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1. 发明授权

US08530191B2 Method for preventing formation of trisulfide derivatives of polypeptides 失效
标题翻译：防止多肽三硫化物衍生物形成的方法
公开(公告)号：US08530191B2
公开(公告)日：2013-09-10
申请号：US12714900
申请日：2010-03-01
申请人： Peter Becker , Thorkild Christensen
发明人： Peter Becker , Thorkild Christensen
IPC分类号： C12N15/18 , C07K1/14 , C07K1/34 , A61K38/27 , A61P5/06 , C07K14/61
CPC分类号： C07K1/1136 , C07K14/61
摘要： A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid medium with a gas, suitably a chemically unreactive gas such as nitrogen or argon.
摘要翻译：减少或基本上阻止在含有多肽问题的液体介质中形成多肽的三硫化物衍生物的方法包括用合适的化学反应性气体如氮气或氩气气体汽提液体介质。

2. 发明申请

US20110204267A1 HYDRAULIC VALVE ARRANGEMENT 有权
标题翻译：液压阀安装
公开(公告)号：US20110204267A1
公开(公告)日：2011-08-25
申请号：US13098563
申请日：2011-05-02
申请人： Thorkild Christensen , Siegfried Zenker , Svend Erik Thomsen
发明人： Thorkild Christensen , Siegfried Zenker , Svend Erik Thomsen
IPC分类号： F16K31/00
CPC分类号： F15B11/05 , E02F9/2225 , E02F9/2267 , F15B2211/20538 , F15B2211/30555 , F15B2211/329 , F15B2211/351 , F15B2211/50518 , F15B2211/50536 , F15B2211/55 , F15B2211/565 , F15B2211/6051 , F15B2211/7053 , F15B2211/7054
摘要： The invention concerns a hydraulic valve arrangement (1) with a supply connection arrangement comprising a high-pressure connection (P) and a low-pressure connection (T), a working connection arrangement comprising two working connections (A, B), which can be connected to a motor (4), a directional valve arrangement (5) located between the supply connection arrangement (P, T) and the working connection arrangement (A, B), and a compensation valve (15) acted upon in a first activation direction by a pressure in a first pressure chamber (33), which is connected to a load-sensing pipe (LS), and, if required, by a spring (32), and in a second activation direction opposite to the first activation direction by a pressure downstream of the directional valve arrangement (5), said pressure acting in a second pressure chamber (34), the compensation valve (15) having an inlet (14) and an outlet (19). In connection with a post-compensated valve, it is endeavoured to adjust the load pressures at the working connections (A, B) in dependence of the direction. For this purpose, each working connection (A, B) is connected to a control system, which amplifies the effect of the pressure in the first pressure chamber (33) on the compensation valve (15) in dependence of a pressure ruling at the working connection (A, B).
摘要翻译：本发明涉及具有包括高压连接（P）和低压连接（T）的供应连接装置的液压阀装置（1），包括两个工作连接（A，B）的工作连接装置，其可以连接到电动机（4），位于供应连接装置（P，T）和工作连接装置（A，B）之间的方向阀装置（5）和补偿阀（15）通过连接到负载传感管（LS）的第一压力室（33）中的压力，以及如果需要，通过弹簧（32）和在与第一激活相反的第二激活方向上的压力的激活方向方向阀装置（5）下游的压力，所述压力作用在第二压力室（34）中，补偿阀（15）具有入口（14）和出口（19）。结合补偿后阀门，努力根据方向调整工作连接（A，B）的负载压力。为此，每个工作连接（A，B）连接到控制系统，该控制系统根据工作中的压力判定放大第一压力室（33）中的压力对补偿阀（15）的影响连接（A，B）。

