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41. 发明授权

US07432392B2 Ester derivatives and medical use thereof 失效
标题翻译：酯衍生物及其医疗用途
公开(公告)号：US07432392B2
公开(公告)日：2008-10-07
申请号：US11362375
申请日：2006-02-27
申请人： Atsushi Hagiwara , Taku Ikenogami , Yasuko Mera , Yukako Sumida , Akio Iida , Toshio Taniguchi , Mitsuru Takahashi
发明人： Atsushi Hagiwara , Taku Ikenogami , Yasuko Mera , Yukako Sumida , Akio Iida , Toshio Taniguchi , Mitsuru Takahashi
IPC分类号： C07C69/34 , C07C69/66 , A01N47/06 , A61K31/21
CPC分类号： C07D241/44 , C07C233/81 , C07D209/08 , C07D213/55 , C07D213/81 , C07D213/82 , C07D239/42 , C07D277/30 , C07D295/192 , C07D333/24 , C07D409/12 , C07D413/12
摘要： A therapeutic agent for hyperlipidemia which has no side effects on the liver unlike conventional MTP inhibitors and has excellent MTP inhibitory activity. Also, provided is an ester compound represented by the general formula (1): or a pharmaceutically acceptable salt thereof.
摘要翻译：与常规MTP抑制剂不同，对肝脏没有副作用且具有优异的MTP抑制活性的高脂血症治疗剂。此外，提供由通式（1）表示的酯化合物：或其药学上可接受的盐。

42. 发明授权

US06881512B2 Separator for fuel cell, process for production thereof, and solid polymer type fuel cell using said separator 失效
标题翻译：用于燃料电池的分离器，其制造方法和使用所述隔板的固体聚合物型燃料电池
公开(公告)号：US06881512B2
公开(公告)日：2005-04-19
申请号：US10013545
申请日：2001-12-13
申请人： Kazuo Saito , Atsushi Hagiwara
发明人： Kazuo Saito , Atsushi Hagiwara
IPC分类号： H01M8/02 , H01M8/10 , H01M8/24
CPC分类号： H01M8/0226 , H01M8/0213 , H01M8/0221 , H01M8/1007 , H01M8/241 , H01M2300/0082 , Y02P70/56
摘要： A separator for fuel cell, formed using a base material obtained from a composition comprising at least a binder, a powdery carbon filler having an average particle diameter of 10 nm to 100 μm, and a short fiber having an average fiber length of 0.03 to 6 mm, in which composition the amount ratio of the above three components is such that the amount of the powdery carbon filler is 200 to 800 parts by weight and the amount of the short fiber is 10 to 300 parts by weight, both per 100 parts by weight of the binder.
摘要翻译：一种燃料电池用隔板，使用由至少含有粘合剂的组合物得到的基材形成，平均粒径为10nm〜100μm的粉末状碳填料，平均纤维长度为0.03〜6的短纤维 mm，其中上述三种组分的量的比例使得粉末状碳填料的量为200至800重量份，短纤维的量为10至300重量份，每100重量份粘合剂的重量。

