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41. 发明申请

WO2007019039A1 METHOD FOR INCREASING A READ-OUT SPEED OF A CCD-DETECTOR 审中-公开
标题翻译：增加CCD检测器读出速度的方法
公开(公告)号：WO2007019039A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/028745
申请日：2006-07-25
申请人： CORNING INCORPORATED , PIECH, Garrett A , WEBB, Michael B
发明人： PIECH, Garrett A , WEBB, Michael B
IPC分类号： G01J3/28 , G01N21/77
CPC分类号： G01N21/7743 , G01J3/2803
摘要： A typical use of linear or two dimensional spectrometers is to expose the detector area (102) , and then shift the photo-electric charges out of the device in a serial fashion. If the illuminating signal (118) is spatially narrow relative to the size of the array, this will drive down the percent of the detector that is utilized, as only a relatively small number of pixels are used to detect the beam. The present invention proposes a method which capitalizes on this spatial under-utilization, and alters the clocking scheme to maximize the read-out speed of the pixels containing signal information. This type of clocking scheme raises the optical power saturation level of the spectrometer. Such an improvement in optical power handling is beneficial for spectrometer based detection of resonant waveguide grating biochemical binding, since in such systems the performance is frequently limited by spectrometer saturation.
摘要翻译：线性或二维光谱仪的典型用途是暴露检测器区域（102），然后将光电荷以串联方式移出设备。如果照明信号（118）相对于阵列的尺寸在空间上窄，则这将驱动所使用的检测器的百分比，因为仅使用相对较少数量的像素来检测光束。本发明提出了一种利用该空间利用不足的方法，并且改变了时钟方案以使包含信号信息的像素的读出速度最大化。这种类型的时钟方案提高了光谱仪的光功率饱和水平。光功率处理的这种改进对于谐振波导光栅生化结合的基于光谱仪的检测是有利的，因为在这样的系统中，性能常常受到光谱仪饱和度的限制。

42. 发明申请

WO2007002865A1 FINING OF BOROALUMINO SILICATE GLASSES 审中-公开
标题翻译：金刚石硅酸盐玻璃的修整
公开(公告)号：WO2007002865A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/025464
申请日：2006-06-28
申请人： CORNING INCORPORATED , ELLISON, Adam, J.
发明人： ELLISON, Adam, J.
IPC分类号： C03C3/091 , C03B17/00 , C03B17/06 , C03B5/08
CPC分类号： C03C3/091 , C03B17/06 , C03C1/004
摘要： Glasses are disclosed which can be used to produce substrates for flat panel display devices, e.g., active matrix liquid crystal displays (AMLCDs). The glasses have MgO concentrations in the range from 1.0 mole percent to 3.0 mole percent and Σ[RO]/[Al 2 O 3 ] ratios greater than or equal to 1.00, where [Al 2 O 3 ] is the mole percent of Al 2 O 3 and Σ[RO] equals the sum of the mole percents of MgO, CaO, SrO, and BaO. These compositional characteristics have been found to improve the melting properties of batch materials used to produce the glass, which, in turn, allows the glasses to be fined (refined) with more environmentally friendly fining agents, e.g., tin as opposed to arsenic and/or antimony.
摘要翻译：公开了可用于制造平板显示装置的基板的玻璃，例如有源矩阵液晶显示器（AMLCD）。玻璃具有在1.0摩尔％至3.0摩尔％范围内的MgO浓度和大于或等于1.00的S [RO] / [Al 2 O 3 O 3]比例，其中[Al 2 O 3]是Al 2 O 3 3的摩尔百分数，S [RO]等于 MgO，CaO，SrO和BaO的摩尔百分数之和。已经发现这些组合特征提高了用于生产玻璃的批料的熔化性能，这又使玻璃用更环保的澄清剂（例如锡）与砷和/ 或锑。

