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    • 41. 发明申请
    • DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A BIOPSY CAVITY
    • 用于安全定位和标记生物密度的装置和方法
    • US20100234726A1
    • 2010-09-16
    • US12777710
    • 2010-05-11
    • D. Laksen SirimanneNatalie V. FawziDouglas S. SuttonGail S. LebovicStanley R. ConstonPeter M. WilsonAnne B. MorrisseyMary Elizabeth Bush
    • D. Laksen SirimanneNatalie V. FawziDouglas S. SuttonGail S. LebovicStanley R. ConstonPeter M. WilsonAnne B. MorrisseyMary Elizabeth Bush
    • A61B5/05
    • A61K49/006A61B90/39A61B2017/00539A61B2090/3925A61B2090/3966A61B2090/3987A61B2090/3995
    • Cavity and sentinel lymph node marking 412 devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
    • 公开了腔和前哨淋巴结标记412装置,标记递送装置和方法。 更具体地说,在插入体中时,腔标记装置和方法使得能够通过放射照相,乳房X线照相术,回声或其它非侵入性成像技术确定腔的中心,取向和周边。 公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法,以确定癌细胞是否已扩散到其上。 组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者,造影剂本身可以是流体,因此不需要单独的载体流体。 该组合物能够(1)沉积在病变中或周围,并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中,以及(2)通过任何数量的无创技术的远程检测。 还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法:(1)在病变中或周围沉积可远程检测的流体,以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及(2)远程检测该节点的位置, 对患者的至少创伤和毒性。 组合物和方法可用于标记活检腔,以及标记前哨淋巴结。 标记方法还可以将所描述的特征与标记装置和递送装置组合。