43. 发明申请

US20050075367A1 Ester compound and medicinal use thereof 失效
标题翻译：酯化合物及其药用
公开(公告)号：US20050075367A1
公开(公告)日：2005-04-07
申请号：US10492831
申请日：2003-02-28
申请人： Atsushi Hagiwara , Yasuhiro Ohe , Naoya Odani , Shizue Watanabe , Taku Ikenogami , Takashi Kawai , Kenya Madono , Toshio Taniguchi
发明人： Atsushi Hagiwara , Yasuhiro Ohe , Naoya Odani , Shizue Watanabe , Taku Ikenogami , Takashi Kawai , Kenya Madono , Toshio Taniguchi
IPC分类号： A61K31/215 , A61K31/216 , A61K31/235 , A61K31/24 , A61K31/245 , A61K31/277 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/4453 , A61K31/4468 , A61K31/5375 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , C07C69/732 , C07C69/76 , C07C69/773 , C07C69/88 , C07C233/81 , C07C235/06 , C07C235/14 , C07C235/16 , C07C235/26 , C07C235/30 , C07C235/34 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/42 , C07C311/04 , C07D205/12 , C07D207/09 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/08 , C07D211/58 , C07D213/55 , C07D213/61 , C07D213/82 , C07D235/06 , C07D263/58 , C07D277/30 , C07D277/56 , C07D295/135 , C07D295/192 , C07D333/24 , C07D211/06 , A61K31/445
CPC分类号： C07D207/404 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/24 , A61K31/245 , A61K31/277 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/4453 , A61K31/4468 , A61K31/5375 , C07C69/732 , C07C69/76 , C07C69/88 , C07C233/81 , C07C235/06 , C07C235/14 , C07C235/16 , C07C235/26 , C07C235/30 , C07C235/34 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/42 , C07C311/04 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D205/12 , C07D207/09 , C07D207/16 , C07D209/08 , C07D211/58 , C07D213/55 , C07D213/61 , C07D213/82 , C07D235/06 , C07D263/58 , C07D277/30 , C07D277/56 , C07D295/135 , C07D295/192 , C07D333/24
摘要： A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″) (wherein R1 and R2 are each hydrogen atom or optionally substituted aryl, etc.; X is —COO— or —CON(R10)—; R3 and R4 are each hydrogen atom, C1-C6alkyl or C1-C6alkoxy, etc.; R5, R6 and R7 are each hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy, etc.; R8 and R9 are each independently hydrogen atom, C1-C6alkyl, —CON(R18)(R19) or —COO(R20), etc.; ring A, ring B and ring C are each independently aryl or heterocycle residue, etc.; Alk1 and Alk2 are each independently alkanediyl, etc.; l and m are each an integer of 0 or 1 to 3) or a prodrug thereof, or a pharmaceutically acceptable salt of either. The therapeutic agent selectively inhibits MTP in the small intestine, thus causes no such side effect as a fatty liver.
摘要翻译：作为高脂血症的新型治疗剂，其为由式（1“）表示的酯化合物（其中R 1和R 2各自为氢原子或任选取代的芳基等; X为-COO-或 -CON（R 10） - ; R 3和R 4各自为氢原子，C 1 -C 6烷基或C 1 -C 6烷氧基等; R 5，R 6和R 7为每个氢原子，C 1 -C 6烷基或C 1 -C 6烷氧基等; R 8和R 9各自独立地为氢原子，C 1 -C 6烷基，-CON（R 18）（R 19）或-COO（R 20）等;环A，环B和环C各自独立地为芳基或杂环残基等; Alk 1和Alk 2各自独立地为烷二基等; l 和m为0或1〜3的整数）或其前药，或其药学上可接受的盐。治疗剂选择性地抑制小肠中的MTP，因此不会引起脂肪肝的副作用。

44. 发明授权

US06803139B2 Electrically conductive resinous composition, fuel cell separator and production thereof, and polymer electrolyte fuel cell 失效
标题翻译：导电性树脂组合物，燃料电池隔板及其制造方法以及聚合物电解质型燃料电池
公开(公告)号：US06803139B2
公开(公告)日：2004-10-12
申请号：US09897638
申请日：2001-07-03
申请人： Kazuo Saito , Atsushi Hagiwara , Yasuo Imashiro , Naofumi Horie , Fumio Tanno , Tsutomu Uehara
发明人： Kazuo Saito , Atsushi Hagiwara , Yasuo Imashiro , Naofumi Horie , Fumio Tanno , Tsutomu Uehara
IPC分类号： H01M804
CPC分类号： H01M8/0226 , H01B1/24 , Y02P70/56
摘要： Disclosed herein are an electrically conductive resinous composition composed mainly of an electrically conductive carbon powder and a binding agent, wherein said binding agent is a mixture of a thermoplastic resin and a carbodiimide compound, a fuel cell separator and a process for production thereof, and polymer electrolyte fuel cell. The present invention permits efficient mass production of fuel cell separators having high elasticity, good releasability, good dimensional accuracy, and good gas impermeability. The polymer electrolyte fuel cell, in which all or part of separators are those pertaining to the present invention, is immune to the cracking of separators at the time of assembling, decreases only a little in output after continuous operation, and exhibits good gas sealing performance and high impact resistance.
摘要翻译：本文公开了主要由导电碳粉末和粘合剂组成的导电性树脂组合物，其中所述粘合剂是热塑性树脂和碳二亚胺化合物的混合物，燃料电池隔板及其制备方法，以及聚合物电解液燃料电池。本发明允许高弹性，良好的脱模性，良好的尺寸精度和良好的不透气性的燃料电池隔板的有效批量生产。其中全部或部分分离器是本发明的分离器的聚合物电解质燃料电池在组装时不受分离器的破裂的影响，连续运行后的输出仅减少一些，并且表现出良好的气体密封性能和高抗冲击性。

