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41. 发明申请

US20110263570A1 PYRIMIDINE DERIVATIVES AS GPCR MODULATORS FOR USE IN THE TREATMENT OF OBESITY AND DIABETES 有权
标题翻译：作为用于治疗糖尿病的GPCR调节剂的吡嗪衍生物
公开(公告)号：US20110263570A1
公开(公告)日：2011-10-27
申请号：US13141227
申请日：2009-12-21
申请人： Bernard R. Neustadt , Andrew Stamford , Jinsong Hao , Charles Lee Jayne , Yan Xia
发明人： Bernard R. Neustadt , Andrew Stamford , Jinsong Hao , Charles Lee Jayne , Yan Xia
IPC分类号： A61K31/55 , A61K31/506 , C07D401/12 , A61P3/00 , C07D498/08 , A61K31/5386 , A61P3/10 , A61P3/04 , C07D401/14 , C07D451/02
CPC分类号： C07D401/14 , C07D401/12 , C07D471/08 , C07D498/08
摘要： The present invention relates to Pyriraidine Derivatives of formula (I), compositions comprising a Pyrimidine Derivative, and methods of using the Pyrimidine Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G protein-coupled receptor (GPCR) in a patient.
摘要翻译：本发明涉及式（I）的嘧啶衍生物，包含嘧啶衍生物的组合物，以及使用嘧啶衍生物治疗或预防肥胖症，糖尿病，糖尿病并发症，代谢障碍，心血管疾病或与 G蛋白偶联受体（GPCR）在患者体内的活性。

42. 发明申请

US20110068896A1 COMMUNICATION DEVICE AND METHOD FOR SENDING A QUICK REPLY MESSAGE 审中-公开
标题翻译：用于发送快速回复消息的通信设备和方法
公开(公告)号：US20110068896A1
公开(公告)日：2011-03-24
申请号：US12711702
申请日：2010-02-24
申请人： YAN XIA
发明人： YAN XIA
IPC分类号： G05B19/00
CPC分类号： H04L51/02
摘要： A communication device and method for sending a quick reply message includes creating at least one fingerprint biometric template, setting a quick reply message corresponding to each of the at least one fingerprint biometric template, and determining if computed fingerprint characteristic values of a user match any fingerprint biometric template. The communication device and method further includes sending a quick reply message corresponding to the fingerprint biometric template of the user if the computed fingerprint characteristic values of a user match any fingerprint biometric template and the communication device is in the message editing mode.
摘要翻译：用于发送快速回复消息的通信设备和方法包括创建至少一个指纹生物测定模板，设置与所述至少一个指纹生物测定模板中的每一个对应的快速回复消息，以及确定所计算的用户的指纹特征值是否匹配任何指纹生物识别模板如果所计算的用户的指纹特征值与任何指纹生物特征模板匹配并且通信设备处于消息编辑模式，则通信设备和方法还包括发送对应于用户的指纹生物测定模板的快速回复消息。

43. 发明授权

US07897601B2 Cannabinoid receptor modulators 失效
标题翻译：大麻素受体调节剂
公开(公告)号：US07897601B2
公开(公告)日：2011-03-01
申请号：US11653558
申请日：2007-01-16
申请人： Samuel Chackalamannil , Mariappan V. Chelliah , Martin C. Clasby , Keith A. Eagen , Jack D. Scott , Yuguang Wang , Yan Xia , William J. Greenlee
发明人： Samuel Chackalamannil , Mariappan V. Chelliah , Martin C. Clasby , Keith A. Eagen , Jack D. Scott , Yuguang Wang , Yan Xia , William J. Greenlee
IPC分类号： A61K31/454 , A61K31/4035 , A61K31/5377 , C07D209/46 , C07D295/04 , C07D401/04
CPC分类号： C07D209/46 , C07C233/31 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/90 , C07D209/44 , C07D209/52 , C07D211/58 , C07D307/83 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/10
摘要： A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, is useful in treating diseases, disorders, or conditions such as obesity, metabolic disorders, addiction, diseases of the central nervous system, cardiovascular disorders, respiratory disorders, and gastrointestinal disorders.
摘要翻译：具有式（I）的通式结构的化合物或其药学上可接受的盐，溶剂化物或酯可用于治疗疾病，病症或病症如肥胖，代谢紊乱，成瘾，中枢神经系统疾病，心血管疾病，呼吸系统疾病和胃肠道疾病。

