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41. 发明申请

US20100068192A1 Method for Production of T Cell Population 审中-公开
标题翻译： T细胞群体生产方法
公开(公告)号：US20100068192A1
公开(公告)日：2010-03-18
申请号：US11992661
申请日：2006-09-27
申请人： Tatsuji Enoki , Akiko Kato , Mitsuko Ideno , Hiroaki Sagawa , Ikunoshin Kato
发明人： Tatsuji Enoki , Akiko Kato , Mitsuko Ideno , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K35/12 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/19 , A61K39/00 , A61K39/0011 , A61K2039/5158 , C12N15/86 , C12N2501/515 , C12N2501/58 , C12N2740/10043 , A61K2300/00
摘要： A method for preparing a T cell population, wherein the T cell population expresses CD45RA and expresses at least one selected from the group consisting of CD62L, CCR7, CD27, and CD28, characterized in that the method comprises the step of culturing a cell population comprising a T cell, in the presence of fibronectin, a fragment thereof or a mixture thereof.
摘要翻译：一种制备T细胞群体的方法，其中所述T细胞群表达CD45RA并表达选自CD62L，CCR7，CD27和CD28的至少一种，其特征在于所述方法包括培养细胞群的步骤，所述细胞群包含在纤连蛋白存在下，其T细胞，其片段或其混合物。

42. 发明申请

US20080038289A1 Antitumor Agent 审中-公开
标题翻译：抗肿瘤剂
公开(公告)号：US20080038289A1
公开(公告)日：2008-02-14
申请号：US11596395
申请日：2005-05-30
申请人： Takashi Kawai , Shigetoshi Mizutani , Tatsuji Enoki , Hiroaki Sagawa , Takeshi Sakai , Kazuo Shimanaka , Ikunoshin Kato
发明人： Takashi Kawai , Shigetoshi Mizutani , Tatsuji Enoki , Hiroaki Sagawa , Takeshi Sakai , Kazuo Shimanaka , Ikunoshin Kato
IPC分类号： A61K36/06 , A61K31/045 , A61P35/00
CPC分类号： A61K36/07 , A23L33/105 , A61K31/047
摘要： According to the present invention, an antitumor agent, an apoptosis-inducing agent or an angiogenesis-suppressing agent having the effect even via an oral route, containing a compound contained in an inexpensive edible basidiomycete or a composition derived from an edible basidiomycete, and a food having the antitumor activity, the apoptosis-inducing activity or the angiogenesis-suppressing activity containing the compound or the composition can be obtained. Therefore, the present invention is particularly useful, especially in the field of a medicine and a health food.
摘要翻译：根据本发明，通过口服途径具有效果的抗肿瘤剂，细胞凋亡诱导剂或血管生成抑制剂，其含有廉价的可食用担子菌或含有可食用担子菌的组合物，以及可以获得具有抗肿瘤活性，含有化合物或组合物的细胞凋亡诱导活性或血管生成抑制活性的食品。因此，本发明特别有用，特别是在药物和保健食品领域。

43. 发明授权

US07217817B1 Agarobiose-containing composition 失效
标题翻译：含琼脂二糖的组合物
公开(公告)号：US07217817B1
公开(公告)日：2007-05-15
申请号：US09979003
申请日：2000-05-08
申请人： Tatsuji Enoki , Hiroaki Sagawa , Takeshi Sakai , Haruo Oyashiki , Hitoshi Sakakibara , Kazuyori Ochiai , Ikunoshin Kato
发明人： Tatsuji Enoki , Hiroaki Sagawa , Takeshi Sakai , Haruo Oyashiki , Hitoshi Sakakibara , Kazuyori Ochiai , Ikunoshin Kato
IPC分类号： C08B37/12 , A61K31/729
CPC分类号： A23G1/48 , A21D2/18 , A23C20/025 , A23F3/163 , A23F3/405 , A23G1/40 , A23G3/346 , A23G3/42 , A23G3/48 , A23G2200/06 , A23L2/52 , A23L2/60 , A23L5/00 , A23L7/00 , A23L7/109 , A23L13/42 , A23L13/428 , A23L13/65 , A23L17/60 , A23L17/70 , A23L21/00 , A23L21/15 , A23L23/00 , A23L27/33 , A23L29/256 , A23L29/30 , A23V2002/00 , C12G3/06 , Y02P20/582 , A23V2250/2124 , A23V2250/704 , A23V2250/708 , A23V2250/032 , A23V2250/0638 , A23V2250/0626 , A23V2250/606
摘要： A material containing agarobiose; a method for preparing the material; and a food, a drink or a seasoning using the material, which is tasty and has the effect of alleviating a stimulant taste and of enhancing the depth of sweetness.
摘要翻译：含有琼脂二糖的物质一种制备该材料的方法; 以及使用该材料的食物，饮料或调味料，其是美味的并且具有减轻兴奋剂味道和增强甜度深度的作用。

