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1. 发明授权

US06327197B1 Structure and method of a column redundancy memory 有权
标题翻译：列冗余存储器的结构和方法
公开(公告)号：US06327197B1
公开(公告)日：2001-12-04
申请号：US09660534
申请日：2000-09-13
申请人： Juhan Kim , Hing Wong
发明人： Juhan Kim , Hing Wong
IPC分类号： G11C700
CPC分类号： G11C29/808
摘要： A memory architecture is disclosed that employs multiple column redundancies which provide multiple options for replacing a defective global odd or even bit line. Each column memory has two multiplexers, one for selecting a global odd bit line and another for selecting a global even bit line. Two or more column redundancies are coupled to each of the multiplexer in the column memory. In a first embodiment, the global odd and even bit lines are connected through odd and even sense amps in a regular column. In a second embodiment, the global odd bit line in a regular column connects through odd sense amps, while the global even bit line in the regular column connects through even sense amps. In a third embodiment, two or more sets of redundancy columns are commonly coupled to a left adjacent regular column and a right adjacent regular column.
摘要翻译：公开了一种采用多列冗余的存储器架构，其提供用于替换有缺陷的全局奇数或偶数位线的多个选项。每列存储器具有两个多路复用器，一个用于选择全局奇数位线，另一个用于选择全局偶数位线。两列或更多列冗余被耦合到列存储器中的多路复用器中的每一个。在第一实施例中，全局奇数和偶数位线通过常规列中的奇数和偶数感测放大器连接。在第二实施例中，常规列中的全局奇数位线通过奇数检测放大器连接，而常规列中的全局偶数位线通过均匀感测放大器连接。在第三实施例中，两组或多组冗余列通常耦合到左相邻规则列和右相邻常规列。

2. 发明授权

US06262928B1 Parallel test circuit and method for wide input/output DRAM 失效
标题翻译：用于宽输入/输出DRAM的并行测试电路和方法
公开(公告)号：US06262928B1
公开(公告)日：2001-07-17
申请号：US09661165
申请日：2000-09-13
申请人： Juhan Kim , Hing Wong
发明人： Juhan Kim , Hing Wong
IPC分类号： G11C2900
CPC分类号： G11C29/02 , G11C29/34
摘要： The present invention discloses a parallel test circuit and method for testing even bit line and odd bit line in a memory block simultaneously. The parallel test circuit comprises an even test circuit for testing an even bit line and an odd test circuit for testing an odd bit line. The parallel test circuit also includes a write circuit for writing data to a bit line, a read circuit including a data sense amp, an output buffer, and a comparator. Furthermore, the present invention provides the capability to conduct disturbance test in neighboring even and odd cells.
摘要翻译：本发明公开了一种用于同时测试存储块中偶数位线和奇数位线的并行测试电路和方法。并联测试电路包括用于测试偶数位线的偶数测试电路和用于测试奇数位线的奇数测试电路。并行测试电路还包括用于将数据写入位线的写入电路，包括数据读出放大器，输出缓冲器和比较器的读取电路。此外，本发明提供了在相邻偶数和奇数单元中进行干扰测试的能力。

3. 发明申请

US20060039901A1 Antibodies for inhibiting blood coagulation and methods of use thereof 审中-公开
公开(公告)号：US20060039901A1
公开(公告)日：2006-02-23
申请号：US11122622
申请日：2005-05-05
申请人： Jin-An Jiao , Hing Wong , Esperanza Nieves , Lawrence Luepschen
发明人： Jin-An Jiao , Hing Wong , Esperanza Nieves , Lawrence Luepschen
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/36 , A61K2039/505 , C07K16/467 , C07K2317/24 , C07K2319/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF.

