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41. 发明授权

US07369889B2 Apparatus for analyzing cardiac events 有权
标题翻译：用于分析心脏事件的装置
公开(公告)号：US07369889B2
公开(公告)日：2008-05-06
申请号：US10521080
申请日：2004-04-02
申请人： Magnus Aström , Leif Sörnmo , Anders Björling
发明人： Magnus Aström , Leif Sörnmo , Anders Björling
IPC分类号： A61N5/04
CPC分类号： A61N1/365
摘要： An apparatus for detecting cardiac events in electrograms has a feature extraction unit that derives features of the cardiac events for discriminating among different types of cardiac events. A clustering unit groups cardiac events with similar features into respective clusters defined by predetermined cluster features. The feature extraction unit determines a feature vector describing waveform characteristics of cardiac events in the electrogram by a wavelet transform. The clustering unit determines the distance between the feature vector and corresponding cluster feature vectors in order to assign the cardiac event in question to that cluster which results in a minimum distance, providing that the minimum distance is less than a predetermined threshold value. A heart stimulator provided with such a cardiac event detecting apparatus detects the occurrence of an arrhythmia and appropriately controls a pulse stimulator to treat the arrhythmia.
摘要翻译：用于检测电描记图中的心脏事件的装置具有导出心脏事件特征的特征提取单元，用于区分不同类型的心脏事件。聚类单元将具有相似特征的心脏事件组合成由预定的聚类特征定义的各个簇。特征提取单元通过小波变换来确定描绘电描记图中的心脏事件的波形特征的特征矢量。聚类单元确定特征向量与对应的群集特征向量之间的距离，以便将所讨论的心脏事件分配给导致最小距离的群集，只要最小距离小于预定阈值即可。设置有这种心脏事件检测装置的心脏刺激器检测心律失常的发生并适当地控制脉冲刺激器来治疗心律失常。

42. 发明授权

US06915158B2 Cardiac stimulating device with morphology sensitive detection and method for automatically creating a morphology template 有权
标题翻译：具有形态敏感检测的心脏刺激装置和自动创建形态学模板的方法
公开(公告)号：US06915158B2
公开(公告)日：2005-07-05
申请号：US09993156
申请日：2001-11-19
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61B5/0402 , A61B5/0472 , A61N1/362 , A61N1/39 , A61B5/0452
CPC分类号： A61B5/0472 , A61B5/04023 , A61N1/3621 , A61N1/3956
摘要： In a method for automatic creation of a template for a morphology sensitive detector for an implantable cardiac stimulating device and a cardiac stimulating device operating according to the method, a predetermined length of the heart signal is recorded and filtered, all deflections exceeding a predetermined amplitude are identified and stored based on the condition that selected deflections must be separated at least by a predetermined amount of time, all selected deflections are categorized into separate classes, and the most representative class or classes for creation of the template is selected.
摘要翻译：在用于自动创建用于可植入心脏刺激装置的形态敏感检测器和根据该方法操作的心脏刺激装置的模板的方法中，记录和过滤心脏信号的预定长度，超过预定幅度的所有偏转是基于所选择的偏转至少必须分开预定的时间量的条件来识别和存储，所有所选择的偏转被分类成单独的类，并且选择用于创建模板的最具代表性的类或类。

43. 发明申请

US20120108987A1 IMPLANTABLE SYSTEMIC BLOOD PRESSURE MEASUREMENT SYSTEMS AND METHODS 审中-公开
标题翻译：可植入系统血压测量系统和方法
公开(公告)号：US20120108987A1
公开(公告)日：2012-05-03
申请号：US13342864
申请日：2012-01-03
申请人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine , Anders Björling
发明人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine , Anders Björling
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/02116 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0452 , A61B5/6846 , A61B2562/0219 , A61N1/36564 , A61N1/36578 , A61N1/36585
摘要： Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.
摘要翻译：本文提供了可植入系统及其使用方法，用于长期监测动脉血压。使用植入电极和植入的传感器获得指示患者心脏的电活动的第一信号和指示患者心脏的机械活动的第二信号。通过测量第一信号的各个特征相对于第二信号的特征之间的时间，可以确定指示收缩压和舒张压的值。在具体实施例中，这些特征用于确定峰值脉冲到达时间（PPAT），其用于确定指示收缩压的值。此外，可以使用在第二信号的最大峰值处的峰 - 峰幅度和指示收缩压的值来确定指示舒张压的值。

