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    • 43. 发明申请
    • VERIFICATION OF PRESSURE METRICS
    • 压力测量的验证
    • US20120283580A1
    • 2012-11-08
    • US13099959
    • 2011-05-03
    • William J. HavelTommy D. BennettYong Kyun ChoRobert T. Taepke, II
    • William J. HavelTommy D. BennettYong Kyun ChoRobert T. Taepke, II
    • A61B5/021
    • A61N1/3702A61B5/0215A61B5/686A61B5/7207A61B5/7239A61N1/36564
    • An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
    • 示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。 该系统基于所测量的心血管压力信号确定多个心血管压力指标,所述心血管压力信号包括指示至少一个心脏脉搏的定时的至少一个心血管压力指标。 该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。 所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较,并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。
    • 46. 发明授权
    • Methods for detecting and monitoring sleep disordered breathing using an implantable medical device
    • 使用可植入医疗装置检测和监测睡眠无序呼吸的方法
    • US07988635B2
    • 2011-08-02
    • US12346290
    • 2008-12-30
    • Yong K. ChoTommy D. BennettBarbro M. Kjellstrom
    • Yong K. ChoTommy D. BennettBarbro M. Kjellstrom
    • A61B5/02
    • A61B5/042A61B5/0215A61B5/4818A61B5/7239
    • A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
    • 识别患者中睡眠呼吸障碍(SDB)的方法包括监测血液动力学压力,导出代表存储间隔内血流动力压力分布的高,中,低值,测量下限范围与满 基于导出的高,中,低值的血流动力压力范围,并使用该比例来确定患者是否经历SDB发作。 本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生,而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生 血流动力学压力。 在本发明的某些其他实施方案中,可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。
    • 49. 发明申请
    • ESTIMATING PULMONARY ARTERY DIASTOLIC PRESSURE
    • 估计脉搏动脉硬化压力
    • US20090299198A1
    • 2009-12-03
    • US12129955
    • 2008-05-30
    • James K. CarneyTommy D. BennettMustafa Karamanoglu
    • James K. CarneyTommy D. BennettMustafa Karamanoglu
    • A61B5/0215A61B5/021
    • A61B5/0215A61B5/02028
    • A method for estimating pulmonary artery diastolic pressure, for a single heart beat, includes establishing a time window for sampling and storing pressure data points from a right ventricular pressure transducer. The time window may be established according to predetermined parameters and/or according to one or more triggering events. An approximate time at which the pulmonary artery valve opens is determined, either via the sampled pressure data points, or via another form of more direct monitoring, during the time window, in order to estimate the pulmonary artery diastolic pressure. A plurality of sets of N pressure data points may be collected, from the sampled data, and, for each collected set, a weighted sum is calculated. Each weighted sum may be employed to evaluate a quality of the sampled data and/or to estimate the pulmonary artery diastolic pressure, if the more direct monitoring of the pulmonary artery valve is not employed.
    • 用于估计单次心跳的肺动脉舒张压的方法包括建立用于从右心室压力传感器采样和存储压力数据点的时间窗口。 可以根据预定参数和/或根据一个或多个触发事件建立时间窗口。 通过采样的压力数据点或在时间窗口期间通过另一种形式的更直接的监测来确定肺动脉瓣打开的大致时间,以便估计肺动脉舒张压。 可以从采样数据收集多组N个压力数据点,并且对于每个收集的集合,计算加权和。 如果不采用更直接的肺动脉瓣监测,则每个加权和可用于评估采样数据的质量和/或估计肺动脉舒张压。
    • 50. 发明授权
    • Methods for detecting and monitoring sleep disordered breathing using an implantable medical device
    • 使用可植入医疗装置检测和监测睡眠无序呼吸的方法
    • US07488291B2
    • 2009-02-10
    • US11237354
    • 2005-09-28
    • Yong K. ChoTommy D. BennettBarbro M. Kjellstrom
    • Yong K. ChoTommy D. BennettBarbro M. Kjellstrom
    • A61B5/02
    • A61B5/042A61B5/0215A61B5/4818A61B5/7239
    • A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
    • 识别患者中睡眠呼吸障碍(SDB)的方法包括监测血液动力学压力,导出代表存储间隔内血流动力压力分布的高,中,低值,测量下限范围与满 基于导出的高,中,低值的血流动力压力范围,并使用该比例来确定患者是否经历SDB发作。 本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生,而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生 血流动力学压力。 在本发明的某些其他实施方案中,可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。