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41. 发明申请

US20090131311A1 Method for Preventing Formation of Trisulfide Derivatives of Polypeptides 审中-公开
标题翻译：防止多肽三硫化物衍生物形成的方法
公开(公告)号：US20090131311A1
公开(公告)日：2009-05-21
申请号：US11813045
申请日：2005-12-20
申请人： Peter Becker , Thorkild Christensen
发明人： Peter Becker , Thorkild Christensen
IPC分类号： A61K38/18 , C07K1/00 , C07K14/00
CPC分类号： C07K1/1136 , C07K14/61
摘要： A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid medium with a gas, suitably a chemically unreactive gas such as nitrogen or argon.
摘要翻译：减少或基本上阻止在含有多肽问题的液体介质中形成多肽的三硫化物衍生物的方法包括用合适的化学反应性气体如氮气或氩气气体汽提液体介质。

42. 发明授权

US5778930A Add-in device for a hydraulic control arrangement 失效
标题翻译：用于液压控制装置的附加装置
公开(公告)号：US5778930A
公开(公告)日：1998-07-14
申请号：US565229
申请日：1995-11-30
申请人： Welm Friedrichsen , Thorkild Christensen
发明人： Welm Friedrichsen , Thorkild Christensen
IPC分类号： F15B11/05 , F15B11/16 , F15B13/04 , F15B13/08
CPC分类号： F15B11/16 , F15B11/05 , F15B13/0402 , F15B2211/405 , F15B2211/40561 , F15B2211/40576 , F15B2211/411 , F15B2211/41509 , F15B2211/455 , F15B2211/465 , F15B2211/505 , F15B2211/50536 , F15B2211/5157 , F15B2211/55 , Y10T137/87185 , Y10T137/87885
摘要： An add-in device for a hydraulic control arrangement provides a function unit (24) to be arranged between successive modules, which function unit takes the connection between the pump channels of the preceding and the subsequent module by way of at least one function slide valve (117, 217) which is arranged to be displaced into several positions. In its positions this function slide valve initiates different functions, by which fluid under pressure is arranged to be admitted to the subsequent control module in at least two different amounts and/or in at least two different levels of pressure. In this manner operation of the subsequent control modules can be better matched to the particular operating conditions that obtain.
摘要翻译：用于液压控制装置的附加装置提供功能单元（24），其被布置在连续的模块之间，功能单元通过至少一个功能滑阀来连接前一个和后续模块的泵通道之间的连接（117,217），其被布置成移位到多个位置。在其位置上，该功能滑阀启动不同的功能，通过该功能将压力下的流体布置成以至少两个不同的量和/或至少两个不同的压力水平被允许进入后续的控制模块。以这种方式，后续控制模块的操作可以更好地与获得的特定操作条件匹配。

43. 发明授权

US5679552A Process for preparing a desired protein 失效
标题翻译：制备所需蛋白质的方法
公开(公告)号：US5679552A
公开(公告)日：1997-10-21
申请号：US450837
申请日：1995-05-25
申请人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli Winnie Ringsted , Torben Ehlern Jessen
发明人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli Winnie Ringsted , Torben Ehlern Jessen
IPC分类号： C07K14/545 , C07K14/61 , C12N9/22 , C12N9/36 , C12N15/62 , C12P21/06 , C12P21/04 , C07H17/00 , C12N15/18
CPC分类号： C12N9/2462 , C07K14/545 , C07K14/61 , C12N15/62 , C12N9/22 , C12P21/06 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75
摘要： A desired protein having the formula: A--B--C--P wherein a) A is Lys or Arg, and B and C are arbitrary amino acids, or b) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro, is produced from a biosynthetically formed amino acid extended protein having the formula: X--A--B--C--P wherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.
摘要翻译：具有下式的所需蛋白质：ABC-P，其中a）A是Lys或Arg，B和C是任意氨基酸，或b）A是不同于Pro，Lys和Arg的任意氨基酸，B和/或C Pro是由具有下式的生物合成形成的氨基酸延伸蛋白产生：XABC-P，其中A，B，C和P如上所定义，X是具有偶数氨基酸的氨基酸序列，其中第一个，从N末端看，与Lys和Arg不同，所有其他不均匀的氨基酸与Pro，Lys和Arg不同，所有偶联氨基酸与Pro不同，通过与酶二肽基氨基肽酶（ DAP I）。在纯状态下获得所需的蛋白质。因此，例如可以通过该过程产生没有Met-hGH含量的hGH。

