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41. 发明申请

US20100262378A1 Cytological Analysis by Raman Spectroscopic Imaging 有权
标题翻译：通过拉曼光谱成像进行细胞学分析
公开(公告)号：US20100262378A1
公开(公告)日：2010-10-14
申请号：US12755463
申请日：2010-06-23
申请人： John Maier , Joseph Demuth , Jeffrey Cohen , Shona Stewart , Lindy McClelland
发明人： John Maier , Joseph Demuth , Jeffrey Cohen , Shona Stewart , Lindy McClelland
IPC分类号： G06F19/00 , G01J3/44 , G06K9/62
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/415 , A61B5/417 , A61B5/418 , A61B5/4519 , G01N21/65
摘要： A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.
摘要翻译：一种产生样品图像的方法，其用于提供样品中细胞的疾病状态。用单色光照射包含电池的样品。评估拉曼散射光。产生拉曼散射光的数字明场图像，并与细胞发射的拉曼散射光组合，由此拉曼散射光提供样品中细胞的疾病状态。该方法还可以用于确定细胞的代谢活性，细胞的炎性状态和/或样品中细胞的感染状态。

42. 发明授权

US07808633B2 Spectroscopic system and method for predicting outcome of disease 有权
标题翻译：光谱系统和预测疾病结局的方法
公开(公告)号：US07808633B2
公开(公告)日：2010-10-05
申请号：US12070010
申请日：2008-02-14
申请人： John Maier , Jeffrey Cohen , Janice L. Panza , Amy J. Drauch
发明人： John Maier , Jeffrey Cohen , Janice L. Panza , Amy J. Drauch
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/44 , G01J2003/2826 , G01N2021/656 , G01N2201/1293 , G01N2201/1296
摘要： A system and method to predict the progression of disease of a test sample. A group of known biological samples is provided. Each known biological sample has an associated known outcome including a non-diseased sample or a diseased sample. A Raman data set is obtained for each known biological sample. Each Raman data set is analyzed to identify a diseased or non-diseased reference Raman data set depending on whether respective biological sample is the non-diseased sample or the diseased sample. A first database is generated where the first database contains reference Raman data sets for all diseased samples. A second database is generated where the second database contains reference Raman data sets for all non-diseased samples. A test Raman data set of a test biological sample is received, where the test biological sample has an unknown disease status. A diagnostic is provided as to whether the test sample is a non-diseased sample or a diseased sample. The diagnostic is obtained by comparing the test Raman data set against the reference Raman data sets in the first and the second databases using a chemometric technique. A prediction of the progression of disease may be then provided.
摘要翻译：一种预测测试样本疾病进展的系统和方法。提供了一组已知的生物样品。每个已知的生物样品具有相关的已知结果，包括非患病样品或患病样品。获得每个已知生物样品的拉曼数据集。分析每个拉曼数据集，以根据相应的生物样品是非患病样品还是患病样品来鉴定患病或非患病参考拉曼数据集。生成第一个数据库，其中第一个数据库包含所有患病样本的参考拉曼数据集。生成第二数据库，其中第二数据库包含所有非患病样本的参考拉曼数据集。接受测试生物样品的测试拉曼数据集，其中测试生物样品具有未知的疾病状态。提供了关于测试样品是否是非患病样品或患病样品的诊断。通过使用化学计量技术将测试拉曼数据集与第一和第二数据库中的参考拉曼数据集进行比较来获得诊断。可以提供疾病进展的预测。

43. 发明申请

US20100034743A1 Raman Characterization of Transplant Tissue 有权
标题翻译：移植组织的拉曼表征
公开(公告)号：US20100034743A1
公开(公告)日：2010-02-11
申请号：US12537513
申请日：2009-08-07
申请人： Jeffrey Cohen , John S. Maier , Shona Stewart
发明人： Jeffrey Cohen , John S. Maier , Shona Stewart
IPC分类号： A61K49/00 , G01J3/44 , G01N21/65 , A61P43/00
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0237 , G01J3/0291 , G01J3/0294 , G01J3/44 , G01N2021/656
摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.
摘要翻译：用于确定样品的疾病状态和临床结果的系统和方法。照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。在一个实施方案中，化学方法是主要成分分析。在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

