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41. 发明申请

WO2014147028A1 MONITORING OF CARDIAC ARREST IN A PATIENT CONNECTED TO AN EXTRACORPOREAL BLOOD PROCESSING APPARATUS 审中-公开
标题翻译：监测与病毒血液加工装置连接的患者的心脏病
公开(公告)号：WO2014147028A1
公开(公告)日：2014-09-25
申请号：PCT/EP2014/055309
申请日：2014-03-17
申请人： GAMBRO LUNDIA AB
发明人： HANSSON, Per , OLDE, Bo , SOLEM, Kristian , STERNBY, Jan
IPC分类号： A61B5/0215 , A61M1/36
CPC分类号： A61B5/6866 , A61B5/02125 , A61B5/0215 , A61B5/02158 , A61B5/4836 , A61B5/7246 , A61B5/7282 , A61B5/746 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M1/369 , A61M2230/04
摘要： A monitoring device (7) operates an input block (30) to acquire a pressure signal from a pressure sensor (6a-6c) in an apparatus for extracorporeal blood processing connected to the vascular system of the subject. A processing block (34) repeatedly processes the pressure signal for generation of a time-sequence of parameter values indicative of pressure pulsations originating from heartbeats in the subject, and an evaluation block (35) evaluates the parameter values for detection of cardiac arrest and, if cardiac arrest is detected, generates a dedicated alarm signal. To reduce the risk for false positives without increasing the risk for false negatives, the monitoring device (7) may acquire and process more than one pressure signal, and/or perform an initial viability check before the monitoring is initiated to ensure that pressure pulsations originating from heartbeats are detectable in the pressure signal(s), and/or separate the monitoring of the pressure signal(s) into a detection phase performed during regular operation of a blood pump in the apparatus, and a verification phase performed during a temporary shutdown of the blood pump.
摘要翻译：监视装置（7）操作输入块（30）以从连接到对象的血管系统的用于体外血液处理的装置中的压力传感器（6a-6c）获取压力信号。处理块（34）重复地处理压力信号以产生指示受试者心跳的压力脉动的参数值的时间序列，并且评估块（35）评估用于检测心跳骤停的参数值，如果检测到心跳停止，则产生专用报警信号。为了降低假阳性风险，而不增加假阴性的风险，监测装置（7）可以在开始监测之前获取并处理多于一个压力信号和/或执行初始生存力检查，以确保起始的压力脉动在压力信号中可以检测到心跳，和/或将压力信号的监测分离成在装置中的血泵的常规操作期间执行的检测阶段，以及在临时关闭期间执行的验证阶段的血泵。

42. 发明申请

WO2013131906A1 DIALYSIS COMPOSITION COMPRISING CITRATE, CALCIUM AND MAGNESIUM 审中-公开
标题翻译：包含柠檬酸盐，钙和镁的透析组合物
公开(公告)号：WO2013131906A1
公开(公告)日：2013-09-12
申请号：PCT/EP2013/054386
申请日：2013-03-05
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Anders , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61K31/194 , A61K33/06 , A61K33/14 , A61P7/08
CPC分类号： A61K9/08 , A61K31/194 , A61K33/06 , A61K33/14 , A61M1/1654 , A61K2300/00
摘要： The present invention concerns dialysis compositions comprising 0.5 to 3 mM citrate, 1 to 5 mM total calcium, and 0 to 1.5 mM total magnesium.
摘要翻译：本发明涉及包含0.5至3mM柠檬酸盐，1至5mM总钙和0至1.5mM总镁的透析组合物。

43. 发明公开

EP3646337A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 有权
公开(公告)号：EP3646337A1
公开(公告)日：2020-05-06
申请号：EP18737166.1
申请日：2018-06-21
申请人： Gambro Lundia AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , WALLENBORG, Anders , FORS, Jonas , LINDGREN, Henrik , HÅKANSSON, Annmargret
IPC分类号： G16H40/40