4. 发明授权

US5804853A Stacked electrical device having regions of electrical isolation and electrical connections on a given stack level 失效
标题翻译：在给定的堆叠级上具有电隔离和电连接区域的堆叠式电气设备
公开(公告)号：US5804853A
公开(公告)日：1998-09-08
申请号：US686881
申请日：1996-07-26
申请人： John Edward Cronin , John Kenneth DeBrosse , Hing Wong
发明人： John Edward Cronin , John Kenneth DeBrosse , Hing Wong
IPC分类号： H01L21/768 , H01L21/8242 , H01L27/108
CPC分类号： H01L27/10852 , H01L27/10808 , H01L2924/0002
摘要： A semiconductor structure having electrical conductors positioned over each other, but electrically isolated from each other, is disclosed. The lower conductor has a recess in its upper surface, and the recess is at least partially filled with an oxide-type material, thereby isolating the lower conductor from the upper conductor. These conductors would normally contact each other because of the somewhat imprecise patterning and etching steps used to fabricate a multitude of conductive elements, e.g., in a very dense semiconductor structure. Stacked capacitor cells incorporating this structure are also disclosed.
摘要翻译：公开了一种半导体结构，其具有彼此相互定位但彼此电隔离的电导体。下导体在其上表面具有凹槽，并且凹部至少部分地填充有氧化物型材料，从而将下导体与上导体隔离。这些导体通常彼此接触，因为用于制造多个导电元件（例如非常致密的半导体结构）的图案化和蚀刻步骤有些不精确。还公开了结合该结构的堆叠电容器电池。

5. 发明授权

US5691946A Row redundancy block architecture 失效
标题翻译：行冗余块架构
公开(公告)号：US5691946A
公开(公告)日：1997-11-25
申请号：US758783
申请日：1996-12-03
申请人： John DeBrosse , Toshiaki Kirihata , Hing Wong
发明人： John DeBrosse , Toshiaki Kirihata , Hing Wong
IPC分类号： G11C11/401 , G11C29/00 , G11C29/04 , H01L21/8242 , H01L27/108 , G11C5/06
CPC分类号： G11C29/80 , G11C29/808 , G11C29/84
摘要： Row redundancy control circuits which effectively reduce design space are arranged parallel to word direction and are arranged at the bottom of the redundancy block. This architecture change makes it possible to effectively lay out the redundancy control block by introducing (1) split-global-bus shared with local row redundancy wires, (2) half-length-one-way row redundancy-wordline-enable-signal wires which allows space saving, and (3) distributed wordline enable decoders designed to take advantage of the saved space. An illegal normal/redundancy access problem caused by the address versus timing skew has also been solved. The timing necessary for this detection is given locally by using its adjacent redundancy match detection. This allows the circuit to operate completely as an address driven circuit, resulting in fast and reliable redundancy match detection. In addition, a sample wordline enable signal (SWLE) is generated by using row redundancy match detection. One two-input OR gate allows the time at which SWLE sets sample wordline (SWL) to be the same as the time at which wordline enable (WLE) signal sets wordline (WL). The time at which SWLE sets SWL remains consistent regardless of mode, eliminating the existing reliability concern. This two-input OR gate combined with row redundancy match detection works as an ideal sample wordline enable generator.
摘要翻译：有效减少设计空间的行冗余控制电路与字方向平行排列，并配置在冗余块的底部。通过引入（1）与本地行冗余线共享的分裂全局总线，（2）半长度单向行冗余字线使能信号线，可以有效地布置冗余控制块这允许节省空间，以及（3）分布式字线使能解码器被设计为利用节省的空间。由地址与时序偏差引起的非法正常/冗余访问问题也已解决。通过使用其相邻的冗余匹配检测在本地给出该检测所需的定时。这允许电路作为地址驱动电路完全操作，导致快速可靠的冗余匹配检测。此外，通过使用行冗余匹配检测来生成采样字线使能信号（SWLE）。一个双输入或门允许SWLE设置采样字线（SWL）的时间与字线使能（WLE）信号设置字线（WL）的时间相同。无论模式如何，SWLE设置SWL的时间保持一致，从而消除了现有的可靠性问题。该双输入OR门与行冗余匹配检测相结合，可作为理想的采样字线使能发生器。

