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41. 发明授权

US5036072A Antiviral agent 失效
标题翻译：抗病毒剂
公开(公告)号：US5036072A
公开(公告)日：1991-07-30
申请号：US469052
申请日：1990-01-23
申请人： Tsunetaka Nakajima , Tadao Okamoto , Masahiro Watanabe , Kazumasa Yokoyama
发明人： Tsunetaka Nakajima , Tadao Okamoto , Masahiro Watanabe , Kazumasa Yokoyama
IPC分类号： C07D239/34 , A61K31/44 , A61K31/4418 , A61K31/505 , A61P31/12 , C07D213/64
CPC分类号： A61K31/44 , A61K31/505
摘要： Use of a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is CH or a nitrogen atom, as an antiviral agent.

42. 发明授权

US4983723A Cycloalkane derivatives 失效
标题翻译：环烷烃衍生物
公开(公告)号：US4983723A
公开(公告)日：1991-01-08
申请号：US129217
申请日：1987-12-07
申请人： Hitoshi Yasuda , Chikara Fukaya , Kanemichi Okano , Kazumasa Yokoyama
发明人： Hitoshi Yasuda , Chikara Fukaya , Kanemichi Okano , Kazumasa Yokoyama
IPC分类号： A61K31/12 , C07C35/06 , C07C35/17 , C07C45/29 , C07C45/68 , C07C49/21 , C07C49/707 , C07C49/713 , A61K31/00 , C07C13/00
CPC分类号： C07C49/21 , C07C35/06 , C07C35/17 , C07C403/08 , C07C403/16 , C07C45/298 , C07C45/68 , C07C2101/14 , C07C2101/16 , Y10S514/927
摘要： A cycloalkane derivative represented by the formula (I): ##STR1## wherein A, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Z, and n are as defined in the specification. The compounds of formula (I) exhibit activities against peptic ulcers and are useful as therapeutic and prophylactic agents for peptic ulcers.
摘要翻译：由式（I）表示的环烷烃衍生物：其中A，R2，R3，R4，R5，R6，R7，Z和n如说明书中所定义。式（I）化合物显示针对消化性溃疡的活性，并且可用作消化性溃疡的治疗和预防剂。

43. 发明授权

US4983584A Therapeutic and prophylactic agents for peptic ulcers 失效
标题翻译：消化性溃疡的治疗和预防剂
公开(公告)号：US4983584A
公开(公告)日：1991-01-08
申请号：US124139
申请日：1987-11-23
申请人： Chikara Fukaya , Hitoshi Yasuda , Toshiaki Akira , Masakazu Iwai , Kanemichi Okano , Kazumasa Yokoyama
发明人： Chikara Fukaya , Hitoshi Yasuda , Toshiaki Akira , Masakazu Iwai , Kanemichi Okano , Kazumasa Yokoyama
IPC分类号： A61K31/045 , A61K31/075 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/70 , C07C47/192 , C07C47/198 , C07C49/11 , C07C49/172 , C07C49/175 , C07C49/497 , C07C49/517
CPC分类号： A61K31/7004 , A61K31/045 , A61K31/075 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/70 , C07C47/192 , C07C47/198 , C07C49/11 , C07C49/172 , C07C49/175 , C07C49/497 , C07C49/517 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers comprising as an effective ingredient a cyclohexane derivative represented by general formula (I): ##STR1## wherein A represents a group shown by formula, >CH.sub.2, ##STR2## wherein X represents ethynylene, vinylene or ethylene, Y represents oxo or a hydroxy group; R.sup.1, R.sup.3, R.sup.4 and R.sup.5 each represents a hydrogen atom or alkyl; R.sup.2 represents a hydrogen atom, alkyl or a group shown by --OR.sup.8 ;R.sup.6 represents a hydrogen atom, oxo or a group shown by --OR.sup.8 ; and R.sup.7 represents a hydrogen atom or a group shown by --OR.sup.8, wherein R.sup.8 represents a hydrogen atom or an organic residue.

44. 发明授权

US4748157A Composition for gastrointestinal ulcers 失效
标题翻译：胃肠溃疡的成分
公开(公告)号：US4748157A
公开(公告)日：1988-05-31
申请号：US827209
申请日：1986-02-04
申请人： Masakazu Iwai , Kazumasa Yokoyama , Tsunekazu Fukushima
发明人： Masakazu Iwai , Kazumasa Yokoyama , Tsunekazu Fukushima
IPC分类号： A61K38/00 , C07K16/18 , A61K37/00 , C07G7/00
CPC分类号： C07K16/18 , A61K38/00 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/929 , Y10S530/866
摘要： Fab or Fc fragment of human IgG which is obtainable by enzymatic digestion of the human IgG is reduced by a reducing agent to sever an interchain of disulfide bonds therein and then blocked the SH radicals formed with alkyl group which may contain other group. The resulting alkylated Fab and Fc fragments display therapeutic and prophylactic action for gastrointestinal ulcers by the oral or parenteral administration.
摘要翻译：通过人IgG的酶消化可获得的人IgG的Fab或Fc片段被还原剂还原，以切断其中二硫键的链间，然后封闭由可能含有其它基团的烷基形成的SH自由基。所得到的烷基化Fab和Fc片段通过口服或肠胃外给药显示对胃肠溃疡的治疗和预防作用。