44. 发明公开

EP3646336A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 有权
公开(公告)号：EP3646336A1
公开(公告)日：2020-05-06
申请号：EP18737165.3
申请日：2018-06-21
申请人： Gambro Lundia AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , LINDGREN, Henrik , FORS, Jonas , HÅKANSSON, Annmargret , WALLENBORG, Anders
IPC分类号： G16H40/40

45. 发明授权

EP2268337B1 BLOOD TREATMENT APPARATUS 有权
公开(公告)号：EP2268337B1
公开(公告)日：2018-10-03
申请号：EP09732249.9
申请日：2009-04-14
申请人： Gambro Lundia AB
发明人： JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
CPC分类号： A61M1/16 , A61M1/1006 , A61M1/1037 , A61M1/1039 , A61M1/106 , A61M1/1065 , A61M1/1086 , A61M1/1601 , A61M1/34 , A61M1/3403 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： A proposed blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Additionally, the fluid pumps are configured to control the operation of the blood pumps via the blood treatment fluid. Moreover, a flow control device is configured to control a trans-membrane flow between the blood side and the a fluid side of the blood treatment unit. Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

46. 发明公开

EP2991640A1 A MULTIPART FLUID SYSTEM AND A SYSTEM FOR CITRATE ANTICOAGUALATION IN AN EXTRACORPOREAL BLOOD CIRCUIT 有权
标题翻译：对于混凝柠檬酸预防流体系统和系统多件IN A血液张福亭
公开(公告)号：EP2991640A1
公开(公告)日：2016-03-09
申请号：EP14721347.4
申请日：2014-04-30
申请人： Gambro Lundia AB
发明人： ÅHL, Petra , GODALY, Gabriela , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61K31/194 , A61K31/7004 , A61K33/10 , A61K33/14 , A61K33/42 , A61P7/08 , A61K9/08 , A61M1/34
CPC分类号： A61K33/42 , A61K9/0019 , A61K9/0026 , A61K31/194 , A61K31/225 , A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/10 , A61K33/14 , A61K47/02 , A61M1/1654 , A61M1/1672 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3672 , A61M1/3675 , A61K2300/00
摘要： The present invention concerns a multipart fluid system for dialysis therapy, wherein the multipart fluid system comprises an anticoagulation fluid and at least one treatment fluid from the group consisting of dialysis fluid and infusion fluids. According to the invention the anticoagulation fluid comprises 15-40 mM citrate; and the at least one treatment fluid comprises 1.5-8 mM citrate and ≧10 mM bicarbonate. The present invention further concerns a system for citrate anticoagulation in an extracorporeal blood circuit.
摘要翻译：本发明涉及多部分流体系统，用于透析治疗，worin选自透析液和输注液的多流体系统抗凝流体的包含与至少一种治疗流体。。据抗凝流体包含15-40 mM柠檬酸盐发明; 和所述至少一个处理流体包括1.5-8 mM柠檬酸盐和≧10mM的碳酸氢盐。本发明还涉及在体外血液回路用于枸橼酸抗凝的系统。

47. 发明公开

EP2349392A1 HEAT EXCHANGER AND METHOD FOR HEAT EXCHANGING 有权
标题翻译： WÄRMEAUSTAUSCHER和热交换过程
公开(公告)号：EP2349392A1
公开(公告)日：2011-08-03
申请号：EP09736197.6
申请日：2009-10-09
申请人： Gambro Lundia AB
发明人： JÖNSSON, Lennart , STERNBY, Jan , NILSSON, Eddie
IPC分类号： A61M1/34
CPC分类号： A61M1/3462 , A61M1/3621 , A61M5/44 , A61M2205/366 , F28D9/0075 , F28D9/0087 , F28D9/0093
摘要： The present invention relates to a method for exchanging heat between a effluent fluid (4) and a blood fluid and a heat exchanger (11) for heat exchange. The heat exchanger comprises a first and a second fluid circuit (19, 20) extending through the heat exchanger. The heat exchanger further comprises a stack of fluid plates (12, 13, 40) and a membrane (16) arranged between each of the fluid plates (12, 13, 40) where one interspace is formed between each fluid plate and membrane. The first and the second fluid circuit (19, 20) is each constituted by a passage extending through the fluid plates and membranes and along the fluid plates and membranes in at least two interspaces (17, 18). According to the method for heat exchanging an effluent fluid (4) is passed through the first fluid circuit (19) and a blood fluid is passed through the second fluid circuit (20) such that the effluent fluid (4) is passed along one side of a membrane (16) and simultaneously the blood fluid is passed along the other side of the membrane (16). Heat is thus exchanged between the effluent fluid (4) and the blood fluid over the membrane (16).

