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41. 发明申请

US20100001722A1 MAGNETIC SENSOR DEVICE WITH SUPPRESSION OF SPURIOUS SIGNAL COMPONENTS 审中-公开
标题翻译：具有抑制SPUIOUS信号组件的磁传感器装置
公开(公告)号：US20100001722A1
公开(公告)日：2010-01-07
申请号：US12518890
申请日：2007-12-12
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen , Jeroen Veen
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen , Jeroen Veen
IPC分类号： G01R33/02
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： The invention relates to a magnetic sensor device for the determination of magnetized particles (3) which comprises a magnetic field generator (1, 1′)(e.g. a conductor wire) that is driven with an excitation current (I1) of a first frequency (f1), and a magnetic sensor element (2) (e.g. a GMR resistance), that is driven with a sensor current (I2) of a second frequency (f2) for generating measurement signals (UGMR). A preprocessed signal (uf) is then generated from the measurement signal (UGMR) that comprises a predetermined frequency (Δf), and an evaluation unit (10) separates from this preprocessed signal a spurious component that does not depend on the presence of magnetized particles (3) in the sample chamber. The spurious component (UQ) may particularly be caused by self-magnetization (H2) of the magnetic sensor element (2) in combination with parasitic (capacitive or inductive) cross-talk. Furthermore, an unknown, variable phase-shift (φSP) in the preprocessed signal (uf) may be determined by varying the ratio between the spurious component and a particle-dependent target component. This variation may for example be achieved if, in an optimization stage (OS), the excitation current (I1) is conducted through a bypass resistor (R, R′) and/or if an additional capacitor is introduced between the magnetic field generator and the magnetic sensor element. The determined phase shift can then be used to adjust the phase of a demodulation signal (udem) such that the spurious component is suppressed.
摘要翻译：本发明涉及一种用于确定磁化颗粒（3）的磁传感器装置，该磁化颗粒包括由第一频率的激励电流（I1）驱动的磁场发生器（1,1'）（例如导线） f1）和由用于产生测量信号（UGMR）的第二频率（f2）的传感器电流（I2）驱动的磁传感器元件（2）（例如，GMR电阻）。然后从包括预定频率（Deltaf）的测量信号（UGMR）生成预处理信号（uf），并且评估单元（10）从该预处理信号中分离出不依赖于磁化颗粒的存在的杂散分量（3）。杂散分量（UQ）可以特别地由磁传感器元件（2）与寄生（电容或电感）串扰的自磁化（H2）引起。此外，预处理信号（uf）中的未知的可变相移（phiSP）可以通过改变杂散分量和粒子相关目标分量之间的比率来确定。例如，如果在优化级（OS）中通过旁路电阻（R，R'）传导励磁电流（I1）和/或如果在磁场发生器和磁传感元件。然后可以使用所确定的相移来调整解调信号（udem）的相位，使得抑制杂散分量。

42. 发明申请

US20090219796A1 RECORD CARRIER IDENTIFICATION USING ASYMMETRY MODULATION 审中-公开
标题翻译：使用不对称调制的记录载体识别
公开(公告)号：US20090219796A1
公开(公告)日：2009-09-03
申请号：US12466630
申请日：2009-05-15
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G11B20/00
CPC分类号： G11B20/00086 , G11B20/00579 , G11B20/00884 , G11B20/1426 , G11B2020/1453
摘要： Record carrier identification information is stored using an asymmetry modulation. This prevents the access to this information through the regular data path of the playback device. The asymmetry information is automatically removed by the playback device because of the inherent data slicing and decoding that takes place in the play back device. A parameter of the asymmetry modulation is used to verify that the record carrier is authentic and not a duplicated record carrier. The parameter is disturbed by duplication processes and thus provides a reliable difficult to circumvent indication of authenticity of the record carrier.
摘要翻译：记录载体识别信息使用不对称调制进行存储。这防止通过播放设备的常规数据路径访问该信息。由于在播放装置中发生的固有数据分片和解码，不对称信息被播放装置自动移除。使用不对称调制的参数来验证记录载体是真实的，而不是重复的记录载体。该参数受到重复过程的干扰，从而提供了难以绕过记录载体真实性的可靠性。

