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41. 发明申请

US20090233887A1 Hydroswellable, Segmented, Aliphatic Polyurethanes and Polyurethane Ureas 审中-公开
标题翻译：耐水性，分段，脂肪族聚氨酯和聚氨酯脲
公开(公告)号：US20090233887A1
公开(公告)日：2009-09-17
申请号：US12380391
申请日：2009-02-26
申请人： Shalaby W. Shalaby , Joel T. Corbett , David R. Ingam , Michael Aaron Vaughn
发明人： Shalaby W. Shalaby , Joel T. Corbett , David R. Ingam , Michael Aaron Vaughn
IPC分类号： A61K31/65 , C08G18/00 , A61K47/34 , A61L24/04 , C08G77/04
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L2430/06 , C08G18/12 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4887 , C08G64/0241 , C08G2230/00 , C08L75/04
摘要： Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
摘要翻译：能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架工程。

42. 发明申请

US20080119848A1 Selectively absorbable/biodegradable, fibrous composite constructs and applications thereof 有权
标题翻译：选择性吸收/可生物降解的纤维复合结构及其应用
公开(公告)号：US20080119848A1
公开(公告)日：2008-05-22
申请号：US11983321
申请日：2007-11-08
申请人： Shalaby W. Shalaby , Shawn Peniston , Kimberly A. Carpenter
发明人： Shalaby W. Shalaby , Shawn Peniston , Kimberly A. Carpenter
IPC分类号： A61B17/04 , A61B17/56
CPC分类号： A61L27/48 , A61L27/54 , A61L27/58 , C08L23/06 , C08L2203/12 , C08L67/04
摘要： A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications. The second group is made of coated and uncoated, warp-knitted mesh constructs for use in hernial, vascular, and urological tissue repair and tissue engineering.
摘要翻译：一系列可选择性吸收/可生物降解的纤维复合材料构造包括生物稳定和可吸收/可生物降解的纱线的不同组合，其组装为最初相互依赖的承载组分，在体内最终用途中转变为显示独立的功能特性。构建体组由两组组成，一组由高柔顺性的纤维增强复合材料制成，由多丝纱构造物增强的分段多轴共聚酯的可吸收基质，其是超高分子量聚乙烯纤维和至少一种可吸收/可生物降解的组合纤维选自由线性分段的丙交酯共聚酯和聚（3-羟基链烷酸酯）制成的丝纤维和复丝纱，可用于矫形，颌面，泌尿，血管，疝修补和组织工程应用中，第二组由涂层和用于疝，血管和泌尿组织修复和组织工程的无涂层，经编网眼构造物。

43. 发明授权

US07264822B2 Conjugated drug-polymer coated stent 有权
标题翻译：共轭药物聚合物涂层支架
公开(公告)号：US07264822B2
公开(公告)日：2007-09-04
申请号：US10116458
申请日：2002-04-03
申请人： Shalaby W. Shalaby , Todd Campbell
发明人： Shalaby W. Shalaby , Todd Campbell
IPC分类号： A61F2/00 , A61K31/34 , A61K31/335 , A61M31/00
CPC分类号： A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： One aspect of the invention is a system for treating vascular conditions, including a catheter, a stent coupled to the catheter, and a polymeric coating on the stent comprising at least one conjugated drug. Each conjugated drug includes a control agent and a bioactive agent, where the control agent controls the elution rate of the bioactive agent.
摘要翻译：本发明的一个方面是用于治疗血管病症的系统，包括导管，与导管联接的支架，以及包含至少一种缀合药物的支架上的聚合物涂层。每种共轭药物包括对照剂和生物活性剂，其中控制剂控制生物活性剂的洗脱速率。

44. 发明授权

US07244445B2 Conformable, absorbable, solid composite preforms and their use for bone tissue engineering 有权
标题翻译：合适的，可吸收的，固体复合预成型件及其在骨组织工程中的应用
公开(公告)号：US07244445B2
公开(公告)日：2007-07-17
申请号：US10626894
申请日：2003-07-24
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61F2/00 , A61F2/28
CPC分类号： A61L27/58 , A61L24/0042 , A61L24/0084 , A61L24/0094 , A61L27/46 , A61L27/48 , A61L2430/02 , C08L67/04
摘要： The present invention is directed to an absorbable, conformable composite preform for use in making a solid bone filler which is an absorbable mixture of oppositely charged, solid microparticulate polyelectrolytes encased in a sealed, flexible, absorbable copolyester fabric construct and is capable of undergoing solidification to a solid, integral mass having a modulus of more than about 0.5 GPa upon contact with an aqueous medium. In an alternative embodiment the absorbable copolyester fabric construct is filled with a mixture of a microparticulate zincophosphate glass or glass-ceramic and at least one material carrying both acidic and basic groups on the same molecule.
摘要翻译：本发明涉及一种用于制造固体骨填料的可吸收，可贴合的复合预型件，固体骨填料是包裹在密封的，柔性的可吸收的共聚酯织物构造体中的相反电荷的固体微粒聚电解质的可吸收混合物，并且能够进行固化与水性介质接触时具有大于约0.5GPa的模量的固体，整体的质量。在另一个实施方案中，可吸收的共聚酯织物构造体填充有微粒状磷酸锌玻璃或玻璃陶瓷与在同一分子上承载酸性和碱性基团的至少一种材料的混合物。

