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41. 发明授权

US06864054B1 Polypeptides from CREB binding protein and related protein p300 for use in transcriptional regulation 失效
标题翻译：来自CREB结合蛋白和相关蛋白p300的多肽用于转录调节
公开(公告)号：US06864054B1
公开(公告)日：2005-03-08
申请号：US09701080
申请日：1999-05-26
申请人： Mark J. O'Connor , Holger Zimmermann
发明人： Mark J. O'Connor , Holger Zimmermann
IPC分类号： G01N33/566 , A61K38/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N15/09 , G01N33/15 , G01N33/68 , C12Q1/68 , C12N7/00
CPC分类号： C07K14/475 , A61K38/00 , C07K14/4702
摘要： A method for determining whether a compound inhibits or disrupts an interaction between a first polypeptide comprising a transcriptional adaptor motif (TRAM) and a second polypeptide comprising a TRAM-interaction motif. The first polypeptide and/or second polypeptide may be Mdm-2, p53, TBP, E2F, YY1, CBP/p300 or TF11B, or a viral polypeptide such as a human papillomavirus (HPV) E6 polypeptide from HPV strain (16) or (18).
摘要翻译：用于确定化合物是否抑制或破坏包含转录衔接子基序（TRAM）的第一多肽与包含TRAM相互作用基序的第二多肽之间的相互作用的方法。第一多肽和/或第二多肽可以是Mdm-2，p53，TBP，E2F，YY1，CBP / p300或TF11B，或来自HPV株（16）或（16）的病毒多肽，例如人乳头状瘤病毒（HPV） 18）。

42. 发明授权

US06459673B1 Apparatus for holding in readiness and selecting at least one storage disk 失效
标题翻译：用于保持准备并选择至少一个存储盘的装置
公开(公告)号：US06459673B1
公开(公告)日：2002-10-01
申请号：US09271533
申请日：1999-03-18
申请人： Volker Becker , Holger Zimmermann
发明人： Volker Becker , Holger Zimmermann
IPC分类号： G11B1704
CPC分类号： G11B17/22 , G11B33/0472
摘要： An apparatus for holding in readiness and selecting at least one storage disk is provided. The apparatus includes threaded rods, each having external threads. The at least one storage disk can be guided in the external threads of the threaded rods. Flights of the external threads coact with individual edge regions of at least one inserted storage disk. The at least one storage disk is displaceable along the threaded rods by rotation of the threaded rods.
摘要翻译：提供一种用于保持准备并选择至少一个存储盘的装置。该装置包括螺纹杆，每个具有外螺纹。可以在螺杆的外螺纹中引导至少一个存储盘。外部线程的航班与至少一个插入的存储盘的各个边缘区域共同作用。所述至少一个存储盘可以通过所述螺杆的旋转沿所述螺杆移动。

43. 发明授权

US06178152B1 Device for playing compact disks 失效
标题翻译：播放光盘的设备
公开(公告)号：US06178152B1
公开(公告)日：2001-01-23
申请号：US09171276
申请日：1999-08-18
申请人： Volker Becker , Anton Mindl , Thomas Westendorf , Holger Zimmermann
发明人： Volker Becker , Anton Mindl , Thomas Westendorf , Holger Zimmermann
IPC分类号： G11B1726
CPC分类号： G11B17/22 , G11B17/021 , G11B17/12
摘要： A device for playing compact disks, particularly for motor vehicles, including a magazine for a plurality of compact disks that is arranged in and is removable from a housing, and a playback unit for playing a compact disk from the magazine, the playback unit being swing-mounted in the housing separately from the magazine and being adjustable by an adjusting mechanism, is characterized in that the magazine includes a swivel mechanism, which enables at least a portion of the compact disks located in holding compartments of the magazine to swivel away from a compact disk positioned on the playback unit, to form an unencumbered swing space between the compact disk to be played that is positioned on the playback unit and the compact disks arranged in the holding compartments of the magazine.
摘要翻译：一种用于播放光盘的装置，特别是用于机动车辆的装置，包括布置在壳体中并可从壳体移除的多个光盘的盒子，以及用于从盒子播放光盘的回放单元，回放单元摆动 - 安装在壳体中，并且可通过调节机构调节，其特征在于，所述盒包括旋转机构，所述旋转机构使得位于所述盒的保持隔间中的至少一部分光盘能够远离定位在重放单元上的光盘，以便在放置在播放单元上的要播放的光盘之间形成一个不受阻碍的摆动空间，以及布置在盒的保持隔间中的光盘。

