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41. 发明申请

US20070064327A1 Servo track having periodic frames of tone field and embedded synchronization marks 有权
标题翻译：伺服轨道具有周期性的帧字段和嵌入式同步标记
公开(公告)号：US20070064327A1
公开(公告)日：2007-03-22
申请号：US11602693
申请日：2006-11-20
申请人： John Koski , Timothy Hughes
发明人： John Koski , Timothy Hughes
IPC分类号： G11B5/09 , G11B21/02
CPC分类号： G11B5/584 , G11B27/107 , G11B27/3027 , G11B2220/90
摘要： Methods and systems for sensing a position of a transducer head with respect to a storage medium. One method includes generating a read signal from a servo track stored on a magnetic storage medium. The servo track includes servo frames of magnetic flux transitions forming detectable servo marks, the servo marks forming a tone field of repeating servo marks oriented at a first azimuth angle and a mid-frame synchronization mark incorporated within the tone field, wherein the tone field provides a metric reference for dimensional measurements between features within the servo frame(s). The number of servo marks in the tone field of each servo frame along a longitudinal direction of the servo track before the mid-frame synchronization mark and after the mid-frame synchronization mark varies with lateral position.
摘要翻译：用于感测换能器头相对于存储介质的位置的方法和系统。一种方法包括从存储在磁存储介质上的伺服轨迹产生读取信号。伺服轨道包括形成可检测的伺服标记的磁通转变的伺服帧，伺服标记形成以第一方位角定向的重复伺服标记的色域和并入该色域内的中间帧同步标记，其中色域提供用于在伺服帧内的特征之间的尺寸测量的度量参考。在中间帧同步标记之前和中间帧同步标记之间的伺服轨迹的纵向方向上的每个伺服帧的色域中的伺服标记的数量随着横向位置而变化。

42. 发明授权

US07131276B2 Pulse tube refrigerator 失效
标题翻译：脉管冰箱
公开(公告)号：US07131276B2
公开(公告)日：2006-11-07
申请号：US10702046
申请日：2003-11-06
申请人： Huaiyu Pan , Timothy Hughes , Keith White
发明人： Huaiyu Pan , Timothy Hughes , Keith White
IPC分类号： F25B9/00
CPC分类号： F28F1/124 , F25B9/10 , F25B9/145 , F25B2309/1408 , F25B2309/1412 , F25B2309/1414 , F25B2309/1415 , F25B2400/17 , F28F1/24
摘要： The present invention relates to pulse tube refrigerators for recondensing cryogenic liquids. In particular, the present invention relates to the same for magnetic resonance imaging systems. In many cryogenic applications components, e.g. superconducting coils for magnetic resonance imaging (mri), superconducting transformers, generators, electronics, are cooled by keeping them in contact with a volume of liquified gases (e.g. helium, neon, nitrogen, argon, methane). In a first aspect, the present invention provides a pulse tube refrigerator PTR pulse tube refrigerator (PTR) arrangement within a cryogenic apparatus, wherein a regenerator tube of the PTR is finned. In this configuration the fins or baffles, are believed to increase the surface area available for distributed heat transfer from the helium atmosphere to the regenerator.
摘要翻译：本发明涉及用于再冷凝低温液体的脉冲管式冰箱。特别地，本发明涉及磁共振成像系统。在许多低温应用中，例如，用于磁共振成像（mri），超导变压器，发电机，电子器件的超导线圈通过使其与一定体积的液化气体（例如氦气，氖气，氮气，氩气，甲烷）保持接触来冷却。在第一方面，本发明提供了一种在低温装置内布置的脉管管制冷器PTR脉冲管制冷器（PTR），其中PTR的再生管被翅片化。在这种构造中，翅片或挡板被认为增加了可用于从氦气气氛到再生器的分布式热传递的表面积。

