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1. 发明授权

US08449891B2 Recombinant flagellin protein and preparation and use thereof 有权
标题翻译：重组鞭毛蛋白及其制备及应用
公开(公告)号：US08449891B2
公开(公告)日：2013-05-28
申请号：US13122409
申请日：2010-08-09
申请人： Huimin Yan , Fang Liu , Jingyi Yang
发明人： Huimin Yan , Fang Liu , Jingyi Yang
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , A61K39/00 , A61K39/02 , A61K39/112 , A61K39/38
CPC分类号： C07K14/255 , A61K39/39 , A61K2039/55594
摘要： The present invention provides an optimized recombinant flagellin protein and preparation and use thereof. The protein is with a deletion in the hypervariable region, said hypervariable region is the region from 180 to 400 amino acid of the flagellin protein, and the proteins include FliCΔ190-278, FliCΔ220-320 or FliCΔ180-400. The method of preparing said protein, comprising introducing a deletion into the hypervariable region of the flagellin protein. First constructed the flagellin protein recombinant plasmid, and then used it as template to construct the flagellin deletion cloning, and expressed and purified. The present invention also provides the use of the recombinant flagellin protein as adjuvant. The recombinant flagellin protein in present invention decreases the potential risks it may have, and decreases its antigenicity and immunogenicity and the inflammatory response induced by it, through deleting its main areas of immunogenicity and antigen activity.
摘要翻译：本发明提供优化的重组鞭毛蛋白及其制备和应用。该蛋白质在高变区具有缺失，所述高变区是鞭毛蛋白的180至400个氨基酸的区域，蛋白质包括FliCDelta190-278，FliCDelta220-320或FliCDelta180-400。制备所述蛋白质的方法，包括向鞭毛蛋白的高变区引入缺失。首先构建鞭毛蛋白重组质粒，然后用它作为模板构建鞭毛蛋白缺失克隆，并进行表达纯化。本发明还提供了重组鞭毛蛋白作为佐剂的用途。本发明的重组鞭毛蛋白降低其可能存在的潜在风险，并通过缺失其主要免疫原性和抗原活性区域降低其抗原性和免疫原性及其诱导的炎性反应。

2. 发明申请

US20110230643A1 RECOMBINANT FLAGELLIN PROTEIN AND PREPARATION AND USE THEREOF 有权
标题翻译：重组FLAGELLIN蛋白及其制备及其用途
公开(公告)号：US20110230643A1
公开(公告)日：2011-09-22
申请号：US13122409
申请日：2010-08-09
申请人： Huimin Yan , Fang Liu , Jingyi Yang
发明人： Huimin Yan , Fang Liu , Jingyi Yang
IPC分类号： C07K14/195 , C07K14/255
CPC分类号： C07K14/255 , A61K39/39 , A61K2039/55594
摘要： The present invention provides an optimized recombinant flagellin protein and preparation and use thereof. The protein is with a deletion in the hypervariable region, said hypervariable region is the region from 180 to 400 amino acid of the flagellin protein, and the proteins include FliCΔ190-278, FliCΔ220-320 or FliCΔ180-400. The method of preparing said protein, comprising introducing a deletion into the hypervariable region of the flagellin protein. First constructed the flagellin protein recombinant plasmid, and then used it as template to construct the flagellin deletion cloning, and expressed and purified. The present invention also provides the use of the recombinant flagellin protein as adjuvant. The recombinant flagellin protein in present invention decreases the potential risks it may have, and decreases its antigenicity and immunogenicity and the inflammatory response induced by it, through deleting its main areas of immunogenicity and antigen activity.
摘要翻译：本发明提供优化的重组鞭毛蛋白及其制备和应用。该蛋白质在高变区具有缺失，所述高变区是鞭毛蛋白的180至400个氨基酸的区域，蛋白质包括FliC＆Dgr; 190-278，FliC＆Dgr; 220-320或FliC＆Dgr; 180-400。制备所述蛋白质的方法，包括向鞭毛蛋白的高变区引入缺失。首先构建鞭毛蛋白重组质粒，然后用它作为模板构建鞭毛蛋白缺失克隆，并进行表达纯化。本发明还提供了重组鞭毛蛋白作为佐剂的用途。本发明的重组鞭毛蛋白降低其可能存在的潜在风险，并通过缺失其主要免疫原性和抗原活性区域降低其抗原性和免疫原性及其诱导的炎性反应。

3. 发明授权

US09119803B2 Carious tooth vaccine and preparation method 有权
标题翻译：龋牙疫苗及其制备方法
公开(公告)号：US09119803B2
公开(公告)日：2015-09-01
申请号：US14234145
申请日：2011-12-29
申请人： Huimin Yan , Wei Shi , Ying Sun , Jingyi Yang
发明人： Huimin Yan , Wei Shi , Ying Sun , Jingyi Yang
IPC分类号： A61K39/09 , A61K39/02 , A61K39/00
CPC分类号： A61K39/092 , A61K39/09 , A61K2039/543 , A61K2039/55594
摘要： The present invention provides a vaccine composition for dental caries caused by S. mutans infection, where the vaccine composition comprises an antigen derived from a surface protein PAc of S. mutans and an adjuvant derived from flagellin. The present invention further provides methods for preparing the vaccine composition. The present invention also provides methods for preventing or curing dental caries caused by S. mutans by administrating to a subject the vaccine composition.
摘要翻译：本发明提供了由变形链球菌感染引起的用于龋齿的疫苗组合物，其中疫苗组合物包含衍生自变形链球菌的表面蛋白PAc的抗原和源自鞭毛蛋白的佐剂。本发明还提供了制备疫苗组合物的方法。本发明还提供了通过向受试者施用疫苗组合物来预防或治愈由变形链球菌引起的龋齿的方法。

4. 发明申请

US20140161836A1 CARIOUS TOOTH VACCINE AND PREPARATION METHOD 审中-公开
标题翻译：重要的真菌疫苗和制备方法
公开(公告)号：US20140161836A1
公开(公告)日：2014-06-12
申请号：US14234145
申请日：2011-12-29
申请人： Huimin Yan , Wei Shi , Ying Sun , Jingyi Yang
发明人： Huimin Yan , Wei Shi , Ying Sun , Jingyi Yang
IPC分类号： A61K39/09
CPC分类号： A61K39/092 , A61K39/09 , A61K2039/543 , A61K2039/55594
摘要： The present invention provides a vaccine composition for dental caries caused by S. mutans infection, where the vaccine composition comprises an antigen derived from a surface protein PAc of S. mutans and an adjuvant derived from flagellin. The present invention further provides methods for preparing the vaccine composition. The present invention also provides methods for preventing or curing dental caries caused by S. mutans by administrating to a subject the vaccine composition.
摘要翻译：本发明提供了由变形链球菌感染引起的用于龋齿的疫苗组合物，其中疫苗组合物包含衍生自变形链球菌的表面蛋白PAc的抗原和源自鞭毛蛋白的佐剂。本发明还提供了制备疫苗组合物的方法。本发明还提供了通过向受试者施用疫苗组合物来预防或治愈由变形链球菌引起的龋齿的方法。

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