44. 发明申请

US20050272809A1 Remedies 失效
标题翻译：补救措施
公开(公告)号：US20050272809A1
公开(公告)日：2005-12-08
申请号：US10529859
申请日：2003-09-29
申请人： Hiromu Ohnogi , Katsumi Sugiyama , Nobuko Muraki , Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Katsumi Sugiyama , Nobuko Muraki , Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A23K1/16 , A23L1/30 , A61P25/00 , A61P43/00 , C07D311/58 , C07D311/80 , A61K31/353 , C07D311/76
CPC分类号： C07D311/80 , A23K20/121 , A23L33/10 , C07D311/58
摘要： The present invention relates to a novel chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R1 is a hydroxyl group, R2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.
摘要翻译：本发明涉及由以下通式表示的新型查耳酮化合物：其中R 1和R 2分别与它们所结合的碳原子一起连接，以形成羟基二甲基己烷环，或其中R 1是羟基，R 2是异己烯基，其衍生物或其盐。此外，本发明涉及需要神经元保护，抑制一氧化氮（NO）产生，抑制醛糖还原酶或抑制白介素产生的疾病的治疗剂或预防剂，以及用于治疗或预防的食品，饮料或饲料的上述疾病，其特征在于，每种都包含上述化合物作为有效成分。

45. 发明申请

US20110158954A1 METHOD FOR PRODUCING GAMMA DELTA T CELL POPULATION 审中-公开
标题翻译：生产GAMMA DELTA T细胞群体的方法
公开(公告)号：US20110158954A1
公开(公告)日：2011-06-30
申请号：US12450017
申请日：2008-03-04
申请人： Mitsuko Ideno , Fumiyo Sakai , Tatsuji Enoki , Ikunoshin Kato
发明人： Mitsuko Ideno , Fumiyo Sakai , Tatsuji Enoki , Ikunoshin Kato
IPC分类号： A61K35/12 , A61P31/04 , A61P31/12 , C12N5/0783 , C12N15/86 , C12N15/867 , C12N15/861
CPC分类号： C12N5/0636 , A61K2035/122 , C12N2501/58 , C12N2501/999 , C12N2533/52
摘要： A method for preparing a γδ T cell population, characterized in that the method includes the step of culturing a cell population containing γδ T cells, in the presence of (a) fibronectin, a fibronectin fragment or a mixture thereof and (b) an activating factor of γδ T cells. According to the present invention, a method for preparing a γδ T cell population is provided. The γδ T cell population obtained by the method is suitably used in, for example, immunotherapy. Therefore, the method of the present invention is expected to greatly contribute to a medical field.
摘要翻译：一种制备γδT细胞群体的方法，其特征在于该方法包括在（a）纤连蛋白，纤连蛋白片段或其混合物存在下培养含有γδT细胞的细胞群的步骤，和（b）活化 γδT细胞因子。根据本发明，提供了制备γδT细胞群体的方法。通过该方法获得的γδT细胞群适用于例如免疫治疗。因此，预期本发明的方法对医疗领域有很大贡献。

