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41. 发明申请

US20100330546A1 OBSTRUCTIVE SLEEP APNEA DEMONSTRATION MODEL DEVICE 失效
标题翻译：阻塞睡眠APNEA演示模型设备
公开(公告)号：US20100330546A1
公开(公告)日：2010-12-30
申请号：US12823109
申请日：2010-06-24
申请人： Charles Richard Lloyd , Richard Klein
发明人： Charles Richard Lloyd , Richard Klein
IPC分类号： G09B23/30
CPC分类号： G09B23/32
摘要： The present invention is an obstructive sleep apnea demonstration model device for a user and a patient. The device includes a vertical display stand with a horizontal base, a vertical front surface and a horizontal flange, a vertical side profile base with a removed oral cavity portion attached to the display stand and disposed within the horizontal flange, a top movable side piece with an upper lip, a set of upper teeth, a hinge and a palate. The device also includes a back elongated movable side piece disposed behind the top side piece that hinges on the palate, a chin assembly side piece with a chin, a lower lip, a set of lower teeth and a tongue and an intraoral appliance that is placed between the upper teeth and the lower teeth to treat the patient with an obstructive sleep apnea condition.
摘要翻译：本发明是用于患者和患者的阻塞性睡眠呼吸暂停演示模型装置。该装置包括具有水平底座，垂直前表面和水平凸缘的垂直显示支架，具有附接到显示支架并且设置在水平凸缘内的移除的口腔部分的垂直侧面基座，上唇，一组上牙，铰链和上颚。该装置还包括一个后伸长的可移动的侧片，该后片设置在铰接在上颚上的顶侧件的后面，具有下巴的下巴组件侧件，下唇，一组下牙和一舌片以及一口腔内器具，在上牙和下牙之间，以阻塞性睡眠呼吸暂停状态治疗患者。

42. 发明申请

US20090258049A1 DRUG ELUTING EXPANDABLE DEVICES 有权
标题翻译：药物释放可扩展装置
公开(公告)号：US20090258049A1
公开(公告)日：2009-10-15
申请号：US12101903
申请日：2008-04-11
申请人： Richard Klein , John Birtles , John Koos , Michael J. Lee
发明人： Richard Klein , John Birtles , John Koos , Michael J. Lee
IPC分类号： A61K9/00 , A61K31/44 , A61K31/337 , A61P43/00
CPC分类号： A61K31/337 , A61F2/82 , A61F2230/0069 , A61F2250/0067 , A61K31/44 , A61L29/10 , A61L29/146 , A61L29/16 , A61L29/18 , A61L31/082 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/00 , A61L2300/204 , A61L2300/21 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2300/802
摘要： The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic effects. Sol gel technology can be used to coat the devices.
摘要翻译：本公开涉及药物洗脱装置及其用途。药物洗脱装置可以在部署过程中允许灌注。涂层可能含有生物活性材料，其一旦部署在患者体内即可洗脱，并且可具有抗增殖，抗炎或抗血栓形成的作用。溶胶凝胶技术可用于涂装设备。

43. 发明申请

US20070071789A1 Bioactive Material Delivery Systems Comprising Sol-Gel Compositions 有权
标题翻译：包含溶胶凝胶组合物的生物活性物质输送系统
公开(公告)号：US20070071789A1
公开(公告)日：2007-03-29
申请号：US11463237
申请日：2006-08-08
申请人： Dimitrios Pantelidis , John Bravman , Jonathan Rothbard , Richard Klein
发明人： Dimitrios Pantelidis , John Bravman , Jonathan Rothbard , Richard Klein
IPC分类号： A61K9/14
CPC分类号： A61L31/088 , A61L27/306 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/608 , C08L83/04
摘要： Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed.
摘要翻译：公开了使用用作生物活性材料储存器的溶胶 - 凝胶组合物涂层的植入式医疗装置，以及使用溶胶 - 凝胶组合物涂层来改善有机和无机基材的粘附性。

44. 发明申请

US20060115512A1 Metallic structures incorporating bioactive materials and methods for creating the same 审中-公开
标题翻译：包含生物活性材料的金属结构及其制造方法
公开(公告)号：US20060115512A1
公开(公告)日：2006-06-01
申请号：US11223234
申请日：2005-09-09
申请人： James Peacock , Richard Klein , Michael Lee
发明人： James Peacock , Richard Klein , Michael Lee
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61F2210/0004 , A61F2250/0068 , A61L31/12 , A61L31/146 , A61L31/148 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/604
摘要： Disclosed herein are methods to create medical devices and implantable medical devices with an electrochemically engineered porous surface that contains one or more bioactive materials to form bioactive composite structures. The bioactive composite structures are prepared using electrochemical codeposition methods to create metallic layers with pores that can be loaded with bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.
摘要翻译：本文公开的方法是用电化学工程化的多孔表面来制造医疗装置和可植入医疗装置，所述多孔表面含有一种或多种生物活性材料以形成生物活性复合结构。使用电化学共沉积方法制备生物活性复合结构以产生具有可装载生物活性材料的孔的金属层。在一个用途中，本发明的可植入医疗装置包括具有生物活性复合结构涂层的支架。