44. 发明授权

US07776889B2 Spirocyclic thrombin receptor antagonists 有权
标题翻译：螺环状凝血酶受体拮抗剂
公开(公告)号：US07776889B2
公开(公告)日：2010-08-17
申请号：US11392324
申请日：2006-03-29
申请人： Samuel Chackalamannil , Mariappan V. Chelliah , Yan Xia
发明人： Samuel Chackalamannil , Mariappan V. Chelliah , Yan Xia
IPC分类号： A61K31/4427 , C07D405/08
CPC分类号： C07D263/52 , C07D413/08
摘要： Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond, the dotted line is optionally a bond or no bond, resulting in a double bond or a single bond, as permitted by the valency requirement and wherein An, En, Mn, Un, Gn, Jn, Kn, R9, R10, R11, R32, R33, B and Het are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
摘要翻译：所述式的杂环取代三环或所述化合物，异构体或外消旋混合物的药学上可接受的盐或溶剂合物，其中代表任选的双键，虚线任选是键或无键，导致双键或单键，如价格要求所允许的，并且其中An，En，Mn，Un，Gn，Jn，Kn，R9，R10，R11，R32，R33，B和Het在本文中定义，其余取代基如说明书中所定义以及含有它们的药物组合物以及通过施用所述化合物治疗与血栓形成，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心力衰竭和癌症相关的疾病的方法。还要求与其它心血管药物联合治疗。

45. 发明授权

US07488752B2 Thrombin receptor antagonists 有权
标题翻译：凝血酶受体拮抗剂
公开(公告)号：US07488752B2
公开(公告)日：2009-02-10
申请号：US11243708
申请日：2005-10-05
申请人： Samuel Chackalamannil , Mariappan V. Chelliah , Yan Xia , Keith A. Eagen
发明人： Samuel Chackalamannil , Mariappan V. Chelliah , Yan Xia , Keith A. Eagen
IPC分类号： A01N43/08 , A61K31/34 , C07D307/00 , C07D307/93 , C07D407/00
CPC分类号： C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/10
摘要： Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein z,1 represents an optional double bond, the dotted line is optionally a bond or no bond, resulting in a double bond or a single bond, as permitted by the valency requirement and wherein A, B, G, M, X, J, n, Het, R3, R10, R11, R32 and R33 are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
摘要翻译：具有下式的杂环取代的三环或所述化合物，异构体或外消旋混合物的药学上可接受的盐或溶剂化物，其中z 1表示任选的双键，虚线任选是键或无键，得到双键或单价，如价格要求所允许的，其中A，B，G，M，X，J，n，Het，R 3，R 10，R 11，R 32和R 33在本文中定义，其余取代基如说明书中所定义，以及含有它们的药物组合物以及通过施用所述化合物治疗与血栓形成，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心力衰竭和癌症相关的疾病的方法。还要求与其它心血管药物联合治疗。

46. 发明申请

US20070270439A1 THROMBIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：硫蛋白受体拮抗剂
公开(公告)号：US20070270439A1
公开(公告)日：2007-11-22
申请号：US11774358
申请日：2007-07-06
申请人： Samuel Chackalamannil , Martin Clasby , William Greenlee , Yuguang Wang , Yan Xia , Enrico Veltri , Mariappan Chelliah
发明人： Samuel Chackalamannil , Martin Clasby , William Greenlee , Yuguang Wang , Yan Xia , Enrico Veltri , Mariappan Chelliah
IPC分类号： A61K31/4427 , A61K31/506 , A61P29/00 , A61P35/00 , A61P9/00 , A61P9/02 , A61P9/06 , A61P9/10 , A61P9/12 , C07D221/00 , C07D239/26
CPC分类号： C07D405/06 , C07D405/14 , C07D417/14
摘要： Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt thereof, wherein: the dotted line represents an optional single bond; represents an optional double bond; n is 0-2; Q is cycloalkyl, optionally substituted by R13 and R14; R13 and R14 are independently selected from (C1-C6)alkyl, (C3-C8)cycloalkyl, —OH, (C1-C6)alkoxy, R27-aryl(C1-C6)alkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halogen and haloalkyl; or R13 and R14 together form a spirocyclic or a heterospirocyclic ring of 3-6 atoms; Het is a mono- or bi-cyclic optionally substituted heteroaryl group; and B is a bond, alkylene, or optionally substituted alkenylene or alkynylene, wherein the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
摘要翻译：具有下式的杂环取代的三环或其药学上可接受的盐，其中：虚线表示任选的单键; “img id =”custom-character-00001“he =”2.79mm“wi =”7.03mm“file =”US20070270439A1-20071122-P00002.TIF“img-content =”character“img-format =”tif“/> 表示可选的双键; n为0-2; Q是环烷基，任选被R 13和R 14取代; R 13和R 14独立地选自（C 1 -C 6 -C 6）烷基，（C