43. 发明申请

WO2006107506A2 SYSTEM AND METHOD FOR PERFORMING G PROTEIN COUPLED RECEPTOR (GPCR) CELL ASSAYS USING WAVEGUIDE-GRATING SENSORS 审中-公开
标题翻译：使用波导光栅传感器进行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：WO2006107506A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/008582
申请日：2006-03-10
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H. , YUEN, Po Ki , LAHIRI, Joydeep
发明人： FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H. , YUEN, Po Ki , LAHIRI, Joydeep
IPC分类号： G01N33/543 , G01N21/77 , G01N33/68
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器来实时监测活细胞内激动剂诱导的GPCR信号传导事件的系统和方法。具体而言，本发明包括使用光学LID生物传感器基于由激动剂诱导的GPCR激活引起的质量重新分布来筛选针对活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自引用光学LID生物传感器以消除对周围温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在另一个扩展的实施方案中，本发明公开了用于在单一介质溶液内的多种类型的细胞中筛选单一类型的细胞中的多种GPCR或多种GPCR的不同方式。在另一个扩展的实施方案中，本发明公开了确认化合物针对活细胞内特定GPCR的生理学或药理学作用的不同方法。

44. 发明申请

WO2006088799A1 SINGLE MODE (SM) FIBER OPTICAL READER SYSTEM AND METHOD FOR INTERROGATING RESONANT WAVEGUIDE-GRATING SENSOR(S) 审中-公开
标题翻译：单模（SM）光纤读取器系统和谐波波导光栅传感器的混合方法（S）
公开(公告)号：WO2006088799A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/005046
申请日：2006-02-13
申请人： CORNING INCORPORATED , GOLLIER, Jacques , PIECH, Garrett A
发明人： GOLLIER, Jacques , PIECH, Garrett A
IPC分类号： G01N21/47 , G01N21/77
CPC分类号： G01N21/7743
摘要： An optical reader system is described herein which has a single mode (SM) optical fiber launch/receive system that uses one or more SM optical fibers to interrogate a biosensor and does not use multimode (MM) optical fibers to interrogate the biosensor. The use of the SM optical fiber launch/receive system effectively reduces angular sensitivity, reduces unwanted system reflections, improves overall angular tolerance, and improves resonant peak reflectivity and resonant peak width. Two specific embodiments of the SM optical fiber launch/receive system are described herein which include: (1) a dual fiber collimator launch/receive system; and (2) a single fiber launch/receive system that interrogates the biosensor at a normal incidence.
摘要翻译：本文描述了一种光学读取器系统，其具有使用一个或多个SM光纤询问生物传感器并且不使用多模（MM）光纤来询问生物传感器的单模（SM）光纤发射/接收系统。使用SM光纤发射/接收系统有效地降低了角度灵敏度，减少了不必要的系统反射，提高了整体角度公差，并且提高了谐振峰值反射率和谐振峰值宽度。本文描述了SM光纤发射/接收系统的两个具体实施例，其包括：（1）双光纤准直器发射/接收系统; 和（2）以正常入射方式询问生物传感器的单纤维发射/接收系统。

45. 发明申请

WO2006072043A2 LABEL-INDEPENDENT DETECTION OF UNPURIFIED ANALYTES 审中-公开
标题翻译：不标记分析的标签独立检测
公开(公告)号：WO2006072043A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/047564
申请日：2005-12-29
申请人： CORNING INCORPORATED , AKLIAN, Mannix, V.
发明人： AKLIAN, Mannix, V.
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00
摘要： The present invention features use of evanescent field sensing to detect or evaluate unpurified, unlabeled analytes in raw samples. Capture molecules capable of binding to an analyte of interest can be immobilized to a sensing surface of an evanescent field sensor. The interaction between the analyte of interest in a raw sample and the immobilized capture molecules alters the refractive index at the sensing surface, thereby producing a detectable signal in the reflected light from the surface. Raw samples amenable to the present invention include, but are not limited to, cell lysates, tissue extracts, bodily fluid, or biologically-derived samples. Evanescent field sensors suitable for the present invention include, but are not limited to, grating-coupled waveguides.
摘要翻译：本发明的特征在于使用瞬逝场感测来检测或评估原始样品中未纯化的未标记分析物。能够结合感兴趣分析物的捕获分子可以被固定到瞬逝场传感器的感测表面。原始样品中感兴趣的分析物与固定的捕获分子之间的相互作用改变了感测表面处的折射率，由此在来自表面的反射光中产生可检测信号。适用于本发明的原始样品包括但不限于细胞裂解物，组织提取物，体液或生物衍生样品。适用于本发明的消逝场传感器包括但不限于光栅耦合波导。

