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41. 发明授权

US06191148B1 Omerazole process and compositions thereof 有权
标题翻译：奥美拉唑法及其组合物
公开(公告)号：US06191148B1
公开(公告)日：2001-02-20
申请号：US09461605
申请日：1999-12-15
申请人： James W. McManus , Nick Anousis , Benjamin Newton Banks , Hui Liu , Lingwen Zhou
发明人： James W. McManus , Nick Anousis , Benjamin Newton Banks , Hui Liu , Lingwen Zhou
IPC分类号： A61K314439
CPC分类号： C07D401/12
摘要： The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in a chlorinated aliphatic hydrocarbon or aromatic hydrocarbon solvent, such as methylene chloride or toluene; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate or formic acid solution and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Omeprazole and compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent and diminished levels of alcoholic solvent are also described.
摘要翻译：本发明描述了一种用于制备，分离和纯化抗溃疡剂奥美拉唑的改进方法，其中硫化物前体pyrmetazole在氯代脂族烃或芳族烃溶剂中与恰好一摩尔当量的间氯过氧苯甲酸在地下反应，如二氯甲烷或甲苯; 通过真空蒸馏从水层除去残留的有机溶剂; 粗产物通过与甲酸烷基酯或甲酸溶液反应结晶并接种获得; 通过在甲醇 - 含水NaOH水溶液中再次析出纯产物，通过地下加入乙酸水溶液至pH 9.0，接种，过滤，洗涤和干燥。还描述了奥美拉唑和不含色谱可检测水平的残留的非酒精有机反应溶剂和降低的醇溶剂水平的奥美拉唑组合物。

42. 发明授权

US5864548A Method and apparatus for fast modulation in synchronous CDMA communications 失效
标题翻译：同步CDMA通信中快速调制的方法和装置
公开(公告)号：US5864548A
公开(公告)日：1999-01-26
申请号：US779263
申请日：1997-01-06
申请人： Hui Liu
发明人： Hui Liu
IPC分类号： H04B1/707 , H04B7/216
CPC分类号： H04B1/707
摘要： A system and method for modulating synchronous CDMA (S-CDMA) signals in antenna array wireless system. By taking advantage of the symmetric property of Walsh code words utilized in S-CDMA perform modulation of signals intended for a plurality of users. The system includes a Fast Hadamard Transform (FHT) Processor that realizes baseband operations including spreading and digital combining in one step. In addition to significant reduction in computations and storage over prior methods, the invention also provides substantial advantages in hardware implementation. While the exemplary embodiment is described in the context of antenna array CDMA systems, the disclosed techniques have general applications in CDMA systems with arbitrary symbol values.
摘要翻译：一种在天线阵列无线系统中调制同步CDMA（S-CDMA）信号的系统和方法。通过利用在S-CDMA中使用的沃尔什码字的对称性来执行针对多个用户的信号的调制。该系统包括一个快速Hadamard变换（FHT）处理器，实现基带操作，包括一步一步的扩展和数字组合。除了相对于现有方法的计算和存储的显着减少之外，本发明还在硬件实现方面提供了显着的优点。虽然在天线阵列CDMA系统的上下文中描述了示例性实施例，但是所公开的技术在具有任意符号值的CDMA系统中具有一般应用。

43. 发明授权

US10676467B2 Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof 有权
公开(公告)号：US10676467B2
公开(公告)日：2020-06-09
申请号：US16025324
申请日：2018-07-02
申请人： Zhude Tu , Adam Rosenberg , Hui Liu , Junbin Han
发明人： Zhude Tu , Adam Rosenberg , Hui Liu , Junbin Han
IPC分类号： C07D413/04 , C07D419/04 , C07D413/10 , C07D271/06 , C07B59/00 , C07D413/12
摘要： Among the various aspects of the present disclosure is the provision of a compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof. Provided are imaging agents for imaging S1P1 and S1P1 associated diseases, disorders, and conditions. Also provided are therapeutic compositions and methods for the treatment of S1P1 associated diseases, disorders, and conditions.

44. 发明授权

US09445581B2 Animal models and therapeutic molecules 有权
标题翻译：动物模型和治疗分子
公开(公告)号：US09445581B2
公开(公告)日：2016-09-20
申请号：US13433084
申请日：2012-03-28
申请人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号： C12P21/00 , A01K67/027 , C12N5/06 , C12P21/08 , C07K16/46 , C12N15/85 , C07K16/12 , C07K16/18 , C07K16/00
CPC分类号： C07K16/462 , A01K67/0278 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1239 , C07K16/1282 , C07K16/18 , C07K16/46 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/56 , C07K2317/92 , C12N15/85 , C12N15/8509 , C12N2015/8518
摘要： The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising the disclosed antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the disclosed methods.
摘要翻译：本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链，如此制备的抗体和抗体链的方法及其衍生物，包括完全人源化抗体; 包含所公开的抗体，抗体链和衍生物的组合物，以及适用于所公开的方法的细胞，非人哺乳动物和载体。

