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41. 发明申请

US20050020686A1 Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient 失效
标题翻译：用ep4激动剂作为活性成分治疗骨质量下降的疾病
公开(公告)号：US20050020686A1
公开(公告)日：2005-01-27
申请号：US10484500
申请日：2002-07-22
申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K45/00 , A61K31/559 , A61P19/08 , A61P19/10 , C07C405/00 , A61K31/557
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

42. 发明授权

US06486414B2 Through-hole structure and printed circuit board including the through-hole structure 有权
标题翻译：通孔结构和印刷电路板包括通孔结构
公开(公告)号：US06486414B2
公开(公告)日：2002-11-26
申请号：US09921245
申请日：2001-08-01
申请人： Kaoru Kobayashi , Hiroyuki Mori , Kimihiro Yamanaka
发明人： Kaoru Kobayashi , Hiroyuki Mori , Kimihiro Yamanaka
IPC分类号： H05K111
CPC分类号： H05K1/0222 , H05K1/024 , H05K1/0251 , H05K1/115 , H05K3/429 , H05K2201/09063 , H05K2201/09618 , H05K2201/09809
摘要： The present invention provides a through-hole structure for connecting a connector to a printed circuit board, the through-hole structure comprising a signal through-hole having a conductive layer therein for supplying a signal to the printed circuit board, power through-holes having a conductive layer therein for supplying power to the printed circuit board, and dielectric constant adjusting portions formed among the signal through-hole and the power through-holes. Moreover, the present invention provides a printed circuit board having the above-described through-hole structure formed therein.
摘要翻译：本发明提供一种用于将连接器连接到印刷电路板的通孔结构，该通孔结构包括其中具有用于向印刷电路板提供信号的导电层的信号通孔，具有用于向印刷电路板提供信号的电力通孔，用于向印刷电路板供电的导电层，以及形成在信号通孔和电源通孔之间的介电常数调节部。此外，本发明提供一种其中形成有上述通孔结构的印刷电路板。

43. 发明授权

US6068995A Method for producing protein 失效
标题翻译：生产蛋白质的方法
公开(公告)号：US6068995A
公开(公告)日：2000-05-30
申请号：US666435
申请日：1996-09-19
申请人： Kaoru Kobayashi , Kenji Tomomitsu , Shinobu Kuwae , Tomoshi Ohya , Toyoo Ohda , Takao Ohmura
发明人： Kaoru Kobayashi , Kenji Tomomitsu , Shinobu Kuwae , Tomoshi Ohya , Toyoo Ohda , Takao Ohmura
IPC分类号： C07K14/765 , C12N1/19 , C12N1/38 , C12N15/00 , C12N15/12 , C12N15/18 , C12P21/00
CPC分类号： C12N15/00 , C07K14/765 , C12N1/38 , C12P21/00
摘要： A method for producing a desired protein, which comprises growing, by a fed-batch culture, a host cell capable of expressing the desired protein, wherein the specific growth rate of the host cell is changed from the initial rate to a predetermined one by successively changing the rate of addition of a substrate which controls the growth of the host cell. According to the mode of change of the rate of substrate addition to the medium of the present invention, optimal patterns of specific growth rate .mu. and specific production rate .rho. can be realized to optimize the fed-batch culture system. As a consequence of the realization, it is made possible to perform a high density culture of the host cell by fed-batch culture, an the desired protein can be produced efficiently in a short time.
摘要翻译： PCT No.PCT / JP95 / 02186 Sec。 371日期1996年9月19日 102（e）1996年9月19日PCT 1994年10月25日PCT公布。公开号WO96 / 12816 PCT 日期：1996年5月2日一种生产所需蛋白质的方法，其包括通过补料分批培养物生长能够表达所需蛋白质的宿主细胞，其中所述宿主细胞的比生长速率从初始速率改变为通过依次改变控制宿主细胞生长的底物的加入速度来预定的。根据本发明介质的底物添加速度的变化方式，可以实现比生长速度mu和比生产率rho的最佳模式，以优化补料分批培养体系。作为实现的结果，可以通过补料分批培养进行宿主细胞的高密度培养，可以在短时间内有效地产生所需的蛋白质。

44. 发明授权

US5691451A Method for sterilizing recombinant human serum albumin pharmaceutical preparation 失效
标题翻译：灭菌重组人血清白蛋白药物制剂的方法
公开(公告)号：US5691451A
公开(公告)日：1997-11-25
申请号：US329176
申请日：1994-10-26
申请人： Tomoshi Ohya , Toyoo Ohda , Shinobu Kuwae , Kenji Tomomitsu , Kaoru Kobayashi , Takao Ohmura
发明人： Tomoshi Ohya , Toyoo Ohda , Shinobu Kuwae , Kenji Tomomitsu , Kaoru Kobayashi , Takao Ohmura
IPC分类号： A61K9/08 , A61K38/16 , A61L2/00 , C07K14/765 , C07K1/00 , C12P21/06
CPC分类号： C07K14/765 , A61L2/0023
摘要： A recombinant human serum albumin (rHSA) pharmaceutical preparation is sterilized by subjecting a pharmaceutical preparation of rHSA obtained by gene manipulation techniques packed in a container in an administration unit to heat treatment at 50.degree. to 80.degree. C. for 30 minutes or more. By the disclosed method, rHSA having high safety can be provided since microorganisms contaminated in rHSA pharmaceutical preparations die as a result of the sterilization method of the present invention.
摘要翻译：重组人血清白蛋白（rHSA）药物制剂通过使包装在给药单元的容器中的基因操作技术获得的rHSA药物制剂在50℃至80℃下加热处理30分钟以上而进行灭菌。通过所公开的方法，可以提供具有高安全性的rHSA，因为由rHSA药物制剂中污染的微生物因本发明的灭菌方法而死亡。

