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41. 发明授权

US08036747B2 System and method of rapid, comfortable parameter switching in spinal cord stimulation 有权
标题翻译：快速，舒适的脊髓刺激参数切换的系统和方法
公开(公告)号：US08036747B2
公开(公告)日：2011-10-11
申请号：US12506827
申请日：2009-07-21
申请人： James R. Thacker , John D. H. King , Kerry Bradley
发明人： James R. Thacker , John D. H. King , Kerry Bradley
IPC分类号： A61N1/37
CPC分类号： A61N1/36071 , A61N1/0551
摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.
摘要翻译：用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。估计的感知水平是基于以前的刺激结果。然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

42. 发明申请

US20110054567A1 METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE SHIFTING 有权
标题翻译：使用脉冲移位在多通道神经网络系统中避免频率锁定的方法
公开(公告)号：US20110054567A1
公开(公告)日：2011-03-03
申请号：US12550213
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/08
CPC分类号： A61N1/36021 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/04004 , A61B5/0488 , A61B5/1118 , A61B5/112 , A61B5/4812 , A61B5/4836 , A61M5/1723 , A61N1/0529 , A61N1/08 , A61N1/306 , A61N1/36025 , A61N1/36031 , A61N1/36034 , A61N1/3605 , A61N1/3606 , A61N1/36062 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36171 , A61N1/36178
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the pulsed electrical waveforms that will potentially overlap temporally are predicted. Stimulation pulses in the respective pulsed electrical waveforms are temporally shifted in a manner that prevents overlap of the potentially overlapping pulse sets while preventing frequency locking between the timing channels.
摘要翻译：提供了一种用于治疗患者的方法和神经刺激系统。多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。可以预测脉冲电波形内可能在时间上重叠的一组刺激脉冲。相应脉冲电波形中的刺激脉冲以防止可能重叠的脉冲组重叠的方式在时间上移位，同时防止定时通道之间的频率锁定。

43. 发明授权

US07853330B2 Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权
标题翻译：用于确定神经刺激导联的相对位置和取向的装置和方法
公开(公告)号：US07853330B2
公开(公告)日：2010-12-14
申请号：US11938490
申请日：2007-11-12
申请人： Kerry Bradley , James Thacker , Michael Moffitt
发明人： Kerry Bradley , James Thacker , Michael Moffitt
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551 , A61N1/3605 , A61N1/37247
摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.
摘要翻译：一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅基于第一和第二单极阻抗的第二电极和双极性阻抗。

44. 发明申请

US20100057163A1 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 有权
公开(公告)号：US20100057163A1
公开(公告)日：2010-03-04
申请号：US12204136
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/34
CPC分类号： A61N1/0553 , A61N1/0551 , A61N1/36071
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

45. 发明申请

US20090157155A1 GRAPHICAL DISPLAY OF ENVIRONMENTAL MEASUREMENTS FOR IMPLANTABLE THERAPIES 审中-公开
标题翻译：用于可植入治疗的环境测量的图形显示
公开(公告)号：US20090157155A1
公开(公告)日：2009-06-18
申请号：US11959355
申请日：2007-12-18
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/37247 , A61N1/37
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. The electrodes are configured for respectively providing electrical stimulation to tissue of the patient. The method comprises measuring physiological parameter information indicative of the coupling efficiencies between the respective electrodes of the array and the tissue, computing numerical values from the measured physiological parameter information, generating a chart representative of the computed numerical values, and displaying the chart to a user.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电极被配置为分别向患者的组织提供电刺激。该方法包括测量指示阵列和组织的各个电极之间的耦合效率的生理参数信息，根据测量的生理参数信息计算数值，生成表示所计算的数值的图表，以及将图表显示给用户。

46. 发明申请

US20080275515A1 APPARATUS AND METHODS FOR STIMULATING TISSUE 审中-公开
标题翻译：用于刺激组织的装置和方法
公开(公告)号：US20080275515A1
公开(公告)日：2008-11-06
申请号：US12173169
申请日：2008-07-15
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/36185 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/36125
摘要： Apparatus and methods for stimulating tissue employing local current imbalance to facilitate more effective stimulation regimens.
摘要翻译：使用局部电流不平衡刺激组织以促进更有效的刺激方案的装置和方法。

47. 发明授权

US07349738B1 Detecting atrial evoked response 有权
标题翻译：检测心房诱发反应
公开(公告)号：US07349738B1
公开(公告)日：2008-03-25
申请号：US10370815
申请日：2003-02-19
申请人： Kerry Bradley , Laurence S. Sloman
发明人： Kerry Bradley , Laurence S. Sloman
IPC分类号： A61N1/08
CPC分类号： A61N1/371 , A61N1/3716
摘要： A pulse is delivered to the atrium using an electrode configuration that includes at least a pulse cathode electrode. Cardiac activity in the atrium is sensed using a unipolar electrode configuration to provide a sensed signal wherein the unipolar electrode configuration does not include the pulse cathode electrode. A determination as to whether the pulse caused an atrial evoked response is made based on a maximum derivative value of the sensed signal with respect to time, a comparison of the sensed signal to a parameter or an integral of the sensed signal with respect to time.
摘要翻译：使用至少包括脉冲阴极的电极配置将脉冲传送到心房。使用单极电极配置来感测心房中的心脏活动以提供感测信号，其中单极电极配置不包括脉冲阴极电极。基于感测信号相对于时间的最大导数值，感测信号与感测信号相对于时间的参数或积分的比较，确定脉冲是否引起心房诱发反应。

