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1. 发明授权

US4986987A Pulsed drug delivery 失效
标题翻译：脉冲给药
公开(公告)号：US4986987A
公开(公告)日：1991-01-22
申请号：US312845
申请日：1989-02-21
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

2. 发明授权

US06773721B1 Osmotic caplet 失效
标题翻译：渗透性囊袋
公开(公告)号：US06773721B1
公开(公告)日：2004-08-10
申请号：US08442210
申请日：1995-05-16
申请人： Patrick S.-L. Wong , Felix Theeuwes , George V. Guittard , Atul D. Ayer
发明人： Patrick S.-L. Wong , Felix Theeuwes , George V. Guittard , Atul D. Ayer
IPC分类号： A61K924
CPC分类号： A61K9/0004 , A61K9/1635 , A61K9/4808 , A61K9/4816 , A61K9/4891
摘要： An osmotic caplet is disclosed comprising an osmotic caplet exit for delivering a preselected dose of drug to a patient in need of therapy.
摘要翻译：公开了渗透性囊片，其包括用于将预选剂量的药物递送至需要治疗的患者的渗透性囊片出口。

3. 发明授权

US4014334A Laminated osmotic system for dispensing beneficial agent 失效
标题翻译：用于分配有益剂的层压渗透系统
公开(公告)号：US4014334A
公开(公告)日：1977-03-29
申请号：US654194
申请日：1976-02-02
申请人： Felix Theeuwes , Atul D. Ayer
发明人： Felix Theeuwes , Atul D. Ayer
IPC分类号： A61F9/00 , A61K9/00 , A61M31/00
CPC分类号： A61K9/0004 , A61F9/0017
摘要： An osmotic system for delivering a beneficial agent to an environment of use is disclosed. The system comprises a laminate surrounding a compartment and has a passageway through the laminate for releasing agent from the compartment. The laminate comprises at least two laminae; one consisting of a semipermeable, polymeric material that is permeable to the passage of an external fluid and maintains its physical and chemical integrity in the environment of use, and one consisting of a semipermeable polymeric material that is permeable to the passage of the fluid, substantially impermeable to the passage of agent and maintains its physical and chemical integrity in the presence of agent. The compartment comprises an active agent that is either soluble in the external fluid and exhibits an osmotic pressure gradient across the laminate against the fluid, or the agent has limited solubility in the fluid and it is mixed with an osmotically effective compound that is soluble in the fluid and exhibits an osmotic pressure gradient across the laminate against the fluid. In operation, agent is released from the system by fluid being imbibed through the laminate into the compartment at a rate controlled by the permeability of the laminate and the osmotic pressure gradient across the laminate producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.
摘要翻译：公开了一种用于将有益剂递送到使用环境的渗透系统。该系统包括围绕隔室的层压板，并具有通过层压板的通道，用于将隔离物释放。层压体包括至少两层; 一种由可渗透外部流体通道并在使用环境中保持其物理和化学完整性的半透性聚合材料组成，并且由可渗透流体的半透性聚合物材料组成，基本上通过试剂不渗透，并在试剂存在下保持其物理和化学完整性。隔室包含可溶于外部流体的活性剂，并且表现出横跨该层压体的流体的渗透压梯度，或者该试剂在流体中具有有限的溶解度，并且与渗透性有效的化合物混合，该化合物可溶于并且表现出跨过层压体抵抗流体的渗透压梯度。在操作中，通过流体通过层压体被吸收到隔室中的剂量从层压体的渗透性控制的速率和穿过层压体的渗透压梯度产生包含溶液的试剂或含化合物的溶液任何操作中的解决方案在长时间内以受控和连续的速率通过通道释放。

4. 发明授权

US5232705A Dosage form for time-varying patterns of drug delivery 失效
标题翻译：药物递送模式的剂型
公开(公告)号：US5232705A
公开(公告)日：1993-08-03
申请号：US864824
申请日：1992-04-01
申请人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
发明人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

5. 发明授权

US5200196A Improvement in pulsed drug therapy 失效
标题翻译：改善脉冲药物治疗
公开(公告)号：US5200196A
公开(公告)日：1993-04-06
申请号：US640469
申请日：1991-01-11
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

6. 发明授权

US5156850A Dosage form for time-varying patterns of drug delivery 失效
标题翻译：用于药物递送时间变化的剂型
公开(公告)号：US5156850A
公开(公告)日：1992-10-20
申请号：US576042
申请日：1990-08-31
申请人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
发明人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K31/155 , A61K31/275 , A61K31/435 , A61K31/55
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

7. 发明授权

US4842867A Pulsed drug delivery of doxylamine 失效
标题翻译：脉冲药物递送多西拉敏
公开(公告)号：US4842867A
公开(公告)日：1989-06-27
申请号：US861188
申请日：1986-05-09
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. Wong
IPC分类号： A61K31/445 , A61K9/00 , A61K9/22 , A61K9/58
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