45. 发明授权

US4613614A Prostaglandin I.sub.2 ester and fat emulsion containing the same 失效
标题翻译：前列腺素I2酯和脂肪乳剂含有相同的
公开(公告)号：US4613614A
公开(公告)日：1986-09-23
申请号：US626422
申请日：1984-06-29
申请人： Chikara Fukaya , Youichiro Naito , Kazumasa Yokoyama
发明人： Chikara Fukaya , Youichiro Naito , Kazumasa Yokoyama
IPC分类号： C07D307/935 , A61K9/107 , A61K31/557 , A61P43/00 , C07D307/937 , A61K31/74 , C07D307/93
CPC分类号： C07D307/937
摘要： There is provided a new ester of prostaglandin of the formula ##STR1## wherein R.sub.1 denotes an alkyl group having 1 to 20 carbon atoms; R.sub.2 denotes a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; and X denotes a group represented by the formula ##STR2## The new ester dissolves in oil easier than prostaglandin I.sub.2 itself and can easily be emulsified in the form of particles of solution in a vegetable oil. The ester in the fat emulsion is more stable than prostaglandin I.sub.2 and its physiological acts which are the same as prostaglandin I.sub.2 are prolonged.
摘要翻译：提供了一种新型的具有式“IMAGE”的前列腺素酯，其中R 1表示具有1至20个碳原子的烷基; R2表示氢原子或碳原子数1〜4的低级烷基，并且X表示由下式表示的基团。新的酯比前列腺素I2本身容易溶于油中，并且可以容易地以植物油中的溶液颗粒的形式乳化。脂肪乳剂中的酯比前列腺素I2更稳定，其与前列腺素I2相同的生理作用延长。

46. 发明授权

US4186253A Perfusate for preserving organ to be transplanted and preserving method 失效
标题翻译：用于保存器官的移植和保存方法
公开(公告)号：US4186253A
公开(公告)日：1980-01-29
申请号：US950071
申请日：1978-10-10
申请人： Kazumasa Yokoyama , Masakazu Iwai , Hiroyuki Okamoto , Noboru Yamada
发明人： Kazumasa Yokoyama , Masakazu Iwai , Hiroyuki Okamoto , Noboru Yamada
IPC分类号： A01N1/00 , A01N1/02 , C12B3/00 , A61K31/025
CPC分类号： A01N1/02 , A01N1/0226
摘要： An organ to be transplanted, such as kidney, can effectively be preserved by perfusion for a considerably long time by the use of a perfusate which is made by mixing a Ringer's solution modified by increasing potassium ion to 8-20 meq/l, a stable perfluorocarbon compound emulsion and albumin, so that the concentration of the perfluorocarbon compound is 7.5 to 12.5% (W/V) and that of albumin is 1-8% (W/V) based on the perfusate.
摘要翻译：通过使用通过将通过增加钾离子修饰的林格氏溶液混合至8-20meq / l而制成的灌注液，可以通过灌注相当长的时间来有效地保存要移植的器官，例如肾脏，稳定的全氟化碳化合物乳液和白蛋白，使得全氟化碳化合物的浓度为7.5至12.5％（W / V），而白蛋白的浓度为基于灌注液的1-8％（W / V）。