45. 发明授权

US09133293B2 Copolymer rubber having a star-shaped block structure, the preparation process and use thereof 有权
标题翻译：具有星形块状结构的共聚物橡胶，其制备方法及其用途
公开(公告)号：US09133293B2
公开(公告)日：2015-09-15
申请号：US13169852
申请日：2011-06-27
申请人： Guozhu Yu , Lin Xu , Xinhe Kang , Nini Wang , Hui Liu , Chuanqing Li
发明人： Guozhu Yu , Lin Xu , Xinhe Kang , Nini Wang , Hui Liu , Chuanqing Li
IPC分类号： C08F2/00 , C08F299/00 , C08J5/14 , C08F297/04 , B60C1/00
CPC分类号： C08F297/044 , B60C1/0016 , Y02T10/862
摘要： Provided is a copolymer rubber, comprising a copolymer having a star-shaped block structure (SIB-PA)n-X, wherein SIB is a block comprising styrene, butadiene, and isoprene as constituent monomers; PA is a block comprising butadiene or isoprene as a constituent monomer; X is the residue of at least one coupling agent; and n=2-4. Also provided is a process for preparing the copolymer rubber and use thereof.
摘要翻译：提供一种共聚物橡胶，其包含具有星形嵌段结构（SIB-PA）n-X的共聚物，其中SIB为包含苯乙烯，丁二烯和异戊二烯作为构成单体的嵌段; PA是包含丁二烯或异戊二烯作为构成单体的嵌段; X是至少一种偶联剂的残基; 并且n = 2-4。还提供了制备共聚物橡胶的方法及其用途。

46. 发明授权

US08983407B2 Selectable PA bias temperature compensation circuitry 有权
标题翻译：可选PA偏置温度补偿电路
公开(公告)号：US08983407B2
公开(公告)日：2015-03-17
申请号：US13288318
申请日：2011-11-03
申请人： William David Southcombe , David E. Jones , Hui Liu , Chris Levesque , Scott Yoder , Terry J. Stockert
发明人： William David Southcombe , David E. Jones , Hui Liu , Chris Levesque , Scott Yoder , Terry J. Stockert
IPC分类号： H04B1/04 , H01Q11/12 , H03F3/19 , H03F3/217 , H03F3/24 , H03F1/30 , H03F3/72
CPC分类号： H03F1/30 , H03F3/19 , H03F3/2175 , H03F3/245 , H03F3/72 , H03F2200/111 , H03F2200/447 , H03F2203/7209
摘要： Radio frequency (RF) power amplifier (PA) circuitry, which transmits RF signals is disclosed. The RF PA circuitry includes a final stage, a final stage current digital-to-analog converter (IDAC), and a final stage temperature compensation circuit. A final stage current reference circuit may provide an uncompensated final stage reference current to the final stage temperature compensation circuit, which receives and temperature compensates the uncompensated final stage reference current to provide a final stage reference current. The final stage IDAC uses the final stage reference current in a digital-to-analog conversion to provide a final stage bias signal to bias the final stage. The temperature compensation provided by the final stage temperature compensation circuit is selectable.
摘要翻译：公开了发射RF信号的射频（RF）功率放大器（PA）电路。 RF PA电路包括最后级，最后一级电流数模转换器（IDAC）和最终级温度补偿电路。最终级电流参考电路可以向最终级温度补偿电路提供未补偿的最终级参考电流，其接收和温度补偿未补偿的最终级参考电流以提供最终级参考电流。最终阶段IDAC在数模转换中使用最后阶段参考电流，以提供最终阶段偏置信号来偏向最后阶段。由最终级温度补偿电路提供的温度补偿是可选择的。

47. 发明授权

US08953612B2 Efficient broadcasting via random linear packet combining 有权
标题翻译：通过随机线性分组组合进行有效的广播
公开(公告)号：US08953612B2
公开(公告)日：2015-02-10
申请号：US13414235
申请日：2012-03-07
申请人： Hui Liu , Mohammad H. Firooz , Sumit Roy
发明人： Hui Liu , Mohammad H. Firooz , Sumit Roy
IPC分类号： H04L12/28 , H04L1/00 , H04H20/42
CPC分类号： H04L1/0076 , H04H20/42 , H04L1/0057 , H04L69/22 , H04W4/06
摘要： Embodiments of systems and methods for efficient broadcasting via random linear packet combining are described. A plurality of data packets are received from a data source according to embodiments. The plurality of data packets is divided into a plurality of data blocks, and bits associated with the plurality of data blocks are multiplied by a set of coefficients to generate a plurality of product values. An encoded data packet having a plurality of encoded data blocks may also be generated by linearly combining the plurality of product values for respective data blocks of each of the plurality of data packets into corresponding encoded data blocks of the encoded data packet. Because each encoded data packet includes information about a complete set of data packets, rather than just a subset, less broadcast redundancy may be required.
摘要翻译：描述了通过随机线性分组组合进行有效广播的系统和方法的实施例。根据实施例，从数据源接收多个数据分组。多个数据分组被分成多个数据块，并且与多个数据块相关联的比特乘以一系列系数以产生多个乘积值。也可以通过将多个数据分组中的每一个的各个数据块的多个乘积值线性地组合成编码数据分组的相应的编码数据块来生成具有多个编码数据块的编码数据分组。因为每个编码的数据分组包括关于完整的一组数据分组的信息，而不仅仅是一个子集，所以可能需要较少的广播冗余。

