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41. 发明授权

US5141752A Delayed drug delivery device 失效
标题翻译：延迟给药装置
公开(公告)号：US5141752A
公开(公告)日：1992-08-25
申请号：US715256
申请日：1991-07-25
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

42. 发明授权

US5126142A Dispenser comprising ionophore 失效
标题翻译：分配器包括离子载体
公开(公告)号：US5126142A
公开(公告)日：1992-06-30
申请号：US641023
申请日：1991-01-11
申请人： Atul D. Ayer , Terry L. Burkoth , Anthony L. Kuczynski , Joseph C. Deters
发明人： Atul D. Ayer , Terry L. Burkoth , Anthony L. Kuczynski , Joseph C. Deters
IPC分类号： A61K9/00
CPC分类号： A61K9/0068 , A61K31/70 , A61K9/0004
摘要： A dispenser is disclosed for delivering a beneficial ionophore to an animal. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising an ionophore and a pharmaceutically acceptable carrier in the space, (3) an expandable hydrophilic composition in the space, (4) a dense member in the space, and (5) at least one exit passageway in the housing for delivering the ionophore from the dispenser.
摘要翻译：公开了用于将有益离子载体输送到动物的分配器。所述分配器包括（1）限定内部空间的半透性外壳，（2）至少一种组合物，其包含所述空间中的离子载体和药学上可接受的载体，（3）所述空间中的可膨胀的亲水性组合物，（4）在空间中，和（5）壳体中的至少一个出口通道，用于从分配器输送离子载体。

43. 发明授权

US4948592A Pulsed drug delivery 失效
标题翻译：脉冲给药
公开(公告)号：US4948592A
公开(公告)日：1990-08-14
申请号：US313211
申请日：1989-02-21
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

44. 发明授权

US4627971A Osmotic device with self-sealing passageway 失效
标题翻译：渗透装置具有自密封通道
公开(公告)号：US4627971A
公开(公告)日：1986-12-09
申请号：US725832
申请日：1985-04-22
申请人： Atul D. Ayer
发明人： Atul D. Ayer
IPC分类号： A61K9/00 , A61K9/26 , A61K9/52 , A61K47/30 , A61J3/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： An osmotic dispensing device is disclosed for delivering a medicine to a biological environment of use. The device comprises a semipermeable wall surrounding a compartment comprising a first layer comprising a beneficial agent formulation and a first passageway in the wall for delivering the beneficial agent formulation from the device, and a second layer of a composition comprising a hydrogel and a means for closing a second passageway formed during the manufacture of the device.
摘要翻译：公开了用于将药物递送到生物生物学环境的渗透分配装置。所述装置包括围绕隔室的半透壁，所述隔室包括第一层，所述第一层包含有益剂制剂和所述壁中的用于从所述装置输送有益剂制剂的第一通道，以及包含水凝胶和用于封闭的装置的组合物的第二层在制造装置期间形成的第二通道。

45. 发明授权

US4008719A Osmotic system having laminar arrangement for programming delivery of active agent 失效
标题翻译：渗透系统具有用于编程递送活性剂的层流布置
公开(公告)号：US4008719A
公开(公告)日：1977-02-22
申请号：US654195
申请日：1976-02-02
申请人： Felix Theeuwes , Atul D. Ayer
发明人： Felix Theeuwes , Atul D. Ayer
IPC分类号： A61F9/00 , A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61F9/0017 , A61K9/0004
摘要： An osmotic system for delivering an agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway for delivering agent from the compartment. The wall is formed of a laminae comprising a lamina consisting of a multiplicity of materials in laminar arrangement with a lamina consisting of a material or of a multiplicity of materials to provide a laminated wall that is permeable to agents and maintains its integrity during the delivery of agent. The compartment contains an agent that is soluble in an external fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or the agent has limited solubility in the fluid and is mixed with an osmotically effective compound soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid. In operation, agent is released from the system by fluid being imbibed through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.
摘要翻译：公开了用于递送试剂的渗透系统。该系统包括围绕隔室的壁，并且具有用于从隔室输送药剂的通道。该壁由薄片形成，该薄片包括由层叠布置的多种材料组成的薄片，该薄片由材料或多种材料组成的薄片组成，以提供层叠壁，所述层压壁可在试剂的输送期间可渗透并保持其完整性代理商隔间含有一种可溶于外部流体的试剂，并且在整个壁上表现出与流体相对的渗透压梯度，或者该试剂在流体中的溶解度有限，并且与可溶于流体的渗透性有效化合物混合并显示出渗透性横跨壁的压力梯度相对于流体。在操作中，通过流体通过壁被吸入到隔室中的流体以由壁的渗透性和穿过壁的渗透压梯度控制的速率从系统释放，产生含溶液的试剂或含化合物的溶液任何操作中的解决方案在长时间内以受控和连续的速率通过通道释放。