44. 发明申请

US20090086203A1 Method for Correlating Spectroscopic Measurements with Digital Images of Contrast Enhanced Tissue 有权
标题翻译：将光谱测量与对比增强组织的数字图像相关联的方法
公开(公告)号：US20090086203A1
公开(公告)日：2009-04-02
申请号：US12329688
申请日：2008-12-08
申请人： Jeffrey Cohen , John S. Maier
发明人： Jeffrey Cohen , John S. Maier
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0289 , G01J3/0291 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/6417 , G01N2021/6423 , G01N2021/656
摘要： A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.
摘要翻译：将拉曼测量与样本的数字图像相关联的系统和方法，以对样本的疾病状态进行分类。对于位于分光装置的视野中的样品获得光谱数据集。从样品中取出样品后，用对比度增强剂处理样品。经处理的样品在分光装置的视野中重新定位，并获得处理过的样品的数字图像。通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，光谱数据集与数字图像相关联。对于样本的光谱数据集，搜索数据库以识别具有良好表征的病理学的已知样品的光谱数据集，其与样品的光谱数据集相匹配。

45. 发明申请

US20080319324A1 DISTINGUISHING BETWEEN INVASIVE DUCTAL CARCINOMA AND INVASIVE LOBULAR CARCINOMA USING RAMAN MOLECULAR IMAGING 有权
标题翻译：使用拉曼分子成像检测入侵性肺癌和入侵性肺癌之间的差异
公开(公告)号：US20080319324A1
公开(公告)日：2008-12-25
申请号：US12206500
申请日：2008-09-08
申请人： John Maier , Shona Stewart , Jeffrey Cohen
发明人： John Maier , Shona Stewart , Jeffrey Cohen
IPC分类号： A61B6/00
CPC分类号： G01J3/02 , A61B5/0059 , A61B5/417 , G01J3/0291 , G01J3/0294 , G01J3/28 , G01J3/2823 , G01J3/36 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N33/57415 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , Y02A90/26
摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.
摘要翻译：一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。用基本上单色的光照射测试乳房样品以产生散射光子，得到测试拉曼数据集。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

46. 发明申请

US20070127022A1 Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue 有权
标题翻译：将光谱测量与对比增强组织的数字图像相关联的方法
公开(公告)号：US20070127022A1
公开(公告)日：2007-06-07
申请号：US11647195
申请日：2006-12-29
申请人： Jeffrey Cohen , John Maier , Robert Schweitzer
发明人： Jeffrey Cohen , John Maier , Robert Schweitzer
IPC分类号： G01J3/28
CPC分类号： G01N21/65 , G01J3/0235 , G01J3/0264 , G01J3/0289 , G01J3/0291 , G01J3/12 , G01J3/2823 , G01J3/44 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6417 , G01N2021/6423 , G01N2021/656
摘要： A system and method of correlating Raman measurements with digital images of a treated sample and using this correlation to classify the disease state of the sample. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. The positional information about the field of view is stored. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. Using the stored positional information for the field of view, the treated sample is repositioned in the spectroscopic device's field of view. A digital image of the treated sample positioned in the field of view is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. A database having a plurality of spectroscopic data sets, for samples having well characterized pathology, is provided. Each spectroscopic data set is linked to a corresponding digital image, and each spectroscopic data set is associated with the known sample. Each corresponding digital image is associated with the known sample treated with a contrast enhancing agent. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample, matching the sample's spectroscopic data set.
摘要翻译：将拉曼测量与处理的样品的数字图像相关联并使用该相关性来分类样品的疾病状态的系统和方法。对于位于分光装置的视野中的样品获得光谱数据集。存储关于视场的位置信息。从样品中取出样品后，用对比度增强剂处理样品。使用所存储的视场的位置信息，处理的样品在分光装置的视场中重新定位。获得定位在视场中的被处理样品的数字图像。通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，光谱数据集与数字图像相关联。提供了具有多个光谱数据集的数据库，用于具有良好表征的病理学的样本。每个光谱数据集与相应的数字图像相关联，并且每个光谱数据集与已知样本相关联。每个相应的数字图像与用对比度增强剂处理的已知样品相关联。对于样本的光谱数据集，搜索数据库以识别与样本的光谱数据集匹配的已知样本的光谱数据集。

