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41. 发明授权

US10537741B2 System and method for choosing electrodes in an implanted stimulator device 有权
公开(公告)号：US10537741B2
公开(公告)日：2020-01-21
申请号：US11295168
申请日：2005-12-05
申请人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
发明人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
IPC分类号： A61N1/36
摘要： A method of selecting a subset of electrodes in a stimulator device implanted in a patient for further clinical evaluation is disclosed. The method comprises measuring at least first and second measurement for each of the plurality of electrodes that are indicative of the ability of the electrode if activated to provide useful therapy to the patient in which the stimulator device is implanted A weight is then determined for each of the measurements. The weight is then applied to each electrode measurement, which measurement may be normalized, and the weighted measurements for each electrode are preferably summed to arrive at a value which itself is indicative of a particular electrode's ability to provide useful therapy to the patient. These values can then be used to determine a subset of the electrodes useful for further clinical evaluation in the patient, which improved the accuracy and speeding determining appropriate patient therapy.

42. 发明授权

US09717910B2 Multiple tunable central cathodes on a paddle for increased medial-lateral and rostral-caudal flexibility via current steering 有权
公开(公告)号：US09717910B2
公开(公告)日：2017-08-01
申请号：US12204114
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K. L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K. L. Peterson
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/0553 , A61N1/36017 , A61N1/36185
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

43. 发明授权

US09278222B2 System and method for converting tissue stimulation programs in a format usable by an electrical current steering navigator 有权
标题翻译：用电流转向导航器可使用的格式转换组织刺激程序的系统和方法
公开(公告)号：US09278222B2
公开(公告)日：2016-03-08
申请号：US12501282
申请日：2009-07-10
申请人： James R. Thacker , Michael Moffitt , Kerry Bradley , David K. L. Peterson
发明人： James R. Thacker , Michael Moffitt , Kerry Bradley , David K. L. Peterson
IPC分类号： A61N1/36 , A61N1/372 , G06F19/00
CPC分类号： A61N1/37264 , A61N1/36071 , A61N1/36146 , A61N1/3615 , A61N1/36167 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63
摘要： A method, computer medium, and system for programming a controller is provided. The controller controls electrical stimulation energy output to electrodes, and stores a set of programmed stimulation parameters associated with the electrodes. The programmed stimulation parameter set is compared with sets of reference stimulation parameters, each of the reference sets of stimulation parameters being associated with the electrodes. If an identical match is determined between the programmed stimulation parameter set and any one of the reference stimulation parameter sets exists based on the comparison, the identically matched stimulation parameter set is selected as an initial stimulation parameter set. If an identical match does not exist, a best between the programmed stimulation parameter set and the reference stimulation parameter sets is determined and selected as the initial stimulation parameter set. The controller is then programmed with a new set of programmable stimulation parameters based on the initial stimulation parameter set.
摘要翻译：提供了一种用于编程控制器的方法，计算机介质和系统。控制器控制对电极的电刺激能量输出，并且存储与电极相关联的一组编程的刺激参数。将编程的刺激参数集与参考刺激参数的集合进行比较，每个参考组的刺激参数与电极相关联。如果在编程的刺激参数集之间确定相同的匹配，并且基于比较存在参考刺激参数集中的任一个，则选择相同匹配的刺激参数集作为初始刺激参数集。如果不存在相同的匹配，则确定编程的刺激参数集和参考刺激参数集之间的最佳值，并将其选为初始刺激参数集。然后基于初始刺激参数集，控制器用一组新的可编程刺激参数进行编程。

44. 发明授权

US08548604B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 失效
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US08548604B2
公开(公告)日：2013-10-01
申请号：US12960722
申请日：2010-12-06
申请人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
发明人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
IPC分类号： A61N1/05
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

45. 发明授权

US08442655B2 Multiple tunable central cathodes on a paddle for increased medial-lateral and rostral-caudal flexibility via current steering 有权
公开(公告)号：US08442655B2
公开(公告)日：2013-05-14
申请号：US12204154
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K. L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K. L. Peterson
IPC分类号： A61N1/34
CPC分类号： A61N1/0551 , A61N1/36071
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

46. 发明授权

US08437857B2 Multiple tunable central cathodes on a paddle for increased medial-lateral and rostral-caudal flexibility via current steering 有权
公开(公告)号：US08437857B2
公开(公告)日：2013-05-07
申请号：US12204136
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K. L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K. L. Peterson
IPC分类号： A61N1/00
CPC分类号： A61N1/0553 , A61N1/0551 , A61N1/36071
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

