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41. 发明授权

US08119768B2 Compositions and methods for modulating AMPA receptor-mediated excitotoxicity 有权
标题翻译：用于调节AMPA受体介导的兴奋性毒性的组合物和方法
公开(公告)号：US08119768B2
公开(公告)日：2012-02-21
申请号：US12310558
申请日：2007-08-31
申请人： Fang Liu
发明人： Fang Liu
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention provides AMPAR excitotoxicity mediating polypeptides comprising the GluR2 NT1-3-2 (Y142-K172) amino acid sequence (SEQ ID NO:1) or the GAPDH(2-2-1-1) (I221-E250) amino acid sequence (SEQ ID NO:2). Also disclosed are nucleotide sequences encoding the polypeptides, methods of inhibiting GAPDH association with the GluR2 subunit or p53. Methods of inhibiting AMPA receptor mediated excitotoxicity using the polypeptides and nucleic acids are also disclosed.
摘要翻译：本发明提供AMPAR兴奋性毒性介导包含GluR2 NT1-3-2（Y142-K172）氨基酸序列（SEQ ID NO：1）或GAPDH（2-2-1-1）（I221-E250）氨基酸的多肽序列（SEQ ID NO：2）。还公开了编码多肽的核苷酸序列，抑制与GluR2亚基或p53的GAPDH结合的方法。还公开了使用多肽和核酸抑制AMPA受体介导的兴奋性毒性的方法。

42. 发明申请

US20110241430A1 METHOD FOR CONTROLLING SYSTEM GAIN OF UPS 审中-公开
标题翻译：控制UPS系统增益的方法
公开(公告)号：US20110241430A1
公开(公告)日：2011-10-06
申请号：US13080341
申请日：2011-04-05
申请人： Fang Liu , Zhongjun Wei , Xiaoyu MI , Xunbin Wu
发明人： Fang Liu , Zhongjun Wei , Xiaoyu MI , Xunbin Wu
IPC分类号： H02J9/00
CPC分类号： H02M3/3376 , H02J9/062 , H02M2001/0058 , Y02B70/1433 , Y02B70/1491 , Y02P80/112 , Y10T307/625
摘要： The present invention discloses a control method for the system gain of a UPS, which includes the steps of: S1: detecting a PFC unit so as to determine whether to start an LLC, and if so, then going to step S2; otherwise, going to step S8; S2: starting the LLC; S3: detecting the mains supply so as to determine whether to switch from the mains supply to a battery, and if so, then going to step S4; otherwise, going to step S5; S4: performing a frequency-fixed adjustment on the LLC with an operating frequency larger than a resonating frequency by a preset magnitude while clearing an integral quantity within a first preset time T1; and performing a frequency-fixed adjustment on the LLC with an operating frequency equal to the resonating frequency while clearing the integral quantity between the first preset time T1 and a second preset time T2, and going to step S8; S5: determining whether the LLC-in-series resonant converter has an overload, and if so, then going to step S6; otherwise, going to step S7; S6: performing a frequency-fixed adjustment on the LLC-in-series resonant converter with the operating frequency equal to the resonating frequency while clearing the integral quantity; and going to the step S8; S7: performing a normal PI adjustment on the LLC-in-series resonant converter; and S8: Ending. The operation condition of the PFC is detected in real time, the LLC is started when the PFC becomes abnormal, and the LLC is adjusted in response to a load during operating so that the system gain is maintained in a monotonously step-down region of a ZVS region.
摘要翻译：本发明公开了一种用于UPS的系统增益的控制方法，包括以下步骤：S1：检测PFC单元以确定是否启动LLC，如果是，则进入步骤S2; 否则，进入步骤S8; S2：启动LLC; S3：检测主电源，以确定是否从电源切换到电池，如果是，则进入步骤S4; 否则，进入步骤S5; S4：在第一预设时间T1内清除积分量的情况下，以大于谐振频率的工作频率在LLC上执行频率固定调整预定幅度; 以及在清除第一预设时间T1和第二预设时间T2之间的积分量的情况下，以等于谐振频率的工作频率对LLC进行频率固定调整，并进入步骤S8; S5：确定LLC串联谐振变换器是否有过载，如果是，则进入步骤S6; 否则，进入步骤S7; S6：在清除积分量的同时，将工作频率等于谐振频率的LLC串联谐振变换器进行频率固定调整; 并进入步骤S8; S7：在LLC串联谐振转换器上执行正常的PI调节; 和S8：结束。 PFC实时检测运行状态，当PFC变为异常时，启动LLC，并在运行期间根据负载调整LLC，使系统增益保持在单调降压区域 ZVS区域。