43. 发明申请

US20090219012A1 MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：用于浓度测量的微电子传感器装置
公开(公告)号：US20090219012A1
公开(公告)日：2009-09-03
申请号：US12299698
申请日：2007-04-24
申请人： Jeroen Hans Nieuwenhuis , Hans Van Zon , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Jeroen Hans Nieuwenhuis , Hans Van Zon , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01N27/74
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01R33/1269
摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.
摘要翻译：本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量信号与相关联的传感器单元（10a-10d）。目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3），参与结合曲线，例如， Langmuir等温线可以适应于采样的测量信号，以确定样品中所需的颗粒浓度。此外，在持续采样过程中，可以动态拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。在本发明的另一个实施例中，检测并计数与目标颗粒移动到敏感区域内部或之内的单个事件。

44. 发明申请

US20090102472A1 MAGNETIC SENSOR DEVICE WITH FIELD GENERATORS AND SENSORS 审中-公开
标题翻译：具有现场发电机和传感器的磁传感器装置
公开(公告)号：US20090102472A1
公开(公告)日：2009-04-23
申请号：US12299704
申请日：2007-05-02
申请人： Jeroen Hans Nieuwenhuis , Hans Zon Van , Josephus Arnoldus Henricus Maria Kahlman
发明人： Jeroen Hans Nieuwenhuis , Hans Zon Van , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G01R33/12
CPC分类号： G01N33/54326 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising magnetic field generators (11, 13) for generating a magnetic excitation field (B) in an investigation region and a magnetic sensor element (12) for measuring magnetic reactions fields (B′) generated by magnetized particles (2) that are bound to binding sites (3) in the investigation region. Both the magnetic field generators (11, 13) and the magnetic sensor element (12) are driven with electrical power, wherein the ratio of the power that is dissipated in said components is kept in a predetermined interval. The magnetic field generators may preferably be realized by excitation wires (11, 13) and the sensor element (12) by a magneto-resistive element, for example a GMR element. In this case, it is preferred that about equal amounts of power are dissipated in the excitation wires (11, 13) and the GMR element (12).
摘要翻译：本发明涉及一种磁传感器装置（10），包括用于在调查区域中产生磁场（B）的磁场发生器（11,13）和用于测量磁反应场（B'）的磁传感器元件（12）由在调查区域中与结合位点（3）结合的磁化颗粒（2）产生。磁力发生器（11,13）和磁性传感器元件（12）都用电力驱动，其中在所述部件中耗散的功率的比率保持在预定的间隔。磁场发生器可以优选地通过激磁线（11,13）和传感器元件（12）由磁阻元件（例如GMR元件）来实现。在这种情况下，优选在激励线（11,13）和GMR元件（12）中消耗大约相等的功率。

45. 发明申请

US20080024118A1 Magneto-Resistive Sensor for High Sensitivity Depth Probing 审中-公开
标题翻译：用于高灵敏度深度探测的磁阻传感器
公开(公告)号：US20080024118A1
公开(公告)日：2008-01-31
申请号：US11569168
申请日：2005-05-17
申请人： Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
发明人： Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
IPC分类号： G01N27/74 , G01N27/72
CPC分类号： G01N27/745 , G01N35/0098 , G01N2035/1053
摘要： A sensor device (40) and a method for detection of the presence of at least one magnetic particle (46) are described. More particularly, a sensor device (40) comprising at least one magnetic field generating means (41) and at least one magnetic sensor element (42) is provided. The sensor device (40) furthermore comprises an exclusion zone (44), such as a spacer (44b) at the sensor surface (45), for excluding magnetic particles or beads (46) in the relative vicinity of the magnetic sensor element (42). The sensor device (40) according to the invention shows high depth or bulk sensitivity.
摘要翻译：描述了传感器装置（40）和用于检测至少一个磁性颗粒（46）的存在的方法。更具体地，提供了包括至少一个磁场产生装置（41）和至少一个磁性传感器元件（42）的传感器装置（40）。传感器装置（40）还包括在传感器表面（45）处的隔离区（44），例如间隔物（44b），用于在磁性传感器元件的相对附近排除磁性颗粒或珠（46） 42）。根据本发明的传感器装置（40）显示出高深度或体积灵敏度。

