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41. 发明授权

US09314222B2 Operation of a remote medical navigation system using ultrasound image 有权
标题翻译：使用超声波图像的远程医疗导航系统的操作
公开(公告)号：US09314222B2
公开(公告)日：2016-04-19
申请号：US12205137
申请日：2008-09-05
申请人： Francis M. Creighton, IV , Rogers C. Ritter , Raju R. Viswanathan , Nathan Kastelein , Jeffrey M. Garibaldi , William Flickinger
发明人： Francis M. Creighton, IV , Rogers C. Ritter , Raju R. Viswanathan , Nathan Kastelein , Jeffrey M. Garibaldi , William Flickinger
IPC分类号： A61B5/05 , A61B8/08 , A61B5/06 , A61B8/00
CPC分类号： A61B8/0833 , A61B5/062 , A61B8/4416
摘要： A method of operating a remote medical navigation system using ultrasound, employs ultrasound imaging from a medical device to supplement or to replace conventional x-ray imaging of the operating region during navigation.
摘要翻译：使用超声波操作远程医疗导航系统的方法使用来自医疗装置的超声成像来补充或替代在导航期间操作区域的常规x射线成像。

42. 发明授权

US08162920B2 Magnetic navigation of medical devices in magnetic fields 有权
标题翻译：医疗器械在磁场中的磁导航
公开(公告)号：US08162920B2
公开(公告)日：2012-04-24
申请号：US10831533
申请日：2004-04-23
申请人： Rogers C. Ritter , Raju R. Viswanathan , Roger N. Hastings
发明人： Rogers C. Ritter , Raju R. Viswanathan , Roger N. Hastings
IPC分类号： A61M31/00 , A61M25/00
CPC分类号： A61B1/00147 , A61M25/0127
摘要： A method of turning a medical device with the assistance of an externally applied magnetic field, in a direction with a component in a plane perpendicular to the direction of the externally applied magnetic field. The method includes applying first torque to the distal end of the medical device by creating magnetic moment at the distal end of the medical device, and applying a second torque to the distal end of the medical device. The second torque may be created by creating a second magnetic moment at the distal end of the device spaced from the first, by using an electrostrictive device, by using a stylette inserted into the device, by using a fluid-driven shaped tube, or otherwise.
摘要翻译：在外部施加的磁场的帮助下，沿与垂直于外部施加的磁场的方向的平面中的分量的方向转动医疗装置的方法。该方法包括通过在医疗装置的远端产生磁矩并将第二扭矩施加到医疗装置的远端，将第一扭矩施加到医疗装置的远端。第二扭矩可以通过使用电致伸缩装置通过使用插入到装置中的通孔，通过使用流体驱动的成形管或以其他方式通过使用流动驱动的成形管产生与装置的远端隔开的第二磁矩来产生。

43. 发明申请

US20110028989A1 NAVIGATION USING SENSED PHYSIOLOGICAL DATA AS FEEDBACK 审中-公开
标题翻译：使用感觉生理数据作为反馈的导航
公开(公告)号：US20110028989A1
公开(公告)日：2011-02-03
申请号：US12773443
申请日：2010-05-04
申请人： Rogers C. Ritter , Raju R. Viswanathan
发明人： Rogers C. Ritter , Raju R. Viswanathan
IPC分类号： A61B19/00
CPC分类号： A61B5/026 , A61B5/028 , A61B5/04011 , A61B5/04012 , A61B5/042 , A61B5/06 , A61B5/062 , A61B5/065 , A61B5/068 , A61B8/06 , A61B8/12 , A61B34/73 , A61B90/06 , A61B2017/00044 , A61B2034/2051 , A61N1/08
摘要： A method for controlling a remote navigation system to navigate a medical device in an operating region in a subject is provided, comprising operating the remote navigation system to bring a sensor carried on a medical device successively into a plurality of locations in a predetermined pattern, and using the sensor to sense a physiological property of the subject in each location. At least once thereafter, the method operates the remote navigation system to bring a sensor carried on a medical device successively into a series of locations in a predetermined pattern relative to at least one location selected from the predetermined pattern in the immediately preceding step based upon the sensed physiological property value, and uses the sensor to sense the physiological property in each location. The method automatically determines the location of a local extreme value of the sensed physiological property, and may be selectively used to locate a maximum value of the sensed physiological property or a minimum of the sensed physiological property. The method may be utilized for sensing one or more physiological properties such as a magnitude of an electrical signal, a conductivity, a temperature, a fluid flow rate or a fluid velocity, or a range of motion of a surface.
摘要翻译：提供了一种用于控制远程导航系统导航对象中的操作区域中的医疗设备的方法，包括：操作所述远程导航系统，使医疗设备上承载的传感器以预定模式连续地进入多个位置;以及使用传感器来感测每个位置的受试者的生理特性。至少在此之后，该方法操作远程导航系统，以使基于医疗设备的传感器相对于在前一步骤中的预定模式中选择的至少一个位置，以预定模式连续地进入一系列位置，基于感测生理特性值，并使用传感器感测每个位置的生理特性。该方法自动地确定所感测的生理特征的局部极值的位置，并且可以选择性地用于定位所感测的生理特性的最大值或感测到的生理特性的最小值。该方法可以用于感测一个或多个生理特性，例如电信号的大小，电导率，温度，流体流速或流体速度或表面的运动范围。