45. 发明授权

US5541782A Magnetic recording and playback apparatus capatible with conventional video signal recording format 失效
标题翻译：磁记录和播放设备与传统视频信号记录格式兼容
公开(公告)号：US5541782A
公开(公告)日：1996-07-30
申请号：US425339
申请日：1995-04-18
申请人： Kaoru Kobayashi , Kenji Shibayama
发明人： Kaoru Kobayashi , Kenji Shibayama
IPC分类号： H04N5/92 , H04N5/919 , H04N5/937 , H04N5/78
CPC分类号： H04N5/919 , H04N5/937
摘要： An HD image signal is recorded and reproduced by a tape head system of a conventional home VTR. An HD image signal (bb) which is of a different broadcasting system from a conventional broadcasting system and contains an information whose amount is larger than that contained in a video signal of the conventional broadcasting system is divided by four by first to eighth memories and resultant four signals are recorded on a magnetic tape through a first to fourth recording signal processing circuits and FM modulators, etc. In reproduction, the four signals are reproduced by FM demodulators and a first to fourth reproduced signal processing circuits, etc., and the HD image signal is produced by using the first to eighth memories.
摘要翻译： HD图像信号由常规家用录像机的磁头系统记录和再现。与传统的广播系统不同的广播系统的HD图像信号（bb），其包含大于常规广播系统的视频信号中所包含的信息量的信息被第一至第八存储器除以四，并且得到四个信号通过第一至第四记录信号处理电路和FM调制器等记录在磁带上。在再现中，四个信号由FM解调器和第一至第四再现信号处理电路等以及HD 通过使用第一至第八存储器产生图像信号。

46. 发明授权

US5294699A Inhibition of coloration of human serum albumin 失效
标题翻译：抑制人血清白蛋白着色
公开(公告)号：US5294699A
公开(公告)日：1994-03-15
申请号：US719443
申请日：1991-06-24
申请人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Fuluhata , Kaoru Kobayashi , Shinobu Kuwae , Hirotoshi Fukutsuka , Tomoshi Ohya , Hiroshi Morise
发明人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Fuluhata , Kaoru Kobayashi , Shinobu Kuwae , Hirotoshi Fukutsuka , Tomoshi Ohya , Hiroshi Morise
IPC分类号： A61K38/16 , A61K38/00 , B01D15/00 , B01D15/04 , C07K1/14 , C07K1/20 , C07K14/435 , C07K14/76 , C07K14/765 , C12N15/09 , C12N15/14 , C12N15/81 , C12P21/02 , C12R1/865 , C07K3/28 , A61K45/02
CPC分类号： C07K14/765 , C12N15/81 , A61K38/00 , C07K2319/02
摘要： A method of inhibiting the coloration of human serum albumin expressed by using the gene manipulation technology which method comprises separating coloring contaminants from said human serum albumin before said coloring contaminants bind to the human serum albumin.
摘要翻译：通过使用基因操作技术抑制人血清白蛋白的着色的方法，该方法包括在所述着色污染物与人血清白蛋白结合之前从所述人血清白蛋白中分离着色污染物。

47. 发明授权

US4939585A Method and apparatus for recording a video format signal having a time code 失效
标题翻译：用于记录具有时间码的视频格式信号的方法和装置
公开(公告)号：US4939585A
公开(公告)日：1990-07-03
申请号：US183963
申请日：1988-04-20
申请人： Tomoyuki Kawaguchi , Kaoru Kobayashi
发明人： Tomoyuki Kawaguchi , Kaoru Kobayashi
IPC分类号： G11B27/28 , G11B27/30 , H04N5/85
CPC分类号： G11B27/3054 , H04N5/85 , G11B2220/20 , G11B2220/2587
摘要： An apparatus and method of recording a video format signal having a vertical blanking interval on a recording medium. The number of frames of the video format signal to be recorded on the recording medium is counted, and a first time code is generated such that one second corresponds to L-frames of the video format signal. The first time code is then incremented N-times within a predetermined period of the video formal signal, thereby obtaining a second time code representing the incremented first time code. The second time code is then inserted into the video blanking interval of the format signal, thereby producing a video format signal having a time code which is relatively close to the actual elapsed time of the signal.
摘要翻译：一种在记录介质上记录具有垂直消隐间隔的视频格式信号的装置和方法。对要记录在记录介质上的视频格式信号的帧数进行计数，生成第一时间码，使得一秒对应于视频格式信号的L帧。然后，第一时间码在视频形式信号的预定时段内递增N次，从而获得表示增加的第一时间码的第二时间码。然后将第二时间码插入格式信号的视频消隐间隔，从而产生具有相对接近信号的实际经过时间的时间码的视频格式信号。