44. 发明申请

US20110008409A1 PHARMACEUTICAL PREPARATION CONTAINING A GESTAGEN, AND KIT AND METHOD FOR TREATING ENDOMETRIOSIS USING THE PREPARATION 审中-公开
标题翻译：含有Gestagen的药物制剂，以及使用制剂治疗子宫内膜异位的药盒和方法
公开(公告)号：US20110008409A1
公开(公告)日：2011-01-13
申请号：US12885919
申请日：2010-09-20
申请人： Christian Seitz , Annemarie Wasserfall , Holger Zimmermann
发明人： Christian Seitz , Annemarie Wasserfall , Holger Zimmermann
IPC分类号： A61F6/08 , A61K31/57 , A61K9/36 , A61P35/00
CPC分类号： A61K31/57
摘要： The pharmaceutical preparation for treating endometriosis contains at least 28, preferably 30, daily dose units, each of which contain dienogest, cyproterone acetate, or chlormadinone acetate at a daily dose that is at most twice that required to inhibit ovulation together with one or more pharmaceutical aids and/or carriers. The daily dose units are administered in a method of prophylaxis and/or therapy of endometriosis continuously during a time interval of at least 169 days or 25 weeks, preferably more than two years. The method effectively reduces endometriosis and associated pain, while undesirable side effects including bone density decrease are reduced or eliminated.
摘要翻译：用于治疗子宫内膜异位症的药物制剂含有至少28个，优选30个日剂量单位，每个剂量单位含有依那诺酯，乙酸环丙孕酮或醋酸氯美他尼酮，其日剂量为抑制排卵所需的一种或多种药物的两倍辅助工具和/或承运人。日剂量单位是在至少169天或25周，优选多于两年的时间间隔内连续预防和/或治疗子宫内膜异位症的方法施用的。该方法有效地减少了子宫内膜异位症和相关的疼痛，而减少或消除包括骨密度降低在内的不期望的副作用。

45. 发明申请

US20090060997A1 PROCESS FOR PRODUCING A PHARMACEUTICAL PREPARATION FOR THERAPEUTIC TREATMENT OF ENDOMETRIOSIS CONTAINING A COMBINATION OF A GESTAGEN AND (6S)-5-METHYLTETRAHYDROFOLATE 审中-公开
标题翻译：生产用于治疗含有牙釉质和（6S）-5-甲基三氟乙酸酯的组合的内膜异位症的药物治疗的制备方法
公开(公告)号：US20090060997A1
公开(公告)日：2009-03-05
申请号：US12185456
申请日：2008-08-04
申请人： Christian Seitz , Annemarie Wasserfall , Holger Zimmermann , Konstanze Diefenbach , Kristina King
发明人： Christian Seitz , Annemarie Wasserfall , Holger Zimmermann , Konstanze Diefenbach , Kristina King
IPC分类号： A61K9/36 , A61K31/519 , A61K31/56 , A61P15/00
CPC分类号： A61K31/519 , A61K9/2054 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： A combination of an anti-androgenic gestagen at a daily dose of from an ovulation-inhibiting dose up to at most twice the ovulation-inhibiting dose and from 0.1 to 10 mg of (6S)-5-methyltetrahydrofolate are used to produce a pharmaceutical preparation for therapeutically treating endometriosis while simultaneously reducing therapy side effects including the negative effect on bone density and/or bone metabolism, reducing the risk of osteoporosis and, in the event of pregnancy, reducing the risk of congenital malformations, such as medullary tube defects, cleft lip, cleft jaw, or cleft palate, and the risk of pregnancy complications, such as detachment of the placenta and premature birth. The preparation is suitable for long-term administration, which continues daily for at least 169 days to at least two years.
摘要翻译：以排卵抑制剂量的日剂量至最多两倍排卵抑制剂量的抗雄激素孕激素和0.1至10mg（6S）-5-甲基四氢叶酸的组合使用来制备药物制剂用于治疗性治疗子宫内膜异位症，同时减少治疗副作用，包括对骨密度和/或骨代谢的负面影响，降低骨质疏松症的风险，并且在怀孕的情况下，降低先天性畸形的风险，例如髓管缺陷，裂口唇腭裂或腭裂，以及怀孕并发症的风险，如胎盘脱离和早产。该制剂适合长期服用，每天持续至少169天至少两年。

