。第一和第二加热步骤的后续连续导致首先从溶胶 - 凝胶膜的暴露区域去除光敏剂成分，其次，从曝光区域去除有机成分，导致区域掺杂具有非线性光学性质的金属氧化物，例如半等离子体等。可以制造光开关，耦合器，波导，分路器，干涉仪波分复用器，布拉格光栅等。也可以使用玻璃基板代替硅，在这种情况下不需要单独的氧化硅表面层。

6. 发明授权

US07391948B2 Optical waveguide structure 失效
标题翻译：光波导结构
公开(公告)号：US07391948B2
公开(公告)日：2008-06-24
申请号：US11093275
申请日：2005-03-28
申请人： Lothar U. Kempen , Rongchung Tyan , Edgar A. Mendoza
发明人： Lothar U. Kempen , Rongchung Tyan , Edgar A. Mendoza
IPC分类号： G02B6/26 , G02B6/10 , G02B6/12 , G02B6/14
CPC分类号： G02B6/1228 , G02B6/2821
摘要： Waveguide structures in which light confinement strength varies along the direction of light propagation are described. The waveguides include a core adapted to propagate light along a path defined by the core and a cladding material that at least partially surrounds the core. The core and the cladding material each have a refractive index profile in the direction of light propagation. One or more of the profiles or lateral core dimensions are varied along the direction of light propagation, thereby causing the degree of light confinement to vary in the direction of light propagation. With such structures it is possible to tailor the velocity of the light propagating through the core and the confinement of the light to the core for any given core cross section. The structures may be used, for example, in mode-matching an input or output of a waveguide and in fabricating compact directional couplers.
摘要翻译：描述光限制强度沿光传播方向变化的波导结构。波导包括适于沿着由芯限定的路径传播光的芯和至少部分地围绕芯的包层材料。芯和包层材料各自在光传播的方向上具有折射率分布。轮廓或横向纤芯尺寸中的一个或多个沿着光传播的方向变化，从而导致光限制的程度在光传播的方向上变化。通过这种结构，可以定制通过芯体传播的光的速度以及将光限制到核心以用于任何给定的核心横截面。该结构可以用于例如波导的输入或输出的模式匹配以及制造紧凑的定向耦合器中。

7. 发明授权

US07283717B2 Integrated optic devices and photosensitive sol-gel process for producing integrated optic devices 失效
标题翻译：用于生产集成光学器件的集成光学器件和光敏溶胶 - 凝胶法
公开(公告)号：US07283717B2
公开(公告)日：2007-10-16
申请号：US11386515
申请日：2006-03-21
申请人： Edgar A. Mendoza , Lothar U. Kempen , Robert A. Lieberman
发明人： Edgar A. Mendoza , Lothar U. Kempen , Robert A. Lieberman
IPC分类号： G02B6/10
CPC分类号： G02B6/12009 , G02B6/122 , G02B6/13 , G02B6/132 , G02B6/2821 , G02B2006/12107 , G02B2006/12119 , G02B2006/12173 , G02F1/01 , G02F1/0126 , G02F1/095 , G02F2001/0113 , G02F2201/307 , G02F2202/38 , H04J14/021
摘要： A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.
摘要翻译：含有有机金属光敏剂的光敏溶胶 - 凝胶膜沉积在硅衬底的含氧化物表面层上。入射到光敏溶胶 - 凝胶膜的白色或紫外光的图案导致光敏剂从溶胶 - 凝胶膜的暴露区域的解离。第一和第二加热步骤的后续连续导致首先从溶胶 - 凝胶膜的暴露区域去除光敏剂成分，其次，从曝光区域去除有机成分，导致区域掺杂具有非线性光学性质的金属氧化物，例如半等离子体等。可以制造光开关，耦合器，波导，分路器，干涉仪波分复用器，布拉格光栅等。也可以使用玻璃基板代替硅，在这种情况下不需要单独的氧化硅表面层。