46. 发明申请

US20110300217A1 HYDROMORPHONE THERAPY 审中-公开
标题翻译：水疗治疗
公开(公告)号：US20110300217A1
公开(公告)日：2011-12-08
申请号：US13212135
申请日：2011-08-17
申请人： Sonya Merrill , Atul D. Ayer , Navjot Chadha , Anthony L. Kuczynsid
发明人： Sonya Merrill , Atul D. Ayer , Navjot Chadha , Anthony L. Kuczynsid
IPC分类号： A61K9/22 , A61P25/00 , A61K9/36 , A61K31/485
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/485
摘要： A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.
摘要翻译：公开了用于治疗疼痛的氢吗啡酮组合物，氢吗啡酮剂型和用于给予氢吗啡酮的方法。

47. 发明授权

US06284274B1 Analgesic tablet compositions 失效
标题翻译：止痛片组合物
公开(公告)号：US06284274B1
公开(公告)日：2001-09-04
申请号：US09518584
申请日：2000-03-03
申请人： Sonya Merrill , Atul D. Ayer , Paul M. Hwang , Anthony L. Kuczynski , Nils W. Ahlgren , Deborah J. Johnson
发明人： Sonya Merrill , Atul D. Ayer , Paul M. Hwang , Anthony L. Kuczynski , Nils W. Ahlgren , Deborah J. Johnson
IPC分类号： A61K924
CPC分类号： A61K9/2054 , A61K9/0004 , A61K9/2009 , A61K9/2027 , A61K9/2031 , A61K31/485
摘要： An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
摘要翻译：公开了一种阿片镇痛组合物和非阿片类镇痛组合物，用于在任一实施方案中将镇痛剂递送至需要缓解疼痛的患者。止痛剂任选地含有非离子表面活性剂和包含碳酸盐或碳酸氢盐的渗透组合物，用于从剂型中输送阿片剂镇痛药和非阿片类止痛剂。

48. 发明授权

US06110499A Phenytoin therapy 失效
公开(公告)号：US06110499A
公开(公告)日：2000-08-29
申请号：US119382
申请日：1998-07-20
申请人： Padmaja Shivanand , Zahedeh Hatamkhany , Barbara F. Laidlaw , Atul D. Ayer
发明人： Padmaja Shivanand , Zahedeh Hatamkhany , Barbara F. Laidlaw , Atul D. Ayer
IPC分类号： A61K9/00 , A61K31/4166 , A61K9/24
CPC分类号： A61K9/0004 , A61K31/4166
摘要： A therapeutic composition, a dosage form and a method are disclosed for administering phenytoin indicated for the management of epilepsy.

49. 发明授权

US5925015A Nutritional support system 失效
标题翻译：营养支持系统
公开(公告)号：US5925015A
公开(公告)日：1999-07-20
申请号：US859627
申请日：1997-05-20
申请人： Richard G. Weyers , Atul D. Ayer , Brenda J. Pollock , Brian L. Barclay , Ernest S. Quan
发明人： Richard G. Weyers , Atul D. Ayer , Brenda J. Pollock , Brian L. Barclay , Ernest S. Quan
IPC分类号： A61M5/168 , A61J15/00 , A61K9/00 , A61M5/14 , A61M37/00
CPC分类号： A61M5/1409 , A61J15/00 , A61J15/008 , A61K9/0004 , A61M2205/6063 , A61M5/1407
摘要： A nutritional system is disclosed, for delivering a colorant dye to a nutritional fluid that flows through the nutritional system.
摘要翻译：公开了用于将着色剂染料递送到流过营养系统的营养液体的营养系统。

50. 发明授权

US5593695A Morphine therapy 失效
标题翻译：吗啡治疗
公开(公告)号：US5593695A
公开(公告)日：1997-01-14
申请号：US449620
申请日：1995-05-24
申请人： Sonya Merrill , Atul D. Ayer , Paul Hwang , Anthony L. Kuczynski
发明人： Sonya Merrill , Atul D. Ayer , Paul Hwang , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/20 , A61K9/36 , A61K31/485 , A61K47/30 , A61P25/04 , A61K9/30
CPC分类号： A61K9/2031 , A61K31/485 , A61K9/0004 , A61K9/2027
摘要： A therapeutic tablet comprising morphine, poly(alkylene oxide) and poly(vinylpyrrolidone) encased by a composition comprising a cellulose polymer.
摘要翻译：包含由包含纤维素聚合物的组合物包裹的吗啡，聚（环氧烷）和聚（乙烯基吡咯烷酮）的治疗片剂。

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