45. 发明授权

US06583157B2 Quinolinyl and benzothiazolyl modulators 有权
标题翻译：喹啉基和苯并噻唑基调节剂
公开(公告)号：US06583157B2
公开(公告)日：2003-06-24
申请号：US09894980
申请日：2001-06-27
申请人： Lawrence R. McGee , Jonathan B. Houze , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
发明人： Lawrence R. McGee , Jonathan B. Houze , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
IPC分类号： A61K3147
CPC分类号： C07D213/70 , C07C311/21 , C07D213/65 , C07D215/12 , C07D215/20 , C07D215/36 , C07D215/48 , C07D217/04 , C07D277/64 , C07D277/68 , C07D277/82 , C07D405/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PAPAR&ggr;. In particular, the compounds of the invention modulate the function of PAPAR&ggr;. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
摘要翻译：提供了可用于治疗或预防由PAPARGAMM介导的病症或病症的化合物，组合物和方法。特别地，本发明的化合物调节PAPARγ的功能。本发明的方法在治疗和/或预防糖尿病，肥胖，高胆固醇血症，类风湿性关节炎和动脉粥样硬化方面特别有用。

46. 发明授权

US06397901B1 Powder material supply device for producing fuel cell separator 有权
标题翻译：用于生产燃料电池隔板的粉末供料装置
公开(公告)号：US06397901B1
公开(公告)日：2002-06-04
申请号：US09649705
申请日：2000-08-25
申请人： Kazuo Saito , Atsushi Hagiwara , Takashi Maki
发明人： Kazuo Saito , Atsushi Hagiwara , Takashi Maki
IPC分类号： H01M472
CPC分类号： H01M8/0226 , B29C31/066 , B29C43/34 , B29K2105/251 , B29K2503/00 , B29K2707/04 , B29L2031/3468 , H01M8/0263 , H01M2300/0082 , Y02P70/56
摘要： A powder material supply device is able to supply powder material to a mold system equally and accurately to produce a fuel cell separator of high surface accuracy, thereby producing a high performance fuel cell. The powder material supply device includes a material supplier which is provided with a plurality of supply openings in a downward direction, a slide plate provided at the lower part of the material supplier and is slidable between a location where all of the supply openings are closed and another location where all the supply openings are opened, and a base to support the material supplier and the slide plate. The base has a single opening with a size substantially corresponding to a size of all of the supply openings.
摘要翻译：粉末材料供给装置能够均匀准确地向模具系统供应粉末材料，以生产高表面精度的燃料电池分离器，从而生产高性能燃料电池。粉料供给装置包括在向下方向上设置有多个供给口的材料供给体，设置在材料供给体的下部的滑动板，能够在所有供给口关闭的位置和所有供应开口打开的另一位置，以及用于支撑材料供应者和滑板的基座。底座具有一个单一的开口，其尺寸基本上对应于所有的供应开口的尺寸。