6. 发明授权

US5268274A Methods and nucleic acid sequences for the expression of the cellulose synthase operon 失效
标题翻译：用于表达纤维素合成酶操纵子的方法和核酸序列
公开(公告)号：US5268274A
公开(公告)日：1993-12-07
申请号：US689008
申请日：1991-04-22
申请人： Arie Ben-Bassat , Roger D. Calhoon , Anna L. Fear , David H. Gelfand , James H. Meade , Rony Tal , Hing Wong , Moshe Benziman
发明人： Arie Ben-Bassat , Roger D. Calhoon , Anna L. Fear , David H. Gelfand , James H. Meade , Rony Tal , Hing Wong , Moshe Benziman
IPC分类号： C07K14/195 , C12N1/21 , C12N9/10 , C12N9/88 , C12N15/52 , C12N15/54 , C12N15/72 , C12N15/74 , C12N15/00 , C12P19/04
CPC分类号： C12N9/1059 , C07K14/195 , C12N15/52 , C12N15/72 , C12N15/74 , C12N9/88 , C12R1/02 , Y10S435/823
摘要： Nucleic acid sequences encoding the bacterial cellulose synthase operon derived from Acetobacter are disclosed. Methods for isolating the genes, vectors containing the genes, and transformed hosts useful for the expression of recombinant bacterial cellulose synthase or production of cellulose are also described.
摘要翻译：公开了编码源自醋杆菌的细菌纤维素合成酶操纵子的核酸序列。还描述了分离基因的方法，含有该基因的载体和用于表达重组细菌纤维素合成酶或纤维素生产的转化宿主。

7. 发明申请

US20100221822A1 Humanized and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria 失效
标题翻译：对革兰氏阳性菌的脂磷壁酸具有特异性的人源化和嵌合抗体
公开(公告)号：US20100221822A1
公开(公告)日：2010-09-02
申请号：US12317718
申请日：2008-12-23
申请人： Gerald W. Fischer , Richard F. Schuman , Hing Wong , Jeffrey R. Stinson
发明人： Gerald W. Fischer , Richard F. Schuman , Hing Wong , Jeffrey R. Stinson
IPC分类号： C12N5/10 , C07H21/04 , C12N15/62
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1267 , C07K16/1271 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/77 , C07K2319/00
摘要： The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse monoclonal antibody has been humanized and the resulting chimeric antibody provides a previously unknown means to diagnose, prevent and/or treat infections caused by gram positive bacteria bearing lipoteichoic acid. This invention also encompasses a peptide mimic of the lipoteichoic acid epitope binding site defined by the monoclonal antibody. This epitope or epitope peptide mimic identifies other antibodies that may bind to the lipoteichoic acid epitope. Moreover, the epitope or epitope peptide mimic provides a valuable substrate for the generation of vaccines or other therapeutics.
摘要翻译：本发明包括与革兰氏阳性细菌的脂磷壁酸结合的单克隆抗体和嵌合抗体。抗体还结合全细菌，增强体外吞噬细菌和杀死细菌，增强体内致死感染的保护作用。小鼠单克隆抗体已经人源化，所得到的嵌合抗体提供了以前未知的用于诊断，预防和/或治疗由具有脂磷壁酸的革兰氏阳性细菌引起的感染的方法。本发明还包括由单克隆抗体限定的脂磷壁酸结合位点的肽模拟物。该表位或表位肽模拟物鉴定可结合脂磷壁酸表位的其它抗体。此外，表位或表位肽模拟物为生成疫苗或其他治疗剂提供了有价值的底物。