46. 发明申请

US20050128890A1 Player for storage media 有权
标题翻译：播放器用于存储媒体
公开(公告)号：US20050128890A1
公开(公告)日：2005-06-16
申请号：US10491251
申请日：2002-09-20
申请人： Volker Becker , Holger Zimmermann
发明人： Volker Becker , Holger Zimmermann
IPC分类号： G11B27/00 , G11B27/10 , G11B27/11 , G11B27/34 , G11B7/085
CPC分类号： G11B27/002 , G11B27/105 , G11B27/11 , G11B27/34 , G11B2220/2529 , G11B2220/2545 , G11B2220/2562 , G11B2220/65
摘要： A player for storage media having a number of data groups is provided, which player enables a data group to be selected in a clearly organized way, particularly when a large number of data groups is stored on such a storage medium. In this context, a read head is provided for reading out the data of a first storage medium, and a read-head control is provided for positioning the read head in the area of a data group to be played, which data group is stored on the first storage medium. In addition, an input unit is provided where, on the one hand, various storage media and, on the other hand, various data groups, are selectable on a selected storage medium to be played. A conversion device is provided, which, in response to the number of data groups on the first storage medium exceeding a predefined value, forms at least two subsets from the number of data groups of the first storage medium, each of these subsets at the input unit being selectable as a different storage medium. The conversion device drives the read-head control as a function of the subset selected as storage medium at the input unit, to position the read head.
摘要翻译：提供了具有多个数据组的存储介质的播放器，该播放器使得能够以清晰有组织的方式选择数据组，特别是当在这种存储介质上存储大量数据组时。在这种情况下，提供读头以读出第一存储介质的数据，并且提供读头控制用于将读头定位在要播放的数据组的区域中，该数据组被存储在第一存储介质。此外，提供了一个输入单元，其中一方面各种存储介质，另一方面，各种数据组可在所选择的要播放的存储介质上选择。提供了一种转换装置，其响应于第一存储介质上的数据组的数量超过预定值，从第一存储介质的数据组的数量形成至少两个子集，这些子集中的每一个在输入端单元可选择为不同的存储介质。转换装置驱动读取头控制作为在输入单元处被选择为存储介质的子集的函数，以定位读取头。

47. 发明授权

US06532200B1 Voltage supply adaptable to current highest voltage demand 失效
标题翻译：电压供应适应当前最高电压需求
公开(公告)号：US06532200B1
公开(公告)日：2003-03-11
申请号：US09622655
申请日：2000-11-17
申请人： Thomas Freitag , Holger Zimmermann , Dieter Baas
发明人： Thomas Freitag , Holger Zimmermann , Dieter Baas
IPC分类号： G11B390
CPC分类号： G11B7/00 , G11B7/0037 , G11B7/0946 , G11B17/0401
摘要： An electrical device allows voltage to be supplied with minimal power loss. The electrical device has elements with differing supply voltage demands. The same supply voltage is supplied in each case to the elements. The supply voltage can be switched over. The supply voltage is set as a function of the currently highest voltage demand of the elements. The electrical device can be configured as a playback device for optical memory disks, and can include a device for driving an optical memory disk inserted into the playback device and for positioning a scanning unit.
摘要翻译：电气设备允许以最小的功率损耗提供电压。电气设备具有不同电源电压要求的元件。在每种情况下，向元件提供相同的电源电压。可以切换电源电压。电源电压被设置为元件当前最高电压需求的函数。电气设备可以被配置为用于光学存储器盘的回放设备，并且可以包括用于驱动插入到回放设备中并用于定位扫描单元的光学存储器盘的设备。