45. 发明授权

US06794485B2 Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom 有权
公开(公告)号：US06794485B2
公开(公告)日：2004-09-21
申请号：US10285040
申请日：2002-10-31
申请人： Shalaby W. Shalaby , Torbjorn Mathisen
发明人： Shalaby W. Shalaby , Torbjorn Mathisen
IPC分类号： C08G6308
CPC分类号： A61L17/12 , A61L31/06 , C08G63/08 , C08G63/64 , C08L67/04
摘要： An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.

46. 发明授权

US06794364B2 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效
标题翻译：聚（2-氨基-2-脱氧-D-葡萄糖）N-酰化衍生物和多肽的离子分子共轭物
公开(公告)号：US06794364B2
公开(公告)日：2004-09-21
申请号：US10251018
申请日：2002-09-20
申请人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
发明人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
IPC分类号： A61K3800
CPC分类号： C08B37/003 , A61K38/31 , A61K47/61 , C08L5/08 , C08L2666/02
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
摘要翻译：包含N-酰化衍生物的共聚物和包含所述共聚物和多肽的组合物，所述多肽包含至少一种有效的离子型胺，其中存在于所述组合物中的所述多肽的至少50重量％离子地结合到所述聚合物。

47. 发明授权

US06780799B2 Antimicrobial fabrics 有权
标题翻译：抗菌面料
公开(公告)号：US06780799B2
公开(公告)日：2004-08-24
申请号：US10453804
申请日：2003-06-03
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： B32B2704
CPC分类号： D06M13/236 , A01N25/10 , A01N25/34 , A01N59/12 , D06M16/00 , D06M2101/20 , Y10T428/2915 , Y10T442/20 , Y10T442/2525 , Y10T442/2762 , Y10T442/2861 , Y10T442/2893 , Y10T442/2918 , Y10T442/60 , A01N31/16 , A01N33/12 , A01N47/44 , A01N59/16 , A01N63/02 , A01N2300/00
摘要： The present invention is directed to surface functionalized fabrics, particularly those based on non-woven polypropylene, wherein the functional groups are capable of binding antimicrobial agents through ionic conjugation to control their release and prolong their antimicrobial activity. The invention also deals with Nylon 6 fabric that is complexed with iodine to control its release and to achieve prolonged antimicrobial activities. Similarly, polypropylene and cellulosic fabrics grafted with N-vinylpyrrolidone are disclosed. The N-vinylpyrrolidone can also complex with iodine to control its release and provide antimicrobial activity over desired periods of time.
摘要翻译：本发明涉及表面官能化织物，特别是基于非织造聚丙烯的织物，其中官能团能够通过离子缀合结合抗微生物剂以控制其释放并延长其抗微生物活性。本发明还涉及与碘络合以控制其释放并实现延长的抗微生物活性的尼龙6织物。类似地，公开了用N-乙烯基吡咯烷酮接枝的聚丙烯和纤维素织物。 N-乙烯基吡咯烷酮也可以与碘络合以控制其释放并在期望的时间段内提供抗微生物活性。

48. 发明授权

US06034198A Modified soy protein and thermoplastic articles therefrom 失效
标题翻译：改性大豆蛋白和热塑性制品
公开(公告)号：US06034198A
公开(公告)日：2000-03-07
申请号：US710203
申请日：1996-09-13
申请人： Shalaby W. Shalaby , Alice H. Brandenburg
发明人： Shalaby W. Shalaby , Alice H. Brandenburg
IPC分类号： A23J3/16 , C08H1/00 , C08L89/00 , A23J1/14 , C08H1/02 , H01L29/76
CPC分类号： A23J3/16 , C08H1/00 , C08L89/00
摘要： The invention relates to a process of chemically modifying soy protein to produce a thermoplastic material. An aqueous alkaline solution of soy protein is mixed with an organic solution of an alkyl or alkenyl succinic anhydride to acylate the protein's amine and hydroxyl groups. The acylated proteins behave as materials capable of forming films with controlled water solubility water vapor permeability. Useful acylating agents include octenyl succinic anhydride (OSA), dodecenyl succinic anhydride (DDSA), and octadecenyl succinic anhydride (ODSA).
摘要翻译：本发明涉及一种化学改性大豆蛋白以生产热塑性材料的方法。将大豆蛋白质的碱性水溶液与烷基或链烯基琥珀酸酐的有机溶液混合以酰化蛋白质的胺和羟基。酰化蛋白质表现为能够形成具有受控水溶性水蒸汽渗透性的膜的材料。有用的酰化剂包括辛烯基琥珀酸酐（OSA），十二碳烯基琥珀酸酐（DDSA）和十八碳烯基琥珀酸酐（ODSA）。

