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1. 发明申请

US20080306494A1 Mesh implant with an interlocking knitted structure 有权
标题翻译：网状植入物具有互锁针织结构
公开(公告)号：US20080306494A1
公开(公告)日：2008-12-11
申请号：US11808563
申请日：2007-06-11
申请人： Henrik Magnusson , Torbjorn Mathisen
发明人： Henrik Magnusson , Torbjorn Mathisen
IPC分类号： A61B17/08 , A61B17/58
CPC分类号： A61F2/0063 , A61F2250/003 , D04B21/12
摘要： A resorbable polymeric mesh implant is provided for use in the reconstruction of soft tissue defects. The mesh implant is provided with an interlocking knitted structure comprising two or more sets of fibers with different times of degradation, allowing a stepwise increase in the relative distension of the overall mesh over time. The filamentous fibers are knitted together, wherein the filaments of the first set of fibers are interlaced into the filaments of the second set of fibers and at least partly traverse the knit pattern of the second set of fibers such that the filaments of the first set of fibers lock the movement of the part of the mesh formed by the second set of fibers.
摘要翻译：提供可再吸收的聚合物网状植入物用于重建软组织缺陷。网眼植入物具有互锁针织结构，其包括具有不同降解时间的两组或更多组纤维，允许随着时间的推移逐渐增加整个网状物的相对膨胀。丝状纤维编织在一起，其中第一组纤维的长丝交织成第二组纤维的长丝，并且至少部分地横过第二组纤维的编织图案，使得第一组纤维的长丝纤维锁定由第二组纤维形成的网的部分的运动。

2. 发明申请

US20070299542A1 Mesh implant for use in reconstruction of soft tissue defects 有权
标题翻译：网状植入物用于重建软组织缺损
公开(公告)号：US20070299542A1
公开(公告)日：2007-12-27
申请号：US11472563
申请日：2006-06-22
申请人： Torbjorn Mathisen , Henrik Magnusson
发明人： Torbjorn Mathisen , Henrik Magnusson
IPC分类号： A61F2/02
CPC分类号： A61F2/0063
摘要： The present invention relates to a resorbable polymeric mesh implant, that is intended to be used in the reconstruction of soft tissue defects. The mesh implant comprises at least a first and a second material, wherein the second material is substantially degraded at a later point in time than the first material following the time of implantation. The mesh implant is adapted to have a predetermined modulus of elasticity that gradually is decreased until the mesh implant is completely degraded and subsequently resorbed. Due to the gradual decrease in the modulus of elasticity of the inventive mesh implant, the regenerating tissue may gradually take over the load applied to the tissue defect area.
摘要翻译：本发明涉及可再吸收的聚合物网状植入物，其旨在用于重建软组织缺陷。网状植入物包括至少第一和第二材料，其中在植入时间之后，第二材料在稍后的时间点比第一材料基本上劣化。网状植入物适于具有逐渐降低的预定的弹性模量，直到网状植入完全降解并随后再吸收。由于本发明的网状植入物的弹性模量的逐渐降低，再生组织可逐渐地承受施加于组织缺损区域的负荷。

3. 发明申请

US20060205910A1 Polyureaurethane material and method of producing a polyureaurethane material 审中-公开
标题翻译：聚脲氨酯材料及其制备方法
公开(公告)号：US20060205910A1
公开(公告)日：2006-09-14
申请号：US11076039
申请日：2005-03-10
申请人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
发明人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
IPC分类号： C08G18/00
CPC分类号： C08G18/4277 , C08G18/10 , C08G18/73 , C08G18/7621 , C08G18/7664 , C08G18/771 , C08G2230/00 , C08G18/302
摘要： The present invention relates to a linear polyureaurethane polymer, comprising in its hard blocks, at least two urea groups. The hard block of the polyureaurethane material is preferably synthesized by using diisocyante groups in the form of lysine diisocyanate (LDI). The soft block component of the polyureaurethane material is preferably poly(epsilon-caprolactone) (PCL). The invention also relates to a method of producing a polyureaurethane polymer, which in short comprises the steps of reacting a soft block component with a diisocyante group in order to prepare a prepolymer component, combining the prepolymer component with a catalyst in order to define a reaction solution and adding water to the reaction solution, preferably carried to the reaction solution in vapour phase.
摘要翻译：线性聚脲聚氨酯聚合物本发明涉及一种在其硬块中包含至少两个脲基的线型聚脲氨酯聚合物。优选通过使用赖氨酸二异氰酸酯（LDI）形式的二异氰酸酯基团来合成聚脲氨酯材料的硬块。聚脲氨酯材料的软嵌段成分优选为聚（ε-己内酯）（PCL）。本发明还涉及一种制备聚脲氨酯聚合物的方法，其中包括以下步骤：使软嵌段组分与二异氰酸酯基反应，以制备预聚物组分，将预聚物组分与催化剂组合以限定反应溶液并向反应溶液中加入水，优选以气相方式携带到反应溶液中。