46. 发明申请

WO2006019836A1 CULTURE FLASK 审中-公开
标题翻译：文化大厦
公开(公告)号：WO2006019836A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/024887
申请日：2005-07-15
申请人： CORNING INCORPORATED , CATTADORIS, Henry, J.
发明人： CATTADORIS, Henry, J.
IPC分类号： C12M1/24
CPC分类号： C12M23/08 , B01L3/502 , C12M23/00
摘要： The present invention provides a flask having a top piece (20) and a bottom piece (22) with optical properties on the interior surface (24) of which cells are grown. The top piece (20) and the bottom piece (22) are joined by a removable elastomeric seal (26). By disengaging the elastomeric seal (26) from the flask body (12), the top piece (20) can be separated from the bottom piece (22) providing access to the flask interior.
摘要翻译：本发明提供一种烧瓶，其具有在细胞生长的内表面（24）上具有光学性质的顶部件（20）和底部件（22）。顶部件（20）和底部件（22）通过可拆卸的弹性密封件（26）连接。通过使弹性密封件（26）与烧瓶主体（12）脱离接合，顶部件（20）可与底部件（22）分开，从而提供通向烧瓶内部的通路。

47. 发明申请

WO2005092740A1 METHOD AND APPARATUS FOR PACKAGING GLASS SUBSTRATES 审中-公开
标题翻译：包装玻璃基板的方法和装置
公开(公告)号：WO2005092740A1
公开(公告)日：2005-10-06
申请号：PCT/US2005/006182
申请日：2005-02-25
申请人： CORNING INCORPORATED , COPPOLA, Frank T , MASHEWSKE, Monica J , TAMMARO, David A , SHI, Youchun
发明人： COPPOLA, Frank T , MASHEWSKE, Monica J , TAMMARO, David A , SHI, Youchun
IPC分类号： B65D85/48
CPC分类号： B65D85/48
摘要： Packages (11) of glass substrates (13) are provided in which the surfaces of the substrates are coated with a water-removable protective coating and then sealed in an air sealing container (19), e.g., a polymer bag or a polymer wrapping, having an internal volume which is vacuumed, filled with an inert atmosphere, or filled with humidity-controlled air prior to sealing. In this way, the substrates can be stored for at least 6 months in an ambient environment having a relative humidity of 90 percent at 50°C without substantial degradation of the protective coating.
摘要翻译：提供玻璃基板（13）的包装（11），其中基材的表面涂覆有可水分去除的保护涂层，然后密封在例如聚合物袋或聚合物包装的空气密封容器（19）中，具有抽真空的内部容积，填充惰性气氛，或在密封之前填充有湿度控制的空气。以这种方式，可以在50℃的相对湿度为90％的环境环境中将基材储存至少6个月，而不会显着降解保护涂层。

48. 发明申请

WO2005015185A1 SUBSTRATE INDEX MODIFICATION FOR INCREASING THE SENSITIVITY OF GRATING-COUPLED WAVEGUIDES 审中-公开
标题翻译：用于提高镀层耦合波长的灵敏度的基板指标修改
公开(公告)号：WO2005015185A1
公开(公告)日：2005-02-17
申请号：PCT/US2004/020673
申请日：2004-06-25
申请人： CORNING INCORPORATED , CARRACCI, Stephen J , MOZDY, Eric J , DESPA, Mircea , SALIK, Mark D
发明人： CARRACCI, Stephen J , MOZDY, Eric J , DESPA, Mircea , SALIK, Mark D
IPC分类号： G01N21/77
CPC分类号： G01N21/7743
摘要： A grating-coupled waveguide (100) and a method are described herein that can be used to detect the presence of a biological substance (e.g., cell, drug, chemical compound) in a sensing region of the Grating-Coupled Waveguide. The Grating-Coupled Waveguide includes a substrate (112), a diffraction grating (108) and a waveguide film (106) that has a higher index of refraction than the substrate which has an index of refraction ? 1.5. The relatively low-index substrate effectively increases the sensitivity of the Grating-Coupled Waveguide by causing the waveguide mode to shift towards a biological substance located in a sensing region above the waveguide film, thereby increasing the field strength of the mode's evanescent tail in this region. In one embodiment, an array of the Grating-Coupled Waveguides are incorporated within the wells of a microplate.
摘要翻译：本文描述了光栅耦合波导（100）和方法，其可用于检测光栅耦合波导的感测区域中生物物质（例如细胞，药物，化合物）的存在。光栅耦合波导包括具有比具有折射率<1.5的衬底更高的折射率的衬底（112），衍射光栅（108）和波导膜（106）。相对低折射率的衬底通过使波导模式朝向位于波导膜上方的感测区域中的生物物质移动，从而有效地增加了光栅耦合波导的灵敏度，从而增加了该区域中模式的渐逝尾部的场强。在一个实施例中，将光栅耦合波导的阵列并入微孔板的孔内。