45. 发明申请

US20060051397A1 Metallic structures incorporating bioactive materials and methods for creating the same 审中-公开
标题翻译：包含生物活性材料的金属结构及其制造方法
公开(公告)号：US20060051397A1
公开(公告)日：2006-03-09
申请号：US11220328
申请日：2005-09-06
申请人： Nathan Maier , Richard Klein
发明人： Nathan Maier , Richard Klein
IPC分类号： A61F2/00 , C25D3/46
CPC分类号： A61L31/16 , A61L31/088 , A61L2300/102 , A61L2300/104 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using electroless and electrophoretic deposition and codeposition methods for providing implantable medical devices coated with bioactive composite structures. In one use, the implantable medical devices of the present invention include stents with bioactive composite structures.
摘要翻译：本文公开了创建包括生物活性复合结构的医疗装置和医疗装置的方法。所述方法包括使用无电泳和电泳沉积和共沉积方法来提供涂覆有生物活性复合结构的可植入医疗装置。在一个用途中，本发明的可植入医疗装置包括具有生物活性复合结构的支架。

46. 发明申请

US20060049121A1 Hanging shoe rack with improved structural features 有权
标题翻译：悬挂鞋架结构特征改善
公开(公告)号：US20060049121A1
公开(公告)日：2006-03-09
申请号：US10934170
申请日：2004-09-03
申请人： Richard Klein , John Scott , Chris Serslev
发明人： Richard Klein , John Scott , Chris Serslev
IPC分类号： A47F7/08
CPC分类号： A47B61/04
摘要： A hanging shoe rack for a closet door or other vertical surface. Frame sections have opposite sides provided with support arms that taper from top to bottom for reduced material requirements. The sections are connected by bars and feet having L-shaped tongues fitting in L-shaped slots with long curved surfaces in contact for enhanced strength. The bars that receive hanger brackets have strong curved connections with the frame sides. The tongues on the bars that hook to the brackets are reinforced by tabs that fit closely in notches in the brackets to resist side to side sway.
摘要翻译：用于衣柜门或其他垂直表面的挂鞋架。框架部分具有相对的侧面，其具有从顶部到底部逐渐变细以减少材料要求的支撑臂。这些部分通过杆和脚连接，具有L形舌片，其配合在具有长弯曲表面的L形槽中，以提高强度。接收吊钩支架的杆与框架侧面有很强的弯曲连接。钩在支架上的杆上的舌头通过在托架中的凹口处紧密配合以防止侧向摇摆的突出部加强。

47. 发明申请

US20050165383A1 Urethral catheter and guide 审中-公开
标题翻译：尿道导管和导管
公开(公告)号：US20050165383A1
公开(公告)日：2005-07-28
申请号：US11031378
申请日：2005-01-07
申请人： Uzi Eshel , Jacob Lazarovitz , Richard Klein
发明人： Uzi Eshel , Jacob Lazarovitz , Richard Klein
IPC分类号： A61F2/00 , A61F2/958 , A61M25/00 , A61M25/06 , A61M27/00
CPC分类号： A61M25/0017 , A61F2/0027 , A61M25/0662 , A61M25/1011 , A61M2025/0037 , A61M2025/1061 , A61M2025/109 , A61M2210/1089
摘要： An indwelling catheter for insertion into a patient's urinary tract is provided that includes first and second tubular members that enable drainage of physiological fluids. An inflatable balloon is attached to the second tubular member. The first and second tubular members are interconnected by a connecting tube forming a gap between the first and second tubular members. The connecting tube is in fluid communication with the balloon to enable the balloon to be inflated via the connecting tube. When the balloon is anchored within the urinary bladder the second tubular member is located within the prostatic urethra with one end in close proximity to the sphincter and the other end protruding into the urinary bladder. The first tubular member is located within the penile urethra with one end in close proximity to the sphincter so that the connecting tube traverses the sphincter permitting voluntary control of the sphincter.
摘要翻译：提供了用于插入患者尿道的留置导管，其包括能够排泄生理流体的第一和第二管状构件。可充气气囊附接到第二管状构件。第一和第二管状构件通过在第一和第二管状构件之间形成间隙的连接管相互连接。连接管与球囊流体连通，以使球囊可以通过连接管膨胀。当气囊锚定在膀胱内时，第二管状构件位于前列腺尿道内，其一端紧邻括约肌，另一端突出到膀胱内。第一管状构件位于阴茎尿道内，其一端靠近括约肌，使得连接管穿过括约肌，允许自动控制括约肌。