44. 发明申请

US20100305640A1 METHOD, DEVICE, IMPLANTABLE STIMULATOR AND DUAL CHAMBER CARDIAC THERAPY SYSTEM 有权
标题翻译：方法，装置，可植入刺激物和双室心脏治疗系统
公开(公告)号：US20100305640A1
公开(公告)日：2010-12-02
申请号：US12446496
申请日：2006-10-31
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/36578 , A61N1/3688
摘要： In a device and method in a dual chamber pacing system operating in an atrial synchronized mode, the cardiac stimulator is connectable to a lead arrangement arranged for sensing atrial electrical and mechanical activity. Upon detection of an atrial arrhythmia based on either of sensed atrial mechanical activity, atrial electrical activity, or a combination thereof, a mode switch from an atrial synchronized ventricle stimulating mode to a non-atrial synchronized mode is triggered.
摘要翻译：在以心房同步模式操作的双室起搏系统中的装置和方法中，心脏刺激器可连接到布置用于感测心房电和机械活动的引线装置。在基于感测到的心房机械活动，心房电活动或其组合中的任一种检测到心房心律失常时，触发从心房同步心室刺激模式到非心房同步模式的模式切换。

45. 发明授权

US07778697B2 Detection of ischemia 有权
标题翻译：检测缺血
公开(公告)号：US07778697B2
公开(公告)日：2010-08-17
申请号：US11667505
申请日：2004-10-11
申请人： Anders Björling , Kjell Norén
发明人： Anders Björling , Kjell Norén
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/02028 , A61B5/053 , A61B5/0538 , A61N1/36521 , A61N1/36557 , A61N1/3684
摘要： In an ischemia detection method, and in an ischemia detector and a cardiac stimulator embodying an ischemia detector, a workload of a patient is measured, as is an ejection fraction (EF) associated with the heart of the patient is determined. A predetermined reference relation between EF and workload for the patient is stored, and an analysis unit detects a state of ischemia of the patient from deviation in the determined EF for various workloads from the stored reference relation.
摘要翻译：在局部缺血检测方法中，在局部缺血检测器和体内缺血检测器的心脏刺激器中，测量患者的工作量，并确定与患者心脏相关联的射血分数（EF）。存储EF和患者的工作负荷之间的预定参考关系，并且分析单元从所存储的参考关系中检测出针对各种工作负载的所确定的EF中的患者的局部缺血状态。

46. 发明授权

US08761882B2 Implantable heart stimulating device and method 有权
标题翻译：可植入心脏刺激装置及方法
公开(公告)号：US08761882B2
公开(公告)日：2014-06-24
申请号：US12299821
申请日：2006-05-16
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3712
摘要： In an implantable heart stimulating device and a method of the operation thereof, device has a control circuit that detects an evoked responses to delivered pacing pulses and to carry out an automatic capture routine. The control circuit is arranged to automatically temporarily disable the automatic capture routine on the basis of at least one of the following criteria: a1) if more than a predetermined number of threshold searches have been performed during a certain time, and b1) if a variable time delay with which the device operates is changed such that a pacing pulse may be delivered by the device during the evoked response time window.
摘要翻译：在可植入心脏刺激装置及其操作方法中，装置具有控制电路，其检测对发出的起搏脉冲的诱发反应并执行自动捕获程序。控制电路被设置为基于以下标准中的至少一个自动临时禁用自动捕获程序：a1）如果在特定时间内已经执行了多于一个预定数量的阈值搜索，并且b1）如果变量改变设备操作的时间延迟，使得在诱发响应时间窗口期间，该设备可以传送起搏脉冲。

