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41. 发明申请

US20130102587A1 New Enzyme Inhibitor Compounds 有权
标题翻译：新型酶抑制剂化合物
公开(公告)号：US20130102587A1
公开(公告)日：2013-04-25
申请号：US13634732
申请日：2011-03-14
申请人： David Evans , Allison Carley , Alison Stewart , Michael Higginbottom , Edward Savory , Iain Simpson , Marianne Nilsson , Martin Haraldsson , Erik Nordling , Tobias Koolmeister
发明人： David Evans , Allison Carley , Alison Stewart , Michael Higginbottom , Edward Savory , Iain Simpson , Marianne Nilsson , Martin Haraldsson , Erik Nordling , Tobias Koolmeister
IPC分类号： C07D471/04 , C07D491/08 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D491/08 , C07D498/08 , C07D519/00
摘要： Disclosed are compounds which inhibit SSAO enzyme activity. Also disclosed are pharmaceutical compositions comprising these compounds and the use of these compounds in the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases, immune disorders and the inhibition of tumour growth.
摘要翻译：公开了抑制SSAO酶活性的化合物。还公开了包含这些化合物的药物组合物以及这些化合物在治疗或预防其中抑制SSAO活性有益的医学病症中的用途，例如炎性疾病，免疫疾病和抑制肿瘤生长。

42. 发明申请

US20120266738A1 MUSIC GAME IMPROVEMENTS 审中-公开
标题翻译：音乐游戏改进
公开(公告)号：US20120266738A1
公开(公告)日：2012-10-25
申请号：US13375015
申请日：2010-05-31
申请人： David Evans , Doug Hardy , Robert Wolf
发明人： David Evans , Doug Hardy , Robert Wolf
IPC分类号： G10H7/00
CPC分类号： G09B15/00 , G10H1/368 , G10H2210/051 , G10H2210/091
摘要： The present invention provides a method of processing musical information. A user can perform a musical piece, using a real musical instrument (e.g. a guitar), which is received as audio input. The audio input is then assessed to determine whether it meets various quality standards—for example, whether the user played at the right pitch, at the right time, or at the right volume. If the audio input meets the standards, audio output is then provided of a professional performance of the musical piece, such that it sounds as if the user is performing the professional audio. The standards can be adjusted to different levels, depending on the user's skill on the musical instrument. At an easy level, low standards may be applied, such that even unskilled or beginner musicians can sound like a professional. For more skilled users, the standards may be more difficult to meet. If the user does not meet the quality standards, alternative audio output may be provided, indicating incorrect performance of the musical piece.
摘要翻译：本发明提供一种处理音乐信息的方法。用户可以使用作为音频输入接收的真实乐器（例如吉他）来执行音乐作品。然后评估音频输入以确定其是否符合各种质量标准 - 例如，用户是否以正确的音调，在正确的时间或以正确的音量播放。如果音频输入符合标准，则音乐输出将被提供给音乐作品的专业演奏，使得听起来好像用户正在执行专业音频。根据用户对乐器的技能，可以将标准调整到不同的级别。在一个简单的层面上，可能会采用低标准，即使是不熟练的或初学者的音乐家也可以听起来像一个专业人士。对于更熟练的用户，标准可能更难以满足。如果用户不符合质量标准，则可以提供替代音频输出，指示乐曲的不正确的表现。

