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1. 发明授权

US5273752A Controlled release dispenser comprising beneficial agent 失效
标题翻译：控制释放分配器包括有益剂
公开(公告)号：US5273752A
公开(公告)日：1993-12-28
申请号：US763393
申请日：1991-09-19
申请人： Atul D. Ayer , Terry L. Burkoth , Anthony L. Kuczynski , Joseph C. Deters
发明人： Atul D. Ayer , Terry L. Burkoth , Anthony L. Kuczynski , Joseph C. Deters
IPC分类号： A61K9/00 , A23K1/18
CPC分类号： A61K9/0068 , A61K31/70 , A61K9/0004
摘要： A dispenser is disclosed for delivering a beneficial agent in a hydrophilic carrier formulation to an animal in a rate-controlled manner. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising a beneficial agent and a pharmaceutically acceptable hydrophilic carrier in the space, (3) an expandable hydrophilic driving member in the space, (4) a density member in the space, and (5) one exit passageway or a multiplicity of exit passageways in the housing for delivering the beneficial agent from the dispenser, the diameter of each exit passageway being of a size to maximize release of the beneficial agent by osmotic pumping and to minimize release of the beneficial agent by diffusion or erosion to substantially avoid mechanical agitation-dependent release of the beneficial agent.
摘要翻译：公开了一种分配器，用于以速率控制的方式将亲水载体制剂中的有益剂递送给动物。所述分配器包括（1）限定内部空间的半透明壳体，（2）至少一种组合物，其包含所述空间中的有益剂和药学上可接受的亲水载体，（3）所述空间中的可膨胀亲水性驱动构件，（4）空间中的密度构件，以及（5）壳体中的一个出口通道或多个出口通道，用于从分配器输送有益物质，每个出口通道的直径具有使得有益剂释放最大化的大小渗透泵送并且通过扩散或侵蚀来最小化有益剂的释放，以基本上避免有益剂的机械搅动依赖性释放。

2. 发明授权

US5126142A Dispenser comprising ionophore 失效
标题翻译：分配器包括离子载体
公开(公告)号：US5126142A
公开(公告)日：1992-06-30
申请号：US641023
申请日：1991-01-11
申请人： Atul D. Ayer , Terry L. Burkoth , Anthony L. Kuczynski , Joseph C. Deters
发明人： Atul D. Ayer , Terry L. Burkoth , Anthony L. Kuczynski , Joseph C. Deters
IPC分类号： A61K9/00
CPC分类号： A61K9/0068 , A61K31/70 , A61K9/0004
摘要： A dispenser is disclosed for delivering a beneficial ionophore to an animal. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising an ionophore and a pharmaceutically acceptable carrier in the space, (3) an expandable hydrophilic composition in the space, (4) a dense member in the space, and (5) at least one exit passageway in the housing for delivering the ionophore from the dispenser.
摘要翻译：公开了用于将有益离子载体输送到动物的分配器。所述分配器包括（1）限定内部空间的半透性外壳，（2）至少一种组合物，其包含所述空间中的离子载体和药学上可接受的载体，（3）所述空间中的可膨胀的亲水性组合物，（4）在空间中，和（5）壳体中的至少一个出口通道，用于从分配器输送离子载体。

3. 发明授权

US5082668A Controlled-release system with constant pushing source 失效
标题翻译：具有恒定推压源的控制释放系统
公开(公告)号：US5082668A
公开(公告)日：1992-01-21
申请号：US595140
申请日：1990-10-09
申请人： Patrick S. L. Wong , Brian L. Barclay , Joseph C. Deters , Felix Theeuwes
发明人： Patrick S. L. Wong , Brian L. Barclay , Joseph C. Deters , Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A device is disclosed comprising a wall that surrounds a compartment. The compartment comprises a beneficial agent composition and a push composition. A passageway in the wall connects the compartment with the exterior of the device for delivering the beneficial agent at a rate governed, in combination, by the wall, the beneficial agent composition and the push composition through the passageway of the device over time.
摘要翻译：公开了一种包括围绕隔室的壁的装置。隔室包含有益剂组合物和推组合物。壁中的通道将隔室与装置的外部连接，用于通过墙壁，有益剂组合物和推动组合物通过装置的通道随时间而被组合地传递有益剂。

4. 发明授权

US4663148A Dispenser comprising telescopically engaging members 失效
标题翻译：分配器包括伸缩接合构件
公开(公告)号：US4663148A
公开(公告)日：1987-05-05
申请号：US829633
申请日：1986-02-14
申请人： James B. Eckenhoff , Felix Theeuwes , Joseph C. Deters
发明人： James B. Eckenhoff , Felix Theeuwes , Joseph C. Deters
IPC分类号： A61K9/00 , A61M31/00 , A61K9/48 , A61K9/52
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译：公开了一种用于将有益剂递送到使用环境的分配器。分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。墙壁上的通道将隔间与分配器的外部相连。

5. 发明授权

US4814180A Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container 失效
标题翻译：代理分配器包括围绕单件或两件式容器的半透壁
公开(公告)号：US4814180A
公开(公告)日：1989-03-21
申请号：US941971
申请日：1986-12-15
申请人： James B. Eckenhoff , Felix Theeuwes , Joseph C. Deters
发明人： James B. Eckenhoff , Felix Theeuwes , Joseph C. Deters
IPC分类号： A61K9/00 , A61K9/22 , A61M31/00 , A61K9/24 , A61K9/26 , A61K9/44
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译：公开了一种用于将有益剂递送到使用环境的分配器。分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。墙壁上的通道将隔间与分配器的外部相连。

