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41. 发明授权

US5378730A Permeation enhancer comprising ethanol and monoglycerides 失效
标题翻译：包含乙醇和单甘油酯的渗透增强剂
公开(公告)号：US5378730A
公开(公告)日：1995-01-03
申请号：US985530
申请日：1992-12-03
申请人： Eun S. Lee , Su Il Yum
发明人： Eun S. Lee , Su Il Yum
IPC分类号： A61K9/00 , A61K9/70 , A61K47/10 , A61K47/14 , A61K31/24 , A61K31/22 , A61K31/60 , A61K31/70
CPC分类号： A61K9/7084 , A61K47/10 , A61K47/14 , A61K9/0014 , B82Y5/00
摘要： Mixtures of ethanol and monoglyceride are disclosed for enhancing the permeation of drugs through skin or mucosa. The monoglyceride is a monoglyceride or a mixture of monoglycerides of fatty acids with a total monoesters content of at least about 90%. Water is also included in the permeation-enhancing mixture.
摘要翻译：公开了乙醇和单甘油酯的混合物，用于增强药物通过皮肤或粘膜的渗透。单酸甘油酯是单酸甘油酯或脂肪酸的单酸甘油酯的混合物，其总单酯含量为至少约90％。渗透增强混合物中还含有水。

42. 发明授权

US5141750A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5141750A
公开(公告)日：1992-08-25
申请号：US271122
申请日：1988-11-14
申请人： Eun Soo Lee , Felix Theeuwes , Patrick Wong S. L. , Su Il Yum , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick Wong S. L. , Su Il Yum , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability emables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性可以从序列和并发应用用于管理诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

43. 发明授权

US5071656A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5071656A
公开(公告)日：1991-12-10
申请号：US271207
申请日：1988-11-14
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Alejandro Zaffaroni
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/7069 , A61K31/21 , A61K9/7084 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

44. 发明授权

US5024663A Self-contained suction pump 失效
标题翻译：自给式抽水泵
公开(公告)号：US5024663A
公开(公告)日：1991-06-18
申请号：US482572
申请日：1990-02-21
申请人： Su Il Yum
发明人： Su Il Yum
IPC分类号： A61B5/155 , A61B10/00
CPC分类号： A61B5/153 , A61B10/0045 , A61B5/15003 , A61B5/150099 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150992 , A61B5/150389 , A61B5/150503
摘要： The present invention is directed to a self-contained suction pump for drawing a fluid, such as a sample of biological fluid from an animal body, and to a method for obtaining a fluid sample. The present invention is particularly useful for repetitive or continuous collection of a series of samples over a period of time.
摘要翻译：本发明涉及一种用于从动物体抽取流体的生物流体样本的自给式抽吸泵以及用于获得流体样品的方法。本发明特别适用于在一段时间内重复或连续收集一系列样品。

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