48. 发明授权

US06371434B1 Spring arrangement apparatus for mounting a vibration-sensitive or shock-sensitive device 失效
标题翻译：用于安装振动敏感或冲击敏感装置的弹簧布置装置
公开(公告)号：US06371434B1
公开(公告)日：2002-04-16
申请号：US09254444
申请日：1999-11-22
申请人： Volker Becker , Ingo Hermanns , Frank Koertje , Thomas Westendorf , Holger Zimmermann , Wilfried Repper
发明人： Volker Becker , Ingo Hermanns , Frank Koertje , Thomas Westendorf , Holger Zimmermann , Wilfried Repper
IPC分类号： F16M1300
CPC分类号： F16F15/04 , G11B33/08
摘要： Spring arrangement for mounting a vibration- or shock-sensitive device attached to a supporting member in a housing, with the supporting member being fastened to the housing by helical spring elements. The supporting member is suspended in the housing by helical spring elements so that each elastic force component of one spring applied to the supporting member in a specific direction is counteracted by at least one elastic force component of another spring applied in the opposite direction so that the supporting member remains approximately in the center of the vibration clearance provided regardless of the position in which the housing is mounted in a motor vehicle. Due to the opposing elastic forces of the springs, the spring constant and therefore the natural frequency of the overall system can be advantageously increased, thus avoiding undesired points of resonance at low frequencies.
摘要翻译：用于将安装在支撑构件的振动或冲击敏感装置安装在壳体中的弹簧装置，其中支撑构件通过螺旋弹簧元件紧固到壳体。支撑构件通过螺旋弹簧元件悬挂在壳体中，使得沿特定方向施加到支撑构件的一个弹簧的每个弹性力分量通过沿相反方向施加的另一个弹簧的至少一个弹力分量抵消，支撑构件保持大致在所提供的振动间隙的中心，而与壳体安装在机动车辆中的位置无关。由于弹簧的相对的弹性力，可以有利地增加弹簧常数和因此整个系统的固有频率，从而避免在低频下的不期望的共振点。

49. 发明授权

US08349820B2 Use of estradiol valerate or 17β-estradiol in combination with dienogest for oral therapy to maintain and/or increase feminine libido 失效
标题翻译：使用戊酸雌二醇或17和bgr-雌二醇联合去甲肾上腺素进行口服治疗以维持和/或增加女性性欲
公开(公告)号：US08349820B2
公开(公告)日：2013-01-08
申请号：US11873595
申请日：2007-10-17
申请人： Susan Zeun , Holger Zimmermann , Susanne Parke
发明人： Susan Zeun , Holger Zimmermann , Susanne Parke
IPC分类号： A61K31/56
CPC分类号： A61K31/565 , A61K31/57 , A61K2300/00
摘要： The invention relates to the use, optionally together with oral contraception, of estradiol valerate or 17β-estradiol in combination with 17α-cyanomethyl-17-β-hydroxyestra-4,9-dien-3-one (dienogest) in a multistage or single-stage combination preparation for oral therapy to maintain and/or increase feminine libido.The total number of daily dose units of the multistage combination and of a pharmaceutically harmless placebo or a single-stage combination and optionally the pharmaceutically harmless placebo-containing or placebo- and hormone-free daily dose units amounts to 28 daily dose units.
摘要翻译：本发明涉及在多级中与17α-氰基甲基-17-＆bgr-羟雌甾-4,9-二烯-3-酮（二烯酸）组合使用，任选地与口服避孕方法一起使用戊酸雌二醇酯或17β-雌二醇或用于口服治疗的单阶段组合制剂以维持和/或增加女性性欲。多级组合和药物无害安慰剂或单级组合和任选的无药物无安慰剂或无安慰剂和无激素的每日剂量单位的日剂量单位的总数为28个日剂量单位。

50. 发明授权

US08153616B2 Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same 有权
标题翻译：口服避孕和口服治疗功能障碍性子宫出血的组合制剂，含有戊酸雌二醇和dienogest及其使用方法
公开(公告)号：US08153616B2
公开(公告)日：2012-04-10
申请号：US11609705
申请日：2006-12-12
申请人： Susan Zeun , Pol Boudes , Angelo Secci , Jan Nedrikat , Holger Zimmermann
发明人： Susan Zeun , Pol Boudes , Angelo Secci , Jan Nedrikat , Holger Zimmermann
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K31/57
摘要： The multiphase combination preparation for oral therapy of dysfunctional uterine bleeding and for oral contraception contains a first phase consisting of 2 daily dosage units, each containing 3 mg of estradiol valerate or
摘要翻译：用于口腔治疗功能障碍性子宫出血和口服避孕药的多相组合制剂含有由2个日剂量单位组成的第一相，每个剂量单位含有3mg戊酸雌二醇或<3mg雌二醇; 第二组由第一组5个每日剂量单位组成，每组由2mg的地诺孕酮与2mg戊酸雌二醇或2mg雌二醇的组合组成，第二组由17个日剂量单位组成，每组包含的3mg的地诺孕酮与2mg戊酸雌二醇或<2mg雌二醇的组合; 第三阶段由2个日剂量单位组成，每个单位含有1毫克戊酸雌二醇或<1毫克雌二醇; 另一个阶段由药物无害安慰剂的2个日剂量单位组成。

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