43. 发明申请

US20110230643A1 RECOMBINANT FLAGELLIN PROTEIN AND PREPARATION AND USE THEREOF 有权
标题翻译：重组FLAGELLIN蛋白及其制备及其用途
公开(公告)号：US20110230643A1
公开(公告)日：2011-09-22
申请号：US13122409
申请日：2010-08-09
申请人： Huimin Yan , Fang Liu , Jingyi Yang
发明人： Huimin Yan , Fang Liu , Jingyi Yang
IPC分类号： C07K14/195 , C07K14/255
CPC分类号： C07K14/255 , A61K39/39 , A61K2039/55594
摘要： The present invention provides an optimized recombinant flagellin protein and preparation and use thereof. The protein is with a deletion in the hypervariable region, said hypervariable region is the region from 180 to 400 amino acid of the flagellin protein, and the proteins include FliCΔ190-278, FliCΔ220-320 or FliCΔ180-400. The method of preparing said protein, comprising introducing a deletion into the hypervariable region of the flagellin protein. First constructed the flagellin protein recombinant plasmid, and then used it as template to construct the flagellin deletion cloning, and expressed and purified. The present invention also provides the use of the recombinant flagellin protein as adjuvant. The recombinant flagellin protein in present invention decreases the potential risks it may have, and decreases its antigenicity and immunogenicity and the inflammatory response induced by it, through deleting its main areas of immunogenicity and antigen activity.
摘要翻译：本发明提供优化的重组鞭毛蛋白及其制备和应用。该蛋白质在高变区具有缺失，所述高变区是鞭毛蛋白的180至400个氨基酸的区域，蛋白质包括FliC＆Dgr; 190-278，FliC＆Dgr; 220-320或FliC＆Dgr; 180-400。制备所述蛋白质的方法，包括向鞭毛蛋白的高变区引入缺失。首先构建鞭毛蛋白重组质粒，然后用它作为模板构建鞭毛蛋白缺失克隆，并进行表达纯化。本发明还提供了重组鞭毛蛋白作为佐剂的用途。本发明的重组鞭毛蛋白降低其可能存在的潜在风险，并通过缺失其主要免疫原性和抗原活性区域降低其抗原性和免疫原性及其诱导的炎性反应。

44. 发明申请

US20100179929A1 SYSTEM FOR FINDING QUERIES AIMING AT TAIL URLs 有权
标题翻译：在尾部URL中查找查询的系统
公开(公告)号：US20100179929A1
公开(公告)日：2010-07-15
申请号：US12351013
申请日：2009-01-09
申请人： Xiaoxin Yin , Vijay Ravindran Nair , Ryan Frederick Stewart , Fang Liu , Junhua Wang , Tiffany Kumi Dohzen , Yi-Min Wang
发明人： Xiaoxin Yin , Vijay Ravindran Nair , Ryan Frederick Stewart , Fang Liu , Junhua Wang , Tiffany Kumi Dohzen , Yi-Min Wang
IPC分类号： G06F15/18 , G06N5/02
CPC分类号： G06F17/30864
摘要： Systems and methodologies for improved query classification and processing are provided herein. As described herein, a query prediction model can be constructed from a set of training data (e.g., diagnostic data obtained from an automatic diagnostic system and/or other suitable data) using a machine learning-based technique. Subsequently upon receiving a query, a set of features corresponding to the query, such as the length and/or frequency of the query, unigram probabilities of respective words and/or groups of words in the query, presence of pre-designated words or phrases in the query, or the like, can be generated. The generated features can then be analyzed in combination with the query prediction model to classify the query by predicting whether the query is aimed at a head Uniform Resource Locator (URL) or a tail URL. Based on this prediction, an appropriate index or combination of indexes can be assigned to answer the query.
摘要翻译：本文提供了改进的查询分类和处理的系统和方法。如本文所述，可以使用基于机器学习的技术从一组训练数据（例如，从自动诊断系统获得的诊断数据和/或其他合适的数据）来构建查询预测模型。随后在接收到查询后，查询对应的一组特征，诸如查询的长度和/或频率，查询中各个单词和/或单词组的单位概率，预先指定的单词或短语的存在在查询等中可以生成。然后可以结合查询预测模型分析生成的特征，以通过预测查询是针对头统一资源定位符（URL）还是尾URL来对查询进行分类。基于该预测，可以分配适当的索引或索引组合来回答查询。