4. 发明申请

US20080302682A1 POUCH FOR TOBACCO OR TOBACCO SUBSTITUTE 审中-公开
标题翻译： FOR。。。。。。。。。。。。。。。。
公开(公告)号：US20080302682A1
公开(公告)日：2008-12-11
申请号：US11761084
申请日：2007-06-11
申请人： Thomas Engstrom , Torbjorn Mathisen
发明人： Thomas Engstrom , Torbjorn Mathisen
IPC分类号： A24F23/02
CPC分类号： A24B13/00
摘要： A smokeless tobacco product adapted for oral administration includes a permeable pouch adapted for administration into a user's mouth and adapted to be removed from the mouth and disposed in nature and smokeless tobacco contained in the pouch. The pouch is made from a degradable polymer whose degradation properties allow the pouch to be essentially intact until the time of disposal and allow the pouch to degrade in nature after disposal.
摘要翻译：适于口服给药的无烟烟草制品包括适于施用于使用者口中的可渗透小袋，并适于从口中移出并在自然界中放置并且包含在袋中的无烟烟草。该袋由可降解的聚合物制成，其降解性质允许袋基本上完整，直到处理时间并且在处理后允许袋在性质上降解。

5. 发明授权

US07070858B2 Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom 有权
公开(公告)号：US07070858B2
公开(公告)日：2006-07-04
申请号：US10630320
申请日：2003-07-30
申请人： Shalaby W. Shalaby , Torbjorn Mathisen
发明人： Shalaby W. Shalaby , Torbjorn Mathisen
IPC分类号： C08G63/08 , C08G69/08 , A61B17/00
CPC分类号： C08G63/64 , A61L17/12 , A61L31/06 , C08G63/08 , Y10T428/13 , Y10T428/139 , Y10T428/31504 , Y10T428/31786 , C08L67/04
摘要： An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.

6. 发明申请

US20080114395A1 Closure Device 审中-公开
标题翻译：封闭装置
公开(公告)号：US20080114395A1
公开(公告)日：2008-05-15
申请号：US11813328
申请日：2006-01-11
申请人： Torbjorn Mathisen , Per Egnelov
发明人： Torbjorn Mathisen , Per Egnelov
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00659
摘要： The invention relates to a medical sealing device (1) for the sealing of a puncture hole in a vessel wall, and comprises an inner member (2), which is adapted to be positioned at an interior surface of the vessel wall, and an outer member (3), which is adapted to be positioned outside the vessel wall, the inner member (2) and the outer member (3) being held together by a retaining member (4). The sealing device (1) comprises further a haemostatic agent (5), which can be provided at an inner side of the outer member (3) to improve the sealing performance of the sealing device (1).
摘要翻译：本发明涉及一种用于在血管壁中密封穿刺孔的医疗密封装置（1），并且包括适于定位在血管壁内表面的内部构件（2）构件（3），其适于定位在容器壁外部，内部构件（2）和外部构件（3）通过保持构件（4）保持在一起。密封装置（1）还包括止血剂（5），其可以设置在外部构件（3）的内侧，以提高密封装置（1）的密封性能。

7. 发明申请

US20060142786A1 Mesh implant for use in reconstruction of soft tissue defects 有权
标题翻译：网状植入物用于重建软组织缺损
公开(公告)号：US20060142786A1
公开(公告)日：2006-06-29
申请号：US11019534
申请日：2004-12-23
申请人： Torbjorn Mathisen , Henrik Magnusson
发明人： Torbjorn Mathisen , Henrik Magnusson
IPC分类号： A61B17/08
CPC分类号： A61L27/58 , A61F2/0063 , A61F2210/0004 , A61F2240/001 , A61F2250/0018 , A61F2250/003 , A61L27/48 , A61L27/56 , A61L31/125 , A61L31/129 , A61L31/148
摘要： The present invention relates to a resorbable polymeric mesh implant, that is intended to be used in the reconstruction of soft tissue defects. The mesh implant comprises at least a first and a second material, wherein the second material is substantially degraded at a later point in time than the first material following the time of implantation. The mesh implant is adapted to have a predetermined modulus of elasticity that gradually is decreased until the mesh implant is completely degraded and subsequently resorbed. Due to the gradual decrease in the modulus of elasticity of the inventive mesh implant, the regenerating tissue may gradually take over the load applied to the tissue defect area.
摘要翻译：本发明涉及可再吸收的聚合物网状植入物，其旨在用于重建软组织缺陷。网状植入物包括至少第一和第二材料，其中在植入时间之后，第二材料在稍后的时间点比第一材料基本上劣化。网状植入物适于具有逐渐降低的预定的弹性模量，直到网状植入完全降解并随后再吸收。由于本发明的网状植入物的弹性模量的逐渐降低，再生组织可逐渐地承受施加于组织缺损区域的负荷。