3. 发明授权

US06854270B2 Hydraulic valve system 失效
标题翻译：液压阀系统
公开(公告)号：US06854270B2
公开(公告)日：2005-02-15
申请号：US10420157
申请日：2003-04-22
申请人： Siegfried Zenker , Thorkild Christensen
发明人： Siegfried Zenker , Thorkild Christensen
IPC分类号： E02F9/22 , F15B11/00 , F15B11/05 , F15B13/04 , F15B11/02
CPC分类号： E02F9/2267 , E02F9/2207 , E02F9/226 , E02F9/2271 , F15B11/003 , F15B11/05 , F15B13/0417 , F15B2211/30505 , F15B2211/3051 , F15B2211/30555 , F15B2211/3111 , F15B2211/3144 , F15B2211/31576 , F15B2211/324 , F15B2211/5059 , F15B2211/513 , F15B2211/5154 , F15B2211/528 , F15B2211/605 , F15B2211/8613
摘要： A hydraulic valve system (1) has a supply connection arrangement having a high-pressure connection (P) and a low-pressure connection (T), a working connection arrangement, having two working connections (A, B) connectable with a motor (2), with a directional valve (4), which is arranged between the supply connection arrangement (P, T) and the working connection arrangement (A, B), and with a compensation valve (8), which is acted upon in a first operation direction by a spring (22) and a pressure in a pressure chamber (23), which is connected with a load-sensing line (LS), and in a second operation direction, which is opposite to the first operation direction, by a pressure at the directional valve (4).
摘要翻译：液压阀系统（1）具有具有高压连接（P）和低压连接（T）的供应连接装置，工作连接装置具有可与电动机连接的两个工作连接（A，B）具有设置在供应连接装置（P，T）和工作连接装置（A，B）之间的方向阀（4）和具有补偿阀（8）的方向阀（4）通过弹簧（22）的第一操作方向和与负载感测线路（LS）连接的压力室（23）中的压力，并且在与第一操作方向相反的第二操作方向上，通过在方向阀（4）处的压力。

4. 发明授权

US06499505B2 Hydraulic valve arrangement 失效
标题翻译：液压阀装置
公开(公告)号：US06499505B2
公开(公告)日：2002-12-31
申请号：US09952364
申请日：2001-09-11
申请人： Siegfried Zenker , Thorkild Christensen , Carl Christian Dixen , Carsten Christensen
发明人： Siegfried Zenker , Thorkild Christensen , Carl Christian Dixen , Carsten Christensen
IPC分类号： F15B1304
CPC分类号： F15B13/01 , F15B11/003 , F15B2211/3051 , F15B2211/30515 , F15B2211/30525 , F15B2211/3111 , F15B2211/3127 , F15B2211/3144 , F15B2211/31576 , F15B2211/327 , F15B2211/329 , F15B2211/6054 , Y10T137/87241
摘要： A hydraulic valve arrangement includes a control valve (3), which, in a first operating position (5), connects a motor connection (21) with a pump connection, in a second operating position (6), connects a motor connection with a tank connection, and, in a locking position (4), disconnects the motor connection (21) from the pump and tank connection. A locking valve (19) is coupled between the control valve (3) and the motor connection (21), dividing the motor line (22) into a first section (23) allocated to the control valve (3) and a second section (24) allocated to the motor connection (21). For the locking valve (19), a pressure release valve (20) in the shape of a seated valve is provided that is fixed to the housing thereby improving control accuracy.
摘要翻译：液压阀装置包括控制阀（3），其在第一操作位置（5）中将马达连接件（21）与泵连接件连接在第二操作位置（6）中，将马达连接件与油箱连接，并且在锁定位置（4）中，断开马达连接（21）与泵和油箱连接。锁定阀（19）联接在控制阀（3）和马达连接件（21）之间，将马达管线（22）分成分配给控制阀（3）的第一部分（23）和第二部分 24）分配给电动机连接（21）。对于锁定阀（19），提供了一种固定在壳体上的带座阀形式的压力释放阀（20），从而提高了控制精度。