49. 发明授权

US5849415A Molecularly bonded inherently conductive polymers on substrates and shaped articles thereof 失效
标题翻译：分子结合的固有导电聚合物在基材和其成型制品上
公开(公告)号：US5849415A
公开(公告)日：1998-12-15
申请号：US687641
申请日：1996-07-26
申请人： Shalaby W. Shalaby , Richard V. Gregory , Jacqueline M. Allan
发明人： Shalaby W. Shalaby , Richard V. Gregory , Jacqueline M. Allan
IPC分类号： C08G61/12 , C08J7/04 , C08J7/12 , C23C14/20 , B32B27/06
CPC分类号： C08J7/047 , C08G61/124 , C08J7/12 , C23C14/20 , C08J2323/02 , C08J2465/00 , Y10T428/31504 , Y10T428/31533 , Y10T428/31536 , Y10T428/31551 , Y10T428/31609 , Y10T428/31678 , Y10T428/31692 , Y10T428/31725 , Y10T428/31786 , Y10T428/31935
摘要： Organic inherently conductive polymers, such as those based on polyaniline, polypyrrole and polythiophene, are formed in-situ onto polymeric surfaces that are chemically activated to bond ionically the conductive polymers to the substrates. The polymeric substrate is preferably a preshaped or preformed thermoplastic film, fabric, or tube, although other forms of thermoplastic and thermoset polymers can be used as the substrates for pretreatment using, most preferably, phosphonylation-based processes followed by exposure to an oxidatively polymerizable compound capable of forming an electrically conductive polymer. The resultant conductive surface imparts unique properties to the substrates and allows their use in antistatic clothing, surface conducting films for electronic components and the like, and electromagnetic interference shielding. In an alternative embodiment, metals such as gold or platinum are bonded to the chemically interactive surface of a preshaped thermoplastic or thermoset article.
摘要翻译：有机固有导电聚合物，例如基于聚苯胺，聚吡咯和聚噻吩的聚合物原位形成在化学活化的聚合物表面上，以将导电聚合物离子地键合到基底上。聚合物基材优选为预成型或预成型的热塑性薄膜，织物或管，尽管其它形式的热塑性和热固性聚合物可用作预处理的底物，最优选基于膦酰基化的方法，随后暴露于氧化可聚合化合物能够形成导电聚合物。所得到的导电表面赋予基底独特的性能，并且允许它们用于抗静电服装，用于电子部件的表面导电膜等以及电磁干扰屏蔽。在替代实施例中，诸如金或铂的金属结合到预成型的热塑性塑料或热固性制品的化学相互作用的表面上。

50. 发明授权

US5691444A Functionalized crystalline polylactones as tougheners for thermosetting resins 失效
标题翻译：官能化结晶聚内酯作为热固性树脂的增韧剂
公开(公告)号：US5691444A
公开(公告)日：1997-11-25
申请号：US567843
申请日：1995-12-06
申请人： Shalaby W. Shalaby , Lance A. Monroe
发明人： Shalaby W. Shalaby , Lance A. Monroe
IPC分类号： C08G63/91 , C08L33/06 , C08L67/04 , C08L67/06 , C08G63/82
CPC分类号： C08L33/06 , C08G63/918 , C08L67/06 , C08L67/04
摘要： A crystalline polylactone is produced having reactive acrylate end groups. When incorporated into a thermosetting resin which includes reactive C.dbd.CH.sub.2 sites, the present functionalized polylactone acts as a toughener, greatly increasing the impact resistance of the final cured product. Also disclosed are carboxyl-bearing polylactones as tougheners for epoxy resin systems.
摘要翻译：生产具有反应性丙烯酸酯端基的结晶聚内酯。当结合到包含反应性C = CH 2位点的热固性树脂中时，本发明的官能化聚内酯作为增韧剂，大大增加了最终固化产物的耐冲击性。还公开了作为环氧树脂体系的增韧剂的含羧基的聚内酯。

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