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    • 42. 发明授权
    • Process for producing optically active 2-alkycysteine, derivative thereof, and processes for production
    • 光学活性2-烷基半胱氨酸及其衍生物的制造方法及其制造方法
    • US07470525B2
    • 2008-12-30
    • US10579772
    • 2004-11-18
    • Yasushi HiguchiAkinori TanakaRyuji HasemiMasaki Sugita
    • Yasushi HiguchiAkinori TanakaRyuji HasemiMasaki Sugita
    • C12P13/12
    • C12P13/12C07B2200/07C07C319/02C07D277/06C07D277/60C07C323/58
    • There is provided a process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by allowing cells of microorganism or treated products thereof having an activity of stereoselective hydrolysis of the amide bond of a 2-alkyl-L-cysteinamide or a salt thereof to act on a 2-alkylcysteinamide consisting of a mixture of D- and L-isomers or a salt thereof; and allowing the obtained 2-alkyl-L-cysteine and 2-alkyl-D-cysteinamide to react with an aldehyde or a ketone, or an acetal or ketal thereof, so as to derive therefrom a 4-alkylthiazolidine-4-carboxylic acid or a salt thereof and a 4-alkylthiazolidine-4-carboxamide or a salt thereof, thereby efficiently separating and obtaining a 2-alkyl-L-cysteine or a salt thereof, or a 2-alkyl-D-cysteine or a salt thereof. There is also provided a process for producing a 4-alkylthiazolidine-4-carboxylic acid or a salt thereof from the 2-alkylcysteine or a salt thereof.
    • 提供了一种制备光学活性2-烷基半胱氨酸或其盐的方法,其特征在于使微生物或其处理产物的细胞具有立体选择性水解2-烷基-L-半胱氨酰胺或盐的酰胺键的活性 作用于由D-和L-异构体的混合物或其盐组成的2-烷基半胱胺酰胺; 并使得到的2-烷基-L-半胱氨酸和2-烷基-D-半胱胺酰胺与醛或酮或其缩醛或缩酮反应,从而得到4-烷基噻唑烷-4-羧酸或 其盐和4-烷基噻唑烷-4-甲酰胺或其盐,从而有效分离并获得2-烷基-L-半胱氨酸或其盐或2-烷基-D-半胱氨酸或其盐。 还提供了由2-烷基半胱氨酸或其盐制备4-烷基噻唑烷-4-羧酸或其盐的方法。
    • 44. 发明申请
    • Process for producing optically active 2-alkycysteine, derivative thereof, and processes for production
    • 光学活性2-烷基半胱氨酸及其衍生物的制造方法及其制造方法
    • US20070037260A1
    • 2007-02-15
    • US10579772
    • 2004-11-18
    • Yasushi HiguchiAkinori TanakaRyuji HasemiMasaki Sugita
    • Yasushi HiguchiAkinori TanakaRyuji HasemiMasaki Sugita
    • C12P13/12
    • C12P13/12C07B2200/07C07C319/02C07D277/06C07D277/60C07C323/58
    • There is provided a process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by allowing cells of microorganism or treated products thereof having an activity of stereoselective hydrolysis of the amide bond of a 2-alkyl-L-cysteinamide or a salt thereof to act on a 2-alkylcysteinamide consisting of a mixture of D- and L-isomers or a salt thereof; and allowing the obtained 2-alkyl-L-cysteine and 2-alkyl-D-cysteinamide to react with an aldehyde or a ketone, or an acetal or ketal thereof, so as to derive therefrom a 4-alkylthiazolidine-4-carboxylic acid or a salt thereof and a 4-alkylthiazolidine-4-carboxamide or a salt thereof, thereby efficiently separating and obtaining a 2-alkyl-L-cysteine or a salt thereof, or a 2-alkyl-D-cysteine or a salt thereof. There is also provided a process for producing a 4-alkylthiazolidine-4-carboxylic acid or a salt thereof from the 2-alkylcysteine or a salt thereof.
    • 提供了一种制备光学活性2-烷基半胱氨酸或其盐的方法,其特征在于使微生物或其处理产物的细胞具有立体选择性水解2-烷基-L-半胱氨酰胺或盐的酰胺键的活性 作用于由D-和L-异构体的混合物或其盐组成的2-烷基半胱胺酰胺; 并使得到的2-烷基-L-半胱氨酸和2-烷基-D-半胱胺酰胺与醛或酮或其缩醛或缩酮反应,从而得到4-烷基噻唑烷-4-羧酸或 其盐和4-烷基噻唑烷-4-甲酰胺或其盐,从而有效分离并获得2-烷基-L-半胱氨酸或其盐或2-烷基-D-半胱氨酸或其盐。 还提供了由2-烷基半胱氨酸或其盐制备4-烷基噻唑烷-4-羧酸或其盐的方法。
    • 45. 发明申请
    • 2-alkylcysteinamide or salt thereof, process for producing these, and use of these
    • 2-烷基半胱氨酰胺或其盐,其制备方法及其用途
    • US20060287398A1
    • 2006-12-21
    • US10552634
    • 2004-04-07
    • Yasushi HiguchiAkinori TanakaRyuji Hasemi
    • Yasushi HiguchiAkinori TanakaRyuji Hasemi
    • A61K31/16
    • C07C323/60C07B2200/07C07C319/02C07C319/06C12P13/12C12P41/006Y10S435/863Y10S435/91
    • A process for producing a 2-alkylcysteinamide, which comprises hydrolysis of a 4-alkylthiazolidine-4-carboxamide represented by the general formula (2) or a salt thereof: wherein R represents a lower alkyl group having 1-4 carbon atoms; and each of R1 and R2 independently represents hydrogen or a lower alkyl group having 1-4 carbon atoms, or R1 and R2 are linked together to form an alicyclic, structure having 4-7 carbon atoms, excluding the case where both R1 and R2 are hydrogen, to give a 2-alkylcysteinamide represented by the general formula (1) or a salt thereof wherein R represents a lower alkyl group having 1-4 carbon atoms. Cells of a microorganism or treated products thereof having activity of stereoselective hydrolysis of a 2-alkyl-L-cysteinamide are allowed to act on the compound represented by the general formula (1) to yield a 2-alkyl-L-cysteine.
    • 一种制备2-烷基半胱氨酰胺的方法,其包括由通式(2)表示的4-烷基噻唑烷-4-甲酰胺或其盐的水解:其中R表示具有1-4个碳原子的低级烷基; 并且R 1和R 2各自独立地表示氢或具有1-4个碳原子的低级烷基,或R 1和R 2独立地表示氢, SUB 2连接在一起形成具有4-7个碳原子的脂环族结构,不包括R 1和R 2都是氢的情况, 得到由通式(1)表示的2-烷基半胱胺酰胺或其盐,其中R表示具有1-4个碳原子的低级烷基。 允许具有2-烷基-L-半胱胺酰胺立体选择性水解活性的微生物或其处理产物的细胞作用于由通式(1)表示的化合物,得到2-烷基-L-半胱氨酸。