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41. 发明申请

US20090076397A1 Adherent Emergency Patient Monitor 审中-公开
标题翻译：贴近紧急病人监护仪
公开(公告)号：US20090076397A1
公开(公告)日：2009-03-19
申请号：US12209259
申请日：2008-09-12
申请人： Imad Libbus , Badri Amurthur , Mark J. Bly , Kristofer J. James , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
发明人： Imad Libbus , Badri Amurthur , Mark J. Bly , Kristofer J. James , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/02 , A61B5/0402 , A61B5/08
CPC分类号： A61B5/04087 , A61B5/6833
摘要： An adherent device comprises an adhesive patch to adhere to a skin of the patient. At least two electrodes are connected to the patch and capable of electrically coupling to the patient. Electrocardiogram circuitry can be coupled to at the least two electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate an accelerometer signal in response to at least one of an activity or a position of the patient. A processor comprising a tangible medium can be configured to communicate with the electrocardiogram circuitry and the accelerometer to generate an alarm signal in response to the electrocardiogram signal and the accelerometer signal.
摘要翻译：粘附装置包括粘附到患者皮肤上的粘贴剂。至少两个电极连接到贴片并且能够电耦合到患者。心电图电路可耦合到至少两个电极以测量患者的心电图信号。加速度计可以机械耦合到粘合贴片，以响应于患者的活动或位置中的至少一个来产生加速度计信号。包括有形介质的处理器可以被配置为与心电图电路和加速度计通信，以响应于心电图信号和加速度计信号产生报警信号。

42. 发明申请

US20090076364A1 Adherent Device for Sleep Disordered Breathing 有权
标题翻译：用于睡眠无序呼吸的粘附装置
公开(公告)号：US20090076364A1
公开(公告)日：2009-03-19
申请号：US12209292
申请日：2008-09-12
申请人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
发明人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
IPC分类号： A61B5/04 , A61N1/00
CPC分类号： A61B5/4818 , A61B5/0002 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/0809 , A61B5/11 , A61B5/14551 , A61B5/6832 , A61B5/6833 , A61B5/7282 , A61B2560/0412 , A61B2562/164
摘要： An adherent device is configured to adhere to the skin of the patient with an adherent patch, for example breathable tape, coupled to at least four electrodes. The device comprises impedance circuitry coupled to the at least four electrodes and configured to measure respiration of the patient to detect sleep apnea and/or hypopnea. The impedance circuitry may be used to measure hydration of the patient. An accelerometer can be mechanically coupled to the adherent patch such that the accelerometer can be coupled to and move with the skin of the patient. Electrocardiogram circuitry to generate an electrocardiogram signal may be coupled to at least two of the at least four electrodes to detect the sleep apnea and/or hypopnea.
摘要翻译：贴附装置被配置为使用与至少四个电极耦合的粘附贴片（例如透气带）粘附到患者的皮肤。该装置包括耦合到至少四个电极并被配置为测量患者的呼吸以检测睡眠呼吸暂停和/或呼吸不足的阻抗电路。阻抗电路可以用于测量患者的水合。加速度计可以机械耦合到粘附贴片，使得加速度计可以耦合到患者皮肤并与患者的皮肤一起移动。用于产生心电图信号的心电图电路可以耦合到至少四个电极中的至少两个，以检测睡眠呼吸暂停和/或呼吸不足。

43. 发明申请

US20090076350A1 Data Collection in a Multi-Sensor Patient Monitor 审中-公开
标题翻译：多传感器患者监护仪中的数据收集
公开(公告)号：US20090076350A1
公开(公告)日：2009-03-19
申请号：US12209528
申请日：2008-09-12
申请人： Mark Bly , Kristofer James , Imad Libbus , Scott Mazar , Jerry Wang
发明人： Mark Bly , Kristofer James , Imad Libbus , Scott Mazar , Jerry Wang
IPC分类号： A61B5/00
CPC分类号： A61N1/08 , A61B5/0006 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/04085 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/1118 , A61B5/145 , A61B5/6833 , A61B7/00 , A61B2560/0209 , A61B2560/0412 , A61N1/37282
摘要： A system for tracking a patient's physiological status and detecting and predicting negative physiological events, with a detecting system and a remote monitoring system. The detecting system includes a plurality of sensors that provide an indication of at least one physiological event of a patient, and a wireless communication device coupled to the plurality of sensors, and configured to transfer patient data from the plurality of sensors to a remote monitoring system. The a remote monitoring system coupled to the wireless communication device, wherein during a registration period, the detecting system being activated for a first time and communicating with the remote monitoring system to register the detecting system and activate data logging.
摘要翻译：利用检测系统和远程监控系统跟踪患者的生理状况和检测和预测负面生理事件的系统。所述检测系统包括多个传感器，其提供患者的至少一个生理事件的指示，以及耦合到所述多个传感器的无线通信设备，并且被配置为将患者数据从所述多个传感器传送到远程监控系统。一种耦合到所述无线通信设备的远程监控系统，其中在注册期间，所述检测系统被第一次激活，并且与所述远程监控系统通信以注册所述检测系统并激活数据记录。