46. 发明申请

US20100317613A1 ACTIVITY ENHANCER FOR DETOXIFYING ENZYME 审中-公开
标题翻译：用于脱氧酶活性增强剂
公开(公告)号：US20100317613A1
公开(公告)日：2010-12-16
申请号：US12445784
申请日：2007-10-11
申请人： Hiromu Ohnogi , Yoko Kudo , Hiroko Nakahara , Tatsuji Enoki , Ikunoshin Kato
发明人： Hiromu Ohnogi , Yoko Kudo , Hiroko Nakahara , Tatsuji Enoki , Ikunoshin Kato
IPC分类号： A61K31/715 , A61P25/00
CPC分类号： A61K31/729 , A23K20/121 , A23L33/105 , A61K31/351 , A61K31/7016 , A61K31/702
摘要： It is intended to provide a drug, a food or a feed which has an effect of enhancing the activity of a second-phase detoxifying enzyme and an effect of increasing intracellular glutathione content.
摘要翻译：旨在提供具有增强第二阶段解毒酶的活性和增加细胞内谷胱甘肽含量的作用的药物，食物或饲料。

47. 发明授权

US09238797B2 Method for production of pluripotent stem cell 有权
标题翻译：多能干细胞的生产方法
公开(公告)号：US09238797B2
公开(公告)日：2016-01-19
申请号：US13003262
申请日：2009-07-07
申请人： Tatsuji Enoki , Fumiko Iwamoto , Toshikazu Nishie , Takahiro Marui , Fuyuko Takashima , Ikunoshin Kato
发明人： Tatsuji Enoki , Fumiko Iwamoto , Toshikazu Nishie , Takahiro Marui , Fuyuko Takashima , Ikunoshin Kato
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N2501/405 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2510/00 , C12N2533/52 , C12N2740/15043 , C12N2740/15071
摘要： The present invention relates to a method for production of a cell population containing a pluripotent stem cell, said method comprising a step of treating a somatic cell which has been contacted with nuclear reprogramming factors under nutrient-starved condition, and/or a step of treating the somatic cell with an agent capable of arresting cell cycle. The present invention allows induction and growth of pluripotent stem cells at high frequency, and it also allows production of pluripotent stem cells with high efficiency. The nuclear reprogramming factors to be used may be any selected from the group consisting of OCT4, SOX2, c-MYC, KLF4, NANOG and LIN28.
摘要翻译：本发明涉及含有多能干细胞的细胞群的生产方法，所述方法包括处理在营养缺乏条件下与核重编程因子接触的体细胞的步骤，和/或处理步骤具有能够阻止细胞周期的药剂的体细胞。本发明允许高倍数的多能干细胞的诱导和生长，并且还允许以高效率生产多能干细胞。要使用的核重编程因子可以选自OCT4，SOX2，c-MYC，KLF4，NANOG和LIN28中的任何一种。

48. 发明申请

US20100247579A1 THERAPEUTIC AGENT FOR CANCER 审中-公开
标题翻译：癌症治疗剂
公开(公告)号：US20100247579A1
公开(公告)日：2010-09-30
申请号：US12599541
申请日：2008-05-08
申请人： Hiroshi Shiku , Shinichi Kageyama , Shigehisa Kitano , Mitsuko Ideno , Keisuke Tomita , Tatsuji Enoki , Kazutoh Takesako , Ikunoshin Kato
发明人： Hiroshi Shiku , Shinichi Kageyama , Shigehisa Kitano , Mitsuko Ideno , Keisuke Tomita , Tatsuji Enoki , Kazutoh Takesako , Ikunoshin Kato
IPC分类号： A61K39/00 , A61K35/12 , C12N5/00 , A61P35/04
CPC分类号： A61K35/14 , A61K39/0011 , A61K45/06 , C12N5/0636 , C12N2501/2302 , A61K2300/00
摘要： The present invention relates to a method for treatment of cancer, which comprises the following steps (A) and (B): (A) applying a treatment which induces the reduction in lymphocytes to a patient; and (B), subsequent to step (A), administering lymphocytes to the patient promptly. The present invention also relates to a cancer therapeutic agent and a cancer treatment kit for use in the method. When the method is used as an immunoreconstructive therapy, the decrease in immunologic competence which may be caused by the reduction in lymphocytes can be avoided and, therefore, the risk of the occurrence of an infectious disease can be decreased.
摘要翻译：本发明涉及一种治疗癌症的方法，其包括以下步骤（A）和（B）：（A）应用诱导淋巴细胞减少至患者的治疗方法; 和（B），在步骤（A）之后，迅速给予患者淋巴细胞。本发明还涉及用于该方法的癌症治疗剂和癌症治疗试剂盒。当该方法用作免疫构建性治疗时，可以避免可能由淋巴细胞减少引起的免疫能力的降低，因此可以降低感染性疾病发生的风险。

