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1. 发明授权

US08153152B2 Oral drug delivery system 有权
公开(公告)号：US08153152B2
公开(公告)日：2012-04-10
申请号：US11888671
申请日：2007-07-31
申请人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
发明人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
IPC分类号： A61K9/64 , A61K31/44 , A61K47/00
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

2. 发明授权

US5629019A Formulations with hydrophobic permeation enhancers 失效
标题翻译：疏水渗透促进剂配方
公开(公告)号：US5629019A
公开(公告)日：1997-05-13
申请号：US064689
申请日：1993-05-20
申请人： Eun Soo Lee , Su Il Yum , Michel J. N. Cormier
发明人： Eun Soo Lee , Su Il Yum , Michel J. N. Cormier
IPC分类号： A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/28 , A61K47/36 , A61K9/06
CPC分类号： A61K47/26 , A61K47/12 , A61K47/14 , A61K47/186 , A61K47/20 , A61K47/28 , A61K47/36 , A61K9/0014 , Y10S514/944 , Y10S514/946 , Y10S514/951
摘要： This invention is directed to a novel formulation for effectively utilizing hydrophobic permeation enhancers for the increased permeability of active agents through the skin or mucosa along with reduction of the lag time between application of the active agent and attainment of a therapeutically effective agent flux, with little or no irritation to the host. The invention is directed to compositions containing a hydrophobic permeation enhancer, which permeation enhancer has been micronized and stabilized in an inert carrier such as water. These compositions can be combined with a biologically active agent to provide enhanced permeability of the active agent to the skin or mucosa.
摘要翻译：本发明涉及一种用于有效利用疏水性渗透增强剂以增加活性剂通过皮肤或粘膜的渗透性的新型制剂，同时减少施用活性剂之间的滞后时间并获得治疗有效的药剂通量或对主机没有刺激。本发明涉及含有疏水渗透增强剂的组合物，该渗透增强剂已经在惰性载体如水中微粉化并稳定。这些组合物可与生物活性剂组合以提供活性剂对皮肤或粘膜的增强的渗透性。

3. 发明授权

US5402777A Methods and devices for facilitated non-invasive oxygen monitoring 失效
标题翻译：便于非侵入式氧气监测的方法和装置
公开(公告)号：US5402777A
公开(公告)日：1995-04-04
申请号：US893480
申请日：1992-06-03
申请人： Jessica A. Warring , David B. Swedlow , Michael J. N. Cormier , Su Il Yum , Lina T. Taskovich , Albert Ollerdessen
发明人： Jessica A. Warring , David B. Swedlow , Michael J. N. Cormier , Su Il Yum , Lina T. Taskovich , Albert Ollerdessen
IPC分类号： A61B5/00 , A61B5/024 , A61N1/30 , A61L15/00
CPC分类号： A61B5/6833 , A61B5/02433 , A61B5/14552
摘要： The present invention is directed to a sensor system for use with a blood characteristic measurement device such as a pulse oximeter, on areas of the body having low normal cutaneous blood flow and for monitoring a blood characteristic such as oxygen saturation and pulse rate of patients, preferably over an extended period of time. The sensor system includes (a) a transdermal device containing a blood perfusion-enhancing agent that is administered in a controlled amount to the skin of a human patient and (b) a skin surface sensor.
摘要翻译：本发明涉及一种用于血液特性测量装置如脉搏血氧计的传感器系统，其具有低正常皮肤血流的身体区域并且用于监测患者的血氧饱和度和脉搏率等血液特性，优选在较长时间内。传感器系统包括（a）透皮装置，其包含以可控量施用于人类患者皮肤的血液灌注增强剂和（b）皮肤表面传感器。

4. 发明授权

US4140117A Cartridge for liquid infusion apparatus 失效
标题翻译：液体输液装置用墨盒
公开(公告)号：US4140117A
公开(公告)日：1979-02-20
申请号：US798507
申请日：1977-05-19
申请人： Richard G. Buckles , Seymour Hoff , Sharon Kehr , Su Il Yum
发明人： Richard G. Buckles , Seymour Hoff , Sharon Kehr , Su Il Yum
IPC分类号： A61M5/142 , A61M5/145 , A61M5/152 , A61M5/155 , A61J7/00
CPC分类号： A61M5/152 , A61M5/145 , A61M5/155 , A61M2005/14204 , Y10S128/12
摘要： A removable cartridge that is used in combination with a liquid drug infusion apparatus that comprises a housing that defines an inlet and outlet and has a recess for receiving the cartridge, a confined flow passageway extending between the inlet and outlet, and a conduit extending from the outlet to the infusion site. The removable cartridge includes: a hollow shell that fits within the recess, is adapted to contain the liquid drug, and has an outlet that is adapted to communicate with the inlet of the housing and the drug contained within the shell; pressure means within the shell that maintains a constant, positive pressure on the drug; and lock means on the shell that engages the housing to reversibly lock the cartridge within the recess.
摘要翻译：一种与液体药物输注装置组合使用的可拆卸的药筒，其包括限定入口和出口的壳体，并且具有用于接收药筒的凹部，在入口和出口之间延伸的限制流动通道和从所述入口和出口延伸的导管出口到输液部位。所述可拆卸的盒包括：适合于所述凹槽内的中空壳，适于容纳所述液体药物，并具有适于与所述壳体的入口和所述壳体内的药物连通的出口; 壳内的压力意味着对药物保持恒定的正压力; 以及壳体上的锁定装置，其与壳体接合以将盒可逆地锁定在凹部内。