43. 发明申请

US20050019704A1 Underlayer compositions for multilayer lithographic processes 失效
公开(公告)号：US20050019704A1
公开(公告)日：2005-01-27
申请号：US10920762
申请日：2004-08-18
申请人： Mahmoud Khojasteh , Timothy Hughes , Ranee Kwong , Pushkara Varanasi , William Brunsvold , Margaret Lawson , Robert Allen , David Medeiros , Ratnam Sooriyakumaran , Phillip Brock
发明人： Mahmoud Khojasteh , Timothy Hughes , Ranee Kwong , Pushkara Varanasi , William Brunsvold , Margaret Lawson , Robert Allen , David Medeiros , Ratnam Sooriyakumaran , Phillip Brock
IPC分类号： C08F30/08 , C08F32/00 , C08F230/08 , C08K5/41 , C08K5/54 , C08L43/04 , C08L45/00 , G03F7/004 , G03F7/038 , G03F7/039 , G03F7/075 , G03F7/09 , G11B5/31 , H01L21/027 , G03F7/00
CPC分类号： G03F7/094 , G03F7/0045 , G03F7/0382 , G03F7/0395 , G03F7/0758 , G11B5/3163
摘要： Compositions suitable for forming planarizing underlayers for multilayer lithographic processes are characterized by the presence of (A) a polymer containing: (i) cyclic ether moieties, (ii) saturated polycyclic moieties, and (iii) aromatic moieties for compositions not requiring a separate crosslinker, or (B) a polymer containing: (i) saturated polycyclic moieties, and (ii) aromatic moieties for compositions requiring a separate crosslinker. The compositions provide outstanding optical, mechanical and etch selectivity properties. The compositions are especially useful in lithographic processes using radiation less than 200 nm in wavelength to configure underlying material layers.

44. 发明授权

US08792960B2 Magnetic resonance method and apparatus for automated analysis of joint inflammation, joint proteoglycan proportion, and joint osteoarthritis 有权
标题翻译：用于自发分析关节炎症，关节蛋白聚糖比例和关节骨关节炎的磁共振方法和装置
公开(公告)号：US08792960B2
公开(公告)日：2014-07-29
申请号：US12710869
申请日：2010-02-23
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： A61B5/055 , A61K49/06 , G01R33/56 , G01R33/20
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61K49/06 , G01R33/20 , G01R33/5601
摘要： In a magnetic resonance method and apparatus for generating an analysis of an inflammation of a joint, for determining a proteoglycan proportion of a joint, and for generating an analysis of osteoarthritis of a joint, for a predetermined region within a body of a patient, a three-dimensional MR image data set is generated with a magnetic resonance imaging scanner. At least, a portion of a joint is located within the region. For each of several different automatically determined layers, a two-dimensional MR image is calculated from the three-dimensional MR image data set. For each layer, the thickness of a predetermined tissue, which is represented in the two-dimensional MR image corresponding to the layer, is determined, by means of which an analysis of a joint inflammation is automatically determined depending on the respective thicknesses. A further layer in the region is also automatically determined and, after injecting a contrast medium, a two-dimensional T1-weighted MR image is generated for this layer, from which a proteoglycan proportion is automatically determined. From the analysis of the joint inflammation and the proteoglycan proportion, it is then possible to perform a reproducible analysis of osteoarthritis of the joint.
摘要翻译：在用于产生关节炎症分析的磁共振方法和装置中，用于确定关节的蛋白聚糖比例，并且用于产生关节骨关节炎的分析，对于患者体内的预定区域，利用磁共振成像扫描器生成三维MR图像数据集。至少，关节的一部分位于该区域内。对于几个不同的自动确定的层中的每一个，从三维MR图像数据集计算二维MR图像。对于每个层，确定在与层相对应的二维MR图像中表示的预定组织的厚度，借助于此，根据各自的厚度自动确定关节炎症的分析。还自动地确定该区域中的另一层，并且在注射造影剂之后，为该层生成二维T1加权MR图像，从其自动确定蛋白多糖比例。从关节炎和蛋白多糖比例的分析可以对关节骨关节炎进行可重复的分析。

45. 发明授权

US08412460B2 Methods and systems for characterizing a cellular constituent using response profiles 有权
标题翻译：使用响应曲线表征细胞成分的方法和系统
公开(公告)号：US08412460B2
公开(公告)日：2013-04-02
申请号：US12686311
申请日：2010-01-12
申请人： Roland Stoughton , Timothy Hughes
发明人： Roland Stoughton , Timothy Hughes
IPC分类号： G06F19/00 , C12Q1/68 , C12N15/09 , G06G7/58
CPC分类号： G06F19/18 , C12Q1/6809 , C12Q1/6837 , C40B30/04 , G01N33/5005 , G01N2500/00 , G06F19/20 , G06F19/24 , C12Q2545/114 , C12Q2521/107 , C12Q2539/113
摘要： The invention relates to methods and systems (e.g., computer systems and computer program products) for characterizing cellular constituents, particularly genes and gene products. In particular, the invention provides methods for assigning or determining the biological function of uncharacterized genes and gene products by using “response profiles,” i.e., measurements of pluralities of cellular constituents in cells having a modified gene or gene product, as phenotypic markers for the gene or gene product. Methods are provided for clustering such response profiles so that similar or correlated response profiles are organized into the same cluster. The invention also provides databases or “compendiums” of response profiles to which the response profile of an uncharacterized gene or gene product can compared.
摘要翻译：本发明涉及用于表征细胞组分，特别是基因和基因产物的方法和系统（例如，计算机系统和计算机程序产品）。特别地，本发明提供了通过使用响应曲线来分配或确定未表征的基因和基因产物的生物学功能的方法，即，具有修饰基因或基因产物的细胞中多种细胞成分的测量，作为该基因的表型标记，或基因产物。提供了用于聚类这种响应简档的方法，使得相似或相关的响应简档被组织到相同的集群中。本发明还提供响应曲线的数据库或汇编，其中非特征基因或基因产物的响应特征可以与之对比。

