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1. 发明授权

US07369889B2 Apparatus for analyzing cardiac events 有权
标题翻译：用于分析心脏事件的装置
公开(公告)号：US07369889B2
公开(公告)日：2008-05-06
申请号：US10521080
申请日：2004-04-02
申请人： Magnus Aström , Leif Sörnmo , Anders Björling
发明人： Magnus Aström , Leif Sörnmo , Anders Björling
IPC分类号： A61N5/04
CPC分类号： A61N1/365
摘要： An apparatus for detecting cardiac events in electrograms has a feature extraction unit that derives features of the cardiac events for discriminating among different types of cardiac events. A clustering unit groups cardiac events with similar features into respective clusters defined by predetermined cluster features. The feature extraction unit determines a feature vector describing waveform characteristics of cardiac events in the electrogram by a wavelet transform. The clustering unit determines the distance between the feature vector and corresponding cluster feature vectors in order to assign the cardiac event in question to that cluster which results in a minimum distance, providing that the minimum distance is less than a predetermined threshold value. A heart stimulator provided with such a cardiac event detecting apparatus detects the occurrence of an arrhythmia and appropriately controls a pulse stimulator to treat the arrhythmia.
摘要翻译：用于检测电描记图中的心脏事件的装置具有导出心脏事件特征的特征提取单元，用于区分不同类型的心脏事件。聚类单元将具有相似特征的心脏事件组合成由预定的聚类特征定义的各个簇。特征提取单元通过小波变换来确定描绘电描记图中的心脏事件的波形特征的特征矢量。聚类单元确定特征向量与对应的群集特征向量之间的距离，以便将所讨论的心脏事件分配给导致最小距离的群集，只要最小距离小于预定阈值即可。设置有这种心脏事件检测装置的心脏刺激器检测心律失常的发生并适当地控制脉冲刺激器来治疗心律失常。

2. 发明授权

US08060190B2 Detection of drastic blood pressure changes 有权
标题翻译：检测急性血压变化
公开(公告)号：US08060190B2
公开(公告)日：2011-11-15
申请号：US11662480
申请日：2005-09-12
申请人： Leif Sörnmo , Kristian Solem
发明人： Leif Sörnmo , Kristian Solem
IPC分类号： A61B5/0402
CPC分类号： A61B5/02405 , A61B5/021 , A61B5/0468 , A61M1/16 , A61M1/3639 , A61M2205/18 , A61M2205/50 , A61M2230/04
摘要： The invention relates to cardiac-activity based prediction of a rapid drop in a patient's blood pressure during hemodialysis. A proposed alarm apparatus includes an input interface, primary and secondary analysis units and an alarm-generating unit. An electrocardiogram signal (HECG) of the patient is received via the input interface by the primary analysis unit, which in response thereto produces a heart-rate-variability signal (PHRV). The secondary analysis unit determines an intensity of ectopic beats (PEBC) based on the electrocardiogram signal (HECG). The alarm-generating unit investigates whether the intensity of ectopic beats (PEBC) is relatively low or relatively high. In case of a relatively low intensity, the unit triggers an alarm signal (α) indicative of an estimated rapid blood pressure decrease if the heart-rate-variability signal (PHRV) fulfills a first alarm criterion. In case of a relatively high intensity, however, the unit triggers the alarm signal (α) if the intensity of the ectopic beats (PEBC) fulfills a second alarm criterion.
摘要翻译：本发明涉及基于心脏活动的预测血液透析期间患者血压的快速下降。所提出的报警装置包括输入接口，主要和次要分析单元以及报警发生单元。通过主分析单元经由输入接口接收患者的心电图信号（HECG），主要分析单元响应于此产生心率变异信号（PHRV）。二次分析单元基于心电图信号（HECG）确定异位搏动（PEBC）的强度。报警机构调查异位搏动（PEBC）的强度是否相对较低或相对较高。在强度相对较低的情况下，如果心率变异信号（PHRV）满足第一警报标准，则该单元触发指示估计的快速血压降低的报警信号（α）。然而，在强度相对较高的情况下，如果异位搏动（PEBC）的强度达到第二警报标准，则该单元触发报警信号（α）。

3. 发明授权

US07085600B2 Cardiac event detector 失效
标题翻译：心脏事件检测器
公开(公告)号：US07085600B2
公开(公告)日：2006-08-01
申请号：US10493272
申请日：2002-09-18
申请人： Magnus Åström , Leif Sörnmo , Salvador Olmos
发明人： Magnus Åström , Leif Sörnmo , Salvador Olmos
IPC分类号： A61B5/04
CPC分类号： A61N1/3704 , A61B5/0452 , H03H17/02
摘要： A detector for detecting a cardiac event in an IEGM has a bank of digital filters composed of at least two filters with substantially different impulse responses corresponding to different properties of the cardiac event. The filters respectively filter different portions of the IEGM and respectively emit a value per time unit corresponding to the morphological resemblance between the IEGM and the finite impulse response. An analyzing unit combines these output values from the filters in a predetermined manner for comparison with predetermined detection criteria.
摘要翻译：用于检测IEGM中的心脏事件的检测器具有由至少两个具有与心脏事件的不同性质相对应的具有显着不同的脉冲响应的滤波器组成的数字滤波器组。滤波器分别对IEGM的不同部分进行滤波，并分别发射对应于IEGM和有限脉冲响应之间的形态相似性的每个时间单位的值。分析单元以预定方式组合来自滤波器的这些输出值，以与预定检测准则进行比较。