5. 发明授权

US5691169A Process for preparing a desired protein 失效
标题翻译：制备所需蛋白质的方法
公开(公告)号：US5691169A
公开(公告)日：1997-11-25
申请号：US402455
申请日：1995-03-10
申请人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli Winnie Ringsted , Torben Ehlern Jessen
发明人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli Winnie Ringsted , Torben Ehlern Jessen
IPC分类号： C07K14/545 , C07K14/61 , C12N9/22 , C12N9/36 , C12N15/62 , C12P21/06 , C12N1/20 , C12P19/56
CPC分类号： C12N9/2462 , C07K14/545 , C07K14/61 , C12N15/62 , C12N9/22 , C12P21/06 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75
摘要： A desired protein having the formula: A-B-C-P wherein a) A is Lys or Arg, and B and C are arbitrary amino acids, or b) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro, is produced from a biosynthetically formed amino acid extended protein having the formula: X-A-B-C-P wherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.
摘要翻译：具有下式的所需蛋白质：ABCP其中a）A是Lys或Arg，B和C是任意氨基酸，或b）A是不同于Pro，Lys和Arg的任意氨基酸，B和/或C是 Pro是由具有下式的生物合成形式的氨基酸延伸蛋白产生的：XABCP其中A，B，C和P如上定义，X是具有偶数氨基酸的氨基酸序列，其中第一个从N末端看，与Lys和Arg不同，所有其他不均匀的氨基酸与Pro，Lys和Arg不同，所有偶联的氨基酸与Pro不同，通过与酶二肽基氨基肽酶（DAP I ）。在纯状态下获得所需的蛋白质。因此，例如可以通过该过程产生没有Met-hGH含量的hGH。

6. 发明授权

US4548035A Hydraulic control apparatus for a servomotor 失效
标题翻译：伺服电机液压控制装置
公开(公告)号：US4548035A
公开(公告)日：1985-10-22
申请号：US441105
申请日：1982-11-12
申请人： Svend E. Thomsen , Thorkild Christensen
发明人： Svend E. Thomsen , Thorkild Christensen
IPC分类号： F15B9/08 , B62D5/09 , F15B9/10
CPC分类号： B62D5/09
摘要： The invention relates to a steering control unit for a bidirectional servomotor which is connectable to steerable wheels. A steering wheel controlled quantity setting unit of a known type has ports connectable to a pump and a return tank and two control ports through which metered quantities of fluid flow to opposite sides of the servomotor and to other parts of the apparatus for actuating the servomotor. A directional control valve for selectivity directing pressurized fluid from a power circuit to opposite sides of the servomotor is controlled by a control circuit containing the setting unit. A utility valve having pressure regulating and control and power valve capabilities is provided. In cases wherein the quantity setting apparatus is remotely located from the regulating valve the length of the signal channels add to the reaction time. Such reaction time is reduced herein by connecting the metering throttle as a fixed throttle between the regulating valve and quantity setting apparatus so that the regulating valve feeds a substantially constant quantity to the control cicuit, and that the quantity setting apparatus comprises a short circuit path to the tank which closes with an increase in the quantity.
摘要翻译：本发明涉及一种用于双向伺服电机的转向控制单元，其可连接到可转向的车轮。已知类型的方向盘控制量设定单元具有可连接到泵和回流罐的端口和两个控制端口，计量量的流体流过伺服电机的相对侧以及用于致动伺服电动机的装置的其它部分。用于将加压流体从功率电路选择性地引导到伺服电动机的相对侧的方向控制阀由包含设定单元的控制电路控制。本发明提供一种具有压力调节和功率阀功能的电力阀。在数量设定装置远离调节阀的情况下，信号通道的长度增加到反应时间。这样的反应时间通过将调节阀和量设定装置之间的固定节流阀连接在一起，使得调节阀向控制电路供给基本上恒定的量，并且量设定装置包括短路路径随着数量的增加关闭的油箱。