8. 发明授权

US4200098A Osmotic system with distribution zone for dispensing beneficial agent 失效
标题翻译：渗透系统具有分配区域用于分配有益剂
公开(公告)号：US4200098A
公开(公告)日：1980-04-29
申请号：US953906
申请日：1978-10-23
申请人： Atul D. Ayer , Felix Theeuwes
发明人： Atul D. Ayer , Felix Theeuwes
IPC分类号： A61J3/07 , A61K9/00 , A61K9/22 , B01J4/04 , A61M7/00
CPC分类号： A61K9/0004 , Y10T428/31536
摘要： An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned distant from the first wall, said second wall a microporous or hydrogel material that extends around the first wall, and (3) a distribution zone interposed between the first and second wall and initially housing a compound soluble in an external fluid that enters the system.In operation, agent is dispensed from the system by fluid passing through the second wall into the zone from which fluid is further being imbibed through the first wall into the compartment forming a solution that is released through the passageway into the zone, and then through the second wall to the exterior of the system.
摘要翻译：公开了用于分配有益试剂的渗透系统。该系统包括（1）半透性材料的第一壁，该第一壁围绕包含药物制剂的隔室，并且具有通过所述壁的通道，用于从所述隔间释放剂，（2）位于远离所述第一壁的第二壁，所述第二壁第二壁是围绕第一壁延伸的微孔或水凝胶材料，以及（3）介于第一和第二壁之间的分配区，并且初始地容纳可溶于进入系统的外部流体的化合物。在操作中，通过流体通过第二壁将流体从系统中分配到进入区域中的流体进一步从第一壁吸入到隔室中，该隔室形成通过通道被释放到该区域中的溶液，然后通过第二个墙壁到系统的外部。

9. 发明授权

US4160020A Therapeutic device for osmotically dosing at controlled rate 失效
标题翻译：用于以受控速率渗透给药的治疗装置
公开(公告)号：US4160020A
公开(公告)日：1979-07-03
申请号：US864954
申请日：1977-12-27
申请人： Atul D. Ayer , Felix Theeuwes
发明人： Atul D. Ayer , Felix Theeuwes
IPC分类号： A61M37/00 , A61K9/00 , A61M29/04 , A61M31/00 , A61K9/24 , A61K9/44
CPC分类号： A61K9/0036 , A61K9/0004
摘要： An osmotic device is disclosed for delivering an active agent. The device comprises a wall surrounding a compartment with a passageway through the wall for releasing the agent. The wall comprises a material permeable to an external fluid and substantially impermeable to agent and at least one additional material independently selected from materials that impart stability to the wall, enhance the permeability of the wall to fluids, or aid in forming the wall. The compartment contains an agent that exhibits an osmotic pressure gradient across the wall against an external fluid, or the agent is mixed with an osmotically effective compound that exhibits an osmotic pressure gradient against the fluid. Agent is released from the device by fluid being imbided through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall, thereby producing a solution containing agent that is released through the passageway at a controlled rate over time.
摘要翻译：公开了用于递送活性剂的渗透装置。该装置包括围绕隔室的壁，通过该壁的通道用于释放该试剂。该壁包括可渗透外部流体的材料，并且基本上不可渗透到试剂和至少一种附加材料，其独立地选自赋予壁稳定性的材料，增强壁对流体的渗透性或有助于形成壁。隔间含有一种在外壁上显示渗透压梯度以抵抗外部流体的试剂，或者该试剂与渗透压梯度相对于流体的渗透性有效化合物混合。通过流体通过壁被渗透到隔室中的剂量通过壁的渗透性和穿过壁的渗透压梯度控制的速率从装置释放，从而产生溶液包含试剂，其通过通道在受控的随着时间的推移。

10. 发明授权

US4285987A Process for manufacturing device with dispersion zone 失效
标题翻译：具有分散区制造装置的方法
公开(公告)号：US4285987A
公开(公告)日：1981-08-25
申请号：US90492
申请日：1979-11-01
申请人： Atul D. Ayer , Felix Theeuwes
发明人： Atul D. Ayer , Felix Theeuwes
IPC分类号： A61K9/00 , A61M7/00
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned distant from the first wall, said second wall a microporous or hydrogel material that extends around the first wall, and (3) a distribution zone interposed between the first and second wall and initially housing a compound soluble in an external fluid that enters the system.In operation, agent is dispensed from the system by fluid passing through the second wall into the zone from which fluid is further being imbibed through the first wall into the compartment forming a solution that is released through the passageway into the zone, and then through the second wall to the exterior of the system.
摘要翻译：公开了用于分配有益试剂的渗透系统。该系统包括（1）半透性材料的第一壁，该第一壁围绕包含药物制剂的隔室，并且具有通过所述壁的通道，用于从所述隔间释放剂，（2）位于远离所述第一壁的第二壁，所述第二壁第二壁是围绕第一壁延伸的微孔或水凝胶材料，以及（3）介于第一和第二壁之间的分配区，并且初始地容纳可溶于进入系统的外部流体的化合物。在操作中，通过流体通过第二壁将流体从系统中分配到进入区域中的流体进一步从第一壁吸入到隔室中，该隔室形成通过通道被释放到该区域中的溶液，然后通过第二个墙壁到系统的外部。

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