47. 发明申请

US20090032993A1 SOLUTION CASTING METHOD AND DEPOSIT REMOVING DEVICE 审中-公开
标题翻译：解决方案和沉积物去除装置
公开(公告)号：US20090032993A1
公开(公告)日：2009-02-05
申请号：US12282409
申请日：2007-03-07
申请人： Kazumasa Yokoyama
发明人： Kazumasa Yokoyama
IPC分类号： B29D7/00 , B29C39/16
CPC分类号： G02B5/3083 , B29C41/26 , B29C41/34 , B29K2001/00 , B29K2001/12
摘要： A drum cleaning device (65) has a nozzle (66). The drum cleaning device (65) is disposed in the upstream from a peel roller (34). A dope (21) is cast onto a surface of the casting drum(32) by using a casting die (30). The casting drum(32) is rotated to form a casting film(33) on the surface. The casting film(33) is cooled by the casting drum(32). Deposits containing fatty acid ester as a main component are precipitated from the casting film(33) onto the surface. The peel roller (34) peels off the casting film(33) as a wet film(38). The drum cleaning device (65) blasts gas mixture containing air and dry ice particles from the nozzle (66) onto the surface.
摘要翻译：鼓清洁装置（65）具有喷嘴（66）。滚筒清洁装置（65）设置在剥离辊（34）的上游。通过使用铸模（30）将涂料（21）浇铸到流延鼓（32）的表面上。铸塑滚筒（32）旋转以在表面上形成流延膜（33）。流延膜（33）由流延鼓（32）冷却。含有脂肪酸酯作为主要成分的沉淀物从浇铸膜（33）沉淀到表面上。剥离辊（34）作为湿膜（38）剥离流延薄膜（33）。鼓清洁装置（65）将含有空气和干冰颗粒的气体混合物从喷嘴（66）喷射到表面上。

48. 发明授权

US06617133B1 Process for purifying recombinant human serum albumin 有权
标题翻译：重组人血清白蛋白纯化方法
公开(公告)号：US06617133B1
公开(公告)日：2003-09-09
申请号：US09317214
申请日：1999-05-24
申请人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
发明人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
IPC分类号： C12P2100
CPC分类号： C07K14/765
摘要： The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a-culture medium containing rHSA and the rHSA-producing host cells, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A350/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.
摘要翻译：本发明提供了通过加热含有rHSA和产生rHSA的宿主细胞的培养基来纯化重组人血清白蛋白（rHSA）的方法，将所述加热溶液向上加入流化床中，其中吸附剂颗粒悬浮以实现与吸附剂颗粒，然后回收含有rHSA的吸附级分，以及包含rHSA的组合物，其在配制成所述白蛋白的25％溶液时显示A350 / A280比率低于0.015。

49. 发明授权

US5962649A Process for purifying recombinant human serum albumin 失效
标题翻译：重组人血清白蛋白纯化方法
公开(公告)号：US5962649A
公开(公告)日：1999-10-05
申请号：US522089
申请日：1995-08-31
申请人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
发明人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
IPC分类号： C07K14/765 , C07K1/16
CPC分类号： C07K14/765
摘要： The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a culture medium containing rHSA and the rHSA-producing host cello, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A35D/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.
摘要翻译：本发明提供了通过加热含有rHSA和产生rHSA的宿主大肠杆菌的培养基来纯化重组人血清白蛋白（rHSA）的方法，将所述加热溶液向上加入到流化床中，其中吸附剂颗粒悬浮以与吸附剂接触颗粒，然后回收含有rHSA的吸附级分，以及包含rHSA的组合物，其在配制成所述白蛋白的25％溶液时显示A35D / A280比率低于0.015。

50. 发明授权

US4983605A Pharmaceutical composition 失效
标题翻译：药物组成
公开(公告)号：US4983605A
公开(公告)日：1991-01-08
申请号：US110284
申请日：1987-10-20
申请人： Nobuo Kondo , Masahiro Kikuchi , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
发明人： Nobuo Kondo , Masahiro Kikuchi , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
IPC分类号： A61K9/14 , A61K9/19 , A61K31/44 , A61K31/50 , A61K31/505 , A61K47/14 , A61K47/26
CPC分类号： A61K31/505 , A61K31/44 , A61K31/50 , A61K9/145 , A61K9/146 , A61K9/19 , A61K47/14 , A61K47/26 , Y10S514/961 , Y10S514/964
摘要： A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, and a benzoyl urea compound (II) having the formula: ##STR2## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, as an active ingredient; a nonionic surfactant as a dispersant; and at least one member selected from the group consisting of a saccharide, a saccharide alcohol, silicic anhydride and a nonionic surfactant, as a disintegrator.
摘要翻译：提供一种药物组合物，其包含选自具有下式的苯甲酰脲化合物（I）的苯甲酰脲化合物（A）：其中X为卤素原子，硝基或三氟甲基，其提供当Y为硝基时，X为卤原子或硝基，Y为氢原子，卤原子，硝基或三氟甲基，Z1为卤原子或三氟甲基，Z2为氢原子或卤素原子，A为= CH-基或氮原子，和具有下式的苯甲酰脲化合物（II）：其中X1和X2各自为氢原子，卤素原子或硝基，条件是当Y为硝基时，X 1为氢原子，Y为氢原子，卤素原子，硝基或三氟甲基，Z为氢原子，卤素原子或三氟甲基作为活性成分; 作为分散剂的非离子表面活性剂; 和选自糖，糖醇，硅酸酐和非离子表面活性剂的至少一种作为崩解剂。

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