48. 发明申请

US20070239228A1 System and method using multiple timing channels for electrode adjustement during set up of an implanted stimulator device 有权
标题翻译：使用多个定时通道的系统和方法用于在植入的刺激器装置的设置期间进行电极调节
公开(公告)号：US20070239228A1
公开(公告)日：2007-10-11
申请号：US11399876
申请日：2006-04-07
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/00
CPC分类号： A61N1/36125 , A61N1/0526 , A61N1/0551 , A61N1/36185
摘要： Methods using multiple timing channels for electrode adjustment during set up of an implanted stimulator device are disclosed. In one embodiment, at least two conditions of electrodes (i.e., electrode combinations, pulse widths, pulse frequencies, pulse amplitudes) can be “simultaneously” tested by providing each condition in its own timing channel. In a preferred embodiment, the pulses in each of the timing channels are interleaved and non-overlapping to preserve the ability of the patient to assess the therapeutic feel of both and to allow some time between pulses for recovery. As well as allowing two sets of electrode conditions to be gauged at the same time, the technique allows the electrode to be manipulated during set up with ease and with a reduced possibility of providing the patient with erroneous results. For example, the two conditions in the two timing channels can comprise initial and target final conditions, and transitioning between from one to the other during device set up is facilitated as compared to the prior art because concerns with electrodes having inconsistent properties in both conditions are alleviated.
摘要翻译：公开了在植入的刺激器装置的设置期间使用多个定时通道用于电极调节的方法。在一个实施例中，通过在其自己的定时通道中提供每个条件，可以“同时”测试电极的至少两个条件（即，电极组合，脉冲宽度，脉冲频率，脉冲幅度）。在优选实施例中，每个定时通道中的脉冲是交错的和不重叠的，以保持患者评估两者的治疗感觉并且允许用于恢复的脉冲之间的一些时间的能力。同时允许同时测量两组电极条件，该技术允许在设置期间容易地操作电极，并且降低为患者提供错误结果的可能性。例如，两个定时通道中的两个条件可以包括初始和目标最终条件，并且与现有技术相比，便于在设备设置期间从一个到另一个之间的转换，因为在两个条件下具有不一致特性的电极的关注是缓解

49. 发明申请

US20070213795A1 Implantable medical lead 审中-公开
标题翻译：可植入医用铅
公开(公告)号：US20070213795A1
公开(公告)日：2007-09-13
申请号：US10839518
申请日：2004-05-05
申请人： Kerry Bradley , B. Lauro
发明人： Kerry Bradley , B. Lauro
IPC分类号： A61N1/05
CPC分类号： A61N1/0558
摘要： An improved percutaneous lead is provided. The lead has a circumferential, concave neck located on the distal portion of the lead and a stylet lumen traversing through the lead including through the concave neck. The concave neck has a narrower circumference than the remainder of the lead. The concave neck is designed to bend up to 45 degrees with a pre-curved stylet inserted into the stylet lumen. The presence of a concave neck permits the ingrowth of tissue into and around the concave neck, thereby helping to anchor the lead post-implant. The concavity in the neck presents no sharp edges to disrupt the isodiametric lead profile.
摘要翻译：提供改进的经皮引线。引线具有位于引线的远端部分上的周向凹入的颈部，以及穿过引线的探针管，包括穿过凹入的颈部。凹颈的圆周比铅的剩余部分窄。凹入的颈部设计成可以弯曲45度，并将预弯曲的探针插入探针管腔中。凹入颈部的存在允许组织向凹入颈部和周围的向内生长，从而有助于固定植入后引线。颈部凹陷不会有尖锐的边缘破坏等参导线轮廓。

50. 发明授权

US07263402B2 System and method of rapid, comfortable parameter switching in spinal cord stimulation 有权
标题翻译：快速，舒适的脊髓刺激参数切换的系统和方法
公开(公告)号：US07263402B2
公开(公告)日：2007-08-28
申请号：US10212585
申请日：2002-08-05
申请人： James R Thacker , John D King , Kerry Bradley
发明人： James R Thacker , John D King , Kerry Bradley
IPC分类号： A61N1/18
CPC分类号： A61N1/36071 , A61N1/0551
摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.
摘要翻译：用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。估计的感知水平是基于以前的刺激结果。然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

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