7. 发明授权

US4266464A Hydraulic control apparatus for servo-motor particularly for vehicle steering 失效
标题翻译：用于伺服电机的液压控制装置，特别适用于车辆转向
公开(公告)号：US4266464A
公开(公告)日：1981-05-12
申请号：US912209
申请日：1978-06-05
申请人： Johannes V. Baatrup , Thorkild Christensen , Tage Christiansen , Svend E. Thomsen
发明人： Johannes V. Baatrup , Thorkild Christensen , Tage Christiansen , Svend E. Thomsen
IPC分类号： B62D5/09 , F15B13/042
CPC分类号： B62D5/09 , Y10T137/86984
摘要： The invention relates to hydraulic control apparatus for a servomotor of the type utilized for vehicle steering systems. Such apparatus has a control circuit controlled by a manually operated device such as a steering wheel and a power circuit connected between the servomotor and a power source such as a hydraulic pump. The power circuit includes resetting apparatus for throttling the return flow branch in a manner so that forces applied to the servomotor in the same direction as actuation are absorbed with a minimum of reactionary movement by the valves on the return flow side of the apparatus.
摘要翻译：本发明涉及一种用于车辆转向系统的伺服电机的液压控制装置。这种装置具有由诸如方向盘的手动操作装置和连接在伺服电动机和诸如液压泵的电源之间的电力电路控制的控制电路。电源电路包括用于以回流流量分支节流的复位装置，使得以与致动相同的方向施加到伺服电动机的力被装置的回流侧上的阀的最小反应运动吸收。

8. 发明授权

US07975598B2 Hydraulic valve arrangement 有权
标题翻译：液压阀装置
公开(公告)号：US07975598B2
公开(公告)日：2011-07-12
申请号：US11956917
申请日：2007-12-14
申请人： Thorkild Christensen , Siegfried Zenker , Svend Erik Thomsen
发明人： Thorkild Christensen , Siegfried Zenker , Svend Erik Thomsen
IPC分类号： F15B13/042
CPC分类号： F15B11/05 , E02F9/2225 , E02F9/2267 , F15B2211/20538 , F15B2211/30555 , F15B2211/329 , F15B2211/351 , F15B2211/50518 , F15B2211/50536 , F15B2211/55 , F15B2211/565 , F15B2211/6051 , F15B2211/7053 , F15B2211/7054
摘要： The invention concerns a hydraulic valve arrangement (1) with a supply connection arrangement comprising a high-pressure connection (P) and a low-pressure connection (T), a working connection arrangement comprising two working connections (A, B), which can be connected to a motor (4), a directional valve arrangement (5) located between the supply connection arrangement (P, T) and the working connection arrangement (A, B), and a compensation valve (15) acted upon in a first activation direction by a pressure in a first pressure chamber (33), which is connected to a load-sensing pipe (LS), and, if required, by a spring (32), and in a second activation direction opposite to the first activation direction by a pressure downstream of the directional valve arrangement (5), said pressure acting in a second pressure chamber (34), the compensation valve (15) having an inlet (14) and an outlet (19). In connection with a post-compensated valve, it is endeavored to adjust the load pressures at the working connections (A, B) in dependence of the direction. For this purpose, each working connection (A, B) is connected to a control system, which amplifies the effect of the pressure in the first pressure chamber (33) on the compensation valve (15) in dependence of a pressure ruling at the working connection (A, B).
摘要翻译：本发明涉及具有包括高压连接（P）和低压连接（T）的供应连接装置的液压阀装置（1），包括两个工作连接（A，B）的工作连接装置，其可以连接到电动机（4），位于供应连接装置（P，T）和工作连接装置（A，B）之间的方向阀装置（5）和补偿阀（15）通过连接到负载传感管（LS）的第一压力室（33）中的压力，以及如果需要，通过弹簧（32）和在与第一激活相反的第二激活方向上的压力的激活方向方向阀装置（5）下游的压力，所述压力作用在第二压力室（34）中，补偿阀（15）具有入口（14）和出口（19）。结合补偿后阀门，努力根据方向调整工作连接（A，B）的负载压力。为此，每个工作连接（A，B）连接到控制系统，该控制系统根据工作中的压力判定放大第一压力室（33）中的压力对补偿阀（15）的影响连接（A，B）。