48. 发明公开

EP2303356A2 METHODS AND DEVICES FOR MONITORING THE INTEGRITY OF A FLUID CONNECTION 有权
标题翻译：方法和设备监测流体连接的完整性
公开(公告)号：EP2303356A2
公开(公告)日：2011-04-06
申请号：EP09769023.4
申请日：2009-06-26
申请人： Gambro Lundia AB
发明人： HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
IPC分类号： A61M1/36 , G01M3/28
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A surveillance device (25) monitors the integrity of a fluid connection (C) between first and second fluid containing systems (S 1, S2) based on at least one time-dependent measurement signal from a pressure sensor (4a-4c) in the first fluid containing system (Sl). The first fluid containing system (Sl) comprises a first pulse generator (3), and the second fluid containing system (S2) comprises a second pulse generator (3 '). The pressure sensor (4a-4c) is arranged to detect first pulses originating from the first pulse generator (3) and second pulses originating from the second pulse generator (3 '). The integrity of the fluid connection (C) is determined based on the presence of second pulses in the measurement signal. The second pulses may be detected by analysing the measurement signal in the time domain and/or by using timing information indicative of the timing of the second pulses in said at least one measurement signal. The analysis may be based on a parameter value that represents a distribution of signal values within a time window of the measurement signal. For example, the parameter value may be calculated as a statistical dispersion measure of the signal values, or may result from a matching of the signal values within the time window to a predicted temporal signal profile of a second pulse. The fluid connection (C) may be established between a human blood system and an extracorporeal blood flow circuit, e.g. for extracorporeal blood treatment.

49. 发明授权

EP1471957B1 Apparatus and its software for determining blood-flow during dialysis 有权
标题翻译：设备和相关软件，以确定透析血流量
公开(公告)号：EP1471957B1
公开(公告)日：2008-03-12
申请号：EP02783349.0
申请日：2002-10-31
申请人： Gambro Lundia AB
发明人： BENE, Bernard , GOUX, Nicolas , HANSSON, Per , HERTZ, Thomas , JANSSON, Olof , PERSSON, Roland , STERNBY, Jan , ASBRINK, Perry
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/30 , A61M1/16 , A61M1/1605 , A61M1/1617 , A61M1/3656 , A61M2202/0498 , A61M2205/13 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/50 , A61M2230/65

50. 发明公开

EP1471957A1 METHOD AND APPARATUS FOR DETERMINING ACCESS FLOW 有权
标题翻译：设备和相关软件，以确定透析血流量
公开(公告)号：EP1471957A1
公开(公告)日：2004-11-03
申请号：EP02783349.0
申请日：2002-10-31
申请人： Gambro Lundia AB
发明人： BENE, Bernard , GOUX, Nicolas , HANSSON, Per , HERTZ, Thomas , JANSSON, Olof , PERSSON, Roland , STERNBY, Jan , ASBRINK, Perry
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/30 , A61M1/16 , A61M1/1605 , A61M1/1617 , A61M1/3656 , A61M2202/0498 , A61M2205/13 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/50 , A61M2230/65
摘要： A method and apparatus for determining a fluid flow rate in a blood access having an upstream position and a downstream position using a blood treatment apparatus including a blood treatment unit having a semi permeable membrane delimiting a first chamber through which blood removed from said blood access passes and a second chamber through which dialysis liquid passes, an arterial line and a venous line, connected to an inlet and an outlet of the first chamber respectively. The method for determining the fluid flow rate involves measurement of the post dialyzer concentration or conductivity before and after a flow reversal. The invention further involves a method for checking the operating configuration of the arterial and venous lines of the blood treatment apparatus.

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