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1. 发明申请

US20120150028A1 System and Method of Chemical Imaging Using Puled Laser Excitation and Time-Gated Detection to Determine Tissue Margins During Surgery 审中-公开
标题翻译：使用激光激光和时间门控检测技术测定手术中的组织边缘的化学成像系统和方法
公开(公告)号：US20120150028A1
公开(公告)日：2012-06-14
申请号：US13316703
申请日：2011-12-12
申请人： Patrick J. Treado , John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
发明人： Patrick J. Treado , John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/4064 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65 , G01N2021/6484 , G01N2201/08
摘要： System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
摘要翻译：使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

2. 发明申请

US20100034743A1 Raman Characterization of Transplant Tissue 有权
标题翻译：移植组织的拉曼表征
公开(公告)号：US20100034743A1
公开(公告)日：2010-02-11
申请号：US12537513
申请日：2009-08-07
申请人： Jeffrey Cohen , John S. Maier , Shona Stewart
发明人： Jeffrey Cohen , John S. Maier , Shona Stewart
IPC分类号： A61K49/00 , G01J3/44 , G01N21/65 , A61P43/00
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0237 , G01J3/0291 , G01J3/0294 , G01J3/44 , G01N2021/656
摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.
摘要翻译：用于确定样品的疾病状态和临床结果的系统和方法。照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。在一个实施方案中，化学方法是主要成分分析。在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

3. 发明授权

US08253936B2 Raman characterization of transplant tissue 有权
标题翻译：移植组织的拉曼表征
公开(公告)号：US08253936B2
公开(公告)日：2012-08-28
申请号：US12537513
申请日：2009-08-07
申请人： Jeffrey Cohen , John S Maier , Shona Stewart
发明人： Jeffrey Cohen , John S Maier , Shona Stewart
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0237 , G01J3/0291 , G01J3/0294 , G01J3/44 , G01N2021/656
摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.
摘要翻译：用于确定样品的疾病状态和临床结果的系统和方法。照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。在一个实施方案中，化学方法是主要成分分析。在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

4. 发明授权

US08078268B2 System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery 有权
标题翻译：使用脉冲激光激发和时间门控检测的化学成像的系统和方法来确定手术期间的组织边缘
公开(公告)号：US08078268B2
公开(公告)日：2011-12-13
申请号：US12565279
申请日：2009-09-23
申请人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J Treado
发明人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J Treado
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/4064 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65 , G01N2021/6484 , G01N2201/08
摘要： System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
摘要翻译：使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

5. 发明申请

US20100081127A1 System and Method of Chemical Imaging Using Pulsed Laser Excitation and Time-Gated Detection to Determine Tissue Margins During Surgery 有权
标题翻译：使用脉冲激光激发和时间门控检测的化学成像系统和方法来确定手术中的组织边缘
公开(公告)号：US20100081127A1
公开(公告)日：2010-04-01
申请号：US12565279
申请日：2009-09-23
申请人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J. Treado
发明人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J. Treado
IPC分类号： C12Q1/70 , C12Q1/06
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/4064 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65 , G01N2021/6484 , G01N2201/08
摘要： System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
摘要翻译：使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

6. 发明授权

US07596404B2 Method of chemical imaging to determine tissue margins during surgery 有权
标题翻译：化学成像方法来确定手术中的组织边缘
公开(公告)号：US07596404B2
公开(公告)日：2009-09-29
申请号：US11361256
申请日：2006-02-24
申请人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
发明人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
IPC分类号： A61B6/00
CPC分类号： G01N21/65 , A61B5/0075 , A61B5/0084 , G01N2021/6484 , G01N2021/656 , G01N2201/08
摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.
摘要翻译：在各种医疗过程中区分组织边缘的方法和系统。用基本上单色的光照射含有生物组织的区域。从照射区域获得拉曼光谱数据。在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

7. 发明授权

US07623232B2 Raman spectral analysis of pathogens 有权
标题翻译：拉曼光谱分析病原体
公开(公告)号：US07623232B2
公开(公告)日：2009-11-24
申请号：US12191496
申请日：2008-08-14
申请人： Shona Stewart , John S. Maier , Patrick J. Treado
发明人： Shona Stewart , John S. Maier , Patrick J. Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： A method of ablating a viable biological pathogen in a sample. A viable biological pathogen in a portion of the sample is identified by irradiating the sample; assessing radiation scattered from the sample for radiation that exhibits a Raman shift characteristic of the viable biological pathogen, and delivering an ablating agent to the identified portion.
摘要翻译：一种在样品中消融活的生物病原体的方法。通过照射样品来鉴定样品部分中的活的生物病原体; 评估从样品中散射的辐射的辐射，其表现出活的生物病原体的拉曼位移特征，并将消融剂递送到所识别的部分。

8. 发明申请

US20080297789A1 Raman Spectral Analysis of Pathogens 有权
标题翻译：病原体拉曼光谱分析
公开(公告)号：US20080297789A1
公开(公告)日：2008-12-04
申请号：US12191496
申请日：2008-08-14
申请人： Shona Stewart , John S. Maier , Patrick J. Treado
发明人： Shona Stewart , John S. Maier , Patrick J. Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： A method of ablating a viable biological pathogen in a sample. A viable biological pathogen in a portion of the sample is identified by irradiating the sample; assessing radiation scattered from the sample for radiation that exhibits a Raman shift characteristic of the viable biological pathogen, and delivering an ablating agent to the identified portion.
摘要翻译：一种在样品中消融活的生物病原体的方法。通过照射样品来鉴定样品部分中的活的生物病原体; 评估从样品中散射的辐射的辐射，其表现出活的生物病原体的拉曼位移特征，并将消融剂递送到所识别的部分。

9. 发明授权

US07428045B2 Raman spectral analysis of pathogens 有权
标题翻译：拉曼光谱分析病原体
公开(公告)号：US07428045B2
公开(公告)日：2008-09-23
申请号：US11206007
申请日：2005-08-17
申请人： Shona Stewart , John S. Maier , Patrick J. Treado
发明人： Shona Stewart , John S. Maier , Patrick J. Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.
摘要翻译：使用施加到水样品的辐射的拉曼散射来评估样品中病原体的发生。该方法可用于检测使用其他方法（如原生动物）难以检测的病原体。使用这些方法可以在水样中检测的生物体的实例包括隐孢子虫属和贾第虫属的原生动物。本文描述的方法具有重要的应用，例如用于在市政水系统中检测隐孢子虫生物体。

10. 发明授权

US07239383B2 Method and apparatus for spectral modulation compensation 有权
标题翻译：光谱调制补偿的方法和装置
公开(公告)号：US07239383B2
公开(公告)日：2007-07-03
申请号：US10879632
申请日：2004-06-30
申请人： John S. Maier , Jason N. Neiss , Shona Stewart , Matthew P. Nelson , Joseph Demuth , Patrick J. Treado
发明人： John S. Maier , Jason N. Neiss , Shona Stewart , Matthew P. Nelson , Joseph Demuth , Patrick J. Treado
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/0297 , G01J3/44 , G01N2021/656
摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.
摘要翻译：本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

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