9. 发明授权

US07456276B2 Peptide purification by means of metal ion affinity chromatography 失效
标题翻译：通过金属离子亲和层析纯化肽
公开(公告)号：US07456276B2
公开(公告)日：2008-11-25
申请号：US10495302
申请日：2002-11-12
申请人： Thorkild Christensen , William Milton Thomas Hearn , Leone Spiccia , Wei Jiang , Therese Jane Mooney , Bimbil Graham
发明人： Thorkild Christensen , William Milton Thomas Hearn , Leone Spiccia , Wei Jiang , Therese Jane Mooney , Bimbil Graham
IPC分类号： C07H1/00 , C07D251/00
CPC分类号： C08J7/12 , B01D15/3828 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/285 , B01J20/286 , B01J20/3265 , B01J45/00 , B01J2220/54 , C07K1/16 , C07K7/08 , C08B11/04 , C08B15/00 , C08B37/0021 , C08B37/0039 , C08F8/00 , C08F20/56
摘要： A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S.
摘要翻译：具有官能度官能度的聚合物底物，其官能团包含至少一个环状金属离子配位配体基团，所述环状配体基团包含至少3个独立地选自N，O和S的金属离子配位供体原子。

10. 发明申请

US20080245222A1 HYDRAULIC VALVE ARRANGEMENT 有权
标题翻译：液压阀安装
公开(公告)号：US20080245222A1
公开(公告)日：2008-10-09
申请号：US11956917
申请日：2007-12-14
申请人： Thorkild Christensen , Siegfried Zenker , Svend Erik Thomsen
发明人： Thorkild Christensen , Siegfried Zenker , Svend Erik Thomsen
IPC分类号： F15B13/042 , F15B11/00 , F15B11/05
CPC分类号： F15B11/05 , E02F9/2225 , E02F9/2267 , F15B2211/20538 , F15B2211/30555 , F15B2211/329 , F15B2211/351 , F15B2211/50518 , F15B2211/50536 , F15B2211/55 , F15B2211/565 , F15B2211/6051 , F15B2211/7053 , F15B2211/7054
摘要： The invention concerns a hydraulic valve arrangement (1) with a supply connection arrangement comprising a high-pressure connection (P) and a low-pressure connection (T), a working connection arrangement comprising two working connections (A, B), which can be connected to a motor (4), a directional valve arrangement (5) located between the supply connection arrangement (P, T) and the working connection arrangement (A, B), and a compensation valve (15) acted upon in a first activation direction by a pressure in a first pressure chamber (33), which is connected to a load-sensing pipe (LS), and, if required, by a spring (32), and in a second activation direction opposite to the first activation direction by a pressure downstream of the directional valve arrangement (5), said pressure acting in a second pressure chamber (34), the compensation valve (15) having an inlet (14) and an outlet (19). In connection with a post-compensated valve, it is endeavoured to adjust the load pressures at the working connections (A, B) in dependence of the direction. For this purpose, each working connection (A, B) is connected to a control system, which amplifies the effect of the pressure in the first pressure chamber (33) on the compensation valve (15) in dependence of a pressure ruling at the working connection (A, B).
摘要翻译：本发明涉及具有包括高压连接（P）和低压连接（T）的供应连接装置的液压阀装置（1），包括两个工作连接（A，B）的工作连接装置，其可以连接到电动机（4），位于供应连接装置（P，T）和工作连接装置（A，B）之间的方向阀装置（5）和补偿阀（15）通过连接到负载传感管（LS）的第一压力室（33）中的压力，以及如果需要，通过弹簧（32）和在与第一激活相反的第二激活方向上的压力的激活方向方向阀装置（5）下游的压力，所述压力作用在第二压力室（34）中，补偿阀（15）具有入口（14）和出口（19）。结合补偿后阀门，努力根据方向调整工作连接（A，B）的负载压力。为此，每个工作连接（A，B）连接到控制系统，该控制系统根据工作中的压力判定放大第一压力室（33）中的压力对补偿阀（15）的影响连接（A，B）。

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