46. 发明授权

US08115482B2 Magnetic resonance anatomical image generating method and system 有权
标题翻译：磁共振解剖图像生成方法及系统
公开(公告)号：US08115482B2
公开(公告)日：2012-02-14
申请号：US12125502
申请日：2008-05-22
申请人： Timothy Hughes
发明人： Timothy Hughes
IPC分类号： G01V3/00 , A61B5/055
CPC分类号： A61B5/055 , A61B5/4514 , G01R33/50 , G01R33/5608 , G01R33/5617
摘要： In a method to generate an anatomical image of an examination area with a magnetic resonance apparatus as well as computer program and magnetic resonance apparatus for implementation of the method, at least one image data set of the examination area and a parameter value map are loaded. The at least one loaded image data set and the loaded parameter value map are processed into an anatomical image. The processing includes a weighting of elements of the at least one image data set with a weighting factor. The weighting factor depends on a parameter value of the parameter value map corresponding to the respective element of the image data set. The generated weighted anatomical image is displayed and/or stored.
摘要翻译：在使用磁共振装置产生检查区域的解剖图像的方法以及用于实现该方法的计算机程序和磁共振装置的方法中，加载了检查区域和参数值映射的至少一个图像数据集。将至少一个加载的图像数据集和加载的参数值图处理成解剖图像。该处理包括利用加权因子加权至少一个图像数据集的元素。权重因子取决于与图像数据集的各个元素相对应的参数值映射的参数值。产生的加权解剖图像被显示和/或存储。

47. 发明申请

US20080150531A1 3D MR IMAGING WITH FAT SUPPRESSION 失效
标题翻译：具有FAT抑制的3D MR成像
公开(公告)号：US20080150531A1
公开(公告)日：2008-06-26
申请号：US11962792
申请日：2007-12-21
申请人： Timothy Hughes , Bernd Kuehn
发明人： Timothy Hughes , Bernd Kuehn
IPC分类号： G01R33/56
CPC分类号： G01R33/561 , G01R33/4824 , G01R33/4828 , G01R33/5602 , G01R33/5607
摘要： In a method for image generation by magnetic resonance with suppression of a spectral component of the magnetic resonance signal during the signal acquisition, k-space is sampled in sub-sections, an excitation pulse for excitation of the spectral component to be suppressed is radiated at a point in time TI before acquisition of each sub-section of k-space, and different TI values are selected for the respective sub-sections.
摘要翻译：在信号采集期间通过抑制磁共振信号的频谱分量的磁共振成像的方法中，在子部分中对k空间进行采样，将要抑制的频谱分量的激励用激励脉冲放射在在获取k空间的每个子部分之前的时间点TI，并且为各个子部分选择不同的TI值。