8. 发明申请

US20050169974A1 Dissolvable medical sealing device 有权
标题翻译：可溶性医用密封装置
公开(公告)号：US20050169974A1
公开(公告)日：2005-08-04
申请号：US10513688
申请日：2003-04-24
申请人： Lars Tenerz , Dan Akerfeldt , Torbjorn Mathisen
发明人： Lars Tenerz , Dan Akerfeldt , Torbjorn Mathisen
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61B17/064 , A61B17/08 , A61L15/00
CPC分类号： A61B17/0057 , A61B17/0643 , A61B2017/00004 , A61B2017/00615 , A61B2017/00659 , A61B2017/00778 , A61B2017/0647 , A61K9/0024 , A61L17/06 , A61L17/10 , A61L26/0009 , A61L26/0061 , A61L31/04 , A61L31/042 , A61L31/148
摘要： The present invention provides a dissolvable medical sealing device (3, 4; 6, 7; 9) for closing a wound in vessel. A sealing device (3, 4, 6, 7, 9) according to the invention is made of a material that dissolves by means of physical processes, rather than by means of chemical or biological processes. Such a sealing device (3, 4; 6, 7; 9) can be made of polyethylene glycol, polypropylene glycol, copolymers containing ethylene glycol and propylene glycol, polyvinyl alcohol or polyvinyl pyrolidone, or any combinations thereof.
摘要翻译：本发明提供一种用于封闭血管中的伤口的可溶解医用密封装置（3,4; 6,7; 9）。根据本发明的密封装置（3,4,6,7,9）由通过物理过程而不是通过化学或生物过程溶解的材料制成。这种密封装置（3,4; 6,7; 9）可以由聚乙二醇，聚丙二醇，含有乙二醇和丙二醇的共聚物，聚乙烯醇或聚乙烯基吡咯烷酮或其任何组合制成。

9. 发明申请

US20050010279A1 Stent 失效
标题翻译：支架
公开(公告)号：US20050010279A1
公开(公告)日：2005-01-13
申请号：US10501536
申请日：2002-12-18
申请人： Lars Tenerz , Par von Malmborg , Torbjorn Mathisen
发明人： Lars Tenerz , Par von Malmborg , Torbjorn Mathisen
IPC分类号： A61F2/84 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/90
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558 , A61F2210/0004 , A61F2230/0054 , A61F2250/003
摘要： Expandable stent for insertion into a body passage having a mesh structure of interconnecting portions (6) joined together by joining portions (5). The stent, when inserted into said body passage, is adapted to dissolve into smaller parts, wherein the joining portions dissolve faster than the interconnecting portions. In a preferred embodiment the joining portions are made from a first material and the interconnecting portions are made from a second material different from said first material, wherein the first material dissolves faster than said second material.
摘要翻译：用于插入具有通过接合部分（5）连接在一起的互连部分（6）的网状结构的主体通道中的可扩展支架。当插入到所述体通道中时，支架适于溶解成更小的部分，其中接合部分比互连部分更快地溶解。在优选实施例中，接合部分由第一材料制成，并且互连部分由不同于所述第一材料的第二材料制成，其中第一材料比所述第二材料更快地溶解。

10. 发明申请

US20060211839A1 Polyureaurethane material and method of producing a polyureaurethane material 审中-公开
标题翻译：聚脲氨酯材料及其制备方法
公开(公告)号：US20060211839A1
公开(公告)日：2006-09-21
申请号：US11356441
申请日：2006-02-17
申请人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
发明人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
IPC分类号： C08G18/00
CPC分类号： C08G18/10 , C08G18/4277 , C08G18/73 , C08G18/7621 , C08G18/7664 , C08G18/771 , C08G2230/00 , C08G18/302
摘要： The present invention relates to a linear polyureaurethane polymer, produced without the use of any chain extender. The hard block of the resulting polymer thus consists of diisocyante groups linked to each other via without the presence of any chain extender component. The hard block of the polyureaurethane material is preferably synthesized by using diisocyante groups in the form of lysine diisocyanate (LDI). The soft block component of the polyureaurethane material is preferably poly(epsilon-caprolactone) (PCL). The invention also relates to a method of producing a polyureaurethane polymer, which in short comprises the steps of reacting a soft block component with a diisocyante group in order to prepare a prepolymer component, combining the prepolymer component with a catalyst in order to define a reaction solution and adding water to the reaction solution, preferably carried to the reaction solution in vapour phase.
摘要翻译：本发明涉及在不使用任何扩链剂的情况下生产的线型聚脲聚氨酯聚合物。因此，所得聚合物的硬嵌段由相互连接的二异氰酸酯基组成，而不存在任何扩链剂组分。优选通过使用赖氨酸二异氰酸酯（LDI）形式的二异氰酸酯基团来合成聚脲氨酯材料的硬块。聚脲氨酯材料的软嵌段成分优选为聚（ε-己内酯）（PCL）。本发明还涉及一种制备聚脲氨酯聚合物的方法，其中包括以下步骤：使软嵌段组分与二异氰酸酯基反应，以制备预聚物组分，将预聚物组分与催化剂组合以限定反应溶液并向反应溶液中加入水，优选以气相方式携带到反应溶液中。

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