45. 发明申请

US20090202862A1 ELECTROPLATED DEVICE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：电镀装置及其制备方法
公开(公告)号：US20090202862A1
公开(公告)日：2009-08-13
申请号：US12305142
申请日：2007-05-28
申请人： Liang Chen , Qing Gong , Yunbo Yi , Fang Liu
发明人： Liang Chen , Qing Gong , Yunbo Yi , Fang Liu
IPC分类号： B32B15/01 , C25D5/10
CPC分类号： C25D5/10 , C25D5/12 , C25D15/02 , Y10T428/12903
摘要： Disclosed is an electroplated product, comprising a base material and an electroplated metal layer including a copper layer on the surface of the base material, wherein the electroplated metal layer further includes a nickel substitute metal layer on the copper layer and the nickel substitute metal is Cu—Sn alloy, Ru, Rh, Pd, or an alloy composed of 2, 3, or 4 elements selected from Ru, Rh, Pd, and Co. A method for preparing the same is also disclosed. The metal electroplated layer of said electroplated product is free of nickel, and therefore will not cause nickel irritation on skin. Furthermore, the electroplated layer also has the advantages of nickel coating, including good smoothness, brightness, wearing resistance, corrosion resistance, and thermal shock resistance, etc.
摘要翻译：公开了一种电镀产品，包括基材和在基材表面上包含铜层的电镀金属层，其中电镀金属层还包括铜层上的镍替代金属层，镍替代金属为Cu -Sn合金，Ru，Rh，Pd或由选自Ru，Rh，Pd和Co的2,3或4种元素组成的合金。还公开了其制备方法。所述电镀产品的金属电镀层不含镍，因此不会对皮肤造成镍的刺激。此外，电镀层还具有镍涂层的优点，包括良好的光滑度，亮度，耐磨性，耐腐蚀性和耐热冲击性等。

46. 发明申请

US20070116797A1 Ejector pin and injection mold with the ejector pin 审中-公开
标题翻译：顶针和注射模具带顶针
公开(公告)号：US20070116797A1
公开(公告)日：2007-05-24
申请号：US11287333
申请日：2005-11-23
申请人： Ching-Chang Wang , Chih-Yu Chen , Jian-Guang Huang , Fang Liu
发明人： Ching-Chang Wang , Chih-Yu Chen , Jian-Guang Huang , Fang Liu
IPC分类号： B29C45/22
CPC分类号： B29C45/401
摘要： An ejector pin includes a pin shaft and a pinhead locating on one end of the pin shaft. The pin shaft and the pinhead are eccentric and have different axle centers. The caliber of the pinhead is bigger than that of the pin shaft. An injection mold with the ejector pin includes a pushing board which forms at least one head-receiving cavity and one shaft hole extending from the head-receiving cavity to receive the ejector pin. The head-receiving cavity and the shaft hole are eccentrically arranged. When the injection mold is opened, the ejector pin stretches into a mold housing formed between a female core and a male core of the injection mold and pushed a product out of the mold housing. The ejector pin is fixed in the pushing board to avoid rotating of the ejector pin when pushing the product out of the mold housing.
摘要翻译：顶针包括销轴和位于销轴的一端上的针头。针轴和针头是偏心的，具有不同的轴心。针头的口径大于针轴的口径。具有推出销的注射模具包括形成至少一个头部接纳腔的推动板和从头部接纳腔延伸以接收顶针的一个轴孔。头部接收腔和轴孔偏心布置。当注射模具打开时，推出销伸展到形成在注射模具的阴芯和阳芯之间的模具壳体中，并将产品推出模具外壳。顶推销固定在推板上，以便在将产品推出模具外壳时避免顶针旋转。

