会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 10. 发明授权
    • Ergoline derivatives and a process for their preparation
    • 艾尔莫林衍生物及其制备方法
    • US4196288A
    • 1980-04-01
    • US856536
    • 1977-12-01
    • Enzo BeaccoLuigi BernardiEnrico Di SalleGiovanni FalconiBianca Patelli
    • Enzo BeaccoLuigi BernardiEnrico Di SalleGiovanni FalconiBianca Patelli
    • A61K31/48A61K31/495A61K31/505C07D457/02
    • C07D457/02
    • New ergoline derivatives are disclosed which are compounds of formula (I) having the structure: ##STR1## wherein R.sub.1 is hydrogen or methoxy; R.sub.2 is hydrogen or methyl; andX is hydroxy, R.sub.3 COO, S--R.sub.4 or NR.sub.5 R.sub.6 in which R.sub.3 is a straight or branched alkyl having from 1 to 6 carbon atoms, unsubstituted- or substituted-phenyl, the substituents being selected from the class consisting of chlorine, bromine, alkyl or alkoxy having from 1 to 4 carbon atoms, cycloalkyl containing from 3 to 6 carbon atoms, or a heterocycle;R.sub.4 is phenyl or a heterocycle, andR.sub.5 and R.sub.6 are alkyl having from 1 to 4 carbon atoms, or together with the N atom to which they are attached, forming a heterocycle. The heterocycle may be a 5- or 6-membered ring which contains from 1 to 3 hetero atoms selected from the class consisting of nitrogen, oxygen and sulphur, and may be saturated or unsaturated, and unsubstituted or substituted by halogen, alkyl having from 1 to 3 carbon atoms, hydroxy, nitro, amino, CONHNH.sub.2 and COOH.
    • 公开了新的麦角灵衍生物,其是具有以下结构的式(I)的化合物:其中R 1是氢或甲氧基; R2是氢或甲基; 并且X是羟基,R 3 COO,S-R 4或NR 5 R 6,其中R 3是具有1至6个碳原子的直链或支链烷基,未取代或取代的苯基,所述取代基选自氯,溴,烷基 或具有1至4个碳原子的烷氧基,含3至6个碳原子的环烷基或杂环; R 4是苯基或杂环,R 5和R 6是具有1至4个碳原子的烷基,或与它们相连的N原子一起形成杂环。 杂环可以是含有1至3个选自氮,氧和硫的杂原子的5或6元环,并且可以是饱和或不饱和的,未取代的或被卤素取代的烷基,具有1个 至3个碳原子,羟基,硝基,氨基,CONHNH 2和COOH。