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1. 发明授权

US08483833B2 Techniques for modifying breathing rate using cardiac pacing 有权
标题翻译：使用心脏起搏改善呼吸频率的技术
公开(公告)号：US08483833B2
公开(公告)日：2013-07-09
申请号：US13103861
申请日：2011-05-09
申请人： Yong Kyun Cho , Mark K. Erickson , Tommy D. Bennett
发明人： Yong Kyun Cho , Mark K. Erickson , Tommy D. Bennett
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/056 , A61N1/3611
摘要： A method includes controlling a cardiac pacing rate of an implantable medical device to control a heart rate of a patient and detecting inhalation and exhalation of the patient. The method further includes determining that the patient is in a resting state, and, in response to determining that the patient is in the resting state, incrementally increasing the pacing rate while exhalation of the patient is detected and incrementally decreasing the pacing rate while inhalation of the patient is detected.
摘要翻译：一种方法包括控制可植入医疗装置的心脏起搏速率以控制患者的心率并检测患者的吸入和呼气。该方法还包括确定患者处于静止状态，并且响应于确定患者处于静止状态，逐渐增加起搏速率，同时检测到患者的呼气，并逐渐降低起搏速率，同时吸入检测到患者。

2. 发明授权

US08467870B2 Techniques for modifying breathing rate using cardiac pacing 有权
标题翻译：使用心脏起搏改善呼吸频率的技术
公开(公告)号：US08467870B2
公开(公告)日：2013-06-18
申请号：US13103839
申请日：2011-05-09
申请人： Yong Kyun Cho , Mark K. Erickson , Tommy D. Bennett
发明人： Yong Kyun Cho , Mark K. Erickson , Tommy D. Bennett
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/3611 , A61N1/36114
摘要： A method includes controlling a cardiac pacing rate of an implantable medical device (IMD) to control a heart rate of a patient and determining that the patient is in a resting state. The method further includes modifying the pacing rate of the IMD for N cardiac cycles in response to determining that the patient is in the resting state. N is an integer greater than 1. Modifying the pacing rate includes incrementally increasing the pacing rate for a first portion of the N cardiac cycles, and incrementally decreasing the pacing rate for a second portion of the N cardiac cycles.
摘要翻译：一种方法包括控制可植入医疗装置（IMD）的心脏起搏速率以控制患者的心率并确定患者处于静止状态。所述方法还包括响应于确定患者处于静止状态而修改IM心脏起搏速率的N个心动周期。 N是大于1的整数。修改起搏速率包括逐渐增加N个心动周期的第一部分的起搏速率，并逐渐降低N个心动周期的第二部分的起搏速率。

3. 发明申请

US20120290033A1 TECHNIQUES FOR MODIFYING BREATHING RATE USING CARDIAC PACING 有权
标题翻译：用CARDIAC PACING修改呼吸速率的技术
公开(公告)号：US20120290033A1
公开(公告)日：2012-11-15
申请号：US13103861
申请日：2011-05-09
申请人： Yong Kyun Cho , Mark K. Erickson , Tommy D. Bennett
发明人： Yong Kyun Cho , Mark K. Erickson , Tommy D. Bennett
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/056 , A61N1/3611
摘要： A method includes controlling a cardiac pacing rate of an implantable medical device to control a heart rate of a patient and detecting inhalation and exhalation of the patient. The method further includes determining that the patient is in a resting state, and, in response to determining that the patient is in the resting state, incrementally increasing the pacing rate while exhalation of the patient is detected and incrementally decreasing the pacing rate while inhalation of the patient is detected.
摘要翻译：一种方法包括控制可植入医疗装置的心脏起搏速率以控制患者的心率并检测患者的吸入和呼气。该方法还包括确定患者处于静止状态，并且响应于确定患者处于静止状态，逐渐增加起搏速率，同时检测到患者的呼气，并逐渐降低起搏速率，同时吸入检测到患者。