44. 发明授权

US5635604A Amino-terminally extended human growth hormone (HGH) 失效
标题翻译：氨基末端延长的人生长激素（HGH）
公开(公告)号：US5635604A
公开(公告)日：1997-06-03
申请号：US450094
申请日：1995-05-25
申请人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli W. Ringsted , Torben E. Jessen
发明人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli W. Ringsted , Torben E. Jessen
IPC分类号： C07K14/545 , C07K14/61 , C12N9/22 , C12N9/36 , C12N15/62 , C12P21/06
CPC分类号： C12N9/2462 , C07K14/545 , C07K14/61 , C12N15/62 , C12N9/22 , C12P21/06 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75
摘要： A desired protein having the formula:A-B-C-P,wherein (a) A is Lys or Arg, and B and C are arbitrary amino acids, or (b) A is an arbitrary amino acid different from Pro, Lys, and Arg, and B and/or C is Pro is produced from a biosynthetically formed amino-terminally extended protein having the formula:X-A-B-C-P,wherein A, B, C are defined above, and X is an amino acid sequence with an even number of amino acids, of which the first amino acid, seen from the N-terminal end, is different from Lys and Arg, all other am/no acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Specifically, P is human growth hormone (hGH). Thus, compositions of hGH may be produced without the presence of Met-hGH.
摘要翻译：具有下式的所需蛋白质：ABCP，其中（a）A是Lys或Arg，B和C是任意氨基酸，或（b）A是不同于Pro，Lys和Arg的任意氨基酸，B和 /或C是Pro由具有下式的生物合成形成的氨基末端延伸蛋白产生：XABCP，其中A，B，C如上定义，X是具有偶数氨基酸的氨基酸序列，其中从N-末端观察到的第一个氨基酸不同于Lys和Arg，所有其他am / no酸都不同于Pro，Lys和Arg，并且所有甚至氨基酸与Pro不同，通过与酶二肽基氨基肽酶（DAP I）。在纯状态下获得所需的蛋白质。具体来说，P是人生长激素（hGH）。因此，可以在不存在Met-hGH的情况下生产hGH的组合物。

45. 发明授权

US5165496A Fully hydraulic steering arrangement for vehicles 失效
标题翻译：车辆全液压转向装置
公开(公告)号：US5165496A
公开(公告)日：1992-11-24
申请号：US723780
申请日：1991-07-01
申请人： Poul H. H. Pedersen , Thorkild Christensen , Johannes V. Baatrup , Svend E. Thomsen
发明人： Poul H. H. Pedersen , Thorkild Christensen , Johannes V. Baatrup , Svend E. Thomsen
IPC分类号： B62D5/09 , B62D5/093 , B62D5/28
CPC分类号： B62D5/28 , B62D5/093
摘要： A control valve is opened (moved from its neutral position) by rotation of a steering wheel to conduct fluid from a pump to a steering meter device that controls the amount of fluid fed to a steering motor arrangement. When the steering motor piston has been displaced by a distance corresponding to the angle of rotation of the steering wheel, the control valve is moved by the steering meter device from its opened condition to its neutral position. A pilot valve controlled actuating device is provided to short circuit the steering meter device to permit continued fluid flow from the pump to the steering motor device and provide a mechanical braking force to the meter device to block rotation thereof and thereby the movement of the control valve to its neutral position. The braking mechanism is resiliently urged to a non-braking position.
摘要翻译：通过旋转方向盘来打开（从其中立位置移动）控制阀，以将流体从泵传导到控制进给转向电动机装置的流体的量的转向计量装置。当转向马达活塞已经移动与方向盘的旋转角度相对应的距离时，控制阀由转向表装置从其打开状态移动到其中立位置。提供先导阀控制致动装置以使转向表装置短路以允许持续的流体从泵流向转向电动机装置并且向仪表装置提供机械制动力以阻止其旋转，从而控制阀的运动到其中立位置。制动机构被弹性地推动到非制动位置。

