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41. 发明申请

US20100234726A1 DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A BIOPSY CAVITY 有权
标题翻译：用于安全定位和标记生物密度的装置和方法
公开(公告)号：US20100234726A1
公开(公告)日：2010-09-16
申请号：US12777710
申请日：2010-05-11
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
IPC分类号： A61B5/05
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking 412 devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译：公开了腔和前哨淋巴结标记412装置，标记递送装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置，对患者的至少创伤和毒性。组合物和方法可用于标记活检腔，以及标记前哨淋巴结。标记方法还可以将所描述的特征与标记装置和递送装置组合。

42. 发明授权

US07662181B2 Methods and devices for use in performing pulmonary procedures 有权
标题翻译：用于执行肺部手术的方法和装置
公开(公告)号：US07662181B2
公开(公告)日：2010-02-16
申请号：US11395396
申请日：2006-03-30
申请人： Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas S. Sutton
发明人： Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas S. Sutton
IPC分类号： A61F2/20 , A61B1/12 , A62B9/02 , A62B9/06
CPC分类号： F16K15/147 , A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/04 , A61F2/24 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , Y10S128/912
摘要： Systems, methods and devices for performing pulmonary procedures, and in particular treating lung disease. A flow control element includes a valve that prevents airflow in the inhalation direction but permits airflow in the exhalation direction. The flow control element is guided to and positioned at the site by a bronchoscope that is introduced into the patient's trachea and used to view the lungs during delivery of the flow control element. The valve may include one, two or more valve elements, and it may be collapsible for easier delivery. A source of vacuum or suction may be used to increase the amount of fluid withdrawn from the lung tissue. A device for measuring hollow structures, such as bronchioles, and a device for removing a previously-placed flow control element are disclosed as well.
摘要翻译：用于执行肺部手术，特别是治疗肺部疾病的系统，方法和装置。流量控制元件包括防止气流沿吸入方向但允许呼气方向气流的阀。流量控制元件被引导到病人气管中并用于在流量控制元件的输送期间观察肺部的支气管镜引导到位置并定位在该位置处。阀可以包括一个，两个或更多个阀元件，并且其可以是可折叠的以用于更容易的输送。可以使用真空源或抽吸源来增加从肺组织排出的流体的量。还公开了一种用于测量诸如细支气管的中空结构的装置和用于去除预先安置的流量控制元件的装置。

43. 发明申请

US20090326439A1 HIGH PRESSURE PRE-BURST FOR IMPROVED FLUID DELIVERY 审中-公开
标题翻译：用于改进流体输送的高压预冲头
公开(公告)号：US20090326439A1
公开(公告)日：2009-12-31
申请号：US12555746
申请日：2009-09-08
申请人： James E. Chomas , Mark E. Deem , Hanson S. Gifford , Douglas S. Sutton
发明人： James E. Chomas , Mark E. Deem , Hanson S. Gifford , Douglas S. Sutton
IPC分类号： A61M5/00 , A61N1/30 , A61B17/32 , A61H1/00
摘要： A needle with multiple injection ports is used in connection with a high-pressure injection system to infuse a treatment solution into a treatment area below the dermis of the skin. The needle has multiple tines that extend outwardly from the injection ports while inside the treatment area to disrupt tissue in the treatment area and to create multiple pathways of infusion. The tines are withdrawn and the needle is partially withdrawn, and solution is injected from the needle into the treatment area at high pressure to infuse the tissue within the treatment area. The burst, infusion, and a treatment such as an energy or third solution may be interleaved and repeated multiple times.
摘要翻译：结合高压注射系统使用具有多个注射口的针，以将治疗溶液注入皮肤真皮下方的治疗区域。针头在处理区域内部具有从注射口向外延伸的多个齿，以破坏治疗区域中的组织并产生多个输注途径。取出齿并将针部分取出，将溶液从针头高压注入治疗区域，以在处理区域内注入组织。突发，输注和诸如能量或第三溶液的治疗可以交错并重复多次。

44. 发明申请

US20090234178A1 SYSTEMS AND METHODS FOR DELIVERING RADIATION THERAPY 有权
公开(公告)号：US20090234178A1
公开(公告)日：2009-09-17
申请号：US12395625
申请日：2009-02-27
申请人： Gail S. LEBOVIC , George D. HERMANN , Douglas S. SUTTON
发明人： Gail S. LEBOVIC , George D. HERMANN , Douglas S. SUTTON
IPC分类号： A61M36/10
CPC分类号： A61N5/1016 , A61N2005/1004
摘要： Described here are conformable brachytherapy applicators. The conformable brachytherapy applicators generally follow the contour of tissue surfaces so that distances between radiation sources and target tissues can be precisely determined and radiation dose clouds can be readily shaped. Systems and methods for using the conformable brachytherapy applicators are also described.

45. 发明申请

US20090234176A1 SYSTEMS AND METHODS FOR DELIVERING RADIATION THERAPY 有权
公开(公告)号：US20090234176A1
公开(公告)日：2009-09-17
申请号：US12395611
申请日：2009-02-27
申请人： Gail S. Lebovic , George D. Hermann , Douglas S. Sutton
发明人： Gail S. Lebovic , George D. Hermann , Douglas S. Sutton
IPC分类号： A61N5/00
CPC分类号： A61N5/1016 , A61N2005/1004
摘要： Described here are conformable brachytherapy applicators. The conformable brachytherapy applicators generally follow the contour of tissue surfaces so that distances between radiation sources and target tissues can be precisely determined and radiation dose clouds can be readily shaped. Systems and methods for using the conformable brachytherapy applicators are also described.