47. 发明授权

US06348279B1 Separator for polymeric electrolyte fuel cell having a roughened surface 有权
标题翻译：具有粗糙表面的高分子电解质燃料电池分离器
公开(公告)号：US06348279B1
公开(公告)日：2002-02-19
申请号：US09288108
申请日：1999-04-08
申请人： Kazuo Saito , Atsushi Hagiwara , Fumio Tanno
发明人： Kazuo Saito , Atsushi Hagiwara , Fumio Tanno
IPC分类号： H01M200
CPC分类号： H01M8/0204 , H01M8/0206 , H01M8/0213 , H01M8/0221 , H01M8/0226 , H01M8/0228 , Y02P70/56
摘要： The present invention provides a separator for a polymer electrolyte fuel cell, having, at the surface contacting with the electrode of the fuel cell, a surface roughness of Ra=0.1 to 10 &mgr;m when measured by a surface roughness tester having a probe of 5 &mgr;m in front end diameter; and a process for producing the above separator for a polymer electrolyte fuel cell, which process comprises immersing a molding of a separator for a polymer electrolyte fuel cell, in an acidic solution. The above separator for a polymer electrolyte fuel cell alleviates the problems of the prior art and has low contact resistance at the interface with the electrode of the fuel cell.
摘要翻译：本发明提供了一种用于固体高分子型燃料电池的隔板，在与具有5um的探针的表面粗糙度测试仪测量时，在与燃料电池的电极接触的表面处，Ra = 0.1〜10μm的表面粗糙度前端直径; 以及制造上述固体高分子型燃料电池用隔板的工序，其特征在于，在酸性溶液中浸渍聚合物电解质型燃料电池用隔膜的成型体。上述用于聚合物电解质燃料电池的隔板缓解了现有技术的问题，并且在与燃料电池的电极的界面处具有低接触电阻。

48. 发明授权

US5972538A Current collector for molten salt battery, process for producing material for said current collector, and molten salt battery using said current collector 失效
标题翻译：用于熔融盐电池的集电器，用于生产用于所述集电器的材料的方法，以及使用所述集电器的熔融盐电池
公开(公告)号：US5972538A
公开(公告)日：1999-10-26
申请号：US856316
申请日：1997-05-14
申请人： Kazuo Saito , Atsushi Hagiwara
发明人： Kazuo Saito , Atsushi Hagiwara
IPC分类号： H01M4/80 , H01M4/66 , H01M10/39
CPC分类号： H01M10/399 , H01M4/663
摘要： A current collector for a molten salt battery using liquid sodium as an anode active material, which current collector has excellent electrolyte resistance and low electrical resistance and is able to be produced simply and rapidly at a low cost, and includes a current collector material in which a carbon composite material obtained by calcining a mixture of expanded powder with a thermosetting resin under a non-oxidizing atmosphere is bonded to a porous carbon material having a porosity of 99 to 30% and an average pore diameter of 0.5 mm to 5 .mu.m. The above current collector is produced by a process including bonding a carbon composite material obtained by calcining a mixture of an expanded graphite powder with a thermosetting resin under a non-oxidizing atmosphere, to a porous carbon material having a porosity of 99 to 30% and an average pore diameter of 0.5 mm to 5 .mu.m, or alternatively, bonding a carbon composite material precursor composed of a mixture of an expanded graphite powder with a thermosetting resin, to the above porous carbon material and then calcining the resulting assembly under a non-oxidizing atmosphere.
摘要翻译：使用液态钠作为负极活性物质的熔融盐电池用集电体，该集电体具有优异的耐电解性和低电阻，能够以低成本简单快速地制造，并且包括集电体材料，其中通过在非氧化性气氛下将发泡粉末与热固性树脂的混合物煅烧而获得的碳复合材料与孔隙率为99〜30％，平均孔径为0.5〜5μm的多孔碳材料接合。上述集电体是通过将非膨胀石墨粉末与热固化性树脂的混合物在非氧化性气氛下进行煅烧而得到的碳复合材料粘合到孔隙率为99〜30％的多孔碳材料上的工序，平均孔径为0.5〜5μm，或者将由膨胀石墨粉末与热固性树脂的混合物组成的碳复合材料前体粘合到上述多孔碳材料上，然后在非水溶液下煅烧所得组合物，氧化气氛。

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