专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US5489582A 14-deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical composition comprising same for treating cardiovascular disorders 失效
标题翻译： 14-脱氧-14α-硬骨苷脂3β-硫代衍生物和包含其的用于治疗心血管疾病的药物组合物
公开(公告)号：US5489582A
公开(公告)日：1996-02-06
申请号：US80525
申请日：1993-06-24
申请人： Mauro Gobbini , Luigi Bernardi , Mara Ferrandi , Piero Melloni , Luisa Quadri , Roberto Villa
发明人： Mauro Gobbini , Luigi Bernardi , Mara Ferrandi , Piero Melloni , Luisa Quadri , Roberto Villa
IPC分类号： A61K31/585 , A61P9/00 , A61P9/12 , C07J19/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07D405/12
CPC分类号： C07J43/003 , C07J19/00 , C07J31/003 , C07J41/0055 , C07J41/0088
摘要： 14-Deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical compositions comprising same for treating cardiovascular disorders, such as heart failure and hypertension, are disclosed.
摘要翻译：公开了用于治疗心血管疾病如心力衰竭和高血压的14-脱氧-14α-硬骨苷脂3β-硫代衍生物和包含其的药物组合物。

42. 发明授权

US5298022A Wearable artificial pancreas 失效
标题翻译：可穿戴人造胰腺
公开(公告)号：US5298022A
公开(公告)日：1994-03-29
申请号：US238
申请日：1993-01-04
申请人： Luigi Bernardi
发明人： Luigi Bernardi
IPC分类号： A61B5/00 , A61M31/00
CPC分类号： A61B5/14865 , A61B5/14528
摘要： A device for the continuous quantitative determination of glucose in the blood of a diabetic patient over a period of 24-36 hours, comprises a container for a saline solution with heparin, a microdialyzing needle inserted into a vein of a diabetic patient, a pump for injecting the solution into the microdialyzing needle, a semipermeable hollow fiber membrane located externally of the needle whereby dialysis occurs between the blood and the solution and only glucose and other substances of low molecular weight below 100,000 daltons go through the membrane and the concentration of the glucose and other substances of low molecular weight below 100,000 daltons inside the needle is proportional to that of the external side of the membrane. The needle is provided with an outgoing conduit, the conduit leads to a sensor, which comprises an enzymatic membrane coupled with a Platinum-Silver electrode. The glucose goes into the conduit, oxidation of glucose to gluconic acid and hydrogen peroxide occurs and the hydrogen peroxide is decomposed to give H.sub.2 O and oxygen with the liberation of two electrons whereby electric current is produced and the concentration of glucose in the blood is determined by determining the amount of current produced.It is possible to vary the dilution ratio of the fluid circulating inside the microdialyzing needle by varying the pump speed so that it is possible to have a ratio of the glucose containing saline solution to the actual concentration of glucose in the blood of 1/2-1/20.
摘要翻译：用于在24-36小时内连续定量测定糖尿病患者血液中的葡萄糖的装置包括用于肝素盐溶液的容器，插入糖尿病患者静脉的微透析针，将溶液注入微型脱水针，位于针的外部的半透性中空纤维膜，其中血液和溶液之间发生透析，并且仅葡萄糖和低分子量低于100,000道尔顿的其它物质通过膜并且葡萄糖的浓度和低于100,000道尔顿内的低分子量的其他物质与膜的外侧成比例。针设置有输出导管，导管通向传感器，传感器包括与铂 - 银电极耦合的酶膜。葡萄糖进入导管，葡萄糖氧化成葡萄糖酸，过氧化氢发生，过氧化氢分解，得到H2O和氧，释放出两个电子，由此产生电流，血液中的葡萄糖浓度由确定产生的电流量。可以通过改变泵速来改变在微脱水针内循环的流体的稀释比，使得可以使含葡萄糖的盐溶液与血液中葡萄糖的实际浓度的比例为1 / 2- 1/20。

43. 发明授权

US5176632A Wearable artificial pancreas 失效
标题翻译：佩戴人造皮革
公开(公告)号：US5176632A
公开(公告)日：1993-01-05
申请号：US527129
申请日：1990-05-22
申请人： Luigi Bernardi
发明人： Luigi Bernardi
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14528
摘要： A device for the continuous quantitative determination of glucose in the blood of a diabetic patient over a period of 24-36 hours, comprises a container for a saline solution with heparin, a microdialyzing needle inserted into a vein of a diabetic patient, a pump for injecting the solution into the microdialyzing needle, a semipermeable hollow fiber membrane located externally of the needle whereby dialysis occurs between the blood and the solution and only glucose and other substances of low molecular weight below 100,000 daltons go through the membrane and the concentration of the glucose and other substances of low molecular weight below 100,000 daltons inside the needle is proportional to that of the external side of the membrane. The needle is provided with an outgoing conduit, the conduit leads to a sensor, which comprises an enzymatic membrane coupled with a Platinum-Silver electrode. The glucose goes into the conduit, oxidation of glucose to gluconic acid and hydrogen peroxide occurs and the hydrogen peroxide is decomposed to give H.sub.2 O and oxygen with the liberation of two electrons whereby electric current is produced and the concentration of glucose in the blood is determined by determining the amount of current produced.