46. 发明授权

US06745946B2 Device for scanning an electromagnetically suspended information carrier 失效
标题翻译：用于扫描电磁暂停信息载体的装置
公开(公告)号：US06745946B2
公开(公告)日：2004-06-08
申请号：US10011881
申请日：2001-12-04
申请人： Gerard Eduard Van Rosmalen , Josephus Arnoldus Henricus Maria Kahlman , Willem Gerard Ophey
发明人： Gerard Eduard Van Rosmalen , Josephus Arnoldus Henricus Maria Kahlman , Willem Gerard Ophey
IPC分类号： G06K1906
CPC分类号： G11B5/012 , G11B5/82 , G11B7/00 , G11B7/0037 , G11B7/24 , G11B17/028 , G11B17/34 , G11B19/2009 , G11B23/0035
摘要： A device for reading and/or writing a disc-shaped information carrier which comprises a support element of a magnetizable material along its circumference. An electromagnetic unit cooperates with the support element and a scanning unit for reading and/or writing the information carrier, which can be rotated about an axis of rotation and positioned with respect to the scanning unit in five degrees of freedom except for the rotational degree around the axis of rotation.
摘要翻译：一种用于读取和/或写入盘形信息载体的装置，其包括沿其圆周的可磁化材料的支撑元件。电磁单元与支撑元件和用于读取和/或写入信息载体的扫描单元相配合，该扫描单元可围绕旋转轴线旋转并相对于扫描单元以相对于扫描单元定位的方式在五个自由度内旋转，除了周围的旋转度旋转轴。

47. 发明授权

US06717994B1 Apparatus for decoding a serial datastream of channel words into a datastream of information words 失效
标题翻译：用于将通道字的串行数据流解码为信息字的数据流的装置
公开(公告)号：US06717994B1
公开(公告)日：2004-04-06
申请号：US09564616
申请日：2000-05-04
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： H04L2706
CPC分类号： H03M5/145 , G11B20/1426
摘要： The invention provides for an apparatus for decoding a serial datastream of channel words into a datastream of information words. The apparatus comprises an input terminal (10) for receiving the serial data stream of channel words, a serial-parallel converter unit (16) means for serial-to-parallel conversion of the serial datastream into a parallel datastream of n-bit intermediate channel words. Further, a clock signal generation unit (14) is present for deriving a first clock signal of a specific frequency from the serial datastream of channel words. A frequency division unit (18) is present for dividing the frequency of the clock signal generated by the generation means by a factor of n, so as to obtain a second clock signal of a reduced frequency. A sync word detection unit (24) is available for detecting sync words present in said serial datastream of channel words. Said sync word detection unit (24) is adapted to receive said n-bit intermediate channel words from said serial-parallel conversion unit (16) under the influence of said second clock signal and is further adapted to generate an offset control signal, said offset control signal being indicative of the relative offset, given in numbers of bits, between the start of a sync word and the location of this start position within an n-bit intermediate channel word. A converter unit (26,32) is present for converting said n-bit intermediate channel words into n-bit phase shifted channel words and for converting said phase shifted channel words into information words in response to said second clock signal and said offset signal.
摘要翻译：本发明提供一种用于将信道字的串行数据流解码为信息字的数据流的装置。该装置包括用于接收信道字的串行数据流的输入端（10），用于将串行数据流串行/并行转换为n位中间信道的并行数据流的串行 - 并行转换器单元（16）话。此外，存在用于从通道字的串行数据流导出特定频率的第一时钟信号的时钟信号生成单元（14）。存在用于将由发生装置产生的时钟信号的频率除以因子n的分频单元（18），以便获得降低频率的第二时钟信号。同步字检测单元（24）可用于检测存在于通道字的所述串行数据流中的同步字。所述同步字检测单元（24）适于在所述第二时钟信号的影响下从所述串行 - 并行转换单元（16）接收所述n位中间信道字，并且还适于产生偏移控制信号，所述偏移控制信号指示同步字开始与n位中间信道字中该起始位置的位置之间以比特数给出的相对偏移量。存在用于将所述n位中间信道字转换为n位相移信道字的A转换器单元（26,32），并且用于响应于所述第二时钟信号和所述偏移信号将所述相移信道字转换成信息字。