48. 发明授权

US08729978B2 Quartz-crystal controlled oscillator 有权
标题翻译：石英晶振控制振荡器
公开(公告)号：US08729978B2
公开(公告)日：2014-05-20
申请号：US13562270
申请日：2012-07-30
申请人： Kazuo Akaike , Tsukasa Kobata , Tomoya Yorita , Kaoru Kobayashi
发明人： Kazuo Akaike , Tsukasa Kobata , Tomoya Yorita , Kaoru Kobayashi
IPC分类号： H03B5/36
CPC分类号： H03L1/022 , H03L1/028
摘要： An atmosphere temperature at which a quartz-crystal oscillator and an oscillation circuit are placed is controlled in high accuracy, and an output frequency with high stability is obtained. If oscillation outputs of first and second quartz-crystal oscillators are set to f1 and f2, and oscillation frequencies of the oscillation outputs at a reference temperature are set to f1r and f2r, respectively, {(f2−f1)/f1}−{(f2r−f1r)/f1r} is calculated by a frequency difference detection unit. A digital value can be obtained by representing this value by 34-bit digital value, corresponding to a temperature. Therefore, this value is treated as a temperature detection value, a difference with a temperature set value is supplied to the loop filter, and the digital value therefrom is converted into a direct-current voltage to control a heater.
摘要翻译：高精度地控制放置石英振荡器和振荡电路的气氛温度，并且获得具有高稳定性的输出频率。如果第一和第二石英晶体振荡器的振荡输出设定为f1和f2，并且将基准温度下的振荡输出的振荡频率分别设定为f1r和f2r，则{（f2-f1）/ f1} - {（ f2r-f1r）/ f1r}由频率差检测单元计算。通过对应于温度的34位数字值表示该值可以获得数字值。因此，将该值作为温度检测值，将与温度设定值的差被提供给环路滤波器，并将其数字值转换为直流电压以控制加热器。

49. 发明申请

US20120202773A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASES ASSOCIATED WITH DECREASE IN BONE MASS COMPRISING EP4 AGONIST AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于治疗与包含EP4激动剂作为主动成分的骨质疏松相关的疾病的药物组合物
公开(公告)号：US20120202773A1
公开(公告)日：2012-08-09
申请号：US13453434
申请日：2012-04-23
申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/4015 , C08B37/16 , A61K31/724 , C07D409/06 , C07D405/10 , C07D405/06 , C07D417/12 , C07D413/12 , C07D417/14 , C07D263/24 , C07D403/12 , C07D409/12 , C07D409/14 , C07D401/12 , A61P19/08 , C07D413/14 , C07D207/26 , B82Y99/00 , B82Y5/00
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

50. 发明授权

US08233519B2 Signal processing unit and wireless communication device 有权
标题翻译：信号处理单元和无线通信设备
公开(公告)号：US08233519B2
公开(公告)日：2012-07-31
申请号：US12382158
申请日：2009-03-10
申请人： Kaoru Kobayashi , Shigeru Takegishi
发明人： Kaoru Kobayashi , Shigeru Takegishi
IPC分类号： H04B1/00
CPC分类号： H04L27/0014 , H04B1/70752 , H04L2027/0036 , H04L2027/0051 , H04L2027/0095
摘要： A signal processing unit and a wireless communication device are provided for making it possible to detect a frequency by means of a small scale operation circuit in a short time. The signal processing unit and the wireless communication device are comprised of a carrier data generating unit; a carrier demodulation unit; a matched filter unit that divides carrier demodulated data into a plurality of portions, carries out despread processing and accumulating operation processing as partial correlation processing, further carries out full addition processing for the partial correlation processing result, and outputs correlation detected data; a correlation peak detecting unit that detects a correlation peak from the correlation detected data and outputs correlation peak position information; a coarse frequency deviation detecting unit that outputs a frequency deviation amount with respect to the carrier demodulated data to the carrier data generating unit; and a fine frequency deviation detecting unit that outputs a fine frequency deviation amount from the correlation detected data and the correlation peak position information to the carrier data generating unit.
摘要翻译：提供信号处理单元和无线通信装置，以便能够在短时间内利用小规模的操作电路来检测频率。信号处理单元和无线通信设备包括载波数据生成单元; 载波解调单元; 将载波解调数据分割为多个部分的匹配滤波器单元，进行解扩处理并积累作为部分相关处理的运算处理，进一步执行部分相关处理结果的全相加处理，并输出相关检测数据; 相关峰值检测单元，根据相关检测数据检测相关峰值，并输出相关峰值位置信息; 粗频率偏差检测单元，向载波数据生成单元输出相对于载波解调数据的频率偏差量; 以及精细频率偏差检测单元，其将相关检测数据和相关峰值位置信息的精细频率偏差量输出到载波数据生成单元。

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