4. 发明申请

US20120290032A1 TECHNIQUES FOR MODIFYING BREATHING RATE USING CARDIAC PACING 有权
标题翻译：用CARDIAC PACING修改呼吸速率的技术
公开(公告)号：US20120290032A1
公开(公告)日：2012-11-15
申请号：US13103839
申请日：2011-05-09
申请人： Yong Kyun Cho , Mark K. Erickson , Tommy D. Bennett
发明人： Yong Kyun Cho , Mark K. Erickson , Tommy D. Bennett
IPC分类号： A61N1/365
CPC分类号： A61N1/056 , A61N1/3611 , A61N1/36114
摘要： A method includes controlling a cardiac pacing rate of an implantable medical device (IMD) to control a heart rate of a patient and determining that the patient is in a resting state. The method further includes modifying the pacing rate of the IMD for N cardiac cycles in response to determining that the patient is in the resting state. N is an integer greater than 1. Modifying the pacing rate includes incrementally increasing the pacing rate for a first portion of the N cardiac cycles, and incrementally decreasing the pacing rate for a second portion of the N cardiac cycles.
摘要翻译：一种方法包括控制可植入医疗装置（IMD）的心脏起搏速率以控制患者的心率并确定患者处于静止状态。所述方法还包括响应于确定患者处于静止状态而修改IM心脏起搏速率的N个心动周期。 N是大于1的整数。修改起搏速率包括逐渐增加N个心动周期的第一部分的起搏速率，并逐渐降低N个心动周期的第二部分的起搏速率。

5. 发明申请

US20120108984A1 INTEGRATED PATIENT CARE 有权
标题翻译：一体化患者护理
公开(公告)号：US20120108984A1
公开(公告)日：2012-05-03
申请号：US12915992
申请日：2010-10-29
申请人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
发明人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
IPC分类号： G06Q50/00 , A61B5/021
CPC分类号： G06F19/3481 , A61B5/0022 , A61B5/021 , A61B5/0215 , A61B5/0537 , A61B5/11 , A61B5/4836 , A61B5/4878 , A61B5/743 , A61B5/7435 , A61N1/37247 , G06F19/00 , G06F19/3456 , G06Q50/22 , G16H40/63 , G16H50/20
摘要： A therapy regimen, e.g., a contingent medication prescription, may be created and automatically distributed to a patient via an integrated patient care system. A clinician may create therapy instructions by at least associating patient conditions with one or more therapy regimens, e.g., medication prescriptions. In some examples, the integrated patient care system may present historical condition data to the clinician to aid the clinician with creating and/or updating the therapy instructions specific to the patient. A therapy module of the integrated patient care system may use the therapy instructions to automatically select a therapy regimen from the therapy instructions based on a patient condition detected based on a sensed physiological parameter. The physiological parameter of the patient may be sensed by an implanted or external sensor. In some examples, the therapy regimen can be presented to the patient according to a predetermined schedule or in response to the detected condition.
摘要翻译：可以创建治疗方案，例如或有药物处方，并通过综合的患者护理系统自动分配给患者。临床医生可以通过至少将患者状况与一种或多种治疗方案（例如药物处方）相关联来产生治疗指导。在一些示例中，综合的患者护理系统可向临床医生呈现历史状态数据，以帮助临床医生创建和/或更新患者特有的治疗指导。综合患者护理系统的治疗模块可以使用治疗指令根据基于检测到的生理参数检测到的患者状况从治疗指令中自动选择治疗方案。患者的生理参数可以通过植入或外部传感器来感测。在一些实例中，治疗方案可以根据预定的时间表或响应于检测到的病症呈现给患者。

6. 发明授权

US08585604B2 Integrated patient care 有权
标题翻译：综合病人护理
公开(公告)号：US08585604B2
公开(公告)日：2013-11-19
申请号：US12915992
申请日：2010-10-29
申请人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
发明人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
IPC分类号： A61B5/02
CPC分类号： G06F19/3481 , A61B5/0022 , A61B5/021 , A61B5/0215 , A61B5/0537 , A61B5/11 , A61B5/4836 , A61B5/4878 , A61B5/743 , A61B5/7435 , A61N1/37247 , G06F19/00 , G06F19/3456 , G06Q50/22 , G16H40/63 , G16H50/20
摘要： A therapy regimen, e.g., a contingent medication prescription, may be created and automatically distributed to a patient via an integrated patient care system. A clinician may create therapy instructions by at least associating patient conditions with one or more therapy regimens, e.g., medication prescriptions. In some examples, the integrated patient care system may present historical condition data to the clinician to aid the clinician with creating and/or updating the therapy instructions specific to the patient. A therapy module of the integrated patient care system may use the therapy instructions to automatically select a therapy regimen from the therapy instructions based on a patient condition detected based on a sensed physiological parameter. The physiological parameter of the patient may be sensed by an implanted or external sensor. In some examples, the therapy regimen can be presented to the patient according to a predetermined schedule or in response to the detected condition.
摘要翻译：可以创建治疗方案，例如或有药物处方，并通过综合的患者护理系统自动分配给患者。临床医生可以通过至少将患者状况与一种或多种治疗方案（例如药物处方）相关联来产生治疗指导。在一些示例中，综合的患者护理系统可向临床医生呈现历史状态数据，以帮助临床医生创建和/或更新患者特有的治疗指导。综合患者护理系统的治疗模块可以使用治疗指令根据基于检测到的生理参数检测到的患者状况从治疗指令中自动选择治疗方案。患者的生理参数可以通过植入或外部传感器来感测。在一些实例中，治疗方案可以根据预定的时间表或响应于检测到的病症呈现给患者。