43. 发明申请

US20120071540A1 Compositions and Methods Using siRNA Molecules and siRNA Cocktails for the Treatment of Breast Cancer 有权
标题翻译：使用siRNA分子和siRNA鸡尾酒治疗乳腺癌的组合物和方法
公开(公告)号：US20120071540A1
公开(公告)日：2012-03-22
申请号：US13141122
申请日：2009-12-31
申请人： Patrick Y. Lu , David Evans , Jun John Xu
发明人： Patrick Y. Lu , David Evans , Jun John Xu
IPC分类号： C07H21/02 , C12N5/09 , A61P35/04 , A61K31/7105
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/113 , C12N2310/17 , C12N2320/31 , C12N2320/32
摘要： The present invention provides small interfering RNA (siRNA) molecules, compositions containing the molecules, and methods of using the molecules and compositions to treat breast cancer. In one aspect, a multi-targeted siRNAi cocktail is disclosed. The siRNA molecules may be encapsulated in nanoparticles to further enhance their anti-cancer activity. The compositions may also be used in combination with other anti-cancer agents, such as bevacizumab.
摘要翻译：本发明提供小干扰RNA（siRNA）分子，含有该分子的组合物，以及使用该分子和组合物治疗乳腺癌的方法。一方面，公开了一种多靶向siRNAi混合物。 siRNA分子可以包封在纳米颗粒中以进一步增强其抗癌活性。组合物也可以与其它抗癌剂如贝伐珠单抗联合使用。

44. 发明申请

US20120015899A1 MODIFIED PLANT VIRUS PARTICLES AND USES THEREFOR 审中-公开
标题翻译：改良植物病毒颗粒及其用途
公开(公告)号：US20120015899A1
公开(公告)日：2012-01-19
申请号：US13125482
申请日：2009-10-25
申请人： George Lomonossoff , David Evans , Elisabet de los Pinos , Frank Sainsbury
发明人： George Lomonossoff , David Evans , Elisabet de los Pinos , Frank Sainsbury
IPC分类号： A61K31/7068 , C12N1/19 , C12N1/21 , A61P35/00 , C12N5/07
CPC分类号： C07K14/005 , A61K48/00 , C07K2319/85 , C12N7/00 , C12N2770/14023 , C12N2770/14042 , C12N2770/14045 , C12N2795/18123 , C12N2810/00 , C12N2810/10 , C12N2810/405
摘要： Aspects of the invention provide modified virus-like particles that are designed for therapeutic applications. In particular, aspects of the invention provide CCMV coat proteins that are modified to generate virus-like particles, including mosaic virus-like particles, that can package and/or deliver one or more diagnostic and/or therapeutic agents. The invention also provides methods for treating subjects with one or more modified virus-like particles.
摘要翻译：本发明的方面提供被设计用于治疗应用的经修饰的病毒样颗粒。特别地，本发明的方面提供了经修饰以产生病毒样颗粒（包括花叶病毒样颗粒）的CCMV外壳蛋白，其可包装和/或递送一种或多种诊断和/或治疗剂。本发明还提供了用一种或多种经修饰的病毒样颗粒治疗受试者的方法。

45. 发明申请

US20100137674A1 BRACHYTHERAPY TREATMENT OF THE SPINE WITH IRRADIATED IMPLANTS 审中-公开
标题翻译：用紫外线植入物进行脊柱的治疗
公开(公告)号：US20100137674A1
公开(公告)日：2010-06-03
申请号：US12626010
申请日：2009-11-25
申请人： David Evans , William Woodburn
发明人： David Evans , William Woodburn
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61F2/30744 , A61F2/44 , A61F2002/2821 , A61F2002/30405 , A61F2002/30495 , A61F2002/30507 , A61F2002/30551 , A61F2002/30601 , A61F2002/30668 , A61F2002/30785 , A61F2002/30843 , A61F2002/4475 , A61F2220/0025 , A61F2250/0001 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179 , A61N2005/1024
摘要： A spinal implant configured to facilitate focused treatment of spinal tumors includes a plurality of irradiated implant seeds configured to concentrate the dosage and duration of radiation treatment of tumors.
摘要翻译：构造成促进脊柱肿瘤的聚焦治疗的脊柱植入物包括多个照射的种植体种子，其被配置为集中肿瘤的放射治疗的剂量和持续时间。