44. 发明申请

US20090062646A1 OPERATION OF A REMOTE MEDICAL NAVIGATION SYSTEM USING ULTRASOUND IMAGE 有权
标题翻译：使用超声波图像的远程医疗导航系统的操作
公开(公告)号：US20090062646A1
公开(公告)日：2009-03-05
申请号：US12205137
申请日：2008-09-05
申请人： Francis M. Creighton, IV , Rogers C. Ritter , Raju R. Viswanathan , Nathan Kastelein , Jeffrey M. Garibaldi , William Flickinger
发明人： Francis M. Creighton, IV , Rogers C. Ritter , Raju R. Viswanathan , Nathan Kastelein , Jeffrey M. Garibaldi , William Flickinger
IPC分类号： A61B8/14
CPC分类号： A61B8/0833 , A61B5/062 , A61B8/4416
摘要： A method of operating a remote medical navigation system using ultrasound, employs ultrasound imaging from a medical device to supplement or to replace conventional x-ray imaging of the operating region during navigation.
摘要翻译：使用超声波操作远程医疗导航系统的方法使用来自医疗装置的超声成像来补充或替代在导航期间操作区域的常规x射线成像。

45. 发明授权

US06529761B2 Digital magnetic system for magnetic surgery 失效
公开(公告)号：US06529761B2
公开(公告)日：2003-03-04
申请号：US09911863
申请日：2001-07-24
申请人： Francis M. Creighton, IV , Bevil J. Hogg , Rogers C. Ritter
发明人： Francis M. Creighton, IV , Bevil J. Hogg , Rogers C. Ritter
IPC分类号： A61B505
CPC分类号： A61B1/00158 , A61B34/20 , A61B34/73 , A61B90/10 , A61B2034/733 , A61B2090/376 , H02K41/00
摘要： A device and a method for guiding or applying force to a magnetic implant within the body of a patient. The device includes a bed for support of the patient, a set of separately energizable electromagnets or separately controllable permanent magnets so arranged to produce magnetic fields of varying orientations in a treatment region of the patient, and a processor that controls the currents in the electromagnets, or shutters on the permanent magnets to produce a selected magnetic field and/or gradient for guiding or moving the implant. The magnets are configured to allow a medical imaging device to be used to provide a real-time display of an operating procedure in which magnetic guidance is used. The method for guiding the implant includes the placing of the body on the bed, which may be servo-controlled, inserting a magnetically-guided implant into the treatment region, arranging the magnets around the body so that they can supply the necessary magnetic fields and/or gradients through appropriate energization of subsets of the magnets, and applying current or shutter control to subsets of the magnets to provide a guiding magnetic field for the implant, which may occur while real-time medical imaging of the procedure is occurring. The bed may be moved under servo control to provide further control of the direction and magnitude of the magnetic field affecting the implant.

46. 发明授权

US06330467B1 Efficient magnet system for magnetically-assisted surgery 失效
标题翻译：用于磁辅助手术的高效磁铁系统
公开(公告)号：US06330467B1
公开(公告)日：2001-12-11
申请号：US09287397
申请日：1999-04-06
申请人： Francis M. Creighton, IV , Andrew F. Hall , Roger N. Hastings , Rogers C. Ritter
发明人： Francis M. Creighton, IV , Andrew F. Hall , Roger N. Hastings , Rogers C. Ritter
IPC分类号： A61B505
CPC分类号： A61B34/73 , A61B1/00158 , A61B34/70 , A61B90/36 , A61B2034/301 , A61B2034/733 , A61B2034/742 , A61M25/0127
摘要： A system for magnetically assisted surgery includes a magnetic support structure, a patient support structure and a magnet having at least four poles attached to the magnetic support structure so that the magnet provides a near-field magnetic field in an operating region of a patient supported by the patient support structure. The magnet is moveable so that the direction of the magnetic field lines in the operating region is adjustable. The magnet may include a pair of essentially semicircular half-segments permanently magnetized and joined in an extremely stable disk configuration. The magnetic field and gradient field provided by the magnet is such that movement of the disk in one plane combined with rotation of the disk is sufficient to orient the magnetic field during surgical use, thereby reducing interference to medical imaging devices needed during surgery. An example of a medical delivery device that may be used for surgery in conjunction with this system is a flexible endoscope or catheter having a series of magnetically permeable rings.
摘要翻译：一种用于磁辅助手术的系统包括磁性支撑结构，患者支撑结构和具有至少四个磁极附接到磁性支撑结构的磁体，使得磁体在患者的操作区域中提供近场磁场，患者支撑结构。磁体是可移动的，使得操作区域中的磁场线的方向是可调节的。磁体可以包括一对基本上半圆形的半段，其永久地磁化并以非常稳定的磁盘配置连接。由磁体提供的磁场和梯度场使得在一个平面中与盘的旋转相结合的盘的移动足以在手术使用期间定向磁场，从而减少对手术期间所需的医学成像装置的干扰。结合该系统可用于手术的医疗输送装置的实例是具有一系列导磁环的柔性内窥镜或导管。