49. 发明申请

WO2004042764A2 SEALING LIGHTING DEVICE COMPONENT ASSEMBLY WITH SOLDER GLASS PREFORM BY USING INDUCTION HEATING 审中-公开
标题翻译：使用电感加热密封灯具组件与焊接玻璃预制件
公开(公告)号：WO2004042764A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/033494
申请日：2003-10-21
申请人： CORNING INCORPORATED
发明人： COOPER, Timothy, J. , SHAH, Kashyap, H.
IPC分类号： H01J9/00
CPC分类号： C03C3/091 , C03C8/24 , C03C27/044 , H01J9/323
摘要： Disclosed is a process for sealing component assembly to an electrical lighting device using induction heating. The assembly comprises the component, such as an electrode lead wire, and a solder glass perform. The process is useful, for example, in hermetically sealing and affixing lamp components, such as electrical lead wires and exhaust tubulation, to a low-pressure fluorescent discharge lamp envelope having phosphor coating already applied thereto. The present invention is particularly suitable for lamp envelopes made of borosilicate glass having a CTE from 0 to 300°C in the range of 30-45x10-7 °C-1.
摘要翻译：公开了使用感应加热将部件组件密封到电照明装置的方法。组件包括诸如电极引线和焊料玻璃的部件。该方法例如在对已经施加有荧光体涂层的低压荧光放电灯外壳进行气密密封和固定诸如电引线和排气管的组件中是有用的。本发明特别适合于具有0至300℃的CTE在30-45×10-7℃-1范围内的硼硅玻璃制成的灯罩。

50. 发明申请

WO2003082755A1 PULLING ROLLS FOR USE IN MANUFACTURING SHEET GLASS 审中-公开
标题翻译：拉丝辊用于制造板玻璃
公开(公告)号：WO2003082755A1
公开(公告)日：2003-10-09
申请号：PCT/US2003/007080
申请日：2003-03-10
申请人： CORNING INCORPORATED
发明人： KAISER, David S , MALDONADO, Jaime
IPC分类号： C03B35/18
CPC分类号： F27D3/026 , C03B17/068 , C03B35/18 , C03B35/185 , C03B35/189 , F27B9/28 , F27D2003/0067 , Y10T29/49549 , Y10T29/49554 , Y10T29/49556
摘要： Pulling rolls (13) for glass ribbons (11) and methods for manufacturing such rolls are provided. The rolls include a shaft (17), a plurality of heat-resistant discs (15) mounted on the shaft in face-to-face contact, and a pair of fittings (25 or 25,31) affixed to the shaft which apply an axial compressive force to the discs. The magnitude of the axial compressive force is adjust so that the portions (27) of the roll surface (33) which contact the glass ribbon during use have a Shore D hardness at room temperature of between 30 and 55. The rolls achieve a long service life without applying excessive force to the glass ribbon or generating high levels of particulate contamination.
摘要翻译：提供了用于玻璃带（11）的拉丝辊（13）和用于制造这种辊子的方法。辊包括轴（17），以面对面接触安装在轴上的多个耐热盘（15）和固定在轴上的一对配件（25或25,31）对盘的轴向压缩力。调整轴向压缩力的大小，使得在使用过程中与玻璃带接触的辊表面（33）的部分（27）在室温下在30和55之间具有肖氏D硬度。辊实现长期使用而不会对玻璃带施加过大的压力或产生高水平的微粒污染。

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