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41. 发明申请

US20120041504A1 APPARATUS FOR REVERSAL OF MYOCARDIAL REMODELING WITH PRE-EXCITATION 有权
标题翻译：用于预先激励改变心肌重塑的装置
公开(公告)号：US20120041504A1
公开(公告)日：2012-02-16
申请号：US13279493
申请日：2011-10-24
申请人： Andrew P. Kramer , Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
发明人： Andrew P. Kramer , Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
IPC分类号： A61N1/368 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译：用电刺激治疗逆转心室重构的装置。通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

42. 发明授权

US08046066B2 Apparatus for reversal of myocardial remodeling with pre-excitation 有权
标题翻译：用于预激发反转心肌重塑的装置
公开(公告)号：US08046066B2
公开(公告)日：2011-10-25
申请号：US12484882
申请日：2009-06-15
申请人： Andrew P. Kramer , Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
发明人： Andrew P. Kramer , Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译：用电刺激治疗逆转心室重构的装置。通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

43. 发明申请

US20110015692A1 COMBINED REMODELING CONTROL THERAPY AND ANTI-REMODELING THERAPY BY IMPLANTABLE CARDIAC DEVICE 有权
标题翻译：可重构心脏器械组合重组控制治疗与抗再感染治疗
公开(公告)号：US20110015692A1
公开(公告)日：2011-01-20
申请号：US12891674
申请日：2010-09-27
申请人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
发明人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
IPC分类号： A61N1/365
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

44. 发明授权

US07869873B2 Method and system for setting cardiac resynchronization therapy parameters 有权
标题翻译：设置心脏再同步治疗参数的方法和系统
公开(公告)号：US07869873B2
公开(公告)日：2011-01-11
申请号：US11681244
申请日：2007-03-02
申请人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译：提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

45. 发明授权

US07292887B2 Apparatus and method for spatially and temporally distributing cardiac electrical stimulation 有权
标题翻译：空间和时间分布心脏电刺激的装置和方法
公开(公告)号：US07292887B2
公开(公告)日：2007-11-06
申请号：US10634232
申请日：2003-08-05
申请人： Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
发明人： Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译：一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力。为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。

46. 发明授权

US07257443B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
标题翻译：用电针信号检测心律的振荡的方法和装置
公开(公告)号：US07257443B2
公开(公告)日：2007-08-14
申请号：US11184325
申请日：2005-07-19
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

47. 发明授权

US07158824B2 Stress reduction pacing for arterial plaque stabilization 失效
标题翻译：用于动脉斑块稳定的应力减轻起搏
公开(公告)号：US07158824B2
公开(公告)日：2007-01-02
申请号：US10664410
申请日：2003-09-16
申请人： Steven D. Girouard , Bruce H. KenKnight , Joseph M. Pastore
发明人： Steven D. Girouard , Bruce H. KenKnight , Joseph M. Pastore
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： A method for stabilizing atherosclerotic plaque with the intra-myocardial portion of a coronary artery is presented. Pacing therapy is utilized to pre-excite ventricular myocardium near the site of a plaque and thereby mechanically unload the myocardial region. Such mechanical unloading results in less deforming stress being transmitted to the plaque during ventricular systole.
摘要翻译：提出了一种用于在冠状动脉内心肌部分稳定动脉粥样硬化斑块的方法。起搏疗法用于预先激发斑块位置附近的心室心肌，从而机械地卸载心肌区域。这种机械卸载导致较少的变形应力在心室收缩期间传递给斑块。

48. 发明授权

US06980851B2 Method and apparatus for determining changes in heart failure status 失效
标题翻译：用于确定心力衰竭状态变化的方法和装置
公开(公告)号：US06980851B2
公开(公告)日：2005-12-27
申请号：US10001223
申请日：2001-11-15
申请人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
发明人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0402
CPC分类号： A61N1/3627 , A61N1/36585
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.
摘要翻译：一种用于操作心律管理装置的方法，其中临床状态矢量被计算为与患者心力衰竭状态相关的多个参数的组合，并且与先前计算的临床状态向量进行比较，以确定指示变化的临床轨迹患者的心力衰竭状态。这种检测到的状态变化可以用作临床工具来评估治疗并自动调整装置的操作。

49. 发明授权

US06842648B2 System and assembly having conductive fixation features 有权
标题翻译：具有导电固定特征的系统和组件
公开(公告)号：US06842648B2
公开(公告)日：2005-01-11
申请号：US10054600
申请日：2002-01-22
申请人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
发明人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0573 , A61N2001/0585
摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.
摘要翻译：一种具有远端电极组件的引线，其适于植入在心脏上或周围的静脉内并且用于连接到用于监测或刺激心脏活动的系统。电极组件包括与非导电固定特征组合的导电固定特征，例如导电尖齿或柔性构件。导电固定特征还包括涂覆有导电材料的尖齿。固定特征还包括可伸缩的导电尖齿。除颤线圈可选地配置在导电尖端的前端，与导电齿结合。

50. 发明授权

US06539257B1 Method and apparatus for treating cardiac arrhythmia 失效
标题翻译：治疗心律失常的方法和装置
公开(公告)号：US06539257B1
公开(公告)日：2003-03-25
申请号：US09660060
申请日：2000-09-12
申请人： Bruce H. KenKnight
发明人： Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3702 , A61B5/0422 , A61N1/3622 , A61N1/3956
摘要： An implantable apparatus for the detection and monitoring of spontaneous cardiac electrogram features in a comprises a cardiac monitoring device and a plurality of subcutaneous cardiac sensing electrodes electrically connected to the monitoring device. The sensing electrodes are configured for sensing cardiac electrogram features when implanted in spatially separate locations in a patient. A storage device contained within the monitoring device is operably associated with the subcutaneous electrodes and stores the cardiac electrogram features. Preferably, the plurality of subcutaneous electrodes are carried by a single elongate lead. A downloading device such as telemetry apparatus or transcutaneous electrical connectors may be provided so that the stored information can be downloaded to a separate apparatus external to the patient. In a preferred embodiment, the apparataus is a defibrillator. Methods of using such apparatus are also disclosed.
摘要翻译：用于检测和监测自发性心电图特征的可植入装置包括心电监测装置和电连接到监测装置的多个皮下心脏感测电极。感测电极被配置用于当植入在患者的空间上分离的位置时感测心脏电图特征。包含在监视装置内的存储装置可操作地与皮下电极相关联并存储心电图特征。优选地，多个皮下电极由单个细长引线承载。可以提供诸如遥测装置或经皮电连接器的下载装置，使得存储的信息可以被下载到患者外部的单独装置。在优选的实施方案中，食物是除颤器。还公开了使用这种装置的方法。

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