46. 发明申请

US20080232884A1 METHOD FOR PRINTING ONTO COLOURED SUBSTRATES 审中-公开
标题翻译：打印到彩色基板上的方法
公开(公告)号：US20080232884A1
公开(公告)日：2008-09-25
申请号：US12021771
申请日：2008-01-29
申请人： Trevor SIMMONDS , Gordon Reynen , David Evans
发明人： Trevor SIMMONDS , Gordon Reynen , David Evans
IPC分类号： B41J11/44
CPC分类号： G06K15/02 , G06K15/021 , G06K2215/0082 , G06K2215/0094
摘要： A method for printing an electronic image comprising a plurality of pixels onto a substrate using a computer-assisted image processing system, said method comprising the step of using alpha channel information in combination with substrate color information to calculate the transparency level that needs to be applied to each pixel.
摘要翻译：一种使用计算机辅助图像处理系统将包括多个像素的电子图像打印到基板上的方法，所述方法包括与基底颜色信息结合使用α通道信息以计算需要应用的透明度水平的步骤到每个像素。

47. 发明申请

US20070221975A1 Bipolar switching PCMO capacitor 有权
标题翻译：双极开关PCMO电容
公开(公告)号：US20070221975A1
公开(公告)日：2007-09-27
申请号：US11805177
申请日：2007-05-22
申请人： Tingkai Li , Lawrence Charneski , Wei-Wei Zhuang , David Evans , Sheng Hsu
发明人： Tingkai Li , Lawrence Charneski , Wei-Wei Zhuang , David Evans , Sheng Hsu
IPC分类号： H01L29/92
CPC分类号： H01L45/04 , H01L45/1233 , H01L45/147 , H01L45/1616
摘要： A multi-layer PrxCa1-xMnO3 (PCMO) thin film capacitor and associated deposition method are provided for forming a bipolar switching thin film. The method comprises: forming a bottom electrode; depositing a nanocrystalline PCMO layer; depositing a polycrystalline PCMO layer; forming a multi-layer PCMO film with bipolar switching properties; and forming top electrode overlying the PCMO film. If the polycrystalline layers are deposited overlying the nanocrystalline layers, a high resistance can be written with narrow pulse width, negative voltage pulses. The PCMO film can be reset to a low resistance using a narrow pulse width, positive amplitude pulse. Likewise, if the nanocrystalline layers are deposited overlying the polycrystalline layers, a high resistance can be written with narrow pulse width, positive voltage pulses, and reset to a low resistance using a narrow pulse width, negative amplitude pulse.
摘要翻译：提供了多层Pr 1 x 1 x x MnO 3（PCMO）薄膜电容器和相关的沉积方法，用于形成双极开关薄膜。该方法包括：形成底部电极; 沉积纳米晶体PCMO层; 沉积多晶的PCMO层; 形成具有双极开关特性的多层PCMO膜; 并形成覆盖PCMO膜的顶部电极。如果多晶层沉积在纳米晶层之上，则可以用窄脉冲宽度，负电压脉冲写入高电阻。 PCMO膜可以使用窄脉冲宽度，正幅度脉冲复位为低电阻。同样，如果纳米晶层沉积在多晶层上，则可以用窄脉冲宽度，正电压脉冲写入高电阻，并使用窄脉冲宽度，负幅度脉冲将其复位为低电阻。

48. 发明申请

US20070112867A1 Methods and apparatus for rank-based response set clustering 审中-公开
标题翻译：基于秩的响应集聚类的方法和装置
公开(公告)号：US20070112867A1
公开(公告)日：2007-05-17
申请号：US11272784
申请日：2005-11-15
申请人： David Evans , Victor Sheftel , Jeffrey Bennett , David Hull
发明人： David Evans , Victor Sheftel , Jeffrey Bennett , David Hull
IPC分类号： G06F17/30
CPC分类号： G06F16/355
摘要： A method for identifying clusters of similar documents from among a set of documents is described. A particular document is selected based on rank from among a ranked set of documents, wherein the ranked set of documents are included among available documents of the set of documents. A probe is generated based on the particular document. The probe comprising one or more features. Documents that satisfy a similarity condition are found from among the available documents using a search based upon the probe. Some or all documents found are associated with a particular cluster of documents. The process can be repeated to generate further clusters. The method can be implemented with a computer, and associated programming instructions can be contained within a compute readable carrier.
摘要翻译：描述了从一组文档中识别类似文档的簇的方法。基于排名的一组文档中的等级选择特定文档，其中所述一组文档的排名集合被包括在该组文档的可用文档中。基于特定文档生成探针。该探针包括一个或多个特征。从使用基于探测的搜索的可用文档中找到满足相似性条件的文档。找到的一些或所有文档与特定的文档集群相关联。可以重复该过程以产生更多的聚类。该方法可以用计算机实现，并且相关联的编程指令可以包含在计算可读载体内。