46. 发明授权

US07510559B2 Obesity treatment tools and methods 有权
公开(公告)号：US07510559B2
公开(公告)日：2009-03-31
申请号：US10729622
申请日：2003-12-05
申请人： Mark E. Deem , Douglas S. Sutton , Hanson S. Gifford, III , Bernard H. Andreas , Ronald G. French
发明人： Mark E. Deem , Douglas S. Sutton , Hanson S. Gifford, III , Bernard H. Andreas , Ronald G. French
IPC分类号： A61B17/00
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.

47. 发明授权

US07503922B2 Obesity treatment tools and methods 有权
公开(公告)号：US07503922B2
公开(公告)日：2009-03-17
申请号：US10402061
申请日：2003-03-27
申请人： Mark E. Deem , Douglas S. Sutton , Hanson S. Gifford, III , Bernard H. Andreas , Ronald G. French
发明人： Mark E. Deem , Douglas S. Sutton , Hanson S. Gifford, III , Bernard H. Andreas , Ronald G. French
IPC分类号： A61B17/08
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using a traumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.

48. 发明授权

US07097650B2 System for tissue approximation and fixation 有权
标题翻译：组织近似和固定系统
公开(公告)号：US07097650B2
公开(公告)日：2006-08-29
申请号：US10686326
申请日：2003-10-14
申请人： Gary Weller , Jamy Gannoe , Craig Gerbi , Douglas S. Sutton , Andrew H. Hancock , Gilbert Mata, Jr.
发明人： Gary Weller , Jamy Gannoe , Craig Gerbi , Douglas S. Sutton , Andrew H. Hancock , Gilbert Mata, Jr.
IPC分类号： A61B17/08
CPC分类号： A61B17/29 , A61B17/07207 , A61B17/1114 , A61B2017/00323 , A61B2017/00353 , A61B2017/00946 , A61B2017/07214 , A61B2017/1103 , A61B2017/2905 , A61B2017/306
摘要： A system for tissue approximation and fixation is described herein. The devices are advanced in a minimally invasive manner within a patient's body to create one or several divisions or plications within a hollow body organ. The system comprises a tissue acquisition and folding device and a tissue stapling or fixation device, each of which is used together as a system. The acquisition device is used to approximate tissue regions from within the hollow body organ and the stapling device is advanced through a main lumen defined through the acquisition device and is used to affix the approximated tissue. The stapling device is keyed to maintain its rotational orientation relative to the acquisition device as well as to provide the user positional information of the stapling device. The acquisition device is also configured to provide lateral stability to the stapling device prior to the stapling device being clamped onto tissue.
摘要翻译：本文描述了用于组织近似和固定的系统。这些装置在患者体内以微创方式前进，以在中空身体器官内产生一个或多个分裂或症状。该系统包括组织采集和折叠装置和组织缝合或固定装置，每个组合装订或固定装置一起用作系统。采集装置用于从中空体器官内部近似组织区域，并且缝合装置前进穿过通过采集装置限定的主腔，并用于固定近似组织。锁定装置被锁定以相对于采集装置保持其旋转定向，并且提供用户装订装置的位置信息。采集装置还被配置为在缝合装置被夹持到组织之前为吻合装置提供侧向稳定性。

49. 发明授权

US07083629B2 Overtube apparatus for insertion into a body 有权
公开(公告)号：US07083629B2
公开(公告)日：2006-08-01
申请号：US10155362
申请日：2002-05-23
申请人： Gary Weller , Craig Gerbi , James Gannoe , Mark E. Deem , Douglas S. Sutton , Hanson S. Gifford, III , Bernard H. Andreas , Ronald G. French
发明人： Gary Weller , Craig Gerbi , James Gannoe , Mark E. Deem , Douglas S. Sutton , Hanson S. Gifford, III , Bernard H. Andreas , Ronald G. French
IPC分类号： A61B17/08
CPC分类号： A61F5/0083 , A61B17/00234 , A61B17/0469 , A61B17/0482 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/072 , A61B17/07207 , A61B17/08 , A61B17/1114 , A61B17/1155 , A61B17/12013 , A61B17/122 , A61B17/29 , A61B2017/00557 , A61B2017/00818 , A61B2017/0648 , A61B2017/0649 , A61B2017/081 , A61B2017/1139 , A61B2017/12018 , A61B2017/2926 , A61B2017/306 , A61B2090/395
摘要： An overtube apparatus for insertion into a body is described herein. The assembly includes an overtube having a lumen defined throughout. The distal end of the overtube member has two or more windows in apposition configured to draw in tissue via a vacuum. A drive tube, which also defines a lumen, is inserted and is freely adjustable within the overtube. A spiral or helical fastener, which is temporarily attached to the drive tube distal end, is positioned within the overtube lumen. Endoscopic devices can be inserted within the drive tube lumen and advanced past the distal ends of both the drive tube and overtube. A pump provides the vacuum to draw apposed regions of tissue from within a hollow body organ into the windows of the overtube. Once the tissue has been invaginated, the drive tube is rotated to advance the fastener into the tissue to fasten them together.

50. 发明授权

US06558400B2 Obesity treatment tools and methods 有权
公开(公告)号：US06558400B2
公开(公告)日：2003-05-06
申请号：US09871297
申请日：2001-05-30
申请人： Mark E. Deem , Douglas S. Sutton , Hanson S. Gifford, III , Bernard H. Andreas , Ronald G. French
发明人： Mark E. Deem , Douglas S. Sutton , Hanson S. Gifford, III , Bernard H. Andreas , Ronald G. French
IPC分类号： A61B1708
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.

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