7. 发明授权

US08827913B2 Verification of pressure metrics 有权
标题翻译：验证压力指标
公开(公告)号：US08827913B2
公开(公告)日：2014-09-09
申请号：US13099959
申请日：2011-05-03
申请人： William J. Havel , Tommy D. Bennett , Yong Kyun Cho , Robert T. Taepke, II
发明人： William J. Havel , Tommy D. Bennett , Yong Kyun Cho , Robert T. Taepke, II
IPC分类号： A61B5/02 , A61B5/00 , A61N1/37 , A61B5/0215 , A61N1/365
CPC分类号： A61N1/3702 , A61B5/0215 , A61B5/686 , A61B5/7207 , A61B5/7239 , A61N1/36564
摘要： An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
摘要翻译：示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。该系统基于所测量的心血管压力信号确定多个心血管压力指标，包括至少一个指示至少一个心脏脉搏的定时的心血管压力指标。该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较，并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。

8. 发明申请

US20120283580A1 VERIFICATION OF PRESSURE METRICS 有权
标题翻译：压力测量的验证
公开(公告)号：US20120283580A1
公开(公告)日：2012-11-08
申请号：US13099959
申请日：2011-05-03
申请人： William J. Havel , Tommy D. Bennett , Yong Kyun Cho , Robert T. Taepke, II
发明人： William J. Havel , Tommy D. Bennett , Yong Kyun Cho , Robert T. Taepke, II
IPC分类号： A61B5/021
CPC分类号： A61N1/3702 , A61B5/0215 , A61B5/686 , A61B5/7207 , A61B5/7239 , A61N1/36564
摘要： An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
摘要翻译：示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。该系统基于所测量的心血管压力信号确定多个心血管压力指标，所述心血管压力信号包括指示至少一个心脏脉搏的定时的至少一个心血管压力指标。该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较，并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。

9. 发明申请

US20090171220A1 METHODS FOR DETECTING AND MONITORING SLEEP DISORDERED BREATHING USING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用可植入医疗器械检测和监测睡眠障碍性呼吸的方法
公开(公告)号：US20090171220A1
公开(公告)日：2009-07-02
申请号：US12346290
申请日：2008-12-30
申请人： Yong Kyun Cho , Tommy D. Bennett , Barbro M. Kjellstrom
发明人： Yong Kyun Cho , Tommy D. Bennett , Barbro M. Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/042 , A61B5/0215 , A61B5/4818 , A61B5/7239
摘要： A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
摘要翻译：识别患者中睡眠呼吸障碍（SDB）的方法包括监测血液动力学压力，导出代表存储间隔内血流动力压力分布的高，中，低值，测量下限范围与满基于导出的高，中，低值的血流动力压力范围，并使用该比例来确定患者是否经历SDB发作。本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生，而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生血流动力学压力。在本发明的某些其他实施方案中，可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。

10. 发明授权

US06641542B2 Method and apparatus to detect and treat sleep respiratory events 有权
公开(公告)号：US06641542B2
公开(公告)日：2003-11-04
申请号：US10133009
申请日：2002-04-26
申请人： Yong Kyun Cho , Luc R. Mongeon , Mark K. Erickson , H. Toby Markowitz
发明人： Yong Kyun Cho , Luc R. Mongeon , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B508
CPC分类号： A61B5/08 , A61B5/0205 , A61B5/4818 , A61N1/3601
摘要： The present invention provides a method and apparatus for detecting and treating sleep respiratory events that includes a plurality of sensors gathering physiological data related to sleep respiratory events. A processor extracts an average cycle length and a frequency of at least one of Cheyne-Stokes respiration and periodic breathing based upon the physiological data, and determines whether therapy is required based on the average cycle length and the frequency.

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