47. 发明授权

US5779694A Magnetic stereotactic system for treatment delivery 失效
公开(公告)号：US5779694A
公开(公告)日：1998-07-14
申请号：US96214
申请日：1993-07-19
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10 , A61M37/00 , A61K9/22 , A61M1/00
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.

48. 发明授权

US5707335A Magnetic stereotactic system and treatment delivery 失效
公开(公告)号：US5707335A
公开(公告)日：1998-01-13
申请号：US464279
申请日：1995-06-05
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10 , A61N2/00
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.

49. 发明授权

US5125888A Magnetic stereotactic system for treatment delivery 失效
标题翻译：用于治疗传递的磁立体定向系统
公开(公告)号：US5125888A
公开(公告)日：1992-06-30
申请号：US463340
申请日：1990-01-10
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.
摘要翻译：处理递送装置包括通过热敏生物降解连接器连接到磁性物体的金属物体和处理载体装置。该载体装置包含待运输的药物，即药物。电磁体位于身体部分的外部，用于产生捕获磁性物体的磁场。该电磁铁可以是附接到机身臂的简单线圈系统，该机器人手臂围绕身体部分移动电磁体，或围绕身体部分的多电磁体系统。在任一情况下，机器人移动的电磁体或多电磁体系统将身体部分内的磁性物体移动到期望的位置。计算机控制机器臂或多电流电流幅度和方向。该计算机还提供用于观察磁性物体和载体装置的位置和移动的可视化。在到达所需位置时，磁性物体被加热，这导致热敏生物降解连接器连接件熔化，从而将含药物载体装置与磁性物体分开。然后，电磁体装置将磁性物体移出身体部分。含处理剂的载体装置保持在期望的位置，药物被输送到特定位置。

50. 发明授权

US4869247A Video tumor fighting system 失效
标题翻译：视频肿瘤治疗系统
公开(公告)号：US4869247A
公开(公告)日：1989-09-26
申请号：US167217
申请日：1988-03-11
申请人： Matthew A. Howard, III , Rogers C. Ritter , Grady, M. Sean
发明人： Matthew A. Howard, III , Rogers C. Ritter , Grady, M. Sean
IPC分类号： A61B19/00 , A61F7/00 , A61F7/12 , A61N1/40 , A61N2/00
CPC分类号： A61N2/00 , A61B34/20 , A61B34/70 , A61B34/73 , A61F7/12 , A61N1/406 , A61B2034/2051 , A61B2034/2072 , A61B2034/732 , A61B2090/101 , A61B2090/365 , A61B2090/3954 , A61F2007/009 , A61F2007/126
摘要： A destructive heat lesion is placed in any location in the brain. A patient's head is secured within a stereotactic frame. After a high resolution CT scan and angiogram or MRI, data is incorporated and analyzed by a computer. This information is then resynthesized and projected as a video image on a screen facing the surgeon. A small magnetic object, perhaps a ball, is inserted into the patient's head via a burr hole drilled through the patient's skull. Using, real time fluoroscopic data superimposed on the computer image of three-dimensional structures, the surgeon is able to control and manipulate the object through the patient's soft brain tissue to a position next to or inside of the tumor area. An energy beam is then fired at the object, causing the more heat efficient object to destroy the brain tumor area. This procedure is repeated until the entire tumor is eradicated by the highly localized hyperthermia. The above procedure can be used to deliver hyperthermia, chemotherapy, radiotherapy and other agents or treatments to the brain and other parts of the body as well.
摘要翻译：破坏性热损伤置于脑中的任何位置。患者的头部固定在立体定向框架内。在高分辨率CT扫描和血管造影或MRI之后，数据由计算机并入并分析。然后将该信息重新合成并作为面向外科医生的屏幕上的视频图像投影。一个小的磁性物体，也许是一个球，通过穿过患者头骨的钻孔插入病人的头部。使用叠加在三维结构的计算机图像上的实时荧光透视数据，外科医生能够通过患者的软脑组织控制和操纵物体到肿瘤区域旁边或内侧的位置。然后在物体上射出能量束，导致更热效率的物体破坏脑肿瘤区域。重复该过程，直到整个肿瘤被高度局限的热疗消除。以上程序也可用于将高热，化学疗法，放射疗法和其他药物或治疗物质递送至大脑和身体其他部位。

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