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41. 发明申请

US20060235209A9 Use of anti-tissue factor antibodies for treating thromboses 审中-公开
公开(公告)号：US20060235209A9
公开(公告)日：2006-10-19
申请号：US10310113
申请日：2002-12-04
申请人： Jin-An Jiao , Hing Wong , Esperanza Nieves , Luis Mosquera
发明人： Jin-An Jiao , Hing Wong , Esperanza Nieves , Luis Mosquera
IPC分类号： A61K39/395 , C07K16/42
CPC分类号： C07K16/36 , A61K2039/505 , C07K16/467 , C07K2317/24 , C07K2319/00
摘要： Disclosed is a method for preventing or treating thrombosis in a mammal such as a primate and particularly a human patient. A preferred method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to human tissue factor (TF). Additional methods and kits are provided.

42. 发明授权

US06610293B1 Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria 失效
公开(公告)号：US06610293B1
公开(公告)日：2003-08-26
申请号：US09097055
申请日：1998-06-15
申请人： Gerald W. Fischer , Richard F. Schuman , Hing Wong , Jeffrey R. Stinson
发明人： Gerald W. Fischer , Richard F. Schuman , Hing Wong , Jeffrey R. Stinson
IPC分类号： C12P2108
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1267 , C07K16/1271 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/77 , C07K2319/00
摘要： The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse monoclonal antibody has been humanized and the resulting chimeric antibody provides a previously unknown means to diagnose, prevent and/or treat infections caused by gram positive bacteria bearing lipoteichoic acid. This invention also encompasses a peptide mimic of the lipoteichoic acid epitope binding site defined by the monoclonal antibody. This epitope or epitope peptide mimic identifies other antibodies that may bind to the lipoteichoic acid epitope. Moreover, the epitope or epitope peptide mimic provides a valuable substrate for the generation of vaccines or other therapeutics.

43. 发明授权

US06327197B1 Structure and method of a column redundancy memory 有权
标题翻译：列冗余存储器的结构和方法
公开(公告)号：US06327197B1
公开(公告)日：2001-12-04
申请号：US09660534
申请日：2000-09-13
申请人： Juhan Kim , Hing Wong
发明人： Juhan Kim , Hing Wong
IPC分类号： G11C700
CPC分类号： G11C29/808
摘要： A memory architecture is disclosed that employs multiple column redundancies which provide multiple options for replacing a defective global odd or even bit line. Each column memory has two multiplexers, one for selecting a global odd bit line and another for selecting a global even bit line. Two or more column redundancies are coupled to each of the multiplexer in the column memory. In a first embodiment, the global odd and even bit lines are connected through odd and even sense amps in a regular column. In a second embodiment, the global odd bit line in a regular column connects through odd sense amps, while the global even bit line in the regular column connects through even sense amps. In a third embodiment, two or more sets of redundancy columns are commonly coupled to a left adjacent regular column and a right adjacent regular column.
摘要翻译：公开了一种采用多列冗余的存储器架构，其提供用于替换有缺陷的全局奇数或偶数位线的多个选项。每列存储器具有两个多路复用器，一个用于选择全局奇数位线，另一个用于选择全局偶数位线。两列或更多列冗余被耦合到列存储器中的多路复用器中的每一个。在第一实施例中，全局奇数和偶数位线通过常规列中的奇数和偶数感测放大器连接。在第二实施例中，常规列中的全局奇数位线通过奇数检测放大器连接，而常规列中的全局偶数位线通过均匀感测放大器连接。在第三实施例中，两组或多组冗余列通常耦合到左相邻规则列和右相邻常规列。

44. 发明授权

US06262928B1 Parallel test circuit and method for wide input/output DRAM 失效
标题翻译：用于宽输入/输出DRAM的并行测试电路和方法
公开(公告)号：US06262928B1
公开(公告)日：2001-07-17
申请号：US09661165
申请日：2000-09-13
申请人： Juhan Kim , Hing Wong
发明人： Juhan Kim , Hing Wong
IPC分类号： G11C2900
CPC分类号： G11C29/02 , G11C29/34
摘要： The present invention discloses a parallel test circuit and method for testing even bit line and odd bit line in a memory block simultaneously. The parallel test circuit comprises an even test circuit for testing an even bit line and an odd test circuit for testing an odd bit line. The parallel test circuit also includes a write circuit for writing data to a bit line, a read circuit including a data sense amp, an output buffer, and a comparator. Furthermore, the present invention provides the capability to conduct disturbance test in neighboring even and odd cells.
摘要翻译：本发明公开了一种用于同时测试存储块中偶数位线和奇数位线的并行测试电路和方法。并联测试电路包括用于测试偶数位线的偶数测试电路和用于测试奇数位线的奇数测试电路。并行测试电路还包括用于将数据写入位线的写入电路，包括数据读出放大器，输出缓冲器和比较器的读取电路。此外，本发明提供了在相邻偶数和奇数单元中进行干扰测试的能力。

45. 发明授权

US5559050A P-MOSFETS with enhanced anomalous narrow channel effect 失效
标题翻译：具有增强的异常窄通道效应的P-MOSFET
公开(公告)号：US5559050A
公开(公告)日：1996-09-24
申请号：US269857
申请日：1994-06-30
申请人： Johann Alsmeier , Wayne F. Ellis , Jack A. Mandelman , Hing Wong
发明人： Johann Alsmeier , Wayne F. Ellis , Jack A. Mandelman , Hing Wong
IPC分类号： H01L21/265 , H01L21/322 , H01L27/092 , H01L29/06 , H01L29/10 , H01L29/78
CPC分类号： H01L29/1095 , H01L27/0921 , H01L29/0642 , H01L29/1033 , H01L29/7838
摘要： An anomalous threshold voltage dependence on channel width measured on 0.25 .mu.m ground rule generation trench-isolated buried-channel p-MOSFETs is used to enhance circuit performance. As the channel width is reduced, the magnitude of the threshold voltage first decreases before the onset of the expected sharp rise in V.sub.t for widths narrower than 0.4 .mu.m. Modeling shows that a "boron puddle" is created near the trench bounded edge as a result of transient enhanced diffusion (TED) during the gate oxidation step, which imposes a penalty on the off-current of narrow devices. TED is governed by interstitials produced by a deep phosphorus implant, used for latchup suppression, diffusing towards the trench sidewall and top surface of the device.
摘要翻译：在0.25微米接地规则生成沟槽隔离埋沟p-MOSFET上测量的通道宽度的异常阈值电压依赖性用于增强电路性能。随着沟道宽度的减小，阈值电压的幅度首先在宽度窄于0.4μm的Vt预期的急剧上升之前降低。建模表明，在栅极氧化步骤期间，由于瞬态增强扩散（TED）的结果，在沟槽界限边缘附近产生“硼熔池”，这对狭窄器件的截止电流造成了惩罚。 TED由深磷植入物产生的间隙控制，用于闭锁抑制，向器件的沟槽侧壁和顶表面扩散。

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