44. 发明授权

US4558049A Antipsycotic benzoxazines 失效
标题翻译：抗精神病药物
公开(公告)号：US4558049A
公开(公告)日：1985-12-10
申请号：US493618
申请日：1983-05-11
申请人： Luigi Bernardi , Ettore Lazzari , Maria L. Malnati , Giuseppe Mazzini , Lorenzo Pegrassi , Alessandro Rossi
发明人： Luigi Bernardi , Ettore Lazzari , Maria L. Malnati , Giuseppe Mazzini , Lorenzo Pegrassi , Alessandro Rossi
IPC分类号： A61K31/535 , A61P25/18 , C07D211/52 , C07D498/10
CPC分类号： C07D211/52
摘要： There are provided compounds of formula 1: ##STR1## wherein R=halogen atom or CN, NH.sub.2 and NO.sub.2 group, and pharmaceutically acceptable salts thereof.The compounds are antipsycotic agents.
摘要翻译：提供式1化合物：其中R =卤素原子或CN，NH 2和NO 2基团，及其药学上可接受的盐。这些化合物是抗精神病药。

45. 发明授权

US4166911A Pyridazinyl-ergoline compounds having neuroleptic activity 失效
标题翻译：具有精神抑制活性的哒嗪基 - 麦角灵化合物
公开(公告)号：US4166911A
公开(公告)日：1979-09-04
申请号：US870095
申请日：1978-01-17
申请人： Luigi Bernardi , Carlo Elli , Giovanni Falconi , Alberto Bonsignori
发明人： Luigi Bernardi , Carlo Elli , Giovanni Falconi , Alberto Bonsignori
IPC分类号： C07D457/02 , A61K31/50
CPC分类号： C07D457/02 , Y10S514/823
摘要： Pyridazinyl-ergoline compounds having neuroleptic activity are obtained by reacting an 8.beta.-tosylmethyl ergoline with the sodium derivative of an amino-pyridazine or a mercaptopyridazine in a dipolar aprotic solvent.
摘要翻译：通过使8β-甲苯基甲基麦角灵与氨基哒嗪或巯基哒嗪的钠衍生物在偶极非质子溶剂中反应，得到具有精神抑制活性的哒嗪基 - 麦角灵化合物。

46. 发明授权

US4125607A Daunosaminyl anthracyclinones and their use 失效
标题翻译：氨基甲酰基蒽环霉素及其用途
公开(公告)号：US4125607A
公开(公告)日：1978-11-14
申请号：US737473
申请日：1976-11-01
申请人： Federico Arcamone , Luigi Bernardi , Pietro Giardino , Aurelio DI Marco
发明人： Federico Arcamone , Luigi Bernardi , Pietro Giardino , Aurelio DI Marco
IPC分类号： A61K31/65 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/252 , C07H15/24
CPC分类号： C07H15/252
摘要： Disclosed is a class of novel daunosaminyl anthracyclinones which are useful in treating Sarcoma 180 ascites.
摘要翻译：公开了一类可用于治疗肉瘤180腹水的新型氨基甲酰基蒽环类抗生素。

47. 发明授权

US4046878A Daunomycin analogues, their preparation and use 失效
标题翻译：道诺霉素类似物，其制备和用途
公开(公告)号：US4046878A
公开(公告)日：1977-09-06
申请号：US579901
申请日：1975-05-22
申请人： Bianca Patelli , Luigi Bernardi , Federico Arcamone , Aurelio Di Marco
发明人： Bianca Patelli , Luigi Bernardi , Federico Arcamone , Aurelio Di Marco
IPC分类号： A61K31/704 , C07H15/252 , A61K31/71 , C07H11/00
CPC分类号： C07H15/252 , Y10S514/908
摘要： Daunomycin analogues of the formula: ##STR1## wherein when each R.sub.1 is hydrogen, each R is hydrogen, chlorine, bromine, methyl or methoxy and when each R.sub.1 is chlorine, bromine or methyl, each R is hydrogen, are useful in treating various mammalian tumors and are prepared by reacting a daunomycinone derivative of the formula: ##STR2## wherein R and R.sub.1 are as defined above with 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-.alpha.-L-lyxopyranose in an inert anhydrous organic solvent in the presence of a catalyst and a hydrogen chloride acceptor.
摘要翻译：道诺霉素类似物，具有下式：其中当每个R 1是氢时，每个R是氢，氯，溴，甲基或甲氧基，并且当每个R 1是氯，溴或甲基时，每个R是氢，可用于治疗各种哺乳动物肿瘤，并且通过使下式的道诺霉素酮衍生物：其中R和R 1如上所定义的道诺霉素酮衍生物与1-氯-2,3,6-三脱氧-3-三氟乙酰氨基-4-三氟乙酰氧基 α-L-吡喃葡萄糖在惰性无水有机溶剂中，在催化剂和氯化氢受体存在下。