46. 发明授权

US5017493A DNA sequence 失效
标题翻译： DNA序列
公开(公告)号：US5017493A
公开(公告)日：1991-05-21
申请号：US470396
申请日：1990-01-25
申请人： Henrik D. Andersen , Hans H. M. Dahl , Thorkild Christensen
发明人： Henrik D. Andersen , Hans H. M. Dahl , Thorkild Christensen
IPC分类号： C12N15/00 , C07H21/04 , C07K14/61 , C12N1/00 , C12N1/21 , C12N15/09 , C12N15/67 , C12N15/70 , C12P21/00 , C12R1/19
CPC分类号： C12N15/70 , C07K14/61
摘要： A DNA sequence containing a ribosome binding site with a SD sequence AGGA and a start codon ATG, comprising a nucleotide sequence having the formula Y.sub.1 . . . Y.sub.m ZVAGGA X.sub.1, X.sub.2 . . . X.sub.n ATG wherein Y.sub.1 . . . Y.sub.m represents a promoter with one or more restriction enzyme sites, m being an integer corresponding to the number of base pairs in the promoter, each X, Y, Z and V is A, T, C or G; n is 9 to 13, and the sequence X.sub.1 . . . X.sub.n cannot contain a start codon.
摘要翻译：包含具有SD序列AGGA和起始密码子ATG的核糖体结合位点的DNA序列，其包含具有式Y1的核苷酸序列。。。 YmZVAGGA X1，X2。。。 XnATG其中Y1。。。 Ym表示具有一个或多个限制酶位点的启动子，m是对应于启动子中碱基对数的整数，每个X，Y，Z和V是A，T，C或G; n为9〜13，序列为X1。。。 Xn不能包含起始密码。

47. 发明授权

US4006663A Hydraulic control means, especially a steering means 失效
标题翻译：液压控制装置，特别是转向装置
公开(公告)号：US4006663A
公开(公告)日：1977-02-08
申请号：US564278
申请日：1975-04-02
申请人： Johannes Vagn Baatrup , Thorkild Christensen
发明人： Johannes Vagn Baatrup , Thorkild Christensen
IPC分类号： B62D5/08 , B62D5/09 , F15B11/02 , F15B13/042
CPC分类号： F15B11/02 , B62D5/08 , B62D5/09 , F15B2211/20538 , F15B2211/30505 , F15B2211/3051 , F15B2211/30525 , F15B2211/3054 , F15B2211/327 , F15B2211/329 , F15B2211/50518 , F15B2211/5151 , F15B2211/55 , F15B2211/6054 , F15B2211/61 , F15B2211/613 , F15B2211/6355 , F15B2211/7054
摘要： The invention relates to a hydraulic control apparatus of the type used in vehicle steering systems. In all such systems there is a reversible type hydraulic motor connected to the steering linkage. The motor has complementary expansible chambers. With the use of control means pressurized fluid is selectively delivered to one chamber which is caused to expand concomitantly with the collapsing of the other chamber from which fluid is returned to a sump. Forces transmitted to the hydraulic motor through the steering linkage by reason of the wheels striking objects such as stones or curbs cause an objectionable effect by reason of fluid being forced out of the motor back into the system. This effect is avoided by providing two valve assemblies for the two ports of the reversible motor which function in the absence of a steering command as ordinary one way check valves which prevent the undesired flow of fluid from either of the motor ports. Each of the valve assemblies has pressure responsive means and is openable when the pressure responsive means is acted upon by pressure. The pressure responsive means of each valve assembly is fluidly connected to the upstream side of the other valve assembly so that both valve assemblies will be open during the normal power steering operation wherein pressurized fluid is admitted to one side of the actuating motor and withdrawn from the other side thereof.
摘要翻译：本发明涉及一种用于车辆转向系统的液压控制装置。在所有这样的系统中，存在连接到转向连杆的可逆式液压马达。电动机具有互补的可膨胀室。通过使用控制装置，加压流体被选择性地输送到一个室，该腔室被引起与另一个腔室的塌缩同时膨胀，从该腔室将流体返回到贮槽。由于车轮撞击物体如石块或路缘石，通过转向连杆传递给液压马达的力，由于流体被迫从电机返回到系统中，造成令人不快的影响。通过为可逆电动机的两个端口提供两个阀组件来避免这种效果，该两个阀组件在没有转向指令的情况下起作为普通单向止回阀的作用，其防止来自任何一个电动机端口的不期望的流体流动。每个阀组件都具有压力响应装置，并且当压力响应装置通过压力作用时可以打开。每个阀组件的压力响应装置流体地连接到另一个阀组件的上游侧，使得在正常动力转向操作期间两个阀组件都将打开，其中加压流体被允许到致动马达的一侧并从的另一面。

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