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41. 发明专利

AU2008248605A1 Assays 未知
公开(公告)号：AU2008248605A1
公开(公告)日：2008-11-13
申请号：AU2008248605
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： TUCHSCHEERER JENS , MOBIUS KLAUS-PETER , SCHULZ TORSTEN , KAISER THOMAS , ERMANTRAUT EUGEN , UHLIG THOMAS , SCHWEINSBERG ALEXANDER VON SCHENK ZU
IPC分类号： B01L3/00
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

42. 发明专利

AU2007324494A1 Methods for optically detecting multiple analytes in a liquid sample with a compressible microfluidic device 未知
公开(公告)号：AU2007324494A1
公开(公告)日：2008-05-29
申请号：AU2007324494
申请日：2007-11-22
申请人： CLONDIAG GMBH
发明人： MOBIUS KLAUS PETER , SCHULZ TORSTEN , SCHWEINSBERG ALEXANDER VON SCHENK ZU , UHLIG THOMAS , KAISER THOMAS
IPC分类号： B01L3/00 , G01N33/543
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones are disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

43. 发明专利

AU2020203279B2 ASSAYS 未知
公开(公告)号：AU2020203279B2
公开(公告)日：2022-10-06
申请号：AU2020203279
申请日：2020-05-20
申请人： CLONDIAG GMBH
发明人： ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS , STEINMETZER KATRIN
IPC分类号： B01L3/00 , B01J19/00 , C12Q1/68
摘要： Abstract A device, comprising a reaction chamber which comprises a first binding member adapted for capturing target compounds and a second binding member adapted for capturing reporter compounds indicative of the presence and/or amount of the target compounds, wherein the first binding member comprises synthetic particles, beads or a porous matrix configured to bind complexes of a capture compound and a target compound and wherein the second binding member is a microarray of reporter specific capture compounds arranged on a surface.

44. 发明专利

AU2014200826B2 ASSAYS 未知
公开(公告)号：AU2014200826B2
公开(公告)日：2016-01-14
申请号：AU2014200826
申请日：2014-02-17
申请人： CLONDIAG GMBH
发明人： ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS , STEINMETZER KATRIN
IPC分类号： C12Q1/68 , B01J19/00 , B01L3/00
摘要： Abstract A method, comprising (a) providing an amount of a reporter compound; a first binding member being configured to bind an anchor group of a capture molecule; a 5 second binding member capable of capturing the reporter compound; an amount of a target nucleic acid capable of forming complexes with the reporter compound, the forming of complexes with the reporter compound inhibiting capturing of the reporter compound by the second binding member; and an amount of capture molecules wherein each capture molecule comprises a binding portion specific to a 10 region of the target nucleic acid and an anchor group; (b) forming complexes each comprising a target nucleic acid and a capture molecule; (c) contacting the complexes with the first binding member to bind at least a subset of the complexes to the first binding member; (d) releasing at least a subset of the amount of target nucleic acid from the first binding member; (e) forming complexes of a subset of the 15 amount of reporter compound with at least a subset of the amount of target nucleic acid; (f) capturing a remaining subset of the amount of reporter compound not in complex with a target nucleic acid on the second binding member; and (g) determining a value indicative of the presence and/or amount of reporter compound captured on the second binding member.

45. 发明专利

AU2008248605B2 Assays 未知
公开(公告)号：AU2008248605B2
公开(公告)日：2014-02-20
申请号：AU2008248605
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： MOBIUS KLAUS-PETER , ERMANTRAUT EUGEN , UHLIG THOMAS , TUCHSCHEERER JENS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , SCHULZ TORSTEN , KAISER THOMAS
IPC分类号： B01L3/00
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.

46. 发明专利

DK2089159T3 ANALYSER 未知
公开(公告)号：DK2089159T3
公开(公告)日：2013-04-22
申请号：DK08750065
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS , MOEBIUS KLAUS-PETER
IPC分类号： B01L3/00

47. 发明专利

NZ580395A Microfluidic networks for performing assays 未知
公开(公告)号：NZ580395A
公开(公告)日：2012-02-24
申请号：NZ58039508
申请日：2008-05-05
申请人： CLONDIAG GMBH
发明人： KAISER THOMAS , MOBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
摘要： Disclosed is a device for detecting an analyte, comprising: a) a cartridge having: a microfluidic channel including an inlet and a detection region in fluid communication with the inlet; b) a microfluidic flow path having an at least partially deformable wall and in fluid communication with the detection region of the channel; and c) a cap having: a sealing member configured to seal with the inlet and form a fluid circuit including the inlet, the microfluidic channel and the microfluidic flow path. Also disclosed is a method comprising: a) introducing a liquid sample into an inlet of a microfluidic channel thereby forming a contiguous liquid slug enclosed by the channel and bounded at a first end by a transport fluid, the liquid sample comprising multiple particles, b) sealing a sealing member of a cap with the inlet and thereby forming a fluid circuit such that the transport fluid provides fluid communication between the first and second ends of the liquid slug, c) forming a mixture comprising at least a portion of the liquid sample and an optical label present within the microfluidic channel by applying a differential pressure to the first and second ends of the liquid slug via the transport fluid and thereby moving the liquid slug within the fluid circuit, d) forming multiple complexes, each complex comprising one of the multiple particles and at least one of the optical labels, and e) detecting complexes present within a subset of the mixture.

48. 发明专利

AT538382T 未知
公开(公告)号：AT538382T
公开(公告)日：2012-01-15
申请号：AT07822829
申请日：2007-11-22
申请人： CLONDIAG GMBH
发明人： SCHULZ TORSTEN , KAISER THOMAS , UHLIG THOMAS , MOEBIUS KLAUS PETER , VON SCHENK ZU SCHWEINSBERG ALEXANDER
IPC分类号： G01N33/543 , B01L3/00
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones are disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

49. 发明专利

DE50312579D1 未知
公开(公告)号：DE50312579D1
公开(公告)日：2010-05-12
申请号：DE50312579
申请日：2003-01-16
申请人： CLONDIAG GMBH
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , EHRICHT RALF , MOEBIUS KLAUS PETER , WAGNER GERD , FISCHER JOACHIM , ELLINGER THOMAS
IPC分类号： B01L3/00 , B01J19/00 , B01L3/14 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C12Q1/6837 , C40B40/02 , C40B40/06 , C40B50/06 , C40B60/12 , C40B60/14 , C40B70/00 , G01N21/17 , G01N21/47 , G01N33/53 , G01N33/543 , G01N37/00

50. 发明专利

AT455864T 未知
公开(公告)号：AT455864T
公开(公告)日：2010-02-15
申请号：AT02782459
申请日：2002-07-05
申请人： CLONDIAG GMBH
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , POSER SIEGFRIED , KAISER THOMAS , MOEBIUS KLAUS-PETER , ULLRICH THOMAS , ADELHELM KARIN
IPC分类号： C12Q1/68 , G01N33/483 , B01J19/00 , C12M1/00 , C12N15/09 , C12Q1/6851
摘要： Disclosed is a method for qualitative and/or quantitative detection of nucleic acid molecules amplified in an amplification reaction such as PCR. The change of the mass of oligonucleotides in an amplification solution, comprising the mass of target DNA and optionally, the mass of oligonucleotide primers, is determined during the amplification reaction. Also disclosed is a device for conducting the method.

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