8. 发明授权

US07016589B2 Thermally-assisted photo-lithographic process using sol-gel derived glass and products made thereby 失效
标题翻译：使用溶胶凝胶衍生的玻璃和由此制成的产品的热辅助光刻工艺
公开(公告)号：US07016589B2
公开(公告)日：2006-03-21
申请号：US09574840
申请日：2000-05-19
申请人： Edgar A. Mendoza , Lothar U. Kempen , Robert A. Lieberman
发明人： Edgar A. Mendoza , Lothar U. Kempen , Robert A. Lieberman
IPC分类号： G02B6/10
CPC分类号： G02B6/12009 , G02B6/122 , G02B6/13 , G02B6/132 , G02B6/2821 , G02B2006/12107 , G02B2006/12119 , G02B2006/12173 , G02F1/01 , G02F1/0126 , G02F1/095 , G02F2001/0113 , G02F2201/307 , G02F2202/38 , H04J14/021
摘要： A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, electro-optic, magneto-optic, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.
摘要翻译：含有有机金属光敏剂的光敏溶胶 - 凝胶膜沉积在硅衬底的含氧化物表面层上。入射到光敏溶胶 - 凝胶膜的白色或紫外光的图案导致光敏剂从溶胶 - 凝胶膜的暴露区域的解离。第一和第二加热步骤的后续连续导致，首先，从溶胶 - 凝胶膜的暴露区域去除光敏剂成分，其次，从曝光区域去除有机成分，导致区域掺杂具有非线性光学性质的金属氧化物，例如半潜，电光，磁光等。可以制造光开关，耦合器，波导，分路器，干涉仪波分复用器，布拉格光栅等。也可以使用玻璃基板代替硅，在这种情况下不需要单独的氧化硅表面层。

9. 发明授权

US06802188B1 Method of making photosensitive monolithic glass apparatus 有权
标题翻译：制造光敏单片玻璃装置的方法
公开(公告)号：US06802188B1
公开(公告)日：2004-10-12
申请号：US09627983
申请日：2000-07-28
申请人： Robert A. Lieberman , Edgar A. Mendoza , David Mintzer
发明人： Robert A. Lieberman , Edgar A. Mendoza , David Mintzer
IPC分类号： C03B802
CPC分类号： G02B5/0247 , C03B19/12 , C03C1/006 , C03C1/008 , C03C4/00 , C03C17/007 , C03C17/02 , C03C2204/08 , C03C2217/213 , C03C2218/113 , C03C2218/32 , G02B5/0252 , G02B5/0268 , G02B5/0278 , G02B5/32
摘要： A partially modified photosensitive monolithic oxide glass apparatus formed through photolithographic imaging. The apparatus may be either a volume apparatus or a layer apparatus. Both types of apparatus may be used to diffuse light in predetermined directions or shapes. The monolithic oxide glass apparatus is capable of withstanding temperatures well beyond glass transition temperatures of plastic light shaping devices and can be formed in convex or concave surfaces through conventionally molding grinding or polishing techniques and can be coated by hot-coating techniques.
摘要翻译：通过光刻成像形成的部分改性的感光单片氧化物玻璃装置。该装置可以是体积装置或层装置。两种类型的装置可以用于在预定方向或形状上漫射光。整体式氧化物玻璃装置能够承受远远超过塑料光整形装置的玻璃化转变温度的温度，并且可以通过常规模制研磨或抛光技术形成在凸面或凹面中，并且可以通过热涂覆技术进行涂覆。

10. 发明授权

US06875467B2 Crack resistant sol-gel wafer coatings for integrated optics 失效
标题翻译：用于集成光学的耐裂纹溶胶 - 凝胶晶片涂层
公开(公告)号：US06875467B2
公开(公告)日：2005-04-05
申请号：US10320313
申请日：2002-12-15
申请人： Fernando A. Sigoli , Lothar U. Kempen , Edgar A. Mendoza
发明人： Fernando A. Sigoli , Lothar U. Kempen , Edgar A. Mendoza
IPC分类号： C03C1/00 , B05D1/38 , B05D3/12
CPC分类号： C03C1/008
摘要： A method of preparing a multi-layer, crack resistant sol-gel glass derived coating on a substrate by removing the outer periphery of each layer before curing the layer and depositing any succeeding layer.
摘要翻译：一种通过在固化该层并沉积任何后续层之前去除每个层的外周来在基底上制备多层抗裂溶胶 - 凝胶玻璃衍生涂层的方法。

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