8. 发明申请

US20100189715A1 HUMANIZED MONOCLONAL ANTIBODIES THAT PROTECT AGAINST SHIGA TOXIN INDUCED DISEASE 审中-公开
标题翻译：保护针对SHIGA诱导性疾病的人类单克隆抗体
公开(公告)号：US20100189715A1
公开(公告)日：2010-07-29
申请号：US12536940
申请日：2009-08-06
申请人： Jeffrey R. Stinson , Hing Wong , Alison D. O'Brien , Clare K. Schmitt , Angela Melton-Celsa
发明人： Jeffrey R. Stinson , Hing Wong , Alison D. O'Brien , Clare K. Schmitt , Angela Melton-Celsa
IPC分类号： A61K39/395 , A61P31/04
CPC分类号： C07K16/1232 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： The present invention describes the preparation and use of biologically and immunologically active humanized monoclonal antibodies to Shiga toxin, a toxin associated with HC and the potentially life-threatening sequela HUS transmitted by strains of pathogenic bacteria. The present invention describes how these humanized antibodies may be used in the treatment or prevention of Shiga toxin induced diseases. One aspect of the invention is the humanized monoclonal antibody which binds Shiga toxin where the constant regions are IgG1-kappa and the variable regions are murine in origin. Yet another aspect of the invention is expression vectors and host cells transformed with such vectors which express the humanized monoclonal antibodies of the present invention.
摘要翻译：本发明描述了生物学和免疫学活性的人源化单克隆抗体与志贺毒素（一种与HC相关的毒素）和潜在的危及生命的后遗症HUS由病原菌菌株传播的制备和应用。本发明描述了这些人源化抗体如何用于治疗或预防志贺毒素诱导的疾病。本发明的一个方面是结合志贺毒素的人源化单克隆抗体，其中恒定区是IgG1-κ，可变区是起源的鼠。本发明的另一方面是用表达本发明的人源化单克隆抗体的载体转化的表达载体和宿主细胞。

9. 发明申请

US20070155703A1 Pharmaceutically active compounds and methods of use thereof 审中-公开
标题翻译：药物活性化合物及其使用方法
公开(公告)号：US20070155703A1
公开(公告)日：2007-07-05
申请号：US11706925
申请日：2007-02-15
申请人： Jin-An Jiao , Lawrence Luepschen , Esperanza Nieves , Hing Wong , Dean Taylor
发明人： Jin-An Jiao , Lawrence Luepschen , Esperanza Nieves , Hing Wong , Dean Taylor
IPC分类号： A61K31/675 , A61K31/66
CPC分类号： C07F9/3873 , A61K31/66 , A61K31/663 , A61K31/675 , C07F9/386
摘要： The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treatment or prophylaxis of undesired thrombosis.
摘要翻译：本发明包括药物活性化合物和治疗方法以及利用或包含一种或多种这类化合物的药物组合物。本发明的化合物特别可用于治疗或预防不期望的血栓形成。

10. 发明申请

US20050271664A1 Antibodies for inhibiting blood coagulation and methods of use thereof 审中-公开
标题翻译：用于抑制血液凝固的抗体及其使用方法
公开(公告)号：US20050271664A1
公开(公告)日：2005-12-08
申请号：US11087528
申请日：2005-03-22
申请人： Hing Wong , Jin-An Jiao , Esperanza Nieves , Lawrence Luepschen
发明人： Hing Wong , Jin-An Jiao , Esperanza Nieves , Lawrence Luepschen
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P7/02 , A61P9/00 , C07K16/28 , C07K16/36 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/08 , C12Q1/68 , C07K16/22
CPC分类号： C07K16/36 , A61K38/00 , A61K39/395 , A61K2300/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
摘要翻译：本发明包括通过以高亲和力和特异性结合天然人TF而提供优异的抗凝血活性的抗体。本发明的抗体可有效抑制体内血液凝固。本发明的抗体可以单独或存在于TF：VIIa复合物中的天然人TF结合，有效地防止因子X结合TF或该复合物，从而减少血液凝固。本发明优选的抗体特异性结合主要为天然人TF的构象表位，该表位提供意想不到的强抗体结合位点。

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