47. 发明申请

US20120089200A1 NEUROSTIMULATION SYSTEM AND METHOD FOR PROVIDING THERAPY TO PATIENT WITH MINIMAL SIDE EFFECTS 有权
标题翻译：用于向患者提供最小化副作用的神经细胞治疗系统和方法
公开(公告)号：US20120089200A1
公开(公告)日：2012-04-12
申请号：US13253735
申请日：2011-10-05
申请人： Emarit A.S. Ranu , Bradley L. Hershey , Kerry Bradley
发明人： Emarit A.S. Ranu , Bradley L. Hershey , Kerry Bradley
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/0553 , A61N1/36171 , A61N1/36182
摘要： A method comprises conveying a pulsed waveform between an electrode and a stimulation site of a spinal cord, thereby evoking the antidromic propagation of action potentials along a first sensory neural fiber creating a therapeutic effect in the tissue region, evoking the orthodromic propagation of action potentials along the first sensory neural fiber potentially creating paresthesia corresponding to the tissue region, and evoking the antidromic propagation of action potentials along a second sensory neural fiber potentially creating a side-effect in another tissue region. The method further comprises conveying electrical energy between an electrode and a blocking site rostral to the stimulation site, thereby blocking the action potentials propagated along the first sensory neural fiber and reducing the paresthesia, and conveying electrical energy between an electrode and a blocking site caudal to the stimulation site, thereby blocking the action potentials propagated along the second sensory neural fiber and reducing the side-effect.
摘要翻译：一种方法包括在电极和脊髓的刺激部位之间传送脉冲波形，从而引起沿着第一感觉神经纤维的动作电位的反向扩散，从而在组织区域产生治疗效果，引起动作电位的正常传播第一感觉神经纤维潜在地产生对应于组织区域的感觉异常，并且引起沿着潜在地在另一组织区域中产生副作用的第二感觉神经纤维的动作电位的反向扩散。该方法还包括将电极和阻塞位点之间的电能传递到刺激部位，从而阻止沿着第一感觉神经纤维传播的动作电位并减少感觉异常，并将电极和阻塞部位尾部之间的电能传递到刺激部位，从而阻止沿着第二感觉神经纤维传播的动作电位并降低副作用。

48. 发明申请

US20120083857A1 TISSUE STIMULATION SYSTEM AND METHOD WITH ANATOMY AND PHYSIOLOGY DRIVEN PROGRAMMING 审中-公开
标题翻译：组织刺激系统和方法与解剖学和生理学驱动程序
公开(公告)号：US20120083857A1
公开(公告)日：2012-04-05
申请号：US13244435
申请日：2011-09-24
申请人： Kerry Bradley , Bradley Hershey
发明人： Kerry Bradley , Bradley Hershey
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/36175 , A61N1/36185
摘要： An external control device for use with a tissue stimulation device and at least one tissue stimulation lead having a plurality of electrodes implanted within a patient comprises a user interface configured for allowing a user to enter first information defining a therapeutic indication and second information defining the location of the at least one tissue stimulation lead relative to an anatomical reference, at least one processor configured for analyzing the first and second information and generating a set of stimulation parameters based on the analysis, and output circuitry configured for transmitting the at least one stimulation parameter set to the tissue stimulation device.
摘要翻译：一种与组织刺激装置一起使用的外部控制装置和至少一个组织刺激引线，其具有植入患者体内的多个电极，该用户界面被配置为允许用户输入定义治疗指示的第一信息和定义位置的第二信息所述至少一个组织刺激引线相对于解剖参考，配置用于分析所述第一和第二信息并基于所述分析产生一组刺激参数的至少一个处理器以及被配置为发送所述至少一个刺激参数的输出电路设置到组织刺激装置。

49. 发明授权

US08065013B2 Method for optimizing search for spinal cord stimulation parameter setting 有权
标题翻译：优化脊髓刺激参数设置搜索的方法
公开(公告)号：US08065013B2
公开(公告)日：2011-11-22
申请号：US11746405
申请日：2007-05-09
申请人： Kerry Bradley , James R. Thacker , Carla M. Woods , John D. King
发明人： Kerry Bradley , James R. Thacker , Carla M. Woods , John D. King
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , Y10S128/92
摘要： A method of transitioning stimulation energy (e.g., electrical stimulation pulses) between a plurality of electrodes implanted within a patient is provided. The method comprises selecting a plurality of stimulation output values (e.g., electrical current amplitude values) for each of the electrodes. The method further comprises selecting a plurality of different modification values for at least one of the electrodes, respectively multiplying the stimulation output values and the modification values to determine modified stimulation output values for the electrode(s), which may optionally be stored in a steering table, and incrementally transitioning the stimulation energy to or from the electrode(s) in accordance with the modified stimulation output values. The modified stimulation output values are stored in a steering table. The modification values may be selected in a manner that maintains paresthesia when transitioning the stimulation energy between the electrodes.
摘要翻译：提供了在植入患者体内的多个电极之间转换刺激能量（例如，电刺激脉冲）的方法。该方法包括为每个电极选择多个刺激输出值（例如，电流振幅值）。该方法还包括为至少一个电极选择多个不同的修改值，分别乘以刺激输出值和修改值，以确定电极的修改的刺激输出值，其可以可选地存储在转向表，并且根据修改的刺激输出值逐渐地将刺激能量转移到电极或从电极移动。经修改的刺激输出值存储在转向表中。可以以在电极之间转换刺激能量时保持感觉异常的方式来选择修饰值。

50. 发明授权

US08036747B2 System and method of rapid, comfortable parameter switching in spinal cord stimulation 有权
标题翻译：快速，舒适的脊髓刺激参数切换的系统和方法
公开(公告)号：US08036747B2
公开(公告)日：2011-10-11
申请号：US12506827
申请日：2009-07-21
申请人： James R. Thacker , John D. H. King , Kerry Bradley
发明人： James R. Thacker , John D. H. King , Kerry Bradley
IPC分类号： A61N1/37
CPC分类号： A61N1/36071 , A61N1/0551
摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.
摘要翻译：用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。估计的感知水平是基于以前的刺激结果。然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

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