47. 发明授权

US06598036B1 Method for serving engineering rules on a network through servlet and applet 有权
标题翻译：通过servlet和applet在网络上提供工程规则的方法
公开(公告)号：US06598036B1
公开(公告)日：2003-07-22
申请号：US09542376
申请日：2000-04-04
申请人： Nanxin Wang , Beverly Joyce Becker , Gregory Allen Kaepp , Fang Liu , Zhengyu Lei , Yan Xue
发明人： Nanxin Wang , Beverly Joyce Becker , Gregory Allen Kaepp , Fang Liu , Zhengyu Lei , Yan Xue
IPC分类号： G06F1518
CPC分类号： G06F17/50 , G06F2217/04
摘要： A method is disclosed for determining the correctness of proposed values or data for engineering parameters. The method incorporates the use of a server side computer and a client side computer connected to each other via an electronic network. The method includes the steps of obtaining a knowledge base of data. The knowledge base is stored on the server side computer. Proposed values or data are generated at the client side computer using an applet. The proposed data is then transmitted over the network from the client side computer to the server side network. The proposed data is then compared against the knowledge base of data using a servlet designed to invoke and utilize computers other than the server side computer that may have rules or facts necessary to test the proposed data. The results are prepared and then transmitted from the server side computer to the client side computer. The client side computer does not require a proprietary application to be resident therein. It merely requires a web browser to access and utilize all of the information resident in the knowledge base stored in the server side computer.
摘要翻译：公开了一种用于确定工程参数的建议值或数据的正确性的方法。该方法包括使用通过电子网络彼此连接的服务器侧计算机和客户端计算机。该方法包括获得数据知识库的步骤。知识库存储在服务器端计算机上。建议的值或数据在客户端计算机上使用小程序生成。所提出的数据然后通过网络从客户端计算机传输到服务器侧网络。然后将所提出的数据与数据的知识库进行比较，该servlet被设计成调用并利用服务器端计算机以外的可能具有测试建议数据所必需的规则或事实的计算机。准备结果，然后从服务器端计算机发送到客户端计算机。客户端计算机不需要驻留在其中的专有申请。它只需要一个网络浏览器来访问和利用驻留在服务器端计算机中存储的知识库中的所有信息。

48. 发明授权

US5672370A Method of producing a dried krill product 失效
标题翻译：生产干磷虾产品的方法
公开(公告)号：US5672370A
公开(公告)日：1997-09-30
申请号：US632832
申请日：1996-04-16
申请人： Timothy Douglas Durance , Fang Liu
发明人： Timothy Douglas Durance , Fang Liu
IPC分类号： A23B4/03 , A23L1/33
CPC分类号： A23B4/03 , Y10S426/805
摘要： A new form of dried krill is provided by a plurality of substantially separate whole dried krill carcasses substantially all of which have a natural red color and sufficient strength and integrity to withstand normal handling without crumbling into small pieces and retain a strong wholesome fish aroma and flavor. The krill are dried by a method wherein a sequence of energy applications are applied at pressures below atmospheric and the surface of the product simultaneously swept by air to remove moisture. During the process the krill are subjected to a tumbling action. The energy applications are preferably microwave energy applications.
摘要翻译：一种新形式的干磷虾由多个基本上分离的全干的磷虾尸体提供，其基本上都具有天然的红色和足够的强度和完整性，可承受正常的处理，而不会破碎成小块，并保持强健的鱼类香气和香味。通过一种方法将磷虾干燥，其中将能量应用序列施加在低于大气压的压力下，并且产品的表面同时被空气扫过以除去水分。在此过程中，磷虾受到滚动的影响。能量应用优选是微波能量应用。

49. 外观设计

USD1035822S1 Solar fountain 有权
公开(公告)号：USD1035822S1
公开(公告)日：2024-07-16
申请号：US29801596
申请日：2021-07-29
申请人： Fang Liu
设计人： Fang Liu
摘要： FIG. 1 is a front view of a solar fountain showing the new design;
FIG. 2 is a back view thereof;
FIG. 3 is a left-side view thereof;
FIG. 4 is a right-side view thereof;
FIG. 5 is a top view thereof;
FIG. 6 is a bottom view thereof; and,
FIG. 7 is a perspective view thereof.
FIG. 8 is a detail view of the portion of the invention encircled in dot-dash lines in FIG. 7.
Broken lines illustrate portions of the solar fountain that form no part of the claimed design. Additional broken lines in FIGS. 7 and 8 designate the detail view areas and form no part of the claimed design.

50. 外观设计

USD970818S1 Mirror 有权
公开(公告)号：USD970818S1
公开(公告)日：2022-11-22
申请号：US29791359
申请日：2022-01-10
申请人： Fang Liu
设计人： Fang Liu

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