48. 发明授权

US08791573B1 Skewed partial column input/output floorplan 有权
标题翻译：偏斜的部分列输入/输出平面图
公开(公告)号：US08791573B1
公开(公告)日：2014-07-29
申请号：US13601894
申请日：2012-08-31
申请人： Hui Liu , Christopher F. Lane , Arifur Rahman , Jianming Huang
发明人： Hui Liu , Christopher F. Lane , Arifur Rahman , Jianming Huang
IPC分类号： H01L23/48 , G06F17/50
CPC分类号： G06F17/5068 , H01L23/5286 , H01L2224/16 , H01L2924/0002 , H01L2924/00012 , H01L2924/00
摘要： Techniques and mechanisms for providing embedded Input/Output (IO) blocks in a floor plan of a semiconductor device are provided, where the embedded IO blocks constitute partial columns (i.e., they do not extend from the bottom through to the top of the semiconductor device). In some embodiments, the partial column IO banks are skewed away from one another. In some embodiments, the partial column IO banks are located away from the center of the semiconductor device. Techniques and mechanisms for implementing symmetrical package routing using skewed partial column IO banks are also provided.
摘要翻译：提供了在半导体器件的平面图中提供嵌入式输入/输出（IO）块的技术和机制，其中嵌入式IO块构成部分列（即，它们不从半导体器件的底部到顶部延伸））。在一些实施例中，部分列IO组彼此偏斜。在一些实施例中，部分列IO组位于远离半导体器件的中心的位置。还提供了使用偏斜部分列IO库来实现对称封装路由的技术和机制。

49. 发明授权

US08771745B2 Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof 有权
标题翻译：前列腺素和前列腺酰胺药物递送系统及其眼内治疗用途
公开(公告)号：US08771745B2
公开(公告)日：2014-07-08
申请号：US13596904
申请日：2012-08-28
申请人： Michael R. Robinson , Hui Liu , Patrick M. Hughes , Lon T. Spada , Alazar N. Ghebremeskel
发明人： Michael R. Robinson , Hui Liu , Patrick M. Hughes , Lon T. Spada , Alazar N. Ghebremeskel
IPC分类号： A61K9/14 , A61K9/00
CPC分类号： A61L31/06 , A61K9/0048 , A61K9/0051 , A61K9/1647 , A61K9/204 , A61K31/216 , A61K31/557 , A61K31/5575 , A61L31/16
摘要： Biocompatible, bioerodible implants and microspheres include latanoprost and a biodegradable polymer effective, when placed intraocular (such as into the subtenon space) to treat glaucoma.
摘要翻译：生物相容性，生物可侵蚀的植入物和微球体包括拉坦前列素和可生物降解的聚合物，当放置眼内（如进入subtenon空间）治疗青光眼时有效。

50. 发明授权

US08749037B1 Multi-access memory system and a method to manufacture the system 有权
标题翻译：多访问存储器系统和一种制造系统的方法
公开(公告)号：US08749037B1
公开(公告)日：2014-06-10
申请号：US13284827
申请日：2011-10-28
申请人： Hui Liu
发明人： Hui Liu
IPC分类号： H01L23/02
CPC分类号： H01L24/49 , H01L24/06 , H01L24/16 , H01L24/17 , H01L24/45 , H01L24/48 , H01L24/81 , H01L25/0652 , H01L25/0657 , H01L2224/0401 , H01L2224/04042 , H01L2224/05554 , H01L2224/0612 , H01L2224/13111 , H01L2224/13144 , H01L2224/16145 , H01L2224/16225 , H01L2224/45144 , H01L2224/48095 , H01L2224/48145 , H01L2224/48227 , H01L2224/49171 , H01L2225/0651 , H01L2225/06513 , H01L2225/06568 , H01L2924/15184 , H01L2924/15192 , H01L2924/15311 , H05K1/0243 , H05K2201/10159 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： A multiple memory access system is disclosed. The system includes a first die disposed on a package substrate. A second die is stacked above the first die. The first die, the second die and the package substrate form a first package. An IC is placed within a close proximity of the first package where the first die communicates with the second die at a first data rate while the first die communicates with the IC at a second data rate. The first data rate is higher than the second data rate.
摘要翻译：公开了一种多存储器存取系统。该系统包括设置在封装衬底上的第一管芯。第二模具堆叠在第一模具上方。第一模具，第二模具和封装衬底形成第一封装。将IC放置在第一封装的紧密附近，其中第一管芯以第一数据速率与第二管芯通信，而第一管芯以第二数据速率与IC通信。第一数据速率高于第二数据速率。

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