48. 发明授权

US06710724B2 Device for encoding/decoding n-bit source words into corresponding m-bit channel words, and vice versa 失效
标题翻译：将n位源字编码/解码为相应的m位通道字的装置，反之亦然
公开(公告)号：US06710724B2
公开(公告)日：2004-03-23
申请号：US09833412
申请日：2001-04-12
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： H03M700
CPC分类号： H04L25/4908 , G11B20/14 , G11B20/1426 , H03M5/14 , H03M5/145
摘要： A device is provided for encoding a stream of data bits of a binary source signal (S) into a stream of data bits of a binary channel signal (C1), wherein the bit stream of the source signal is divided into n-bit source words (x1, X2). The device includes converting means adapted to convert the source words into corresponding m-bit channel words (y1, y2, y3). Each n-bit source word together with another n-bit source word forms a pair of source words. The values of the n-bit source words differ only in the value of the bit in the qth bit position, q being a constant. The pairs of source words are divided into a first part of pairs and a remaining part of pairs. The converting means are further adapted to convert n-bit source words belonging to the first part of pairs into corresponding m-bit channel words, in such a manner that the conversion for each of the n-bit source words is parity preserving, and to convert n-bit source words belonging to the remaining part of pairs into corresponding m-bit channel words, in such a manner that the conversion for each of the n-bit source words is parity inverting. A decoding device is also provided for decoding the channel signal obtained by means of the encoding device.
摘要翻译：提供了一种用于将二进制源信号（S）的数据比特流编码为二进制信道信号（C1）的数据比特流的装置，其中源信号的比特流被划分为n比特源字（x1，X2）。该装置包括适于将源字转换成相应的m位通道字（y1，y2，y3）的转换装置。每个n位源字与另一个n位源字形成一对源字。 n位源字的值仅在q位位置的位的值不同，q是常数。源字对被分为对的第一部分和对的剩余部分。转换装置还适于将属于第一部分对的n比特源字转换为相应的m比特信道字，使得每个n比特源字的转换是奇偶校验，并且将属于剩余部分对的n位源字转换成相应的m位通道字，使得每个n位源字的转换是奇偶校验反转。还提供了一种解码装置，用于对通过编码装置获得的信道信号进行解码。

49. 发明授权

US08822227B2 Magnetic bead actuation using feedback for FTIR biosensor 有权
标题翻译：磁珠激励使用FTIR生物传感器的反馈
公开(公告)号：US08822227B2
公开(公告)日：2014-09-02
申请号：US12865864
申请日：2009-02-02
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G01N21/00 , G01N27/74 , G01N33/543 , G01N21/55 , G01N35/00
CPC分类号： G01N33/54333 , G01N21/552 , G01N27/745 , G01N33/54373 , G01N35/0098
摘要： A method for controlling actuation of label particles in a biosensor device, e.g., using frustrated total internal reflection, includes applying a predetermined actuation force on the label particles and determining the effect of the applied actuation force in a binding volume or surface of a sensor cartridge of the biosensor device. A feedback control of the actuation force is applied.
摘要翻译：用于控制生物传感器装置中的标签颗粒的致动的方法，例如使用受挫的全内反射，包括对标签颗粒施加预定的致动力并确定施加的致动力对传感器盒的装订体积或表面的影响的生物传感器装置。施加致动力的反馈控制。

50. 发明授权

US08797028B2 Sensor device for target particles in a sample 有权
标题翻译：样品中目标颗粒的传感器装置
公开(公告)号：US08797028B2
公开(公告)日：2014-08-05
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： A sensor device and a method for the determination of the amount of target particles at a contact surface adjacent to a sample chamber include detecting, by a detector, the target particles in the sample chamber by a sensor element, and providing at least one corresponding sensor signal. An evaluation unit determines the amount of target particles in a first zone at the contracts surface and in a second zone a distance away from the contact surface based on this sensor signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions, such as wavelength and/or angle of incidence, may be used to extract information about the first and second zones. In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone.
摘要翻译：用于确定与样品室相邻的接触表面处的目标颗粒的量的传感器装置和方法包括通过检测器通过传感器元件检测样品室中的目标颗粒，并且提供至少一个相应的传感器信号。评估单元基于该传感器信号确定在合同表面处的第一区域中的目标颗粒的量和距接触表面一定距离的第二区域中的目标颗粒的量。在光学测量方法中，可以使用在诸如波长和/或入射角的不同操作条件下发生的沮丧的全内反射来提取关于第一和第二区域的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区域中不同地激励磁性目标颗粒。

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