44. 发明申请

US20090076348A1 Injectable Device for Physiological Monitoring 有权
标题翻译：用于生理监测的注射装置
公开(公告)号：US20090076348A1
公开(公告)日：2009-03-19
申请号：US12209430
申请日：2008-09-12
申请人： Yatheendhar D. Manicka , Badri Amurthur , Mark Bly , Kristofer James , Imad Libbus , Scott Mazar , Jerry Wang
发明人： Yatheendhar D. Manicka , Badri Amurthur , Mark Bly , Kristofer James , Imad Libbus , Scott Mazar , Jerry Wang
IPC分类号： A61B5/00
CPC分类号： A61B5/7282 , A61B5/0031 , A61B5/0205 , A61B5/02055 , A61B5/0422 , A61B5/053 , A61B5/07 , A61B5/076 , A61B5/1118 , A61B5/14503 , A61B5/4875 , A61B5/686 , A61B5/7232 , A61B2560/0214 , A61B2560/0468 , A61B2562/0219 , A61B2562/04 , A61B2562/06 , A61B2562/16 , A61N1/37205 , G06F19/00
摘要： An injectable detecting device is provided for use in physiological monitoring. The device includes a plurality of sensors axially spaced along a body that provide an indication of at least one physiological event of a patient, a monitoring unit within the body coupled to the plurality of sensors configured to receive data from the plurality of sensors and create processed patient data, a power source within the body coupled to the monitoring unit, and a communication antenna external to the body coupled to the monitoring unit configured to transfer data to/from other devices.
摘要翻译：提供可用于生理监测的可注射检测装置。该装置包括沿主体轴向间隔开的多个传感器，其提供患者的至少一个生理事件的指示;耦合到多个传感器的身体内的监测单元，其配置成从多个传感器接收数据并产生处理患者数据，耦合到监测单元的身体内的电源，以及耦合到监视单元的身体外部的通信天线，该通信天线被配置为向/从其他设备传送数据。

45. 发明申请

US20090076344A1 Multi-Sensor Patient Monitor to Detect Impending Cardiac Decompensation 有权
标题翻译：多传感器病人监护仪检测即将进行的心脏衰竭
公开(公告)号：US20090076344A1
公开(公告)日：2009-03-19
申请号：US12209279
申请日：2008-09-12
申请人： Imad Libbus , Mark J. Bly , Kristofer J. James , Scott T. Mazar , Jerry S. Wang
发明人： Imad Libbus , Mark J. Bly , Kristofer J. James , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B5/0002 , A61B5/0004 , A61B5/0006 , A61B5/0008 , A61B5/01 , A61B5/02055 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/04085 , A61B5/04087 , A61B5/044 , A61B5/0452 , A61B5/0531 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0816 , A61B5/1114 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4875 , A61B5/6833 , A61B5/6843 , A61B5/6885 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B2560/0412 , A61B2560/0468 , A61B2562/0209 , A61B2562/0214 , A61B2562/043 , A61B2562/164 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Systems and methods of detecting an impending cardiac decompensation of a patient measure at least two of an electrocardiogram signal of the patient, a hydration signal of the patient, a respiration signal of the patient or an activity signal of the patient. The at least two of the electrocardiogram signal, the hydration signal, the respiration signal or the activity signal are combined with an algorithm to detect the impending cardiac decompensation.
摘要翻译：检测患者即将到来的心脏代偿失调的系统和方法测量患者的心电图信号，患者的水合信号，患者的呼吸信号或患者的活动信号中的至少两个。将心电图信号，水合信号，呼吸信号或活动信号中的至少两个与算法组合以检测即将进行的心脏代偿失调。

46. 发明申请

US20090048641A1 BAROREFLEX STIMULATION TO TREAT ACUTE MYOCARDIAL INFARCTION 有权
标题翻译： BAROREFLEX刺激治疗急性心肌梗塞
公开(公告)号：US20090048641A1
公开(公告)日：2009-02-19
申请号：US12257079
申请日：2008-10-23
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/36117 , A61N1/36564
摘要： An aspect of the present subject relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator, a myocardial infarction detector, and a controller. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode. The myocardial infarction detector detects an event indicative of myocardial infarction. The controller is connected to the baroreflex stimulator and to the myocardial infarction detector, and is adapted to apply a baroreflex therapy in response to a detected event indicative of myocardial infarction. Other aspects are provided herein.
摘要翻译：本发明的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心肌梗死检测器和控制器。压力反射刺激器通过电极施加压力反射刺激信号。心肌梗塞检测器检测到指示心肌梗死的事件。控制器连接到压力反射刺激器和心肌梗塞检测器，并且适于对检测到的指示心肌梗塞的事件应用压力反射疗法。本文提供了其他方面。