49. 发明申请

US20070005081A1 System, apparatus, and method for fastening tissue 有权
标题翻译：用于紧固组织的系统，装置和方法
公开(公告)号：US20070005081A1
公开(公告)日：2007-01-04
申请号：US11174357
申请日：2005-06-30
申请人： Thomas Findlay , David Evans
发明人： Thomas Findlay , David Evans
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0469 , A61B2017/00243 , A61B2017/00575 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/0488
摘要： A tissue fastening device includes a suture clip holder and a suture cutter. A suture clip can be releasably secured to the suture clip holder, and a suture line or lines can pass through the clip and adjacent the suture cutter. A first movement of a control handle causes the suture clip to be released from the suture clip holder, and a second movement of the control handle causes the suture cutter to cut the suture line or lines. The first movement is different from the second movement. The first movement can be rotational, with the second movement being longitudinal. Alternatively, the first movement can be longitudinal, with the second movement being rotational. The device may include a main body, an inner body, and an outer body.
摘要翻译：组织固定装置包括缝合夹夹持器和缝合线切割器。缝线夹可以可释放地固定到缝合夹保持器，并且缝合线或线可以穿过夹子并且邻近缝合线切割器。控制手柄的第一运动使得缝合夹从缝合夹夹持器释放，并且控制手柄的第二运动使得缝合线切割器切割缝合线或线。第一动作不同于第二动作。第一运动可以是旋转的，第二运动是纵向的。或者，第一运动可以是纵向的，第二运动是旋转的。该装置可以包括主体，内部主体和外部主体。

50. 发明申请

US20070000596A1 Methods of Forming Metal Foil Ply Replacement in Composite Structures 有权
标题翻译：在复合结构中形成金属箔层更换方法
公开(公告)号：US20070000596A1
公开(公告)日：2007-01-04
申请号：US11530582
申请日：2006-09-11
申请人： Willard Westre , David Evans , Edward Li , Marc Piehl , Eric Sager
发明人： Willard Westre , David Evans , Edward Li , Marc Piehl , Eric Sager
IPC分类号： B29C70/00
CPC分类号： B32B15/08 , B32B3/14 , B32B7/12 , B32B38/08 , B32B2260/021 , B32B2260/046 , Y02T50/43 , Y10T156/1089 , Y10T156/109 , Y10T156/1092 , Y10T156/1093 , Y10T428/1234 , Y10T428/12444 , Y10T428/19 , Y10T428/192 , Y10T428/197 , Y10T428/24752
摘要： Laminate structures and methods for forming same are disclosed. In one embodiment, a laminate structure includes a metal-polymer composite lamina. The metal-polymer composite lamina has a first face and a second face spaced apart, and extends to a terminal edge. The lamina includes a ply of fiber-reinforced polymer that extends between the first face and the second face and has an interior edge. The interior edge defines at least one cutout. A ply of metal foil extends between the first face and the second face substantially from the interior edge filling the at least one cutout.
摘要翻译：公开了层合结构及其形成方法。在一个实施方案中，层压结构包括金属 - 聚合物复合层。金属 - 聚合物复合薄片具有间隔开的第一表面和第二表面，并且延伸到末端边缘。薄片包括在第一面和第二面之间延伸并具有内部边缘的纤维增强聚合物层。内部边缘限定至少一个切口。一层金属箔基本上从填充至少一个切口的内边缘在第一面和第二面之间延伸。

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