47. 发明申请

US20100324432A1 METHOD AND DEVICE TO DETECT EATING, TO CONTROL ARTIFICIAL GASTRIC STIMULATION 审中-公开
标题翻译：检测药物的方法和装置，控制人造气刺激
公开(公告)号：US20100324432A1
公开(公告)日：2010-12-23
申请号：US12526137
申请日：2007-02-21
申请人： Anders Björling , Kjell Norén , Malin Öhlander
发明人： Anders Björling , Kjell Norén , Malin Öhlander
IPC分类号： A61B5/026
CPC分类号： A61N1/36007 , A61B5/026 , A61B5/0261 , A61B5/0265 , A61B5/028 , A61B5/0295 , A61B5/0535 , A61B5/4238 , A61B5/6876 , A61B5/6884 , A61B8/06
摘要： In a method and device for detecting the intake of food in a subject at least one parameter related to the blood flow and/or perfusion of a blood vessel and/or an organ in the digestive system of a patient is monitored by a sensor attached to, or in, a blood vessel or organ of the digestive system. The value of each monitored parameter is analyzed and may be used to control the activity of a gastric stimulator.
摘要翻译：在用于检测受试者中食物摄入的方法和装置中，与患者的消化系统中的血流和/或器官的血流和/或器官相关的至少一个参数由附接到或在消化系统的血管或器官中。分析每个监测参数的值，并可用于控制胃刺激剂的活性。

48. 发明申请

US20100121398A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MONITORING VALVE MOVEMENTS OF A HEART 审中-公开
标题翻译：用于监测心脏瓣膜运动的可植入医疗装置和方法
公开(公告)号：US20100121398A1
公开(公告)日：2010-05-13
申请号：US12597227
申请日：2007-04-27
申请人： Anders Björling , Cecilia Tuvstedt , Kenth Nilsson , Kjell Norén
发明人： Anders Björling , Cecilia Tuvstedt , Kenth Nilsson , Kjell Norén
IPC分类号： A61N1/368
CPC分类号： A61N1/36521 , A61N1/36578 , A61N1/3682
摘要： An implantable medical device for monitoring the movements of the valve planes of the heart to determine at least one hemodynamic measure reflecting a mechanical functioning of a heart of a patient, includes an impedance measuring circuit that measures impedance between at least electrode pairs including at least one electrode placed substantially at the level of the valve plane. The measured impedances reflect valve plane movements. A hemodynamic parameter determining circuit determines at least one hemodynamic parameter based on the impedances reflecting the mechanical functioning of the heart.
摘要翻译：一种可植入医疗装置，用于监测心脏的瓣膜平面的移动以确定反映患者心脏的机械功能的至少一个血流动力学量度，包括阻抗测量电路，其测量至少包括至少一个电极基本上位于阀平面的水平面上。测量的阻抗反映了阀平面运动。血液动力学参数确定电路基于反映心脏的机械功能的阻抗来确定至少一个血液动力学参数。

49. 发明授权

US06745075B2 Method and apparatus for detection of premature atrial contraction 失效
标题翻译：用于检测早产性心房收缩的方法和装置
公开(公告)号：US06745075B2
公开(公告)日：2004-06-01
申请号：US10027156
申请日：2001-12-20
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1362
CPC分类号： A61N1/056 , A61N1/3622
摘要： In a method for identifying and classifying premature atrial contractions, a cardiac lead having multiple electrodes, electrically separated from each other, at its tip is placed in contact with cardiac tissue, so that at least two of the electrodes are simultaneously in contact with the cardiac tissue. When a depolarization wave arrives at the tip, respective unipolar signals are detected from multiple electrodes in contact with the cardiac tissue, and these signals are analyzed, such as by identifying a time offset between pairs of the signals, to identify a propagation direction of the depolarization wave. Dependent on this propagation direction, the depolarization wave is classified as representing a normal sinus beat or a premature atrial contraction. By further analysis, the premature atrial contraction, if present, is classified as originating either from the right atrium or the left atrium.
摘要翻译：在用于识别和分类早产性心房收缩的方法中，将具有在其尖端处彼此电分离的多个电极的心脏引线放置成与心脏组织接触，使得至少两个电极同时与心脏接触组织。当去极化波到达尖端时，从与心脏组织接触的多个电极检测相应的单极信号，并且例如通过识别信号对之间的时间偏移来分析这些信号，以识别信号的传播方向去极化波。取决于该传播方向，去极化波被分类为表示正常的窦性心跳或过早的心房收缩。通过进一步的分析，如果存在早产性心房收缩，则被分类为来自右心房或左心房。

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