48. 发明申请

US20050108121A1 Open loop stored value system 审中-公开
标题翻译：开环存储值系统
公开(公告)号：US20050108121A1
公开(公告)日：2005-05-19
申请号：US10714437
申请日：2003-11-14
申请人： Amber Gravett , Todd Nuzum , Richard Klein
发明人： Amber Gravett , Todd Nuzum , Richard Klein
IPC分类号： G06Q20/00 , G07F17/26 , G06F17/60
CPC分类号： G06Q20/12 , G06Q20/18 , G06Q40/00 , G07F17/26
摘要： According to the invention, a payment system for open loop stored benefit products is disclosed. The payment system includes a web-accessible platform, a web interface, a credit processing system, and a translation system. The web-accessible platform is available to a payor for purchase of a stored value account for use by a payee. The web-accessible platform communicates with a first application interface. The stored benefit account is backed by an account issuer and is accepted by a network of unrelated merchants who accept payments from the account issuer. The web interface allows the payor and/or the payee to interact with the web-accessible platform. The credit processing system communicates with a second application interface. The translation system translates between the first application interface and the second application interface.
摘要翻译：根据本发明，公开了一种开环存储利益产品的支付系统。支付系统包括网络可访问平台，网络界面，信用处理系统和翻译系统。网络可访问平台可用于付款人购买存储值帐户以供收款人使用。网络可访问平台与第一应用接口进行通信。存储的利益账户由账户发行商支持，并被接收来自账户发行人的付款的不相关的商家网络接受。网络界面允许付款人和/或收款人与网络可访问的平台进行交互。信用处理系统与第二应用接口进行通信。翻译系统在第一应用程序接口和第二应用程序接口之间进行转换。

49. 发明申请

US20050092615A1 Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices 失效
标题翻译：金属复合涂层，用于从可植入装置的表面输送治疗剂
公开(公告)号：US20050092615A1
公开(公告)日：2005-05-05
申请号：US10701262
申请日：2003-11-03
申请人： Matthew Birdsall , Richard Klein , Nathan Maier
发明人： Matthew Birdsall , Richard Klein , Nathan Maier
IPC分类号： A61L27/30 , A61L27/40 , A61L27/54 , A61L29/10 , A61L29/12 , A61L29/16 , A61L31/08 , A61L31/12 , A61L31/16 , C25D5/12
CPC分类号： A61L31/16 , A61L31/088 , A61L2300/102 , A61L2300/104 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.
摘要翻译：公开了一种用于可植入医疗装置的金属复合涂层及其形成方法。该复合涂层包括形成在该装置的表面上的至少一个金属或金属粘结层，随后是连接层上的一个或多个附加层的化学电化学包层。一种或多种治疗或生物活性剂与至少一种无电化学电化学包层共沉积。

50. 发明申请

US20050054994A1 Catheters with suction capability and related methods and systems for obtaining biosamples in vivo 审中-公开
标题翻译：具有抽吸能力的导管和用于在体内获得生物样品的相关方法和系统
公开(公告)号：US20050054994A1
公开(公告)日：2005-03-10
申请号：US10827741
申请日：2004-04-19
申请人： Iulian Cioanta , Richard Klein , Jacob Lazarovitz
发明人： Iulian Cioanta , Richard Klein , Jacob Lazarovitz
IPC分类号： A61B10/00 , A61B10/02 , A61F2/958 , A61M25/04 , A61B17/20 , A61M1/00
CPC分类号： A61B10/02 , A61B10/0045 , A61B10/007 , A61M25/04 , A61M25/1002 , A61M25/1011
摘要： Methods, systems, and computer program products for obtaining a sample in vivo and/or treating a subject include positioning an elongated transurethral catheter in the prostatic urethra of a subject, the catheter having a bladder anchoring balloon, at least one biosample entry port disposed axially away from the bladder anchoring balloon, and an axially extending biosample flow channel in fluid communication with the biosample entry port held internally in the catheter. The anchoring balloon is inflated to position the catheter so that the fluid entry port is proximate the prostatic urethra of the subject and prostatic fluid is suctioned from the prostatic urethra into the biosample entry port and into the biosample flow channel. The catheter can include a thermal treatment balloon and/or dilatation balloon and the suctioned sample can be obtained concurrently with, during, or proximate in time to the applied treatment. The catheter can be configured to allow urine to drain therethrough during the treatment/collection of the sample while keeping the urine isolated from the collected prostatic fluid sample.
摘要翻译：用于在体内获得样品和/或治疗受试者的方法，系统和计算机程序产品包括将细长的经尿道导管定位在受试者的前列腺尿道中，所述导管具有膀胱锚定球囊，至少一个生物样本入口端口远离气囊锚定气囊，以及轴向延伸的生物样品流动通道，其与保持在导管内部的生物样品入口端口流体连通。锚定球囊被充气以定位导管，使得流体进入端口靠近受试者的前列腺尿道，并且前列腺液体从前列腺尿道吸入生物样本入口并进入生物样本流动通道。导管可以包括热处理球囊和/或扩张球囊，并且抽吸样品可以在施用的治疗时间期间，期间或接近时间获得。导管可以被配置成允许尿液在样品的处理/收集期间从其中排出，同时保持尿液与收集的前列腺液体样品分离。

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