48. 发明申请

US20070070545A1 Servo track having periodic frames of tone field and embedded synchronization marks 有权
标题翻译：伺服轨道具有周期性的帧字段和嵌入式同步标记
公开(公告)号：US20070070545A1
公开(公告)日：2007-03-29
申请号：US11602872
申请日：2006-11-20
申请人： John Koski , Timothy Hughes
发明人： John Koski , Timothy Hughes
IPC分类号： G11B5/78
CPC分类号： G11B5/584 , G11B27/107 , G11B27/3027 , G11B2220/90
摘要： Methods and systems for sensing a position of a transducer head with respect to a storage medium. One method includes generating a read signal from a servo track stored on a magnetic storage medium. The servo track includes servo frames of magnetic flux transitions forming detectable servo marks, the servo marks forming a tone field of repeating servo marks oriented at a first azimuth angle and a mid-frame synchronization mark incorporated within the tone field; wherein the tone field provides a metric reference for dimensional measurements between features within the servo frame(s). The number of servo marks in the tone field of each servo frame along a longitudinal direction of the servo track before the mid-frame synchronization mark and after the mid-frame synchronization mark varies with lateral position.
摘要翻译：用于感测换能器头相对于存储介质的位置的方法和系统。一种方法包括从存储在磁存储介质上的伺服轨迹产生读取信号。伺服轨道包括形成可检测的伺服标记的磁通转变的伺服帧，伺服标记形成以第一方位角定向的重复伺服标记的色域和并入该色域内的中间帧同步标记; 其中所述音调字段提供用于所述伺服帧内的特征之间的尺寸测量的度量参考。在中间帧同步标记之前和中间帧同步标记之间的伺服轨迹的纵向方向上的每个伺服帧的色域中的伺服标记的数量随着横向位置而变化。

49. 发明申请

US20050259349A1 Servo track having periodic frames of tone field and embedded synchronization marks 失效
标题翻译：伺服轨道具有周期性的帧字段和嵌入式同步标记
公开(公告)号：US20050259349A1
公开(公告)日：2005-11-24
申请号：US10854078
申请日：2004-05-24
申请人： John Koski , Timothy Hughes
发明人： John Koski , Timothy Hughes
IPC分类号： G11B5/584 , G11B20/12 , G11B27/10 , G11B27/30
CPC分类号： G11B5/584 , G11B27/107 , G11B27/3027 , G11B2220/90
摘要： Methods and systems for sensing a position of a transducer head with respect to a storage medium. One method includes generating a read signal from a servo track stored on a magnetic storage medium. The servo track includes servo frames of magnetic flux transitions forming detectable servo marks, the servo marks forming a tone field of repeating servo marks oriented at a first azimuth angle and a mid-frame synchronization mark incorporated within the tone field, wherein the tone field provides a metric reference for dimensional measurements between features within the servo frame(s). The number of servo marks in the tone field of each servo frame along a longitudinal direction of the servo track before the mid-frame synchronization mark and after the mid-frame synchronization mark varies with lateral position.
摘要翻译：用于感测换能器头相对于存储介质的位置的方法和系统。一种方法包括从存储在磁存储介质上的伺服轨迹产生读取信号。伺服轨道包括形成可检测的伺服标记的磁通转变的伺服帧，伺服标记形成以第一方位角定向的重复伺服标记的色域和并入该色域内的中间帧同步标记，其中色域提供用于在伺服帧内的特征之间的尺寸测量的度量参考。在中间帧同步标记之前和中间帧同步标记之间的伺服轨迹的纵向方向上的每个伺服帧的色域中的伺服标记的数量随着横向位置而变化。

50. 发明申请

US20050238692A1 Biomedical adhesive 审中-公开
标题翻译：生物医用胶
公开(公告)号：US20050238692A1
公开(公告)日：2005-10-27
申请号：US10515164
申请日：2003-05-21
申请人： Timothy Hughes
发明人： Timothy Hughes
IPC分类号： G02C7/02 , A61F2/14 , A61F2/16 , A61L24/00 , A61L24/04 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/34 , C08F220/28 , C08F230/08 , C08F255/02 , C08F259/08 , C08F283/06 , C08F283/12 , C08F290/00 , C08F290/06 , C09J11/06 , C09J171/02 , C09J201/00 , A61L2/00 , A61F2/00
CPC分类号： C08F290/062 , A61F2/14 , A61L27/18 , A61L27/34 , A61L2430/16 , C08F290/02 , C08L71/02
摘要： The biomedical adhesives of the invention provide a reactive surface to adhere or crosslink to tissue and may be used, for example, as ready-to-use corneal onlay in ophthalmic surgery. The invention provides a method for bonding a bulk material to a corresponding nucleophilic or electrophilic surface including attaching a multifunctionally activated bulk material compound to the bulk material and contacting a functional group of the compound with the surface under conditions permitting covalent linkage between the bulk material and the functional group.
摘要翻译：本发明的生物医学粘合剂提供了粘附或交联至组织的反应性表面，并且可用于例如眼科手术中的即用型角膜镶嵌物。本发明提供了一种用于将散装材料粘合到相应的亲核或亲电表面的方法，包括将多功能活化的散装材料化合物连接到本体材料上，并且使化合物的官能团与表面接触，条件是允许散装材料和功能组。

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