47. 发明申请

US20050250091A1 Raman molecular imaging for detection of bladder cancer 审中-公开
标题翻译：拉曼分子成像检测膀胱癌
公开(公告)号：US20050250091A1
公开(公告)日：2005-11-10
申请号：US11000545
申请日：2004-11-30
申请人： John Maier , Amos Shapiro , Jeffrey Cohen
发明人： John Maier , Amos Shapiro , Jeffrey Cohen
IPC分类号： A61B5/00 , C12Q1/00 , G01N21/65 , G01N33/574
CPC分类号： A61B5/202 , A61B5/0059 , A61B5/415 , A61B5/417 , A61B5/418 , G01N21/65 , G01N21/658 , G01N33/57407 , G01N2021/656
摘要： Raman molecular imaging is used to differentiate between normal tissue and benign and malignant lesions of bladder and other tissues, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the cancerous state of cells can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the cancerous state of the individual cells in the field of view.
摘要翻译：拉曼分子成像用于区分正常组织和膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾脏，乳腺和结肠以及非上皮组织，如骨髓和脑。可以将与细胞癌状态相关的拉曼散射数据与视觉图像数据组合以产生混合图像，其描绘细胞结构的放大视图和与视野中的各个细胞的癌症状态有关的信息。

48. 发明授权

US08553732B2 Cytological analysis by raman spectroscopic imaging 有权
标题翻译：通过拉曼光谱成像进行细胞学分析
公开(公告)号：US08553732B2
公开(公告)日：2013-10-08
申请号：US12755463
申请日：2010-06-23
申请人： John Maier , Joseph Demuth , Jeffrey Cohen , Shona Stewart , Lindy McClelland
发明人： John Maier , Joseph Demuth , Jeffrey Cohen , Shona Stewart , Lindy McClelland
IPC分类号： H01S3/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/415 , A61B5/417 , A61B5/418 , A61B5/4519 , G01N21/65
摘要： A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.
摘要翻译：一种产生样品图像的方法，其用于提供样品中细胞的疾病状态。用单色光照射包含电池的样品。评估拉曼散射光。产生拉曼散射光的数字明场图像，并与细胞发射的拉曼散射光组合，由此拉曼散射光提供样品中细胞的疾病状态。该方法还可以用于确定细胞的代谢活性，细胞的炎性状态和/或样品中细胞的感染状态。

49. 发明授权

US08253936B2 Raman characterization of transplant tissue 有权
标题翻译：移植组织的拉曼表征
公开(公告)号：US08253936B2
公开(公告)日：2012-08-28
申请号：US12537513
申请日：2009-08-07
申请人： Jeffrey Cohen , John S Maier , Shona Stewart
发明人： Jeffrey Cohen , John S Maier , Shona Stewart
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0237 , G01J3/0291 , G01J3/0294 , G01J3/44 , G01N2021/656
摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.
摘要翻译：用于确定样品的疾病状态和临床结果的系统和方法。照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。在一个实施方案中，化学方法是主要成分分析。在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

50. 发明申请

US20120062873A1 SYSTEM AND METHOD FOR DIAGNOSING THE DISEASE STATE OF BREAST TISSUE USING SWIR 审中-公开
标题翻译：用SWIR诊断乳腺组织疾病状态的系统和方法
公开(公告)号：US20120062873A1
公开(公告)日：2012-03-15
申请号：US13153775
申请日：2011-06-06
申请人： Shona Stewart , John Maier , Jeffrey Cohen
发明人： Shona Stewart , John Maier , Jeffrey Cohen
IPC分类号： G01N21/00 , G01J3/44 , G01N21/64 , G01J5/08
CPC分类号： A61B5/417 , A61B5/0075 , G01J3/02 , G01J3/0291 , G01J3/28 , G01J3/2823 , G01J3/36 , G01J3/44 , G01J2003/2826 , G01N21/35 , G01N21/6456 , G01N21/65 , G01N33/57415 , G01N2021/1765 , G01N2021/1793 , G01N2021/6423 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G01N2800/7028
摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference SWIR data sets is provided where each reference SWIR data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test SWIR data set. The test SWIR data set is compared to the plurality of reference SWIR data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.
摘要翻译：一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。提供了包含多个参考SWIR数据集的数据库，其中每个参考SWIR数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。用基本上单色的光照射测试乳房样品以产生散射的光子，得到测试SWIR数据集。使用化学计量技术将测试SWIR数据集与多个参考SWIR数据集进行比较。基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

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