6. 发明授权

US4765989A Osmotic device for administering certain drugs 失效
标题翻译：用于给予某些药物的渗透装置
公开(公告)号：US4765989A
公开(公告)日：1988-08-23
申请号：US902915
申请日：1986-09-02
申请人： Patrick S. L. Wong , Brian L. Barclay , Joseph C. Deters , Felix Theeuwes
发明人： Patrick S. L. Wong , Brian L. Barclay , Joseph C. Deters , Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译：公开了渗透系统，其包括围绕隔室的至少一部分半渗透材料的壁。隔室含有渗透组合物，其包含选自硝苯地平，哌唑嗪和多沙唑嗪的有益药物，以及第二和不同的渗透组合物。墙壁上的通道将第一个组合物与系统的外部连接起来。

7. 发明授权

US4692326A Dispenser comprising inner positioned soft or hard capsule 失效
标题翻译：分配器包括内置的软胶囊或硬胶囊
公开(公告)号：US4692326A
公开(公告)日：1987-09-08
申请号：US829353
申请日：1986-02-14
申请人： James B. Eckenhoff , Felix Theeuwes , Joseph C. Deters
发明人： James B. Eckenhoff , Felix Theeuwes , Joseph C. Deters
IPC分类号： A61K9/00 , A61M31/00 , A61K9/48 , A61K9/52
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeble wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译：公开了一种用于将有益剂递送到使用环境的分配器。分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。墙壁上的通道将隔间与分配器的外部相连。

8. 发明授权

US4627850A Osmotic capsule 失效
标题翻译：渗透胶囊
公开(公告)号：US4627850A
公开(公告)日：1986-12-09
申请号：US548219
申请日：1983-11-02
申请人： Joseph C. Deters , Felix Theeuwes , Kevin J. Mullins , James B. Eckenhoff
发明人： Joseph C. Deters , Felix Theeuwes , Kevin J. Mullins , James B. Eckenhoff
IPC分类号： A01N25/10 , A01N25/34 , A61J3/07 , A61K8/00 , A61K8/11 , A61K8/18 , A61K8/73 , A61K9/00 , A61K9/52 , A61L9/04 , A61M31/00 , A61Q13/00 , A61Q19/10 , B01J4/04 , C11B9/00
CPC分类号： A61K9/0004 , Y10S526/93 , Y10T428/249958 , Y10T428/249988 , Y10T428/31772
摘要： An osmotic capsule is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic capsule comprises an outer semipermeable wall surrounding and laminating an inner capsule wall formed of a different polymeric composition than the outer wall. The walls define an interior space containing the beneficial agent formulation. A passageway through the walls connects the exterior of the osmotic capsule with the interior of the osmotic capsule.
摘要翻译：公开了一种用于将有益剂制剂递送到使用环境的渗透性胶囊。渗透性胶囊包括围绕并层压由与外壁不同的聚合物组合物形成的内胶囊壁的外半透壁。墙壁限定了含有有益剂制剂的内部空间。穿过墙壁的通道将渗透胶囊的外部与渗透胶囊的内部连接。

9. 发明授权

US4576604A Osmotic system with instant drug availability 失效
标题翻译：渗透系统具有即时药物可用性
公开(公告)号：US4576604A
公开(公告)日：1986-03-18
申请号：US472333
申请日：1983-03-04
申请人： George V. Guittard , Joseph C. Deters , Felix Theeuwes , Richard Cortese
发明人： George V. Guittard , Joseph C. Deters , Felix Theeuwes , Richard Cortese
IPC分类号： A61K9/00 , A61K9/22 , A61K9/58
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering a beneficial agent. The device comprises a wall surrounding a compartment containing an agent, a passageway in the wall connecting the exterior of the device with the compartment, and (a) an agent in the wall or (b) an agent carried on the wall in the wall. The device delivers the agent from the compartment and the wall.
摘要翻译：公开了用于递送有益剂的渗透装置。该装置包括围绕包含试剂的隔室的壁，连接装置外部与隔室的通道，和（a）壁中的试剂或（b）承载在墙壁上的试剂。该设备从隔室和墙壁传送代理。

10. 发明授权

US5186942A Nicardipine therapy 失效
标题翻译：尼卡地平治疗
公开(公告)号：US5186942A
公开(公告)日：1993-02-16
申请号：US793988
申请日：1991-11-18
申请人： Joseph C. Deters , David R. Swanson , Stephen C. DeRosa
发明人： Joseph C. Deters , David R. Swanson , Stephen C. DeRosa
IPC分类号： A61K9/00 , A61K31/44
CPC分类号： A61K31/44 , A61K9/0004
摘要： A dosage form is disclosed comprising a member selected from the group consisting of nicardipine and its pharmaceutically acceptable salts for administering to a patient in need of cardio-vascular therapy.
摘要翻译：公开了一种剂型，其包含选自尼卡地平及其药学上可接受的盐的成员，用于向需要心血管治疗的患者施用。

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