48. 发明授权

US5591734A 17-(3-furyl)-5.beta., 14.beta.-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same 失效
标题翻译：对心血管系统有活性的17-（3-呋喃基）-5β，14β-雄甾烷衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5591734A
公开(公告)日：1997-01-07
申请号：US106893
申请日：1993-08-16
申请人： Luisa Quadri , Luigi Bernardi , Giuseppe Bianchi , Patrizia Ferrari , Piero Melloni , Loredana Valentino
发明人： Luisa Quadri , Luigi Bernardi , Giuseppe Bianchi , Patrizia Ferrari , Piero Melloni , Loredana Valentino
IPC分类号： A61K31/565 , A61K31/56 , A61K31/58 , A61K31/585 , A61P9/00 , A61P9/10 , A61P9/12 , C07J1/00 , C07J17/00 , C07J41/00 , C07J43/00 , C07J71/00
CPC分类号： C07J41/0005 , C07J17/00 , C07J41/0088 , C07J43/003 , C07J71/0021
摘要： The present invention relates to a group of 17-(3-furyl)- and (4-pyridazinyl) 5.beta.,14.beta.-androstane derivatives, active on the cardiovascular system, to processes for their preparation and to pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension.
摘要翻译：本发明涉及对心血管系统有活性的一组17-（3-呋喃基） - 和（4-哒嗪基）5β，14β-雄甾烷衍生物，其制备方法和含有其的药物组合物治疗心血管疾病如心力衰竭和高血压。

49. 发明授权

US5556846A 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstadiene derivatives active on the cardiovascular system, and pharmaceutical compositions containing same 失效
标题翻译：在心血管系统上活性的17-杂环基-14β-5α-雄甾烷，雄甾烯和雄二醇衍生物衍生物，以及含有它们的药物组合物
公开(公告)号：US5556846A
公开(公告)日：1996-09-17
申请号：US128116
申请日：1993-09-29
申请人： Piero Melloni , Luigi Bernardi , Mara Ferrandi , Marco Frigerio , Marina Mauro , Luisa Quadri
发明人： Piero Melloni , Luigi Bernardi , Mara Ferrandi , Marco Frigerio , Marina Mauro , Luisa Quadri
IPC分类号： A61K31/565 , A61K31/575 , A61K31/58 , A61P9/00 , A61P9/12 , C07J1/00 , C07J9/00 , C07J17/00 , C07J31/00 , C07J33/00 , C07J41/00 , C07J43/00 , C07J51/00
CPC分类号： C07J31/006 , C07J1/0011 , C07J17/00 , C07J31/003 , C07J33/002 , C07J41/0005 , C07J41/0055 , C07J41/0088 , C07J43/003 , C07J51/00 , C07J9/00
摘要： 17-Heterocyclyl-5.alpha.-14.beta.-androstane, androstene and androstadiene of formula (I): ##STR1## wherein: Y is oxygen or guanidinoimino, when a double bond exists at position 3;Y is hydroxy, OR.sup.2 or SR.sup.2, when a single bond exists at position 3;R is a saturated or unsaturated mono- or biheterocyclic ring, containing one or more heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen, unsubstituted or substituted by one or more of halogen, hydroxymethyl, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, sulfonamido, C.sub.1 -C.sub.6 lower alkyl or COR.sup.3 ; andR.sup.1 is hydrogen, methyl, ethyl or n-propyl substituted by OH or NR.sup.4 R.sup.5.
摘要翻译： 17-杂环基-5α-14β-雄甾烷，式（I）的雄甾烯和雄二烯二烯：其中：当3位存在双键时，Y为氧或胍基亚氨基; 当3位存在单键时，Y是羟基，OR2或SR2; R是饱和或不饱和的单或双杂环，其含有一个或多个选自氧，硫和氮的杂原子，未被取代或被一个或多个卤素，羟甲基，烷氧基，氨基，烷基氨基，二烷基氨基，氰基，硝基，亚磺酰氨基，C 1 -C 6低级烷基或COR 3; 并且R 1是被OH或NR 4 R 5取代的氢，甲基，乙基或正丙基。

50. 发明授权

US5432169A Cyclopentanperhydrophenanthren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders 失效
标题翻译：环戊二氢海藻灰17β-（3-呋喃基）-3-衍生物和包含其的用于治疗心血管疾病的药物组合物
公开(公告)号：US5432169A
公开(公告)日：1995-07-11
申请号：US81111
申请日：1993-06-25
申请人： Luisa Quadri , Luigi Bernardi , Patrizia Ferrari , Mauro Gobbini , Piero Melloni , Loredana Valentino
发明人： Luisa Quadri , Luigi Bernardi , Patrizia Ferrari , Mauro Gobbini , Piero Melloni , Loredana Valentino
IPC分类号： A61K31/58 , A61P9/00 , A61P9/12 , C07J17/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J71/00
CPC分类号： C07J31/003 , C07J17/00 , C07J41/0055 , C07J41/0088 , C07J43/003 , C07J71/0021
摘要： Cyclopentanperhydrophenantren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension, are disclosed.
摘要翻译：公开了环戊二氢苯丙氨酸-17β-（3-呋喃基）-3-衍生物和含有其用于治疗心力衰竭和高血压的心血管疾病的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式