4. 发明授权

US08311619B2 Detection of drastic blood pressure changes 有权
标题翻译：检测急性血压变化
公开(公告)号：US08311619B2
公开(公告)日：2012-11-13
申请号：US12066478
申请日：2006-08-10
申请人： Leif Sörnmo , Kristian Solem
发明人： Leif Sörnmo , Kristian Solem
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/746 , A61B5/0402 , A61B5/0452 , A61B5/7203 , A61B5/7264 , A61M1/30
摘要： A cardiac-activity based prediction of a rapid drop in a patient's blood pressure during extracorporeal blood treatment is disclosed. A proposed alarm apparatus includes a primary beat morphology analysis unit bank of secondary analysis units and an alarm generating unit. The primary beat morphology analysis unit discriminates heart beats in a received basic electrocardiogram signal, classifies each beat into one out of at least two different beat categories, and associates each segment of the signal with relevant event-type data. The event-type data and the basic electrocardiogram signal together form an enhanced electrocardiogram signal, based upon which the primary beat morphology analysis unit determines whether one or more secondary signal analyses should be performed. Depending on the enhanced electrocardiogram signal's properties, the bank of secondary analysis units performs none, one or more of up to at least two different types of secondary analyses, and for each analysis performed produces a respective test signal. The alarm generating unit receives the test signals, and triggers an alarm signal indicative of an estimated rapid blood pressure decrease, if at least one alarm criterion is fulfilled.
摘要翻译：公开了一种基于心脏活动的预测体外血液治疗期间患者血压迅速下降的预测。所提出的报警装置包括二次分析单元的主拍形态分析单元组和报警发生单元。主要搏动形态分析单元鉴别接收到的基本心电图信号中的心跳，将每个节拍分为至少两个不同节拍类别中的一个，并且将每个信号段与相关的事件类型数据相关联。事件类型数据和基本心电图信号一起形成增强的心电图信号，基于该心电图信号，初步搏动形态分析单元确定是否应执行一个或多个次要信号分析。根据增强的心电图信号的性质，二次分析单元组不执行至多两种不同类型的辅助分析中的一个或多个，并且对于执行的每个分析，都产生相应的测试信号。如果满足至少一个报警标准，则报警发生单元接收测试信号，并触发指示估计的快速血压下降的报警信号。

5. 发明授权

US08287725B2 Prediction of rapid symptomatic blood pressure decrease 有权
标题翻译：预测快速症状性血压下降
公开(公告)号：US08287725B2
公开(公告)日：2012-10-16
申请号：US12308052
申请日：2007-06-04
申请人： Leif Sörnmo , Kristian Solem , Bo Olde
发明人： Leif Sörnmo , Kristian Solem , Bo Olde
IPC分类号： B01D61/12 , A61B5/024
CPC分类号： A61B5/14551 , A61B5/021 , A61B5/02116 , A61M1/3639 , A61M2205/18 , A61M2205/50 , A61M2230/30
摘要： The invention relates to prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (Pps) with respect to a peripheral body part (105) of the subject (P) is registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. An initial pulse magnitude measure is calculated based on a pulse shape parameter (Pps) received at a first instance. During a measurement period subsequent to the first instance, a respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (Pps). It is further investigated, for each pulse magnitude measure in the measurement period, whether or not the measure fulfills a decision criterion relative to the initial pulse magnitude measure. An alarm triggering signal (α) is generated if the decision criterion is found to be fulfilled.
摘要翻译：本发明涉及预测受试者血压中快速有症状的下降，例如，在治疗期间或在操作飞行器时。为此目的，通过适于检测血管中的光反应变化的脉搏血氧仪（110）来记录相对于被检体（P）的外周身体部分（105）的脉搏形状参数（Pps）。基于在一次接收的脉冲形状参数（Pps）来计算初始脉冲幅度测量。在第一次之后的测量周期期间，基于接收的脉冲形状参数（Pps）的数量来计算相应的脉冲幅度测量。对于测量周期中的每个脉冲幅度测量，进一步研究测量是否满足相对于初始脉冲幅度测量的判定标准。如果发现满足判定标准，则产生报警触发信号（α）。

6. 发明授权

US07117029B2 Method of and apparatus for deriving indices characterizing atrial arrhythmias 有权
公开(公告)号：US07117029B2
公开(公告)日：2006-10-03
申请号：US10260838
申请日：2002-09-30
申请人： Martin Stridh , Leif Sörnmo
发明人： Martin Stridh , Leif Sörnmo
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/7264
摘要： In a method of and apparatus for deriving indices characterizing atrial arrhythmias, a temporally isolated portion of a digital representation of a time-domain electrical signal originating from the atria of a patient is frequency analyzed to provide a corresponding frequency spectrum. The obtained frequency spectrum is compared with a template frequency spectrum, selectively adapted dependent on previously obtained frequency spectra from different temporally isolated portions, to determine a frequency shift value and an amplitude value that optimize a correlation between the two spectra. An output representing the two determined values is used, possibly together with parameters describing the template frequency spectrum, to classify an atrial arrhythmia manifest in the digital representation.

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