5. 发明授权

US3993069A Liquid delivery device bladder 失效
标题翻译：液体输送装置膀胱
公开(公告)号：US3993069A
公开(公告)日：1976-11-23
申请号：US605690
申请日：1975-08-18
申请人： Richard G. Buckles , Harold M. Leeper , Su Il Yum , Alan S. Michaels
发明人： Richard G. Buckles , Harold M. Leeper , Su Il Yum , Alan S. Michaels
IPC分类号： A61J1/00 , A61J1/05 , A61M5/152 , B65D83/00 , A61M5/00 , B65D35/18
CPC分类号： A61J1/05 , A61M5/152 , B65D83/0061 , Y10S128/12
摘要： An improvement in liquid dispensers, especially those used to infuse liquid drugs into patients from an expansible elastomeric bladder of specific geometry and elastomeric properties, is disclosed. The improvement is in making the bladder from an elastomeric composition whose stress relaxation does not exceed 10%, and whose low frequency hysteresis does not exceed 10%.
摘要翻译：公开了液体分配器的改进，特别是那些用于将液体药物从具有特定几何形状和弹性体特性的可膨胀弹性体囊注入患者的液体分配器。改进之处在于使弹性体组合物的应力松弛不超过10％，其低频滞后不超过10％。

6. 发明申请

US20190167590A1 Micronized Opioid Compositions, Formulations and Dosage Forms and Methods of Making Same 审中-公开
公开(公告)号：US20190167590A1
公开(公告)日：2019-06-06
申请号：US16142639
申请日：2018-09-26
申请人： Michael Zamloot , Cherng-Chyi Fu , De-Hwa Chao , Andrei Blasko , Su Il Yum
发明人： Michael Zamloot , Cherng-Chyi Fu , De-Hwa Chao , Andrei Blasko , Su Il Yum
IPC分类号： A61K9/14 , A61K9/16 , A61K31/485
摘要： Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a DV90 particle size distribution of less and or equal to 10μ or less than or equal to 20μ are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.

7. 发明授权

US08415401B2 Oral pharmaceutical dosage forms 有权
公开(公告)号：US08415401B2
公开(公告)日：2013-04-09
申请号：US12315868
申请日：2008-12-05
申请人： Su Il Yum , Wendy Chao , Huey-Ching Su , Roger Fu , Michael Zamloot
发明人： Su Il Yum , Wendy Chao , Huey-Ching Su , Roger Fu , Michael Zamloot
IPC分类号： A61K47/00
CPC分类号： A61K9/4866 , A61K9/48 , A61K9/4858 , A61K31/137 , A61K31/4402 , A61K31/4458 , A61K31/485
摘要： Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.

8. 发明授权

US08252320B2 Transdermal delivery system for sufentanil 有权
标题翻译：舒芬太尼透皮给药系统
公开(公告)号：US08252320B2
公开(公告)日：2012-08-28
申请号：US11888661
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61K31/445 , A61K31/4468 , A61K31/4535
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

9. 发明授权

US08252319B2 Transdermal delivery system for sufentanil 有权
公开(公告)号：US08252319B2
公开(公告)日：2012-08-28
申请号：US11888650
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61K31/445 , A61K31/4468 , A61K31/4535
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

10. 发明申请

US20090123518A1 Biodegradable implants with controlled bulk density 审中-公开
标题翻译：具有可控堆积密度的可生物降解植入物
公开(公告)号：US20090123518A1
公开(公告)日：2009-05-14
申请号：US12288537
申请日：2008-10-20
申请人： Su Il Yum , Sanjay Goskonda , Huey-Ching Su
发明人： Su Il Yum , Sanjay Goskonda , Huey-Ching Su
IPC分类号： A61F2/00 , A61K38/22
CPC分类号： A61K9/0024 , A61K9/0004 , A61K38/09
摘要： Disclosed solid water permeable implants that include a water permeable polymer and an osmotically active drug formulation that comprises a drug; wherein the solid water permeable implant has a ratio R of bulk density of the solid water permeable implant to osmotic pressure of the drug formulation wherein R is greater than about 0.244 grams/milliliter-atm. Also disclosed are methods of making and using such solid water permeable implants.
摘要翻译：公开的固体水可渗透植入物，其包括水可渗透聚合物和包含药物的渗透活性药物制剂; 其中固体水可渗透植入物具有固体水可渗透植入物的体积密度与药物制剂的渗透压的比R，其中R大于约0.244克/毫升。还公开了制造和使用这种固体水可渗透植入物的方法。

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