49. 发明申请

US20120149108A1 CELL PRESERVATION METHOD 审中-公开
标题翻译：电池保存方法
公开(公告)号：US20120149108A1
公开(公告)日：2012-06-14
申请号：US13389601
申请日：2010-08-17
申请人： Masashige Tanabe , Tomomi Isono , Tatsuji Enoki
发明人： Masashige Tanabe , Tomomi Isono , Tatsuji Enoki
IPC分类号： C12N5/07
CPC分类号： A01N1/0221
摘要： A method for cryopreservation of cells characterized by the use of a solution containing, as essential components, a sodium salt, a potassium salt, a saccharide, a cryoprotectant, and a hydrogencarbonate salt and/or a carbonate salt, the solution further optionally containing a component selected from the group consisting of proteins, magnesium salts, and calcium salts. According to the present invention, a method for cryopreservation of cells capable of maintaining a high viability rate after thawing, and a cryopreservation solution used in the cryopreservation are provided. In addition, by using the method for cryopreservation, the cells can be preserved in a state of maintaining a high viability rate even after thawing, and also maintaining their physiological functions; further, a cell washing step after freezing and thawing is unnecessary, thereby making it very useful in the fundamental researches of cells and the application studies on the medical treatment.
摘要翻译：一种用于冷冻保存细胞的方法，其特征在于使用含有钠盐，钾盐，糖类，冷冻保护剂和碳酸氢盐和/或碳酸盐的必要成分的溶液，该溶液还可任选地含有组分选自蛋白质，镁盐和钙盐。根据本发明，提供了一种在解冻后能够保持高存活率的细胞的低温保存方法和用于冷冻保存的冷冻保存溶液。此外，通过使用冷冻保存方法，即使在解冻后也能够将细胞保持在维持高生存率的状态，并且还保持其生理功能; 此外，不需要冷冻和解冻后的细胞洗涤步骤，从而使其在细胞的基础研究和医学应用研究中非常有用。

50. 发明申请

US20110117653A1 METHOD FOR PRODUCTION OF PLURIPOTENT STEM CELL 有权
标题翻译：生产超细胞干细胞的方法
公开(公告)号：US20110117653A1
公开(公告)日：2011-05-19
申请号：US13003262
申请日：2009-07-07
申请人： Tatsuji Enoki , Fumiko Iwamoto , Toshikazu Nishie , Takahiro Marui , Fuyuko Takashima , Ikunoshin K
发明人： Tatsuji Enoki , Fumiko Iwamoto , Toshikazu Nishie , Takahiro Marui , Fuyuko Takashima , Ikunoshin K
IPC分类号： C12N15/86
CPC分类号： C12N5/0696 , C12N2501/405 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2510/00 , C12N2533/52 , C12N2740/15043 , C12N2740/15071
摘要： The present invention relates to a method for production of a cell population containing a pluripotent stem cell, said method comprising a step of treating a somatic cell which has been contacted with nuclear reprogramming factors under nutrient-starved condition, and/or a step of treating the somatic cell with an agent capable of arresting cell cycle. The present invention allows induction and growth of pluripotent stem cells at high frequency, and it also allows production of pluripotent stem cells with high efficiency. The nuclear reprogramming factors to be used may be any selected from the group consisting of OCT4, SOX2, c-MYC, KLF4, NANOG and LIN28.
摘要翻译：本发明涉及含有多能干细胞的细胞群的生产方法，所述方法包括处理在营养缺乏条件下与核重编程因子接触的体细胞的步骤，和/或处理步骤具有能够阻止细胞周期的药剂的体细胞。本发明允许高倍数的多能干细胞的诱导和生长，并且还允许以高效率生产多能干细胞。要使用的核重编程因子可以选自OCT4，SOX2，c-MYC，KLF4，NANOG和LIN28中的任何一种。

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