47. 发明申请

US20070203183A1 Diaryl piperidines as CB1 modulators 审中-公开
标题翻译：二芳基哌啶作为CB1调节剂
公开(公告)号：US20070203183A1
公开(公告)日：2007-08-30
申请号：US11652227
申请日：2007-01-11
申请人： Jack Scott , Jay Weinstein , Michael Miller , Andrew Stamford , Eric Gilbert , Yan Xia , William Greenlee , Sarah Li
发明人： Jack Scott , Jay Weinstein , Michael Miller , Andrew Stamford , Eric Gilbert , Yan Xia , William Greenlee , Sarah Li
IPC分类号： A61K31/454 , C07D211/54 , A61K31/445 , C07D401/02
CPC分类号： C07D211/18 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/30 , C07D211/32 , C07D211/58 , C07D211/60 , C07D211/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/10
摘要： A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome (e.g., obesity, waist circumference, lipid profile, and insulin sensitivity), neuroinflammatory disorders, cognitive disorders, psychosis, addictive behavior, gastrointestinal disorders, and cardiovascular conditions.
摘要翻译：具有式（I）的通式结构的化合物或其药学上可接受的盐，溶剂化物或酯可用于治疗疾病，病症或病症如代谢综合征（例如，肥胖，腰围，脂质分布和胰岛素敏感性），神经炎症性疾病，认知障碍，精神病，成瘾行为，胃肠道疾病和心血管疾病。

48. 发明申请

US20060239519A1 Method and apparatus for extracting cerebral ventricular system from images 失效
标题翻译：从图像中提取脑室系统的方法和装置
公开(公告)号：US20060239519A1
公开(公告)日：2006-10-26
申请号：US10547441
申请日：2003-02-27
申请人： Wieslaw Nowinski , Yan Xia , Aamer Aziz , Qingmao Hu
发明人： Wieslaw Nowinski , Yan Xia , Aamer Aziz , Qingmao Hu
IPC分类号： G06K9/00
CPC分类号： G06K9/342 , G06K9/3233 , G06K2209/05 , G06T7/11 , G06T7/187 , G06T2207/10088 , G06T2207/20156 , G06T2207/30016
摘要： A method and apparatus for extracting a cerebral ventricular system from images of one or more cerebral ventricular regions comprises defining multiple regions of interest (ROI) in the images, defining seed points within each ROI, growing images of ventricular regions while correcting for leakages into extraventricular space and connecting the ventricular regions grown
摘要翻译：一种用于从一个或多个脑室区域的图像提取脑室系统的方法和装置包括在图像中定义多个感兴趣区域（ROI），在每个ROI内定义种子点，增加心室区域的图像，同时校正泄漏到室内空间和连接心室生长

49. 发明申请

US20060079684A1 Thrombin receptor antagonists 有权
标题翻译：凝血酶受体拮抗剂
公开(公告)号：US20060079684A1
公开(公告)日：2006-04-13
申请号：US11243708
申请日：2005-10-05
申请人： Samuel Chackalamannil , Mariappan Chelliah , Yan Xia , Keith Eagen
发明人： Samuel Chackalamannil , Mariappan Chelliah , Yan Xia , Keith Eagen
IPC分类号： C07D413/02 , C07D405/02
CPC分类号： C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/10
摘要： Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond, the dotted line is optionally a bond or no bond, resulting in a double bond or a single bond, as permitted by the valency requirement and wherein A, B, G, M, X, J, n, Het, R3, R10, R11, R32 and R33 are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
摘要翻译：式中的杂环取代三环或所述化合物，异构体或外消旋混合物的药学上可接受的盐或溶剂化物，其中表示可选的双键，虚线是可选的键或无键，导致双重键或单键，如价格要求所允许的，并且其中A，B，G，M，X，J，n，Het，R 3，R 10，本文定义了R 11，R 32和R 33，并且其余的取代基如说明书中所定义，以及药物含有它们的组合物和通过施用所述化合物治疗与血栓形成，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心力衰竭和癌症相关的疾病的方法。还要求与其它心血管药物联合治疗。

50. 发明授权

US06645987B2 Nor-seco himbacine derivatives useful as thrombin receptor antagonists 有权
标题翻译：可用作凝血酶受体拮抗剂的非硫代芥酸衍生物
公开(公告)号：US06645987B2
公开(公告)日：2003-11-11
申请号：US09880222
申请日：2001-06-13
申请人： Samuel Chackalamannil , Mariappan V. Chelliah , Yan Xia
发明人： Samuel Chackalamannil , Mariappan V. Chelliah , Yan Xia
IPC分类号： A61K31443
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D405/06 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Heterocyclic-substituted compounds of the formula or a pharmaceutically acceptable salt thereof, are disclosed.
摘要翻译：公开了取代的杂环取代的化合物或其药学上可接受的盐。

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