47. 发明申请

US20080243212A1 SYSTEMS AND METHODS FOR THERMAL NEUROINHIBITION 有权
标题翻译：用于热神经元的系统和方法
公开(公告)号：US20080243212A1
公开(公告)日：2008-10-02
申请号：US11693001
申请日：2007-03-29
申请人： Eric G. Lovett , Imad Libbus , Joseph Walker
发明人： Eric G. Lovett , Imad Libbus , Joseph Walker
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61F7/10 , A61F2007/0056
摘要： Disclosed herein, among other things, is system for thermal neuroinhibition. According to an embodiment, the system includes at least one implantable fluid-filled conduit adapted to be placed adjacent to a neural target. The system also includes an implantable housing including a power source, a heat pump deriving power from the source and connected to the conduit, and a controller within the housing. The controller is connected to the heat pump, and is adapted to control the heat pump to effect fluid flow in the conduit to cool the neural target using electromechanical refrigeration to reversibly inhibit neural activity as part of a medical treatment.
摘要翻译：本文公开了除了其它之外，是用于热神经抑制的系统。根据一个实施例，该系统包括适于邻近神经靶标放置的至少一个可植入流体填充导管。该系统还包括可植入壳体，该可植入壳体包括电源，源自源并连接到导管的热泵以及壳体内的控制器。控制器连接到热泵，并且适于控制热泵来实现管道中的流体流动，以使用机电制冷来冷却神经靶标，以可逆地抑制作为医疗治疗的一部分的神经活动。

48. 发明申请

US20080195188A1 IMPLANTABLE MEDICAL DEVICE WITH FIXATION MECHANISM 审中-公开
标题翻译：具有固定机构的可植入医疗器械
公开(公告)号：US20080195188A1
公开(公告)日：2008-08-14
申请号：US11673186
申请日：2007-02-09
申请人： Imad Libbus , Randy Westlund
发明人： Imad Libbus , Randy Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61N1/36114 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Miniature implantable medical devices each include a fixation mechanism to prevent the device from migrating in the body of a patient after implantation. The fixation mechanism is activated after the device is positioned in the body. In one embodiment, the miniature implantable medical devices each include a circuit to deliver neurostimulation. In one embodiment, the fixation mechanism includes one or more externally activated anchoring devices each configured to switch from a substantially non-anchoring state to a substantially anchoring state in response to an externally applied energy. In another embodiment, implantable medical devices are magnetically attracted to each other to prevent the devices from migrating in the body after implantation.
摘要翻译：微型可植入医疗装置各自包括固定机构，以防止装置在植入后在患者体内迁移。在装置定位在体内后，固定机构被激活。在一个实施例中，微型可植入医疗装置各自包括用于递送神经刺激的电路。在一个实施例中，固定机构包括一个或多个外部激活的锚固装置，其各自被配置为响应于外部施加的能量而从基本上非锚定状态转换到基本锚定状态。在另一个实施例中，可植入医疗装置彼此磁吸引以防止装置在植入后在体内迁移。

49. 发明申请

US20080086185A1 DISTRIBUTED NEUROMODULATION SYSTEM FOR TREATMENT OF CARDIOVASCULAR DISEASE 有权
标题翻译：用于治疗心血管疾病的分布式神经调节系统
公开(公告)号：US20080086185A1
公开(公告)日：2008-04-10
申请号：US11539301
申请日：2006-10-06
申请人： Badri Amurthur , Steven D. Girouard , Imad Libbus
发明人： Badri Amurthur , Steven D. Girouard , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/36114 , A61N1/37247 , A61N1/3787
摘要： A distributed system is described that employs electrical neural stimulation to modulate autonomic activity and which allows titration of the neural stimulation therapy in accordance with physiological measurements reflective of autonomic activity and/or physiological variables affected by the neural stimulation. Such a system may include a plurality of implantable neuromodulation units that communicate with one another over a network.
摘要翻译：描述了一种使用电神经刺激来调节自主活动的分布式系统，并且其允许根据反映受神经刺激影响的自主活动和/或生理变量的生理测量来滴定神经刺激疗法。这样的系统可以包括通过网络彼此通信的多个可植入神经调节单元。

50. 发明申请

US20080086181A1 IMPLANTABLE DEVICE FOR RESPONSIVE NEURAL STIMULATION THERAPY 有权
标题翻译：用于反应性神经刺激治疗的可植入装置
公开(公告)号：US20080086181A1
公开(公告)日：2008-04-10
申请号：US11539289
申请日：2006-10-06
申请人： Badri Amurthur , Imad Libbus
发明人： Badri Amurthur , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/36521
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. In one embodiment, the duty cycle for delivering neural stimulation is adjusted in accordance with one or more measured physiological variables.
摘要翻译：本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。在一个实施例中，根据一个或多个测量的生理变量来调整用于递送神经刺激的占空比。

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